Role of Echocardiography in Patients Treated with Cardiotoxic Drugs

Published on 21/06/2015 by admin

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Last modified 21/06/2015

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8 Role of Echocardiography in Patients Treated with Cardiotoxic Drugs

Basic Principles

TABLE 8-1 COMMON CHEMOTHERAPY AND ANTI-CANCER AGENTS ASSOCIATED WITH SIGNIFICANT CARDIOTOXICITY

Type of Agent Potential Cardiac Complication
Anthracyclines  
Doxorubicin Early postinfusion, transient, often reversible decline in LVEF; arrhythmias, myopericarditis; more commonly, a decline in LVEF > 1 year after therapy
Tyrosine Kinase Inhibitors  
Trastuzumab Potentially reversible, significant decline in LVEF
Bevacizumab Hypertension, arterial thrombosis
Sunitinib Decline in LVEF, hypertension
Sorafenib Myocardial infarction, hypertension
Imatinib Diastolic dysfunction, pericardial effusion
Alkylating Agents  
Cisplatin Hypertension, vascular dysfunction
Cyclophosphamide Pericarditis/myocarditis, decline in LVEF with high doses
Antimetabolites  
5-Fluorouracil Coronary vasospasm, myocardial ischemia
Antimicrotubules  
Paclitaxel Arrhythmia, heart failure