Nuclear and cytoplasmic changes in leukocytes

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 0 (0 votes)

This article have been viewed 2247 times

14 Nuclear and cytoplasmic changes in leukocytes

Hyposegmentation of neutrophils

image

Figure 14–1A Hyposegmentation—peanut-shaped nucleus (PB ×1000).

image

Figure 14–1B Hyposegmentation—bilobed nucleus (PB ×1000).

image

Figure 14–1C Non-segmented nucleus (PB ×1000)

Description:

Peanut-shaped, bilobed or non-segmented, granulocyte nucleus with the coarse chromatin of a mature cell.

Associated with:

Pelger-Hüet anomaly, pseudo-Pelger-Hüet anomaly

Note:

Pelger-Hüet anomaly is inherited and affects the majority of granulocytes. Pseudo-Pelger–Hüet is acquired, affects less than 50% of granulocytes and is usually accompanied by other morphologic indications of malignancy such as seen in myeloproliferative or myelodysplastic disorders (see Chapters 17 and 18).

Hypersegmentation of neutrophils

image

Figure 14–2A Hypersegmented neutrophil (PB ×1000).

image

Figure 14–2B Hypersegmented neutrophil (PB ×1000).

Description:

Six or more lobes in granulocyte nucleus

Associated with:

Megaloblastic anemias; chronic infections; myelodysplastic syndrome; rarely inherited

Vacuolation

image

Figure 14–3A Vacuoles.

image

Figure 14–3B Vacuoles.

Description:

Unstained circular area within the cytoplasm.

Number:

Few to many

Associated with:

Bacterial or fungal infection, poisoning, burns, chemotherapy, artifact

Note:

Rarely may contain micro-organisms or pigment.

DÖHLE BODY

image

Figure 14–4A Döhle body.

image

Figure 14–4B Döhle body

Buy Membership for Hematology, Oncology and Palliative Medicine Category to continue reading. Learn more here

Related posts:

Variations in size and color of erythrocytes Introduction to peripheral blood smear examination Microorganisms Erythrocyte maturation Diseases affecting erythrocytes Variations in shape and distribution of erythrocytes