Nonenveloped (Naked) DNA Viruses

Published on 18/02/2015 by admin

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Last modified 18/02/2015

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Chapter 21

Nonenveloped (Naked) DNA Viruses

Adenoviridae

• Midsized viruses with a linear double-stranded DNA genome and naked, icosadeltahedral capsid that has fibers extending from the vertices.

Pathogenesis

Adenoviral illnesses (Table 21-1)

TABLE 21-1

Common Illnesses Associated with Adenoviruses

Type of illness Clinical features
Acute febrile pharyngitis Fever, sore throat, cough, coryza, and other symptoms that may mimic streptococcal infection
Most common in young children (<3 yr)
Acute respiratory disease Rapid onset of fever, cough, sore throat, rhinorrhea, and cervical adenitis
Occurs mostly in military recruits
Pharyngoconjunctival fever Similar to acute pharyngitis but accompanied by conjunctivitis (“pink eye”)
Occurs in older children, often in outbreaks associated with use of poorly chlorinated swimming pools
Preauricular lymphadenopathy important diagnostic finding
Atypical pneumonia Nonproductive cough with pulmonary infiltrates and effusions
Seen in children and adults
Epidemic keratoconjunctivitis Inflamed pebbled conjunctiva (pink eye) in adults similar to conjunctivitis in children but of longer duration and followed by keratitis
Usually associated with irritation to eye by dust or other debris
Gastroenteritis Diarrhea with possible vomiting primarily in infants and young children due to serotypes 40-42
Other serotypes (e.g., 25-28) cause diarrhea in hospitalized patients.
Acute appendicitis Lymphoid hyperplasia in appendix compromises blood supply leading to acute inflammation.

Laboratory identification

Transmission

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