Brenner Tumor

Published on 10/03/2015 by admin

Filed under Obstetrics & Gynecology

Last modified 22/04/2025

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Brenner Tumor

Synonyms/Description

Transitional cell tumor of the ovary
Typically asymptomatic, rare, benign ovarian tumor

Etiology

These tumors account for approximately 3.2% of ovarian epithelial neoplasms and typically occur in the fourth to sixth decades of life. They belong to the combined surface epithelial-stromal group of tumors, although they have been described as having similar histologic appearance to transitional cell tumors of the urothelium.

Ultrasound Findings

These masses are typically solid, hypoechoic, frequently contain some calcifications, and have minimal detectable color Doppler flow. Approximately 25% of the time, there is a cystic component indicating the possible presence of a co-existent cystic epithelial neoplasm, such as a serous or mucinous cystadenoma. These cystic components can have solid papillations, and they may be malignant (about 15% of cases).

Differential Diagnosis

Most Brenner tumors appear similar sonographically to other solid ovarian masses such as fibromas-thecomas, and can be mistaken for pedunculated fibroids. Those with complex cystic components are indistinguishable from serous and mucinous cystadenoma/cystadenocarcinoma, or endometrioid carcinoma.

Clinical Aspects and Recommendations

These are rare ovarian masses that are typically asymptomatic. Management depends on the type of mass, which can be benign, proliferative, or (rarely) malignant. If intervention is indicated, surgical management is undertaken.

Figures

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Figure B4-1 A 1- to 10-cm Brenner tumor masquerading as a pedunculated fibroid. Note the heterogeneous texture of the tumor with linear shadows similar to fibromas.

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Figure B4-2 Longitudinal view of a Brenner tumor with extensive calcification and shadowing.

Suggested Reading

Athey P.A., Siegel M.F. Sonographic features of Brenner tumor of the ovary. J Ultrasound Med. 1987;6:367–372.

Dierickx I., Valentin L., Van Holsbeke C., Jacomen G., Lissoni A.A., Licameli A., Testa A., Bourne T., Timmerman D. Imaging in gynecological disease (7): clinical and ultrasound features of Brenner tumors of the ovary. Ultrasound Obstet Gynecol. 2012;40:706–713.

Green G.E., Mortele K.J., Glickman J.N., Benson C.B. Brenner tumors of the ovary: sonographic and computed tomographic imaging features. J Ultrasound Med. 2006;25:1245–1251.

Hermanns B., Faridi A., Rath W., Füzesi L., Schröder W. Differential diagnosis, prognostic factors, and clinical treatment of proliferative Brenner tumor of the ovary. Ultrastruct Pathol. 2000;24:191–196.

Hiroi H., Osuga Y., Tarumoto Y., Shimokama T., Yano T., Yokota H., Taketani Y. A case of estrogen-producing Brenner tumor with a stromal component as a potential source for estrogen. Oncology. 2002;63:201–204.

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