Miscellaneous cells

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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22 Miscellaneous cells

Hematologic manifestations of systemic disorders

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FIGURE 22-1A Gaucher cell (BM ×1000).

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FIGURE 22-1B Niemann-Pick disease (BM ×1000).

Description:

The Gaucher cell is a macrophage 20 to 80 μm in diameter, with one or more small, round to oval eccentric nuclei; cytoplasm has crumpled tissue paper appearance; found in bone marrow, spleen, liver, and other affected tissue.

Description:

The Niemann-Pick cell is a macrophage, 20 to 90 μm in diameter, with a small eccentric nucleus and foamy cytoplasm. It is found in bone marrow and lymphoid tissue. The peripheral blood of patients with Niemann-Pick disease may exhibit vacuolated lymphocytes.

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FIGURE 22-1C Lymphocyte from Sanfilippo Syndrome (PB ×1000).

Description:

Peripheral blood lymphocytes containing azurophilic granules occasionally surrounded by halos

Associated with:

Mucopolysaccharide storage disorders

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FIGURE 22-1D Alder-Reilly anomaly (PB ×1000).

(Courtesy Dennis P. O’Malley, MD, Clarient, Inc., Aliso Viejo, CA.)

Description:

Deep purple to lilac granules difficult to distinguish from toxic granulation; occur in neutrophils and occasionally eosinophils and basophils

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FIGURE 22–1E May-Hegglin Anomaly. Note Döhle-like body at arrow (PB ×1000).

Description:

Characterized by thrombocytopenia with large platelets and large basophilic inclusions resembling Döhle bodies in granulocytes and monocytes with the absence of toxic granulation

Note:

These inclusions are sporadically visible by light microscopy but always detectable by electron microscopy. The ultrastructure varies from that of Döhle bodies.

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FIGURE 22–1F Chédiak-Higashi anomaly neutrophil with granules (PB ×1000).

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FIGURE 22–1G Chédiak-Higashi anomaly eosinophil with granules (PB ×1000).

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FIGURE 22–1H Chédiak-Higashi anomaly lymphocyte with granule (PB ×1000).

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FIGURE 22–1I Chédiak-Higashi anomaly monocyte with granules (PB ×1000).

Description:

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