TRACHEAL, LARYNGEAL, AND OROPHARYNGEAL INJURIES

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CHAPTER 32 TRACHEAL, LARYNGEAL, AND OROPHARYNGEAL INJURIES

Structural mobility and elasticity are characteristics of the upper airway that make injury to these structures infrequent. Skeletal protection is also provided anteriorly by the mandible and sternum and posteriorly by the bony spinal column1 (Figure 1). Upper airway injuries are identified in only 0.03% of patients admitted to major trauma centers. These injuries are frequently lethal, which explains their higher reported occurrence in autopsy series.2,3 Penetrating mechanisms of injury are more common than blunt mechanisms of injury,1,2,4 the true incidence of which is unknown.1,5 Twenty-one percent of patients with upper airway injuries die within the first 2 hours after hospitalization.6 The diagnosis is often delayed in patients without immediate life-threatening upper airway trauma.6,7 Such delays often result in serious late complications.8,9 Limited experience in nonoperative and operative management of airway injuries has led to a wide variety of recommendations that may be considered under various clinical scenarios. For unstable, immediate life-threatening upper airway injuries, rapid airway control by any available means is essential for patient survival. Most authors agree that tracheal intubation through an open wound that communicates with the tracheobronchial tree is appropriate.1 Stable patients may benefit from bronchoscopic-guided tracheal intubation distal to the injury site, and blind endotracheal tube placement is almost always a poor choice for airway control.10 Airway injuries are always challenging to even the most experienced surgeon since traditional approaches to airway control are often contraindicated.

ANATOMY OF UPPER AIRWAY

Pharynx

Surgical Anatomy

The pharynx consists of the following elements:

image

Figure 2 Contents of the oropharynx.

(From Gray’s Anatomy, 39th ed. St. Louis, Churchill Livingstone/Mosby, 2004, figure 33.4, with permission.)

image

Figure 4 Posterior view of the laryngeal cartilages and ligaments.

(From Gray’s Anatomy, 39th ed. St. Louis, Churchill Livingstone/Mosby, 2004, figure 36.3, with permission.)

PHARYNGEAL INJURY

Diagnosis

The initial clinical scenario varies. Patients with nonlethal injuries commonly present with dysphagia and odynophagia. Patients with more severe injuries may present with aphonia, dyspnea, hemoptysis, and severe acute respiratory failure that may rapidly lead to asphyxia if not treated.16 Injuries to the esophagus and pharynx are difficult to diagnose and may be missed during the management of other immediate life-threatening injuries. Oral bleeding, drooling, and subcutaneous emphysema all suggest upper digestive tract or airway injury.16 When possible, careful examination of the oropharynx and hypopharynx should be performed at the bedside.

Lateral views of the neck and cervical CT scan may identify soft tissue air (Figures 5 and 6). A nonionic contrast-enhanced esophagram and/or esophagoscopy are indicated if injury is clinically suspected.17 Contrast leak may be revealed on esophagram (see Figure 5).

LARYNX

Surgical Anatomy

The larynx is a functional “valve” separating the trachea from the upper aero-digestive tract. It is primarily an organ of communication (the voice box), but also serves as an important regulator of respiration. The larynx is necessary for effective coughing and for creating Valsalva maneuvers. The larynx also prevents aspiration during swallowing.

The larynx is composed of the following elements:

image

Figure 7 Superior view of laryngeal cartilages together with cricothyroid, quadrangular, and related ligaments and membranes.

(From Gray’s Anatomy, 39th ed. St. Louis, Churchill Livingstone/Mosby, 2004, figure 36.7, with permission.)

Laryngeal Injury

Incidence

Laryngeal and cervical tracheal injuries account for less than 1% of trauma cases seen in most major trauma centers.2,17 These injuries are rare compared to the total number of injuries that occur to the head and neck area. Experience in managing laryngeal trauma is limited because of these small numbers. External laryngeal trauma occurs in 1/30,000 emergency room visits.18,19 The rare nature of laryngeal injuries is a consequence of multiple factors, including protection by the mandible and sternum, delayed or missed diagnoses of minor laryngeal injuries in major multitrauma victims, and patient mortality at the scene from airway loss and asphyxiation.20

Although rare, initial management of laryngeal injuries affects the immediate probability of patient survival and long-term quality of life. The larynx is a well-protected structure that is both anatomically and functionally complex. Blunt and penetrating laryngeal injuries may cause chronic problems with aspiration, phonation, and respiration.20

Diagnosis

Adherence to the essential principles of initial assessment delineated in the Advanced Trauma Life Support (ATLS)® Manual is recommended. The ABCs (airway, breathing, circulation), concomitant resuscitation of the trauma victim, and a thorough secondary survey are essential for optimal management of airway injuries.22 Early recognition of these injuries requires a high index of suspicion based on mechanism of injury and findings identified during cervical and chest examination. Clinical signs and symptoms may include stridor, acute respiratory distress, cervical tenderness, subcutaneous emphysema, and cervical hematoma when associated with major vascular injury.23 Hemoptysis suggests that an intralaryngeal laceration may be present.23 This is more common with penetrating injury, but also occurs from blunt laryngeal trauma with an associated laryngeal cartilage fracture.23 Diagnostic procedures such as direct laryngoscopy, fiber-optic bronchoscopy, and cervical helical, contrast-enhanced multidetector (16 slices minimum) computed tomography (CT) with angiography are all beneficial if the patient’s clinical condition permits performing these tests.17,24 A sample algorithm for the evaluation of patients with laryngeal injuries is described (Figure 8).

TRACHEA

Surgical Anatomy

The trachea is a cartilaginous and membranous tube. It extends from the lower part of the larynx, at the level of the sixth cervical vertebra, to the upper border of the fifth thoracic vertebra. There it divides into the two main stem bronchi. The trachea is an ellipsoid cylinder that is flattened posteriorly. The average adult trachea measures about 11 cm in length with a diameter that varies from 2 to 2.5 cm. The pediatric trachea is smaller, more deeply placed, and more mobile. Half of the trachea lies within the neck and half is intrathoracic. The anterior two thirds of the trachea are composed of 18 to 22 “U”-shaped cartilages. The membranous posterior wall of the trachea is in apposition with the anterior wall of the esophagus. The bifurcation of the mainstem bronchi forms the carina at approximately the fourth to fifth thoracic vertebrae. The trachea is supplied with blood by the inferior thyroid arteries. Similarly named veins form the thyroid venous plexus. Tracheal innervation is derived from the vagus nerves, the recurrent laryngeal nerves, and from the sympathetic chain. The recurrent laryngeal nerve lies within the tracheoesophageal groove formed by the close proximity of the lateral aspects of the trachea and the esophagus (Figures 9, 10, and 11).

image

Figure 9 Anatomy of the larynx, cervical, and upper thoracic trachea.

(Copyright 2001 Benjamin Cummings, an imprint of Addison Wesley Longman, Inc.)

image

Figure 10 The cartilages of the larynx, trachea, and bronchi: anterior aspect.

(From Gray’s Anatomy, 39th ed. St. Louis, Churchill Livingstone/Mosby, 2004, figure 63.12, with permission.)

Tracheal Injury

Incidence

Disruption of the tracheobronchial tree is a rare occurrence and most surgeons’ experience is limited. On average, one such case is seen per year in large trauma centers.25 Bertelsen and Howitz4 reviewed 1178 postmortem reports of trauma deaths and found 33 (2.8%) with tracheal and/or bronchial disruptions. Of these 33 cases, 27 were dead at the scene.4

Complete cervical transection is rarer still. The true incidence (and tracheobronchial injuries in general) is unknown.26,27 There have been a number of case reports and small series described in the literature; however, the extant surgical experience remains limited.26

Knowledge of emergency airway management is essential. Loss of the airway in this clinical circumstance can rapidly lead to serious complications and/or the patient’s demise.17,28

Mortality in those patients who do not have complete airway loss at the time of injury is due to the severity of associated injuries. Those patients who arrive alive to a trauma center with isolated tracheobronchial injuries, including complete transection, have a reasonable chance for survival if the trauma surgeon has mastered the skills required for managing a difficult airway.29

Beskin30 reported the first successful repair of a complete cervical transection after blunt trauma in 1957. Hood and Sloan31 in 1959 collected 18 cases of tracheobronchial injury in the world literature. Complete tracheal transection was “rarely found.” In a more recent series, Eckert et al.3 reported a total of 105 tracheobronchial injuries, of which 75 were from penetrating trauma and 30 from blunt trauma. Of these, only 24 patients survived the transfer from the scene of the accident to the trauma center. Of the 30 blunt trauma victims reported in this series, 18 were dead on arrival at the emergency department. The majority of those who arrived alive, regardless of the mechanism of injury, had no other associated injuries (15 of 24 [63%]), and the remainder had only one other associated injury, including esophageal injuries (9 of 24 [37%]).3 In the same series, the most commonly injured segment of the tracheobronchial tree in survivors was the cervical trachea (37%). The total number of complete tracheal transections in Ecker and associates’ series is unknown.

Kelly et al.6 reviewed 106 patients with tracheobronchial injuries of which only 6 had a blunt mechanism of injury.6 They concluded that a surgeon must adopt a rapid, aggressive surgical approach to these patients in order to prevent lethal outcomes.6

Mechanism of Injury

Diagnosis

A thorough physical examination and knowledge of the mechanism of injury are the first and most important steps in diagnosing a tracheobronchial injury. Clinical findings suggesting airway injury vary according to the mechanism of injury. Cicala et al.32 reviewed nine patients following stab wounds. A laceration directly communicating with the airway was present in five cases. Subcutaneous emphysema was apparent on physical examination and on lateral cervical spine radiograph in three cases. Only one patient had no obvious clinical or radiographic findings to suggest an airway injury. This patient had a small puncture laceration of the cricotracheal membrane which was diagnosed by bronchoscopy. The majority of patients presenting with gunshot wounds to the trachea will show physical or radiographic finding that suggest airway injury on a plain radiograph of the neck or chest.32 In the study by Cicala and colleagues,32 two patients with gunshot wounds to the cervicothoracic trachea developed tension pneumothorax with massive air leak during resuscitation. Two others had fractures of the thyroid cartilage without any airway compromise. One was diagnosed by direct palpation on physical examination. The other patient was diagnosed by cervical CT scan. Hemoptysis, in addition to other findings, was noted in two of the gunshot wound victims.32

Blunt trauma patients who survive to the emergency department may present with a wide spectrum of clinical signs and symptoms dependant on the severity and location of the injury to the cervical thoracic trachea. Blunt cervical tracheal injury may create severe respiratory compromise leading to rapid acute respiratory failure and asphyxia. Alternatively, patients with less severe injuries may present with stridor, hoarseness, hemoptysis, and subcutaneous emphysema.24,32

Plain radiographs of the neck and chest may be diagnostic. Subcutaneous emphysema in the neck and chest wall on plain radiographs or CT scan should prompt further evaluation if clinical suspicion favors a major airway injury.16,1012,32 Fiberoptic bronchoscopy is the first step in confirming a tracheal injury.27,33 Indications for bronchoscopy include a large pneumomediastinum, persistent pneumothorax, or a large, persistent air leak after placement of a functional thoracostomy tube; persistent atelectasis; and expanding severe subcutaneous emphysema.34 Bronchoscopy is the most accurate and reliable means to establish the diagnosis, determine the site and define the extent of the injury.35 Debate remains as to whether rigid or flexible bronchoscopy is superior in this setting. Disadvantages of rigid bronchoscopy include the need for a general anesthetic and a stable cervical spine. Flexible bronchoscopy does not require a general anesthetic, and may be used in patients whose cervical spine may be injured. Fiber-optic bronchoscopy is not only diagnostic, but may also be useful in establishing an airway with bronchoscopically guided endotracheal tube placement.36

Preoperative assessment of the vocal cords in this setting is strongly recommended. Direct laryngoscopy may be necessary to evaluate the function of the vocal cords. The presence of a recurrent laryngeal nerve injury causing vocal cord paralysis may assist the operating surgeon in determining whether tracheostomy is needed regardless of the location or extent of airway injury.37,38

SURGICAL MANAGEMENT

Surgical management includes appropriate nonoperative observation (by a trauma surgeon) as well as operative intervention. Initial airway management must be approached with caution. Patients who are spontaneously breathing and maintaining adequate oxygenation and ventilation should not be intubated unless their clinical condition deteriorates. Patients intubated prior to arrival in the emergency department should undergo flexible bronchoscopy as soon as possible. Careful intubation over a bronchoscope, performed by an experienced bronchoscopist, is the optimal approach for those patients who require early airway control for clinical deterioration or for treatment of other life-threatening injuries. Intubation is ideally performed in the operating room where emergent cricothyroidotomy or tracheostomy can be performed if necessary. The trauma surgeon must be prepared to extend the tracheostomy incision to a median sternotomy if the distal trachea retracts into the mediastinum. Clinical deterioration may still occur as positive pressure ventilation is applied if the injury is distal to the tracheostomy. High-frequency ventilation or low tidal volume ventilation with additional tube thoracostomies may be necessary.

Nonoperative Management

Small iatrogenic injuries from endotracheal intubation or from minimal blunt force trauma can often be safely observed. Most injuries from high energy blunt force trauma and all penetrating injuries are not generally considered for nonoperative management.

Gomez-Caro et al.39 recently reported the successful management of 17 patients with iatrogenic tracheobronchial injuries between 1993 and 2003. Many of these lesions were as large as 4 cm in length. The authors reported no complications or deaths directly caused by nonoperative management. Clinical and endoscopic follow-up in 14 of 17 patients was uneventful. Guidelines for nonoperative management include vital signs stability, no associated esophageal injury, no issues with mechanical ventilation or intubation (if necessary), no development of severe subcutaneous emphysema or mediastinal emphysema, and no signs of sepsis.39 Additional requirements for nonoperative management have been published.27 These include only small tracheobronchial lacerations, such as those with less than one-third of the circumference of the trachea, well-opposed edges, no significant tissue loss, no associated injuries, and no need for positive pressure ventilation. Intubation as well as tracheostomy should ideally be avoided. When necessary, endotracheal intubation with placement of the endotracheal tube balloon distal to the tear has been proposed by Marquette et al.40 This technique has been successfully used on three occasions by one of the authors (SN). Nonoperative management includes administering prophylactic antibiotics and proton pump inhibitors, very close observation, and close bronchoscopic follow-up.27 A sample algorithm is provided in Figure 12.

Operative Management

Patients diagnosed with a major tracheobronchial injury should always undergo surgery unless medical instability or severe associated injuries are significantly prohibitive.41,42 In those situations, all efforts are made to support and stabilize the patient while maintaining adequate oxygenation and ventilation. High-frequency ventilation may be helpful. Permissive hypercapnia using very low tidal volumes (less than 5 ml/kg) has also been successfully used.43

The majority of patients are optimally managed with early surgery. The site of injury dictates the operative approach. These injuries are often challenging to even the most experienced surgeon, and appropriate consultation with an otolaryngologist for high cervical injuries or a thoracic surgeon for more distal intrathoracic injuries may be helpful.

Most cervical injuries are approached through a transverse collar incision. This incision can be extended cephalad along the anterior border of either sternocleidomastoid muscle, depending on the location of the primary and any associated injuries. Penetrating cervical injuries can often be approached directly, incorporating the wound into the incision. This may be necessary to achieve early airway control.

Blunt cervical tracheal injuries are also approached through a transverse collar incision just above the sternal notch. The chest should always be prepped for median sternotomy. An upper median sternotomy is immediately performed if the distal trachea retracts into the chest. Do not necessarily expect to find the trachea in its usual midline position. We have experienced one case where the distal trachea, upon entry into the chest, retracted 10 cm below the sternal notch and 10 cm to the left of midline.

Most blunt intrathoracic tracheobronchial injuries occur within 2–3 cm of the carina. A right posterolateral thoracotomy through the fourth or fifth intercostal space provides the best exposure unless the injury is on the left more than 2–3 cm distal to the carina. In this situation, a left posterolateral thoracotomy through the fifth intercostal space is preferred.

Prior consultation with the anesthesiologist is crucial. A variety of endotracheal tubes, connectors, and ventilator tubing should be available on the operative table prior to opening the chest. Intubation over a bronchoscope in the operating room is best for optimal tube placement. Double-lumen tubes are beneficial for providing single-lung ventilation. However, their larger size may cause further damage and hinder the operative repair. Positioning the patient for thoracotomy and opening the chest may cause rapid deterioration from hypoxemia and hypoventilation. Opening the chest quickly with direct intubation of a major bronchus through the operative field may be necessary. The surgeon may also be able to direct the orotracheal tube from the upper trachea into the uninjured bronchus to provide one lung ventilation. If the anatomy of the injury is not completely known, two ventilators should be available in the operating room so that bilateral single lung ventilation can be provided if needed. The Univent® endobronchial blocker may also be helpful if there is active bleeding from one of the mainstem or segmental bronchi. This device incorporates an endotracheal tube with a maneuverable device that can be directed into and occlude a mainstem bronchus, an intermediate trunk, or a lobar bronchus.44

Repair of the trachea and bronchi requires optimal debridement of all devitalized tissue and primary end-to-end anastomosis. Either permanent or absorbable monofilament sutures are preferred. The authors prefer a running monofilament absorbable suture. All knots are tied external to the lumen to reduce the risk of granuloma formation. Management “pearls” are provided in Table 1.

Table 1 Management Pearls for Acute Laryngotracheal Trauma

Source: Mathisen DJ, Grillo H: Laryngotracheal trauma. Ann Thorac Surg 43(3):254–262, 1987.

MORBIDITY

Early Complications

In the early postinjury period following tracheal or laryngeal injury, loss of airway represents the greatest immediate threat. The need for definitive airway control is dictated by clinical signs of respiratory insufficiency such as dyspnea, tachypnea, hypoxemia, or massive hemoptysis. When laryngeal injury is suspected, care should be taken when passing the tube through the area of injury as partial tears can be converted into complete tears. Tension pneumothorax and massive subcutaneous emphysema may lead to mechanical ventilatory failure from mechanical constraints limiting pulmonary expansion. Endotracheal intubation can be attempted with extreme caution. When advancing the tube past the vocal cords care should be taken if tracheal injury is present or suspected. Nasotracheal intubation with a no. 7 or smaller cuffed endotracheal tube over a flexible bronchoscope has been proposed as one option in the stable patient.12,45 This should ideally be performed in the operating room or wherever conditions for performing an immediate surgical airway are optimal. Identification of the injury and strategically guided tube placement may be possible while minimizing iatrogenic trauma during intubation. This technique may be particularly useful in cases of nearcomplete or complete tracheal transection when suspected preoperatively to advance the tube into the distal tracheal segment.45 This maneuver must be performed by an experienced bronchoscopist. Even in cases when complete tracheal transection has occurred, adequate ventilation and oxygenation may be achieved with intubation of only the proximal tracheal remnant provided that the paratracheal tissues of the neck and superior mediastinum are still intact. Caution should be taken in this setting at the time of operation or attempted surgical airway control when entering this space from a cervical incision; rapid ventilatory failure and cardiopulmonary collapse can occur when this air space is entered and this distal tracheal segment has not been secured with an airway.26,46 The distal tracheal segment may retract back into the superior mediastinum and be difficult to access from a cervical incision. This may be prevented by performing a sternotomy prior to entering the pretracheal space when complete tracheal transection is suspected preoperatively.26

Tension pneumothorax can lead to rapid cardiopulmonary collapse if not quickly recognized and treated. While temporary improvement may be achieved, needle thoracostomy should be reserved for patients with impending cardiopulmonary collapse in the prehospital or emergency department setting. Immediate placement of one or more tube thoracostomies is the ideal treatment and may be life-saving. Patients with tracheobronchial injuries may develop a large air leak following pleural space drainage. In addition to increasing the negative pressure suction applied to the pleural space, advanced ventilatory strategies may be required to improve gas exchange. Low tidal volume ventilation, high-frequency jet ventilation, and highfrequency oscillatory ventilation have all been used with success to reduce peak airway pressure, increase mean airway pressure, reduce air leak, and promote healing at the site of injury.43,47,48

Pneumomediastinum may occur following tracheobronchial injury. Although hemodynamic compromise has been reported from air under pressure in the mediastinum, this appears to be unusual.35,49 Treatment is directed toward the underlying injury and resolution following injury repair, and recovery is the rule.

Subcutaneous emphysema can be massive, spreading to all areas of the body very quickly. Although treatment with multiple incisions or drains has been advocated,50,51 the emphysema itself has no direct adverse sequelae and is usually self-limiting.

Massive bleeding into the airways suggests an associated major vascular injury. Initial treatment should be directed at identification and control of hemorrhage from this injury. Large volumes of bloodshed into the airway can lead to airway obstruction and profound hypoxemia from impaired gas exchange. Following definitive airway control the endotracheal cuff should be advanced beyond the site of bleeding into the airway if possible. Bronchoscopic lavage of retained blood and clots may be of further benefit in clearing retained hemorrhage and improving hypoxemia.

Associated injuries are common and account for a substantial portion of early morbidity. A high index of suspicion for these injuries is maintained throughout early evaluation. Patient management based on ATLS® guidelines will minimize associated morbidity.52

Late Complications

Late complications following tracheal injury are often related to the integrity of the area of injury or site of surgical repair.

The incidence of tracheobronchial stenosis following injury is 3.8%–9.3% following surgical repair.41,53 Stenosis may also occur when nonoperative management of a tracheal or bronchial tear is attempted.43 Initial measures to reduce inflammation include corticosteroid therapy and proton pump inhibitors or H2 blockers to reduce aspiration of acidic gastric contents. Steroid therapy is controversial. The risks of immunosuppression and compromised wound healing must be compared to the benefits of reduced scarring and stenosis.54,55 Steroids may be beneficial during nonoperative management to reduce stenosis from hypertrophic granulation tissue, but there are currently no large studies to refute or support this therapy. Factors associated with a higher incidence of tracheal stenosis include degree of tracheal injury and increased time to operative repair.56 Others have not found increased stenosis rates when operative repair is delayed.41,57 Timing of operative repair is determined by associated injuries and overall physiologic status. Surgical repair should proceed as soon as possible to reduce this potential complication. Good surgical technique can reduce postoperative tracheal stenosis. Complete debridement of devitalized tissue, wide mobilization to reduce anastomotic tension and possibly the use of absorbable sutures are principles that may reduce inflammation and enhance normal healing repair site. Vascularized pedicles of muscle, usually the sternocleidomastoid or the strap muscles, sewn as a buttress to the anastomotic site have been shown to reduce the rate of anastomotic dehiscence, leak, and subsequent fistula formation.41 Tracheal stenosis is suspected when stridor, dyspnea, or air hunger develop following tracheal repair or injury.54 Usually the history is one of worsening progression over several days to weeks. Voice changes may occur simultaneously. Other symptoms may include postobstructive atelectasis or pulmonary sepsis, particularly following bronchial or distal segment repairs.57

Flexible or rigid bronchoscopy provides an accurate diagnosis and an opportunity for simultaneous treatment. Modern multidetector CT scanners are also highly sensitive and specific for diagnosing tracheobronchial pathology.58,59 Anatomic detail with three-dimensional reconstruction is very useful in planning operative or interventional repair. Treatment options include (1) endoscopic dilatation with steroid therapy60; (2) silicone, metal, or Teflon stent placement61,62; (3) Nd-Yag laser ablation of scar tissue63; or (4) open surgical repair. All of these treatments have been individually successful, and the therapeutic approach in any given patient must be individualized based on the extent of stenosis, severity of comorbid conditions and the experience and resources of each surgeon and facility. Many different open surgical techniques have been described but general principles should include resection and debridement of tracheal scar with tracheal mobilization and primary end-to-end anastomosis with absorbable suture.

Tracheoesophageal fistula may occur following a delay in diagnosis and/or treatment of esophageal and/or tracheal injuries. A high index of suspicion for esophageal or tracheal injury must be maintained whenever the other is identified, and thorough evaluation with bronchoscopy, esophagoscopy, or esophagography is usually required. Careful and thorough intraoperative evaluation at surgery is mandatory. Full mobilization of the cervical esophagus and intraluminal instillation of methylene blue have been advocated to avoid missing a subtle esophageal tear. Following identification of a late tracheoesophageal fistula, delayed repair is planned following medical stabilization, treatment of aspiration pneumonitis or pneumonia, and gastrostomy tube placement. Repair consists of wide esophageal and tracheal mobilization, debridement to healthy tissue, and primary end-to-end anastomosis. Transposition of a vascularized pedicle of muscle between the areas of repair to be dictated by the anatomic location of the fistula is mandatory to reduce anastomotic dehiscence and recurrent fistula formation.41

Voice changes such as dysphonia and laryngeal stenosis can occur following laryngeal injury when architectural relationships within the voice box are altered by healing. Poor outcomes are associated with injuries that create significant mucosal disruption, arytenoid dislocation, or exposed cartilage. One series reported an association between delays in operative repair beyond 24 hours and increased rates of airway stenosis ranging from 13%–31%.64 Laryngeal stenting, particularly when one or both vocal cords are mobile, helps preserve the voice by normalizing the shape of the anterior commissure. Stents should be removed as soon as possible (usually 10–14 days) because of the risk of compromised mucosal perfusion with prolonged usage.65

Vocal cord paralysis from recurrent laryngeal nerve injury may be unilateral or bilateral following tracheal or laryngeal injuries. Cricotracheal separation carries a 60% risk of recurrent nerve injury, which is often bilateral.55 Resolution of neurapraxia and nerve regeneration may occur up to 1 year following injury, resulting in resolution of vocal cord paralysis in some cases.

Laryngeal webs, granulomas, and hypertrophic granulation can develop several months following laryngeal trauma. Follow-up endoscopy with laser ablation can prevent chronic problems from these less serious complications.64

Other Potentially Life-Threatening Complications

Pharyngeal injuries can lead to serious complications particularly when the diagnosis is delayed. Retropharyngeal abscess is uncommon but potentially life threatening if upper airway obstruction or mediastinitis develops.66 A short course of prophylactic antibiotics may reduce the risk of this complication. The diagnosis is usually apparent upon inspection of the oropharynx and palatine tonsils. Retropharyngeal air may be present on lateral cervical radiograph. If present, further evaluation should include cervical and mediastinal CT scan. Surgical drainage of the abscess and broad spectrum intravenous antibiotics are indicated. Surgical intensive care unit admission and possible intubation may be necessary in severe cases.67

Injury to the internal carotid artery should also be considered whenever an impalement injury of the posterior pharynx is diagnosed. Asymptomatic dissection of the internal carotid artery followed by arterial occlusion or embolization to the cerebral vasculature may develop over several hours to days resulting in severe neurologic deficits. Therefore, a high index of suspicion and screening with angiography should be performed when clinical presentation suggests this possibility.67 CT angiography (CTA) has improved in recent years with the multidetector scanners. Experience suggests that CTA may be a good screening tool to identify these injuries.6870 Anticoagulation to prevent propagation and occlusion of the dissection is standard therapy, but experience with carotid stents is growing. Carotid stenting may be an alternative in selected cases. Surgical repair of the internal carotid artery is usually impossible due to the distal location of most lesions.70

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