Pharmacology – 1

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Last modified 23/05/2015

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43 Pharmacology – 1

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1. Chronic administration of agonists results in both receptor desensitization and down-regulation.
2. Antagonists bind with agonists and prevent them reaching the receptors.
3. The area under the curve is greater if the drug elimination is faster.
4. In zero-order kinetics the rate of elimination is directly proportional to the amount of drug remaining.
5. Second messengers are characteristic of ion-channel receptors.
6. Therapeutic index is the ratio of the maximum tolerated concentration and the minimum effective concentration.
7. The binding of two acetylcholine molecules at the two beta subunits of a nicotinic receptor-channel results in the opening of that channel.
8. Albumin has a low affinity for acidic drugs.
9. D-Cycloserine enhances the extinction of fear.
10. Dopamine neurons that innervate the nucleus accumbens have their cell bodies in the ventral tegmental area of the midbrain.
11. Lithium decreases dopaminergic effects in the CNS.
12. Bromocriptine decreases dopaminergic effects in the CNS.
13. D₁ and D₂ receptors belong to the same family.
14. Endorphins are implicated in the gate theory of pain.
15. Glutamate is an NMDA antagonist.
16. Melatonin has a narrow therapeutic index.
17. Nicotinic receptors control cation channels.
18. Nicotine improves cognitive performance in non-smokers.
19. Nicotinic receptors are ligand-gated.
20. Noradrenaline reuptake inhibitors increase the sensitivity of presynaptic α₂-receptors.
21. The QT interval is dependent on heart rate.
22. 5-HT_1A receptors are called 5-HT_B receptors.
23. Some serotonin receptors are metabotropic while others are ionotropic.
24. 5-HT₃ receptor is ionotropic.
25. Substance P antagonists reduce pain.