Chapter 3 The body cavities and the diaphragm
The embryo takes on a three-dimensional shape during the fourth week when the edges of the embryonic disc are brought to the ventral surface of the embryo by lateral and longitudinal folding. Folding of the embryo results in the formation of the gut tube and converts the intra-embryonic coelom into a closed cavity. The process of folding is described in Chapter 1.
The body cavities arise from the three parts of the coelomic cavity, and become the future pericardial, pleural and peritoneal cavities. Delicate serous membranes, derived from the lateral plate mesoderm, line the walls of those cavities and cover the organs. The main function of the body cavities is to provide space for development, expansion and movement of organs such as heart, lungs and liver. The body cavities are lined by two serous layers: the somatic mesoderm, which is in contact with the ectoderm, and the splanchnic mesoderm which adheres to the endoderm (see Fig. 1.10C). The term ‘somatic’ refers to the body wall; therefore the somatic mesoderm will give rise to the parietal layer of the serous membranes. The term ‘splanchnic’ is used for organs, and the splanchnic mesoderm will form the visceral layer of serous membranes.
Septum transversum and intra-embryonic coelom
Before folding
The septum transversum is a sheet of mesoderm that appears on day 22 rostral to the developing heart (Fig. 3.1). Before folding, the intra-embryonic coelom appears as a horseshoe- or U-shaped cavity (Fig. 3.2). The bend of the U lies anteriorly, and represents the part of the coelomic cavity from which the pericardial cavity will develop. Each limb of the U consists of two cavities: (1) a pericardioperitoneal canal, from which the pleural cavity will develop, and (2) a peritoneal cavity which lies in the future abdomen. In the umbilical region, the peritoneal cavities in each limb open into the chorionic cavity or the extra-embryonic coelom. This communication allows the herniation of midgut loops into the umbilical cord (see Chapter 7).
After folding
As a result of the enlarging head fold, the heart, with its pericardial cavity, swings ventral to the foregut. The septum transversum, initially cranial to the pericardial cavity, finally is wedged between the heart and the neck of the yolk sac. The pericardial cavity now opens into the paired pericardioperitoneal canals, which run on either side of the foregut to reach the peritoneal cavity. These canals end in two openings on the dorsolateral aspect of the foregut; therefore, at this stage the septum transversum is an incomplete partition between the thorax and abdomen (Fig. 3.3
