Opacification of GB with high-density, radiopaque fluid
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Fluid-fluid level on upright film
Rarely opacification of cystic duct or common bile duct (CBD)
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Exclamation sign: Coexisting milk of calcium bile and gallstones in CBD
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Occurs only in patients who also have milk of calcium bile in gallbladder
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CT: High-attenuation (> 150 HU) sediment
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MR: Low signal on T2WI and layers dependently
Differentiate from gallstones which are discrete nodules with low T2WI signal
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Ultrasound
Mixed echogenicity, layering material within GB which might cause acoustic shadowing
Echogenicity slightly higher than typical sludge, but may be indistinguishable from sludge if no shadowing
May have associated gallstones
TOP DIFFERENTIAL DIAGNOSES
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Vicarious excretion of contrast
PATHOLOGY
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Etiology: Chronic cystic duct obstruction with resultant biliary stasis
CLINICAL ISSUES
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Incidental finding which may be asymptomatic
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Most patients have symptoms of biliary colic
Symptoms may be due to either milk of calcium bile or concomitant gallstones
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Associated with complications similar to cholelithiasis
Acute cholecystitis, pancreatitis, obstructive jaundice
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No treatment in asymptomatic patients
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Cholecystectomy only for symptomatic patients
TERMINOLOGY
Synonyms
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Limy bile syndrome, calcium carbonate bile
Definitions
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High-density calcium carbonate precipitate within gallbladder (GB) lumen
IMAGING
General Features
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Best diagnostic clue
High-density layering liquid/sediment within GB
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Location
GB lumen
Radiographic Findings
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Radiography
Opacification of GB with high-density, radiopaque fluid
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Fluid-fluid level on upright film
Related
Diagnostic Imaging_ Gastrointes - Michael P Federle