Normal Labor, Delivery, and Postpartum Care

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Chapter 8 Normal Labor, Delivery, and Postpartum Care

ANATOMIC CONSIDERATIONS, OBSTETRIC ANALGESIA AND ANESTHESIA, AND RESUSCITATION OF THE NEWBORN

Labor is a process that permits a series of extensive physiologic changes in the mother to allow for the delivery of her fetus through the birth canal. It is defined as progressive cervical effacement and dilation resulting from regular uterine contractions that occur at least every 5 minutes and last 30 to 60 seconds.

The role of the obstetrician is to anticipate and manage abnormalities that may occur to either the maternal or the fetal process. When a decision is made to intervene, it must be considered carefully because each intervention carries not only potential benefits but also potential risks. In most cases, the best management may be close observation and, when necessary, cautious intervention.

image Anatomic Characteristics of the Fetal Head and Maternal Pelvis

Vaginal delivery necessitates the accommodation of the fetal head to the bony pelvis.

FETAL HEAD

The head is the largest and least compressible part of the fetus. Thus, from an obstetric viewpoint, it is the most important part, whether the presentation is cephalic or breech.

The fetal skull consists of a base and a vault (cranium). The base of the skull has large, ossified, firmly united, and noncompressible bones. This serves to protect the vital structures contained within the brain stem.

The cranium consists of the occipital bone posteriorly, two parietal bones bilaterally, and two frontal and temporal bones anteriorly. The cranial bones at birth are thin, weakly ossified, easily compressible, and interconnected only by membranes. These features allow them to overlap under pressure and to change shape to conform to the maternal pelvis, a process known as “molding.”

Sutures

The membrane-occupied spaces between the cranial bones are known as sutures. The sagittal suture lies between the parietal bones and extends in an anteroposterior direction between the fontanelles, dividing the head into right and left sides (Figure 8-1). The lambdoid suture extends from the posterior fontanelle laterally and serves to separate the occipital from the parietal bones. The coronal suture extends from the anterior fontanelle laterally and serves to separate the parietal and frontal bones. The frontal suture lies between the frontal bones and extends from the anterior fontanelle to the glabella (the prominence between the eyebrows).

Diameters

Several diameters of the fetal skull are important (see Figures 8-1 and 8-2). The anteroposterior diameter presenting to the maternal pelvis depends on the degree of flexion or extension of the head and is important because the various diameters differ in length. The following measurements are considered average for a term fetus:

The transverse diameters of the fetal skull are as follows:

The average circumference of the term fetal head, measured in the occipitofrontal plane, is 34.5 cm.

PELVIC ANATOMY

Bony Pelvis

The bony pelvis is made up of four bones: the sacrum, coccyx, and two innominates (composed of the ilium, ischium, and pubis). These are held together by the sacroiliac joints, the symphysis pubis, and the sacrococcygeal joint. The union of the pelvis and the vertebral column stabilizes the pelvis and allows weight to be transmitted to the lower extremities.

The sacrum consists of five fused vertebrae. The anterior-superior edge of the first sacral vertebra is called the promontory, which protrudes slightly into the cavity of the pelvis. The anterior surface of the sacrum is usually concave. It articulates with the ilium at its upper segment, with the coccyx at its lower segment, and with the sacrospinous and sacrotuberous ligaments laterally.

The coccyx is composed of three to five rudimentary vertebrae. It articulates with the sacrum, forming a joint, and occasionally the bones are fused.

The pelvis is divided into the false pelvis above and the true pelvis below the linea terminalis. The false pelvis is bordered by the lumbar vertebrae posteriorly, an iliac fossa bilaterally, and the abdominal wall anteriorly. Its only obstetric function is to support the pregnant uterus.

The true pelvis is a bony canal and is formed by the sacrum and coccyx posteriorly and by the ischium and pubis laterally and anteriorly. Its internal borders are solid and relatively immobile. The posterior wall is twice the length of the anterior wall. The true pelvis is the area of concern to the obstetrician because its dimensions are sometimes not adequate to permit passage of the fetus.

Pelvic Planes

The pelvis is divided into the following four planes for descriptive purposes:

These planes are imaginary, flat surfaces that extend across the pelvis at different levels. Except for the plane of greatest diameter, each plane is clinically significant.

The plane of the inlet is bordered by the pubic crest anteriorly, the iliopectineal line of the innominate bones laterally, and the promontory of the sacrum posteriorly. The fetal head enters the pelvis through this plane in the transverse position.

The plane of greatest diameter is the largest part of the pelvic cavity. It is bordered by the posterior midpoint of the pubis anteriorly, the upper part of the obturator foramina laterally, and the junction of the 2nd and 3rd sacral vertebrae posteriorly. The fetal head rotates to the anterior position in this plane.

The plane of least diameter is the most important from a clinical standpoint because most instances of arrest of descent occur at this level. It is bordered by the lower edge of the pubis anteriorly, the ischial spines and sacrospinous ligaments laterally, and the lower sacrum posteriorly. Low transverse arrests generally occur in this plane.

The plane of the pelvic outlet is formed by two triangular planes with a common base at the level of the ischial tuberosities. The anterior triangle is bordered by the subpubic angle at the apex, the pubic rami on the sides, and the bituberous diameter at the base. The posterior triangle is bordered by the sacrococcygeal joint at its apex, the sacrotuberous ligaments on the sides, and the bituberous diameter at the base. This plane is the site of a low pelvic arrest.

Pelvic Diameters

The diameters of the pelvic planes represent the amount of space available at each level. The key measurements for assessing the capacity of the maternal pelvis include the following:

The average lengths of the diameters of each pelvic plane are listed in Table 8-1.

TABLE 8-1 AVERAGE LENGTH OF PELVIC PLANE DIAMETERS

Pelvic Plane Diameter Average Length (cm)
Inlet True (anatomic) conjugate 11.5
  Obstetric conjugate 11
  Transverse 13.5
  Oblique 12.5
  Posterior sagittal 4.5
Greatest diameter Diagonal conjugate 12.75
  Transverse 12.5
Midplane Anteroposterior 12
  Bispinous 10.5
  Posterior sagittal 4.5-5
Outlet Anatomic anteroposterior 9.5
  Obstetric anteroposterior 11.5
  Bituberous 11
  Posterior sagittal 7.5

Pelvic Inlet

The pelvic inlet has five important diameters (Figure 8-3). The anteroposterior diameter is described by one of two measurements. The true conjugate (anatomic conjugate) is the anatomic diameter and extends from the middle of the sacral promontory to the superior surface of the pubic symphysis. The obstetric conjugate represents the actual space available to the fetus and extends from the middle of the sacral promontory to the closest point on the convex posterior surface of the symphysis pubis.

The transverse diameter is the widest distance between the iliopectineal lines. Each oblique diameter extends from the sacroiliac joint to the opposite iliopectineal eminence.

The posterior sagittal diameter extends from the anteroposterior and transverse intersection to the middle of the sacral promontory.

Pelvic Outlet

The pelvic outlet has four important diameters (Figure 8-4). The anatomic anteroposterior diameter extends from the inferior margin of the pubis to the tip of the coccyx, whereas the obstetric anteroposterior diameter extends from the inferior margin of the pubis to the sacrococcygeal joint. The transverse (bituberous) diameter extends between the inner surfaces of the ischial tuberosities, and the posterior sagittal diameter extends from the middle of the transverse diameter to the sacrococcygeal joint.

PELVIC SHAPES

Based on the general bony architecture, the pelvis may be classified into four basic types (Figure 8-5).

ENGAGEMENT

Engagement occurs when the widest diameter of the fetal presenting part has passed through the pelvic inlet. In cephalic presentations, the widest diameter is biparietal; in breech presentations, it is intertrochanteric.

The station of the presenting part in the pelvic canal is defined as its level above or below the plane of the ischial spines. The level of the ischial spines is assigned as “zero” station, and each centimeter above or below this level is given a minus or plus designation, respectively, for a total length of 10 cm.

In most women, the bony presenting part is at the level of the ischial spines when the head has become engaged. The fetal head usually engages with its sagittal suture in the transverse diameter of the pelvis. The head position is considered to be synclitic when the biparietal diameter is parallel to the pelvic plane and the sagittal suture is midway between the anterior and posterior planes of the pelvis. When this relationship is not present, the head is considered to be asynclitic (Figure 8-6).

There is a distinct advantage to having the head engage in asynclitism in certain situations. In a synclitic presentation, the biparietal diameter entering the pelvis measures 9.5 cm; but when the parietal bones enter the pelvis in an asynclitic manner, the presenting diameter measures 8.75 cm. Therefore, asynclitism permits a larger head to enter the pelvis than would be possible in a synclitic presentation.

CLINICAL PELVIMETRY

The diameters that can be clinically evaluated can be assessed at the time of the first prenatal visit to screen for obvious pelvic contractions, although some obstetricians believe that it is better to wait until later in pregnancy when the soft tissues are more distensible and the examination is less uncomfortable and possibly more accurate.

The clinical evaluation is started by assessing the pelvic inlet. The pelvic inlet can be evaluated clinically for its anteroposterior diameter. The obstetric conjugate can be estimated from the diagonal conjugate, which is obtained on clinical examination (see Figure 8-3).

The diagonal conjugate is approximated by measuring from the lower border of the pubis to the sacral promontory using the tip of the second finger and the point where the base of the index finger meets the pubis (Figure 8-7). The obstetric conjugate is then estimated by subtracting 1.5 to 2 cm, depending on the height and inclination of the pubis. Often the middle finger of the examining hand cannot reach the sacral promontory; thus, the obstetric conjugate is considered adequate. If the diagonal conjugate is greater than or equal to 11.5 cm, the anteroposterior diameter of the inlet is considered to be adequate.

The anterior surface of the sacrum is then palpated to assess its curvature. The usual shape is concave. A flat or convex shape may indicate anteroposterior constriction throughout the pelvis.

The midpelvis cannot accurately be measured clinically in either the anteroposterior or transverse diameter. A reasonable estimate of the size of the midpelvis, however, can be obtained as follows. The pelvic side walls can be assessed to determine whether they are convergent rather than having the normal, almost parallel, configuration. The ischial spines are palpated carefully to assess their prominence, and several passes are made between the spines to approximate the bispinous diameter. The length of the sacrospinous ligament is assessed by placing one finger on the ischial spine and one finger on the sacrum in the midline. The average length is 3 fingerbreadths. If the sacrospinous notch that is located lateral to the ligament can accommodate two-and-a-half fingertips, the posterior midpelvis is most likely of adequate dimensions. A short ligament suggests a forward inclination of the sacrum and a narrowed sacrospinous notch (see Figure 8–5, pg 95).

Finally, the pelvic outlet is assessed. This is done by first placing a fist between the ischial tuberosities. An 8.5-cm distance is considered an adequate transverse diameter. The posterior sagittal measurement should also be greater than 8 cm. The infrapubic angle is assessed by placing a thumb next to each inferior pubic ramus and then estimating the angle at which they meet. An angle of less than 90 degrees is associated with a contracted transverse diameter in the midplane and outlet.

PREPARATION FOR LABOR

Before actual labor begins, a number of physiologic preparatory events usually occur.

Cervical Effacement

Before the onset of parturition, the cervix is frequently noted to soften as a result of increased water content and collagen lysis. Simultaneous effacement, or thinning of the cervix, occurs as it is taken up into the lower uterine segment (Figure 8-8B). Consequently, patients often present in early labor with a cervix that is already partially effaced. As a result of cervical effacement, the mucous plug within the cervical canal may be released. The onset of labor may thus be heralded by the passage of a small amount of blood-tinged mucus from the vagina (“bloody show”).

STAGES OF LABOR

There are four stages of labor, each of which is considered separately. These stages in actuality are definitions of progress during labor, delivery, and the puerperium.

The first stage is from the onset of true labor to complete dilation of the cervix. The second stage is from complete dilation of the cervix to the birth of the baby. The third stage is from the birth of the baby to delivery of the placenta. The fourth stage is from delivery of the placenta to stabilization of the patient’s condition, usually at about 6 hours postpartum.

First Stage of Labor

LENGTH

The length of the first stage may vary in relation to parity; primiparous patients generally experience a longer first stage than do multiparous patients (Table 8-2). Because the latent phase may overlap considerably with the preparatory phase of labor, its duration is highly variable. It may also be influenced by other factors, such as sedation and stress. The active phase begins when the cervix is 3 to 4 cm dilated in the presence of regularly occurring uterine contractions. The minimal dilation during the active phase of the first stage is nearly the same for primiparous and multiparous women: 1 and 1.2 cm/hour, respectively. If progress is slower than this, evaluation for uterine dysfunction, fetal malposition, or cephalopelvic disproportion should be undertaken.

TABLE 8-2 CHARACTERISTICS OF NORMAL LABOR

Characteristic Primipara Multipara
Duration of first stage 6-18 hr 2-10 hr
Rate of cervical dilation during active phase 1 cm/hr 1.2 cm/hr
Duration of second stage 30 min to 3 hr 5-30 min
Duration of third stage 0-30 min 0-30 min

CLINICAL MANAGEMENT OF THE FIRST STAGE

Certain steps should be taken in the clinical management of the patient during the first stage of labor.

Second Stage of Labor

At the beginning of the second stage, the mother usually has a desire to bear down with each contractionThis abdominal pressure, together with the uterine contractile force, combines to expel the fetus. During the second stage of labor, fetal descent must be monitored carefully to evaluate the progress of labor. Descent is measured in terms of progress of the presenting part through the birth canal.

In cephalic presentations, the shape of the fetal head may be altered during labor, making the assessment of descent more difficult. Molding is the alteration of the relationship of the fetal cranial bones to each other as a result of the compressive forces exerted by the bony maternal pelvis. Some molding is necessary for delivery under normal circumstances. If cephalopelvic disproportion is present, the amount of molding will be more pronounced. Caput is a localized, edematous swelling of the scalp caused by pressure of the cervix on the presenting portion of the fetal head. The development of both molding and caput can create a false impression of fetal descent.

The second stage generally takes from 30 minutes to 3 hours in primigravid women and from 5 to 30 minutes in multigravida.

MECHANISM OF LABOR

Six movements of the baby enable it to adapt to the maternal pelvis: descent, flexion, internal rotation, extension, external rotation, and expulsion (Figure 8-10). These movements are discussed here for both an occipitoanterior and occipitoposterior position at engagement. The mechanism of labor for other presentations is discussed in Chapter 13.

CLINICAL MANAGEMENT OF THE SECOND STAGE

As in the first stage, certain steps should be taken in the clinical management of the second stage of labor.

DELIVERY OF THE FETUS

When delivery is imminent, the patient is usually placed in the lithotomy position, and the skin over the lower abdomen, vulva, anus, and upper thighs is cleansed with an antiseptic solution. Uncomplicated deliveries, particularly in multiparous women, may be carried out in the supine position with the thighs flexed. The left lateral position may be used to deliver patients with hip or knee joint deformities that prevent adequate flexion, or for patients with a superficial or deep venous thrombosis in one of the lower extremities.

As the perineum becomes flattened by the crowning head, an episiotomy may be performed to prevent perineal lacerations. The performance of episiotomies may result in a higher proportion of lacerations that involve the anal sphincter (third degree) or anal mucosa (fourth degree). Although these more extensive lacerations may be surgically repaired, there is an increasing awareness of the occasional complication of anal incontinence of gas or feces following vaginal delivery.

To facilitate delivery of the fetal head, a Ritgen maneuver may be performed (Figure 8-11). The right hand, draped with a towel, exerts upward pressure through the distended perineal body, first to the supraorbital ridges and then to the chin. This upward pressure, which increases extension of the head and prevents it from slipping back between contractions, is counteracted by downward pressure on the occiput with the left hand. A recent (2008) randomized trial from Sweden found simple manual perineal support to be equally effective.

Once the head is delivered, the airway is cleared of blood and amniotic fluid using a bulb suction device. The oral cavity is cleared initially and then the nares are cleared. Suction of the nares is not performed if fetal distress or meconium-stained liquor is present because it may result in gasping and aspiration of pharyngeal contents. A second towel is used to wipe secretions from the face and head.

After the airway has been cleared, an index finger is used to check whether the umbilical cord encircles the neck. If so, the cord can usually be slipped over the infant’s head. If the cord is too tight, it can be cut between two clamps.

Following delivery of the head, the shoulders descend and rotate into the anteroposterior diameter of the pelvis and are delivered (Figure 8-12). Delivery of the anterior shoulder is aided by gentle downward traction on the externally rotated head. The brachial plexus may be injured if excessive force is used. The posterior shoulder is delivered by elevating the head. Finally, the body is slowly extracted by traction on the shoulders.

After delivery, blood will be infused from the placenta into the newborn if the baby is held below the mother’s introitus. Usually, the cord is clamped and cut within 15 to 20 seconds. Delayed cord clamping can result in neonatal hyperbilirubinemia as additional blood is transferred from the placenta to the newborn infant. The newborn is then placed under an infant warmer.

Third Stage of Labor

Immediately after the baby’s delivery, the cervix and vagina should be thoroughly inspected for lacerations and surgical repair performed if necessary. The cervix, vagina, and perineum may be more readily examined before the separation of the placenta because no uterine bleeding should be present to obscure visualization.

PERINEAL LACERATIONS

Perineal lacerations, with or without episiotomy, may be classified as follows:

If an episiotomy has been performed (Figure 8-13),it should be repaired as illustrated in Figure 8-14Absorbable sutures (00) should be used, and a rectal examination should ensure that the sutures have not inadvertently transected the rectal mucosa. A third-degree tear (Figure 8-15) should be repaired as shown in Figure 8-16.

image Induction and Augmentation of Labor

Induction of labor is the process whereby labor is initiated by artificial means; augmentation is the artificial stimulation of labor that has begun spontaneously.

In the absence of the natural onset of labor, pharmacologic methods may be used to initiate labor. However, labor should be induced only after appropriate assessment of the mother and fetus and an explanation to the patient of the indications for induction. In the absence of a medical indication for labor induction, fetal maturity should be confirmed by either appropriate pregnancy dating, ultrasonic measurements, or amniotic fluid analysis (e.g., lecithin/sphingomyelin [L/S] ratio).

Cervical effacement and softening (ripening) occur before the onset of spontaneous labor. Cervical ripening frequently does not occur before a decision about labor induction, yet the success of induction is dependent on these necessary changes in the cervix.

Several mechanical and pharmacologic approaches promote cervical ripening before the actual induction of uterine contractions. Local application of prostaglandins may be used. Currently approved pharmacologic treatments include intravaginal application of prostaglandin E2 using a vaginal insert called Cervidil (on a string), which can be removed quickly if the medication causes hyperstimulation. Cytotec, a synthetic prostaglandin E1 analogue, has been approved for cervical ripening. One 25-μg tablet placed intravaginally effectively initiates cervical ripening. Although prostaglandin administration has been demonstrated to shorten the duration of labor induction, the impact on cesarean birth rates due to failed induction has been minimal.

Other methods of cervical ripening may include intrauterine placement of catheters or the use of osmotic dilators (see Figure 26-4). Manual separation of the chorioamnion from the lower uterine segment does not necessarily speed the onset of labor. Although controversial, artificial rupture of the membranes may be used to increase uterine activity, and perhaps to speed cervical change, when performed in conjunction with administration of oxytocin.

In addition to cervical ripening, induction of labor requires the initiation of effective uterine contractions. Oxytocin is identical to the natural pituitary peptide, and it is the only drug approved for induction and augmentation of labor. Pitocin is the synthetic preparation. The physician must be fully aware of the indications and the contraindications for the use of oxytocin (Table 8-3). In general, induction of labor before term is indicated only when the continuation of pregnancy represents a significant risk to the fetus or mother. In some situations, induction may be indicated at term, as in the case of premature rupture of the membranes. Induction at term for convenience is not appropriate unless the patient has a history of previous precipitous delivery (less than 3 hours) or lives an unusually long distance from the hospital.

TABLE 8-3 INDICATIONS AND CONTRAINDICATIONS FOR INDUCTION AND AUGMENTATION OF LABOR

Induction Augmentation
INDICATIONS  
Maternal  

Fetoplacental     CONTRAINDICATIONS   Maternal   Absolute   Contracted pelvis Same contraindications as for maternal and fetoplacental Relative   Prior uterine surgery   Classic cesarean birth   Complete transection of uterus (myomectomy, reconstruction)   Overdistended uterus   Fetoplacental   Preterm fetus without lung maturity   Acute fetal distress   Abnormal presentation  

In general, any condition that makes normal labor dangerous for the mother or fetus is a contraindication to induction or augmentation of labor. The most common contraindication has been prior uterine surgery in which there has been complete transection of the uterine wall. However, a previous lower transverse incision is no longer considered a contraindication to a trial of labor. This is referred to as vaginal birth after cesarean (VBAC).

Induction of labor before term for maternal or fetal indications must not be undertaken without the assessment of fetal pulmonary maturity, provided that a delay will not jeopardize the mother or fetus. Fetal lung maturity can most often be accelerated within 24 to 48 hours by the use of glucocorticoids.

TECHNIQUE FOR INDUCTION AND AUGMENTATION OF LABOR

A hospital obstetric service must establish guidelines for the proper use of oxytocin for induction and augmentation of labor. In general, an assessment and plan of management must be outlined in the patient’s medical record. Indications for induction of labor should be clearly stated. It is helpful to assess the likelihood of success by a careful pelvic examination to determine the Bishop score, which evaluates the status of the cervix and the station of the fetal head (Table 8-4). A high score (9 to 13) is associated with a high likelihood of a vaginal delivery, whereas a low score (<5) is associated with a decreased likelihood of success (65% to 80%). Before induction is begun, the patient’s blood must be typed and screened for antibodies. A blood specimen should be held in the laboratory in case crossmatching becomes necessary. Continuous electronic monitoring of the fetal heart rate and uterine activity is required during induction. An internal uterine catheter for monitoring uterine pressure is suggested if intensity cannot be adequately assessed.

Oxytocin Infusion

Several principles should be followed when oxytocin is used to induce or augment labor:

Substantial variation exists regarding the initial dose, incremental dose, and time interval between dose increments when oxytocin is used for labor induction and augmentation. Well-performed clinical studies have supported both low-dose (1 to 30 mU/min) and high-dose (4 to 40 mU/min) protocols, as seen in Table 8-5It is not surprising that many protocols use “moderate” doses of oxytocin. Generally, intervals between dose increments should be no less than 20 minutes to permit time for steady-state plasma levels of oxytocin to be achieved and to prevent an increased risk for uterine hyperstimulation.

TABLE 8-5 METHOD OF OXYTOCIN INFUSION FOR INDUCTION OR AUGMENTATION

SOLUTION
10 units of oxytocin in 1000 mL of 5% dextrose or balanced salt solution (10 mU/mL)
ADMINISTRATION
Piggyback into main IV line; administer solution by infusion pump
  Low-Dose Protocol High-Dose Protocol
Starting dose 1 mU/min 4 mU/min
Increment 1 mU/min 4 mU/min
Interval 20 min 20 min
Limited by 5 contractions in 10 min 7 contractions in 15 min
Maximal dose 20-30 mU/min 40 mU/min

image Puerperium

The puerperium consists of the period following delivery of the baby and placenta to about 6 weeks postpartum. During the puerperium, the reproductive organs and maternal physiology return toward the prepregnancy state, although menses may not return for much longer.

ANATOMIC AND PHYSIOLOGIC CHANGES

image Breastfeeding

There are many advantages to breastfeeding. First, breast milk is the ideal food for the newborn, is inexpensive, and is usually in good supply. Second, breastfeeding accelerates the involution of the uterus because suckling stimulates the release of oxytocin, thereby causing increased uterine contractions. Third, and probably most important, there are immunologic advantages for the baby from breastfeeding. Various types of maternal antibodies are present in breast milk. The predominant immunoglobulin is secretory immunoglobulin A (IgA), which provides protection in the infant’s gut by preventing attachment of harmful bacteria (e.g., Escherichia coli) to cells on the mucosal surface. This prevents the bacteria from penetrating the bowel wall. It is also thought that maternal lymphocytes pass through the infant’s gut wall and initiate immunologic processes that are not yet well understood. Breastfeeding thereby provides the newborn with passive immunity against certain infectious diseases until its own immune mechanisms become fully functional by 3 to 4 months.

LACTATION

Various hormones, such as estrogen, progesterone, human chorionic gonadotropin, cortisol, insulin, prolactin, and placental lactogen, play an important role in preparing the breasts for lactation. At delivery, two events are instrumental in initiating lactation. First is the drop in placental hormones, particularly estrogen. Before delivery, these hormones interfere with the lactogenic action of prolactin. Second, suckling stimulates the release of prolactin and oxytocin. The latter causes contraction of the myoepithelial cells in the alveoli and milk ducts. The suckling stimulus is thought to be important for milk production, as well as for the ejection of colostrum and milk.

On about the second day after delivery, colostrum is secreted. Its content is composed mostly of protein, fat, and minerals. It is the colostrum that contains secretory IgA. After about 3 to 6 days, the colostrum is replaced by mature milk. The content of milk varies considerably depending on the nutritional status of the mother and the gestational age at the time of delivery. In general, the major components of breast milk are proteins, lactose, water, and fat. The major proteins synthesized in the human breast, which are unique and are not found in cows’ milk, are casein, lactalbumin, and ß-lactoglobulin. Essential amino acids are delivered from the mother’s blood, and some of the nonessential amino acids can be synthesized in the breast. In addition, breast milk is a source of omega-3 fatty acids, which are important for early brain development.

COMPLICATIONS OF BREASTFEEDING

Drug Passage to the Newborn

Because an infant may ingest up to 500 mL of breast milk per day, maternally administered drugs that pass into breast milk may have a significant effect on the infant. The amount of drug found in breast milk depends on the maternal dose, the rate of maternal clearance, the physicochemical properties of the drug, and the composition of the breast milk with respect to fat and protein. The gestational age of the infant may also be a determinant of the ultimate drug effect. Table 8-6 lists selected drugs with their reported newborn effects.

TABLE 8-6 EFFECTS OF MATERNAL DRUG INGESTION ON BREASTFEEDING INFANTS

Drug Reported Infant Effects
SEDATIVE-HYPNOTICS  
Diazepam Sedation
ANTIPSYCHOTICS  
Chlorpromazine No adverse effects reported
Haloperidol No adverse effects reported
NONNARCOTIC ANALGESICS  
Acetaminophen No adverse effects reported
Salicylates Theoretical risk for platelet dysfunction
ANTICONVULSANTS  
Phenobarbital Sedation
Phenytoin Sedation, decreased sucking
NARCOTICS  
Heroin May cause addiction
Methadone Infant death reported
Meperidine No adverse effects reported
ANTIBIOTICS  
Penicillin May modify bowel flora, cause allergy, or interfere with sepsis work-up
Ampicillin Same as for penicillin
Erythromycin Same as for penicillin
Nitrofurantoin Theoretical risk for hemolytic anemia in infants with glucose-6-phosphate dehydrogenase deficiency
Tetracycline Same as for penicillin; theoretical risk for discoloration of teeth and inhibition of bone growth
DIGOXIN No adverse effects reported
THYROID DRUGS  
Thyroxine May interfere with screening for hypothyroidism
Propylthiouracil Nodular goiter
ANTIHYPERTENSIVES  
Methyldopa No adverse effects reported
Propranolol No adverse effects reported
THEOPHYLLINE One case of infant irritability following maternal administration of a rapidly absorbed oral preparation

See Chapters 7 and 16.

image Obstetric Analgesia and Anesthesia

The goal of obstetric analgesia and anesthesia is to provide effective pain relief for the mother during the course of labor and delivery that is safe for her and her baby and that has minimal or no adverse effects on the progress and outcome of labor. Anesthetic practices have evolved to include an increased reliance on highly effective and safe regional anesthetic techniques, using low-concentration combinations of narcotics and local anesthetics in order to minimize the adverse effects of each. Maternal anesthetic risk has also declined owing to the increased awareness of the safety benefits of regional over general anesthesia for cesarean birth. Maternal mortality due to anesthesia has decreased to less than 1 in 500,000 mothers.

OPTIONS FOR LABOR PAIN RELIEF

Nonpharmacologic methods include education and psychoprophylaxis (Lamaze method), emotional support, back massage, hydrotherapy, biofeedback, transcutaneous electrical nerve stimulation (TENS), acupuncture, and hypnosis (hypnobirthing). Scientific assessment of these methods has yielded inconsistent results. Acupuncture decreases pain in most studiesThese techniques tend to work best early in the first stage of labor when the pain is least intense and may decrease pharmacologic use at that time.

Pharmacologic treatment options include parenteral narcotics, regional analgesia (epidural, spinal, combined spinal-epidural, paracervical, caudal, and pudendal nerve blocks), and inhalational analgesia.

Parenteral narcotics have very limited efficacy for the relief of labor pain. They work best in the early first stage when the pain is primarily visceral and less intense. All opioids readily cross the placental barrier and may cause neonatal respiratory depression depending on the dose and timing relative to delivery. They may also cause decreased fetal heart rate variability (not necessarily due to fetal acidosis) and impair neonatal breastfeeding. Fentanyl and nalbuphine have the shortest neonatal half-lives of the commonly used parenteral narcotics.

Neuraxial analgesia (medication injected into the spinal column) is undoubtedly the most effective form of labor pain relief. Lumbar epidural analgesia is the most common form of neuraxial analgesia used to treat labor pain, and its use has been steadily increasing to 60% nationally. It may be used to provide pain relief for the first and second stages of labor, and, by injecting a higher concentration of local anesthetic, the block may be intensified and extended to provide surgical anesthesia for cesarean delivery or postpartum tubal ligation. There is no fixed cervical dilation at which it is appropriate to provide epidural analgesia as long as the patient is having regular, painful contractions. Modern epidural management includes an initial bolus of local anesthetic (bupivacaine, ropivacaine, or lidocaine) and narcotic (fentanyl or sufentanil) to achieve a T10 sensory level, followed by an infusion of a dilute solution of the same agents until delivery. Pain during the first stage of labor is conducted along the sympathetic fibers, entering the spinal cord between T10 and L2. Dilute solutions can be used that permit ambulation, or the “walking epidural.” The goal is to avoid motor block to minimize any adverse effects on maternal expulsive efforts in the second stage.

A pudendal nerve block anesthetizes somatic afferent nerve fibers entering the spinal cord at sacral segments S2 to S4. It is usually effective at relieving the perineal pain of the second stage of labor, along with the pain of episiotomy and episiotomy repair. It does not affect the ongoing pain of uterine contractions.

ANESTHESIA FOR CESAREAN DELIVERY

The type of anesthesia selected for cesarean delivery is determined by the urgency of the surgery, the presence or absence of a preexisting epidural catheter for labor, and the patient’s medical condition, pregnancy-related complications, and presence of any contraindications to regional anesthesia. Absolute and relative contraindications to regional anesthesia are listed in Box 8-1All patients requiring anesthesia for surgery must have an airway examination regardless of how urgent the surgery is. A brief history must also be elicited. If the history or the physical examination suggests that the intubation will be difficult (Box 8-2), the patient must have a regional anesthetic or an awake intubation, or the operation must be started under local anesthesia.

All patients are premedicated with a nonparticulate antacid. Routine monitors are placed, including noninvasive blood pressure monitors, electrocardiograph, and pulse oximeter, and adequate left uterine displacement must be instituted. Supplemental oxygen is provided. A crystalloid preload (bolus over 30 to 60 minutes) of 10 to 15 mL/kg is given before regional anesthesia.

For elective or urgent cesarean delivery (nonemergency), regional anesthesia is preferred because the airway is maintainedComplications involving loss of the airway are the leading causes of anesthetic-related maternal mortality and are usually associated with general anesthesia. General anesthesia carries a 16-fold higher risk of anesthesia-related maternal mortality compared with regional anesthesia (Table 8-7). Parturients have a higher risk for airway complications than nonpregnant patients because they have (1) an 8 times higher chance of failed intubation, (2) a 60% increased oxygen consumption, (3) a decreased functional residual capacity (FRC) resulting in a lower oxygen store, and (4) an increased risk for aspiration.

TABLE 8-7 CAUSES OF ANESTHETIC-RELATED MATERNAL DEATHS IN THE UNITED STATES, 1979-1990

Causes Anesthesia Deaths (%)
Airway problems  
Aspiration 23
Induction, intubation problems 12
Inadequate ventilation 12
Respiratory failure 2
Local anesthetic toxicity 13
High spinal, epidural 9
Cardiac arrest 23
Overdosage 1
Anaphylaxis 1

If no epidural is in place, a spinal block is frequently used. A comparison of the characteristics of spinal and epidural anesthesia is shown in Table 8-8.

TABLE 8-8 COMPARISON OF SPINAL AND EPIDURAL ANESTHESIA

Spinal Epidural
ADVANTAGES
Faster Can tailor duration to need
Technically easier Lower chance of postdural puncture headache
More reliable Slower onset
Defined end point Beneficial in patients with cardiac and hypertensive disorders
Minimal chance of patchy block

Denser block   Lower drug exposure for mother and fetus   No chance of systemic toxicity   DISADVANTAGES Defined (limited) duration Slower onset Higher chance of postdural puncture headache (limited by use of small-bore, pencil-point needles)

General anesthesia is employed for cesarean delivery in three situations: (1) there is extreme urgency without a preexisting, functional epidural catheter; (2) there is a contraindication to regional anesthesia; or (3) regional anesthesia has failed. When a relative contraindication to regional anesthesia is present, the benefits of regional anesthesia frequently outweigh the risks in the pregnant patient.

The protocol for general anesthesia for cesarean birth includes oral administration of nonparticulate antacid (sodium citrate), routine monitoring and left uterine displacement, preoxygenation for at least four vital capacity breaths, and rapid sequence induction of anesthesia with cricoid pressure followed by intubation to prevent regurgitation and pulmonary aspiration of gastric contentsOnce the correct position of the endotracheal tube has been confirmed by end-tidal CO2 and auscultation of the lungs, surgery may begin.

Induction agents for general anesthesia include propofol (most commonly), thiopental, etomidate (when cardiovascular stability is particularly desired), and ketamine (for hypovolemic or asthmatic patients). The muscle relaxant used to facilitate intubation is succinylcholine (unless contraindicated), owing to its rapid onset and brief duration of action. If contraindicated, vecuronium or rocuronium may be used. Oxygen delivery is maintained at 50% to 100% until delivery if the baby is stressed. Nitrous oxide may be added. After induction, a potent inhalational agent is administered and at a modest level (0.5 minimum alveolar concentration [MAC]) to minimize myometrial relaxation. Narcotics may be administered after the delivery of the baby to reduce the need for inhalational anesthesia and provide postoperative pain relief. The patient must be extubated only when fully awake to minimize the risk for aspiration.

PATIENTS WHO BENEFIT FROM EARLY ANESTHETIC CONSULTATION

General anesthesia can usually be avoided if an epidural catheter is already in place, so it is helpful to identify those patients who are at increased risk for requiring surgery, and those patients who have a normal chance of needing surgery but would pose an especially high anesthetic risk. Patients who are at increased risk for emergency surgery may be advised to get a preemptive epidural catheter early to avoid the risks of a crash cesarean under general anesthesia (e.g., breech presentation, multiple gestation, prematurity, macrosomia, poor fetal heart rate tracing, severe preeclampsia, morbid obesity). These fetuses may also benefit from the improved uterine blood flow and controlled delivery that epidural analgesia allows.

Mothers who are at particularly high anesthetic risk should receive a prelabor consultation for significant preexisting medical conditions (e.g., difficult airway; see Box 8-2); significant respiratory, cardiac, or neurologic disease; spinal surgery; and suspected or known susceptibility to malignant hyperthermia.

Unintended Consequences of Regional Anesthesia or Analgesia

Patients who receive epidural analgesia for labor pain have a similar duration of the first stage of labor, but the second stage may be prolonged by 15 minutes on average. Theoretically, a prolongation of the second stage could arise from effects of the release of endogenous oxytocin, prostaglandin F2a, and other hormones responsible for the propagation of labor. Prolongation of the second stage could also be due to impaired ability to push (unlikely as long as motor block is avoided by appropriate adjustment of the epidural infusion), or decreased maternal urge to push due to sensory blockade. The latter can usually be overcome by appropriate coaching and decreasing or halting the epidural infusion.

Other side effects and complications of regional anesthesia or analgesia include fever (0.5°C increased body temperature), headache, and backache. The association with maternal fever may be due to (1) an alteration in the thermoregulatory threshold, (2) interference with peripheral thermoreceptor input to the central nervous system, (3) shifting heat calories from the core to the periphery by vasodilation, or (4) an imbalance between maternal heat production and loss (decreased hyperventilation, decreased lower body sweating, increased shivering).

The risk for headache is about 1% to 2% with spinal anesthesia, and it is lower with an epidural (less than 1%). It occurs when there is an unintended dural puncture (“wet tap”). Postdural puncture headaches are self-limited, usually resolving within 5 to 7 days. Cerebrospinal fluid leaks through the hole in the dura, resulting in low intracranial pressure. The hallmark is a severe positional headache—little or no headache supine, sudden onset of severe headache when sitting upright or standing. The dural hole will heal in about 1 week or can be sealed with an epidural blood patch. Symptomatic treatment includes narcotics, nonsteroidal antiinflammatory drugs, caffeine, sumatriptan, and abdominal binder.

There appears to be no association between new-onset, long-term back pain and labor epidural analgesiaThe risk for new, chronic back pain in parturients is high (up to 47%) whether or not they have had an epidural.

image Preparation for Extrauterine Life

Prematurity is the leading cause of poor neonatal outcome because the fetus has not yet progressed through complete stages of anatomic development and biochemical maturation. Even the fetus delivered at term undergoes changes before and with the onset of labor.

During pregnancy, fetal thyroxine (T4) is converted to reverse triiodothyronine (rT3), which is metabolically inactive. Several days before the onset of term labor, cortisol levels increase in the fetus and induce a change in thyroid hormone dynamics. Cortisol induces the enzyme system, allowing the conversion of T4 to triiodothyronine (T3), which is metabolically more active and necessary for neonatal thermogenesis. At birth, there is a surge of thyroid-stimulating hormone (TSH), and at no time during life does this hormone reach such high levels as it does 30 minutes after birth. This is followed by a hyperthyroid neonatal state for several days, which is necessary for the newborn to maintain its body temperature.

A second change that occurs with the onset of labor is a change in fetal breathing activity. Fetal breathing, as observed by real-time ultrasonography, is rarely observed once labor is established. This is thought to be associated with a decrease in pulmonary fluid dynamics that may be important for the onset of respiration after delivery and the retention of surfactant in the lungs.

Finally, labor is a stress to the fetus that stimulates the release of catecholamines. This may be responsible for the mobilization of glucose, lung fluid absorption, alterations in the perfusion of organ systems, and, possibly, the onset of respiration. Only at times of severe stress later in life are catecholamine levels as high as those at birth.

FACILITATING NEONATAL ADAPTATION

The physician performing the delivery should delegate the responsibility for neonatal resuscitation. All nurses working in the delivery room should be trained in techniques of neonatal assessment and resuscitation. If risk factors increase the likelihood of delivering a depressed infant, a pediatrician trained in neonatal resuscitation should be summoned.

Following delivery of a normal newborn, the following important steps should occur:

image Resuscitation of the Asphyxiated Infant

During the past 15 years, increasing emphasis has been placed on transferring the mother with a high-risk pregnancy to a tertiary care regional center before labor, rather than transferring the sick neonate after delivery.

Ideally, at the time of delivery, a segment of cord should be doubly clamped to allow blood gas determinations on cord arterial and venous blood. These serve as a baseline to assess the severity of the neonatal hypoxia and acidosis.

A stepwise sequence of procedures is necessary to enable a smooth transition to a normal metabolic state (Figure 8-18).

image

FIGURE 8-18 A time-based approach to the possible resuscitation of a normal and apneic or cyanotic newborn.

(Used with permission of the American Academy of Pediatrics: Summary of Major Changes to the 2005 AAP/AHA Emergency Cardiovascular Care Guidelines for Neonatal Resuscitation: Translating Evidence-Based Guidelines to the NRP. Vol 15, No. 2, Fall/Winter 2005.)

4 CORRECT BIOCHEMICAL ABNORMALITIES

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