Chapter 64 Potential Drug Interactions in Physical Medicine
Potential interactions of 22 medications commonly prescribed in physical rehabilitation are based on two studies.1,2 Read the table from left to right. For example, the drug under column A interacts with the drugs under column B, C, D, E, and F. Consult a PDR for contraindications and associated complications. Also, note the FDA (2002)3 warning about the abrupt discontinuation of intrathecal baclofen; in rare cases, the practice has led to death.
1 Braverman SE, Howard RS, Bryant PR, et al. Potential drug interactions in a physical medicine and rehabilitation clinic. Am J Phys Med Rehabil. 1996;75(1):44-49.
2 Parrish RHII. Pharmacotherapy practice in a rehabilitation hospital. Hosp Pharm. 1995;30(9):783-785.
3 U.S. Food and Drug Administration. MedWatch 2002 safety alert—Lioresal (baclofen injection). Available at: http://www.fda.gov/medwatch/SAFETY/2002/safety02.htm#drugs. Accessed December 7, 2005
