Nuclear and cytoplasmic changes in leukocytes

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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14 Nuclear and cytoplasmic changes in leukocytes

Hyposegmentation of neutrophils

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Figure 14–1A Hyposegmentation—peanut-shaped nucleus (PB ×1000).

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Figure 14–1B Hyposegmentation—bilobed nucleus (PB ×1000).

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Figure 14–1C Non-segmented nucleus (PB ×1000)

Description:

Peanut-shaped, bilobed or non-segmented, granulocyte nucleus with the coarse chromatin of a mature cell.

Associated with:

Pelger-Hüet anomaly, pseudo-Pelger-Hüet anomaly

Note:

Pelger-Hüet anomaly is inherited and affects the majority of granulocytes. Pseudo-Pelger–Hüet is acquired, affects less than 50% of granulocytes and is usually accompanied by other morphologic indications of malignancy such as seen in myeloproliferative or myelodysplastic disorders (see Chapters 17 and 18).

Hypersegmentation of neutrophils

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Figure 14–2A Hypersegmented neutrophil (PB ×1000).

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Figure 14–2B Hypersegmented neutrophil (PB ×1000).

Description:

Six or more lobes in granulocyte nucleus

Associated with:

Megaloblastic anemias; chronic infections; myelodysplastic syndrome; rarely inherited

Vacuolation

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Figure 14–3A Vacuoles.

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Figure 14–3B Vacuoles.

Description:

Unstained circular area within the cytoplasm.

Number:

Few to many

Associated with:

Bacterial or fungal infection, poisoning, burns, chemotherapy, artifact

Note:

Rarely may contain micro-organisms or pigment.

DÖHLE BODY

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Figure 14–4A Döhle body.

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Figure 14–4B Döhle body

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