Introduction

Fluoroscopy has become an invaluable tool for interventional pain procedures. Its use has allowed a significant improvement in correct needle placement. In addition, advanced procedures such as discograms and kyphoplasty would be impossible to perform effectively or safely without this imaging modality. Although fluoroscopy provides significant benefits in effectiveness and safety in performing injections, it is not without its own risks. Fluoroscopy relies on ionizing radiation, which is known to cause a number of deleterious effects. Other imaging modalities have been developed to address the shortcomings of fluoroscopy but have their own weaknesses. This chapter addresses radiation safety, the deleterious effects of radiation exposure with respect to the patient and practitioner, and alternative modalities.

Terminology

Any discussion of radiation safety requires a basic understanding of the nomenclature specific to this field. The literature is inconsistent in its use of units, with no standardization on using conventional or SI units. Fortunately, for the purposes of the clinician using fluoroscopy, many of these units can often be considered equivalent. Exposure is a quantity of radiation intensity. It is expressed in the conventional units of Roentgen (R) and the SI units of Coulomb/kg (C/kg). The energy absorbed from the exposure is described in conventional units as radiation absorbed dose (rad) and in SI units as Gray (Gy). Different types of radiation cause different biologic effects despite having similar absorbed doses. To predict the biologic effect from different types of radiation, rad is converted to radiation equivalent man (rem) or Sievert (Sv) in SI units. This conversion is accomplished by multiplying either rad or Gy by a quality factor unique to the type of radiation. As an example, whereas the quality factor for x-ray radiation is 1, it is 20 for α particle or fast neutron radiation.¹ This quality factor of 1 allows exposure, dose, and dose equivalent to be considered equal for practical purposes despite their different meanings and uses, so 1 R ≈ 1 rad ≈ 1 rem. Conversions between units are summarized in Table 11-1.

Radiation Physics

Radiation is energy transmitted as waves or particles. The radiation used in fluoroscopy is from a narrow band of the electromagnetic spectrum known as x-rays. X-rays are generated by passing a current (measured in milliamperes or mA) through a negatively charged heated filament (the cathode). The electrons that are produced are accelerated via high voltage (kilovolt peak or kVp) toward the positively charged anode. The energy released at the anode-electron interaction is X-radiation. The x-rays that pass through the body are captured either by film or an image intensifier to form an image that is useful for diagnostic purposes.

The image produced by the X-radiation can be altered by either modulating the current or voltage of the x-ray tube. A higher tube current (mA) will cause an increase in the number of electrons striking the anode and thus increase the number of x-rays produced. By increasing the voltage (kVp), the released electrons will have higher energy, and thus the X-radiation will have higher energy and penetrance. The amount of radiation reaching the image intensifier over a period of time is called the radiographic density; the higher the amount of radiation, the brighter the image appears on the fluoroscope monitor. In general, a 15% increase in kVp will have the same effect on radiographic density as doubling the mA.² Modern C-arms incorporate automatic brightness control (ABC) to optimize the brightness and contrast of the image. This is accomplished by automatic adjustment of mA and kVp.¹

Background radiation is unavoidable radiation from both natural sources as well as medical procedures. The average individual receives approximately 3.6 mSv/yr with 15% of this coming from medically necessary radiation when averaged across the population.² The amount of background radiation from natural sources varies according to region.³

Basics of C-Arm Design

X-radiation is produced in the x-ray tube and directed toward the image intensifier. The image intensifier is composed of two phosphor screens. The input phosphor is spherical, and in combination with the output phosphor, the x-ray image is amplified and converted to visible light, allowing a TV camera to then transmit the image to a screen distant from the image intensifier. Collimation is the process of restricting the x-ray beam to only the clinically important anatomic area. The two types of collimators are iris and adjustable. An adjustable collimator is composed of lead shutters that can be closed to create a rectangular field. An iris variable aperture collimator creates a smaller circular field of radiation. Both collimators reduce the radiation field that reaches the image intensifier and the overall dose to the patient. A basic anatomy of a typical C-arm can be seen in Fig. 11-1.

Fig. 11-1 Illustration of C-arm.

Two types of distortion can occur because of the construction of the image intensifier. Vignetting is the decreased spatial resolution and brightness at the periphery of the fluoroscopic image. The second is pincushion distortion, which is caused by the spherical construction of the input phosphor.² This creates a fisheye effect as signal from the spherical input phosphor is transmitted to the flat output phosphor. A visual description of this effect can be seen in Fig. 11-2. Both of these distortions can be avoided by placing the anatomic structure of interest in the center of the fluoroscopic image.

Fig. 11-2 Example of pincushion distortion.

Radiation Biology

Damage to the body from radiation occurs from direct cellular damage and indirect damage from creation of reactive oxygen species. Direct cellular damage is most likely to occur in cells that are in the G1 or M phases of the cell cycle. In the G1 stage, proteins are synthesized that prepare the cell for replication. During the M stage, DNA is packaged tightly into chromosomes, and there is an increased risk of a lethal double-strand DNA break.⁴ Not all radiation damage is lethal to the cell because complex mechanisms repair both single- and double-strand DNA breaks.⁵ The repair process is usually completed in 1 to 2 hours, so an increase in time between radiation doses causes an increase in cell survival.⁴

Indirect cellular damage is the result of hydrolysis of water, resulting in production of reactive oxidative species. Two-thirds of radiation-induced DNA damage is attributable to hydroxyl radicals.⁴ For example, a reactive oxygen species may combine with protein, resulting in the loss of important enzymatic activity in the cell.⁶ Antioxidants that can scavenge free radicals are therefore important in minimizing this type of damage. Molecules that have sulfhydryl groups and amine groups can scavenge these destructive entities.⁴

Damage Caused by Radiation

The effects of radiation on the body are divided into deterministic (nonstochastic) and probabilistic (stochastic). Deterministic effects are directly related to the dose received and exhibit a threshold below which the effect does not normally occur and above which the effect is dose dependent. Typically, these effects are related to cell death. An example is found in skin injury from exposure to radiation. An acute dose of 2 Gy causes early transient erythema, which occurs several hours after the dose and resolves within days.⁷ At an acute dose of 7 Gy, permanent epilation (loss of hair) occurs in about 3 weeks. Table 11-2 gives a more complete enumeration of deterministic effects.⁸ As described later in this chapter, many of the deterministic effects are not seen because of relatively low doses of radiation administered in the typical interventional pain fluoroscopy suite.

Table 11-2 Skin Entrance Dose Thresholds for Radiation-Induced Skin Injury

From Brown KR, Rzucidlo ER: Acute and chronic radiation injury, J Vasc Surg 53(suppl):15S-21S, 2011.