2 Overcoming medication errors in paediatric emergencies
Potential sources of medication errors
Doctors and nursing staff members who are not experienced in paediatric emergency medicine or the management of paediatric emergencies are especially at risk of making medication-related errors (see Table 2.1 for a breakdown of the types of errors that may lead to incorrect administration of a medication). Studies have shown that 10% to 15% of paediatric medication orders are erroneous, and that nearly one third of medication errors lead to harm in children. The potential for harm is higher in smaller children and infants and in the critically ill or injured, possibly because of the administration of multiple medications, limited time to double-check doses and altered pharmacokinetics and pharmacodynamics resulting from the physiological insults.
Type of error | Nature of error |
---|---|
Knowledge errors |
• Body weight not measured accurately.
• Inaccurate prediction method employed.
• Incorrect dose calculation – arithmetical errors.
• Incorrect dose dilution – wrong mass or volume of drug or diluent.
• Incorrect calculation of volume of dilution to administer.
• Incorrect volume administration.
• Incorrect weight type used for dose calculation – total body weight/lean body weight/ideal body weight (this has not yet been established in children).
• Inherent variability of drug content in manufacturer’s packaging (ampoule or vial). This is normally required to be within 10 to 15% of the stated mass of drug. For example, an ampoule of adrenaline 1 mg may contain anything between 0.9 mg and 1.15 mg of adrenaline. This consequently may lead to up to a 15% error in drug dose delivery.
• Complications related to drug preservatives, vehicles or diluents: the paucity of IV drug preparations designed for children has many unfortunate complications.