Newborn and Early Childhood Respiratory Disorders

Published on 23/05/2015 by admin

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Last modified 23/05/2015

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Newborn and Early Childhood Respiratory Disorders

Clinical Manifestations Common with Newborn and Early Childhood Respiratory Disorders

Respiratory disorders are the leading causes of admission to the neonatal intensive care unit (NICU). Essential to the understanding of respiratory distress of the neonate is the axiom “Oxygen is the primary nutrient of the human body.” The clinical manifestations presented by a baby in early respiratory distress include lethargy, cyanosis, increased respiratory rate, nasal flaring, expiratory grunting, intercostal retractions, substernal retraction, tachycardia, increased blood pressure, and acute alveolar hyperventilation with hypoxemia. The late, ominous manifestations include a decreased respiratory rate, gasping respirations, apnea, bradycardia, decreased blood pressure, and acute ventilatory failure with both CO2 retention and hypoxemia.

Although many of the pathophysiologic mechanisms and clinical manifestations presented by the newborn with a respiratory disorder are identical to those seen in the older child or adult, some of the pathophysiologic mechanisms and clinical manifestations are unique to the newborn. The more important clinical manifestations associated with neonatal respiratory disorders and the primary pathophysiologic mechanisms responsible for these clinical manifestations are outlined in this chapter.

Clinical Manifestations Associated with More Negative Intrapleural Pressures during Inspiration

The thorax of the newborn infant is quite flexible—that is, the compliance of the infant’s thorax is high. This flexibility is a result of the large amount of cartilage found in the skeletal structure of newborns. Because of the structural alterations associated with many newborn respiratory disorders, however, the compliance of the infant’s lungs is low. In an effort to offset the decreased lung compliance, the infant must generate more negative intrapleural pressures during inspiration. This condition causes the following (see Figure 31-1):

Expiratory Grunting

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