The immediate postanesthesia phase is when the patient is most vulnerable to complications (see Chapter 29).¹ Many drugs that have residual anesthetic effects well into the postanesthesia period are used in modern anesthesia care. These agents include the potent inhaled agents, muscle relaxants, benzodiazepines, and opioids. Respiratory depression is the most common adverse event in the postanesthesia care unit (PACU); therefore the use and understanding of the various opioid agents optimize patient outcomes. In addition, the reduction of pain in the PACU is one of the primary focuses of care in the perianesthesia phase. In addition to assessing pain, the perianesthesia nurse must take into the evaluation of pain the preoperative, intraoperative, and postanesthesia phase of the surgical patient. Because all pain-reducing drugs must be taken into account during the pain assessment in the PACU, the mixed action or agonist-antagonist combination drugs are presented in this chapter. With a detailed description of the major opioids used in the perianesthesia period provided, the PACU nurse will be able to make excellent informed decisions in regard to the anticipated outcome of the patient of pain reduction and comfort.

Concept of opioids and opioid receptors

Opioids are the substances, either natural or synthetic, that are administered into the body (exogenous) and bind to specific receptors to produce a morphine-like or opioid agonist effect. The endogenous opioids are the endorphins. The endorphins, which are produced in the body, attach to the opioid receptors in the central nervous system (CNS) to activate the body’s pain modulating system. The term opioid is used because of the multitude of synthetic drugs with morphine-like actions; with the advent of receptor physiology, opioid has replaced the term narcotic, which is derived from the Greek word for “stupor” and usually refers to both the production of the morphine-like effects and the physical dependence.²

The naturally occurring alkaloids of opium are divided into two classes: phenanthrene and benzylisoquinoline. The principal phenanthrene series of drugs includes morphine, codeine, and thebaine. Papaverine and noscapine, which lack opioid activity, represent the benzylisoquinoline alkaloids of opium.³

The synthetic opioids have been produced with the modification of the chemical structure of the phenanthrene class of drugs. Drugs such as fentanyl (Sublimaze) and meperidine (Demerol) are examples of synthetic opioids.²^,⁴

The identification of specific opioid receptors has enhanced the understanding of the agonist and antagonist actions of this category of drugs. The opioid receptors are located in the CNS, principally in the brain stem and spinal cord. These receptors have been determined by the pharmacologic effect they produce when stimulated by a specific agonist along with how the effect is blocked by a specific antagonist. The three major categories of opioid receptors are the mu (μ), delta (δ), and kappa (κ).⁴^,⁵

The mu receptors are mainly responsible for the production of supraspinal analgesia effects with stimulation. These receptors are further divided into mu-1 and mu-2 types. Activation of the mu-1 receptors results in analgesia; when the mu-2 receptors are stimulated, hypoventilation, bradycardia, physical dependence, euphoria, and ileus can result. The mu receptors are activated by morphine, fentanyl, and meperidine. The drug that is specific to the mu-1 receptor is meptazinol, which is supraspinal in regard to analgesia; the mu-2 receptor analgesia occurs at the spinal level. Other characteristics of the mu-1 and mu-2 receptors are summarized in Table 22-1. Stimulation of the kappa receptors results in spinal analgesia, dysphoria, hallucinations, hypertonia, tachycardia, tachypnea, mydriasis, sedation, and miosis, with little effect on ventilation. The drugs that possess both opioid agonist and antagonist activities, such as nalbuphine (Nubain), have their principal action on the kappa opioid receptors. The delta opioid receptors, when stimulated, serve to modulate the activity of the mu receptors and cause depression and urinary retention. The drug naloxone (Narcan) attaches to all the opioid receptors and thus serves as an antagonist to all the opioid agonists (see Table 22-1).²^,⁴

Table 22-1 Characteristics of Various Opioid Receptors

Opioids

Opioids, or narcotics, are used often in anesthesia practice. They are usually used in the nitrous-opioid (balanced) techniques, which involve the use of an opioid, nitrous oxide, and oxygen, with or without a muscle relaxant, and propofol for induction.

The effects of opioids generally last well into the PACU phase, and every perianesthesia nurse should have a good knowledge of the pharmacologic actions of each opioid that is administered to the patient in the perioperative phase of the surgical experience.

The administration of opioids in the perioperative period is not without the concern of overdose. The major signs of overdose with opioids are miosis, hypoventilation, and coma. If the patient becomes severely hypoxemic, mydriasis can occur. Airway obstruction is a strong possibility because the skeletal muscles become flaccid. Hypotension and seizures can also occur. The treatment for an opioid overdose is mechanical ventilation and the slow titration of naloxone. Consideration must always be given to the fact that some patients who become overdosed with an opioid may indeed be already physically dependent. Naloxone can precipitate an acute withdrawal syndrome.²

Meperidine hydrochloride

Meperidine (Demerol) was discovered in 1939 by Eisleb and Schauman. Because it is chemically similar to atropine, it was originally introduced as an antispasmodic agent and was not used as an opioid anesthetic agent until 1947. The main action of this drug is similar to morphine; it stimulates the subcortical mu receptors, which results in an analgesic effect. Meperidine is approximately one tenth as potent as morphine and has a duration of action of 2 to 4 hours. The onset of analgesia is prompt (10 minutes) after subcutaneous or intramuscular administration. All pain, especially visceral, gastrointestinal, and urinary tract, is satisfactorily relieved. This drug causes less biliary tract spasm than morphine; however, in comparison with codeine, meperidine causes greater biliary tract spasm. It produces some sleepiness but causes little euphoria or amnesia. Meperidine increases the sensitivity of the labyrinthine apparatus of the ear, which explains the dizziness, nausea, and vomiting that sometimes occur in ambulatory patients.²^,⁴

This opioid may slow the rate of respiration, but the rate generally returns to normal within 15 minutes after intravenous injection. The tidal volume is not changed appreciably. In equivalent analgesic doses, meperidine depresses respiration to a greater extent than does morphine. Some authors have noted that meperidine can release histamine from the tissues. Occasionally, urticarial wheals form over the veins where meperidine has been injected. The usual treatment is discontinuation of the use of meperidine and, if the reaction is severe, administration of diphenhydramine (Benadryl). Diphenhydramine further sedates the patient, however, and should be administered only if truly warranted.

Meperidine in therapeutic doses does not cause any significant untoward effects on the cardiovascular system. When this drug is administered intravenously, it usually causes a transient increase in heart rate. With intramuscular administration, no significant change in heart rate is observed. One of the major concerns with this drug is orthostatic hypotension, probably caused by meperidine’s interference with the compensatory sympathetic nervous system reflex. After administration of meperidine, a patient should be repositioned slowly in a “staged” approach to avoid any possibility of hypotension.

Meperidine is generally metabolized in the liver; less than 5% is excreted unchanged by the kidneys. However, because of a toxic metabolite of meperidine, patients who are administered this drug may have seizures.² Meperidine is partially metabolized to normeperidine which has some analgesic effects, but more importantly, lowers the seizure threshold and can induce CNS excitability. Meperidine probably should not be administered to elderly patients because renal dysfunction may occur and less tolerance to normeperidine.

Because of its spasmolytic effect, meperidine is the drug of choice for biliary duct, distal colon, and rectal surgery. It offers the advantages of little interference with the physiologic compensatory mechanisms, low toxicity, smooth and rapid recovery, prolonged postoperative analgesia, excellent cardiac stability in patients at poor risk, and ease of detoxification and excretion.²^,⁴^,⁵ Meperidine is used most often with procedures now, and not typically for long-term pain management because of the effects of normeperidine over time.

Fentanyl

Janssen and colleagues ⁸ introduced a series of highly potent meperidine derivatives that were found to render the patient free of pain without affecting certain areas in the CNS. Fentanyl (Sublimaze) appeared to be of special interest. In regard to analgesic properties, fentanyl is approximately 80- to 125-fold more potent as morphine and has a rapid onset of action of 5 to 6 minutes and a peak effect within 5 to 15 minutes. The analgesia lasts 20 to 40 minutes when administered intravenously. Via the intramuscular route, the onset of action is 7 to 15 minutes; the analgesia usually lasts 1 to 2 hours. When fentanyl is administered as a single bolus, 75% of the drug undergoes first-pass pulmonary uptake. That is, the lungs serve as a large storage site and this nonrespiratory function of the lung (see Chapter 12) limits the amount of fentanyl that actually reaches the systemic circulation. If the patient receives multiple doses of fentanyl via single injections or infusion, the first-pass pulmonary uptake mechanism becomes saturated and the patient has a prolonged emergence because of increased duration of the drug. Consequently, during the admission of the patient to the PACU, the postanesthesia nurse must determine the frequency and amount of intraoperative fentanyl administration. Patients who have received a significant amount of fentanyl via infusion or via titration should be continuously monitored for persistent or recurrent respiratory depression. In addition, fentanyl has been implicated in what is called a delayed-onset respiratory depression

Buy Membership for Critical Care Medicine Category to continue reading. Learn more here