Mature lymphoproliferative disorders

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 22/04/2025

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19 Mature lymphoproliferative disorders

Mature lymphoproliferative disorders frequently are derived from a single clone of cells. Although this group of diseases involves lymphocytes, the morphological presentation is variable. The integration of clinical and morphological disease features with immunophenotyping is necessary for appropriate recognition and classification. Only representative samples are included in this atlas.

NOTE: Sustained absolute lymphocytosis in an adult should be investigated to differentiate reactive from malignant processes. Characteristics of reactive lymphocytes are listed in Table 14-1.

Chronic lymphocytic leukemia

FIGURE 19–1A Small lymphocytes with smudge cells at arrows (PB ×500).

FIGURE 19–1B Albumin smear-same patient as presented in figure 19-1A (PB ×500).

FIGURE 19–1C Small lymphocytes with smudge cell (PB ×1000).

FIGURE 19–1D (BM ×500).

Plasma cell myeloma

FIGURE 19–4A Plasma cells. Note rouleaux (PB ×500).

FIGURE 19–4B Plasma cells (PB ×1000).

FIGURE 19–4C Plasma cells, one multi-nucleated (BM ×500).

FIGURE 19–4D Plasmablast (BM ×1000). Note the lighter blue cytoplasm with the indistinct hof and the slightly eccentric nucleus with 2 distinct nucleoli.

FIGURE 19–4E Proplasmacyte (PB ×1000). The cytoplasm is darker blue and the perinuclear hof is distinct. The nucleus is eccentric and the nucleolus is partially masked by the clumped chromatin.

FIGURE 19–4F Flame cell (BM ×1000). Associated with plasma cells that are producing IgA.

FIGURE 19–4G Mott cell (Morula cell, grape cell) (BM ×1000). Plasma cell containing multiple round globules of immunoglobulin, which stain pink, colorless, or blue.

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