Mature lymphoproliferative disorders

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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19 Mature lymphoproliferative disorders

Mature lymphoproliferative disorders frequently are derived from a single clone of cells. Although this group of diseases involves lymphocytes, the morphological presentation is variable. The integration of clinical and morphological disease features with immunophenotyping is necessary for appropriate recognition and classification. Only representative samples are included in this atlas.

NOTE: Sustained absolute lymphocytosis in an adult should be investigated to differentiate reactive from malignant processes. Characteristics of reactive lymphocytes are listed in Table 14-1.

Chronic lymphocytic leukemia

FIGURE 19–1A Small lymphocytes with smudge cells at arrows (PB ×500).

FIGURE 19–1B Albumin smear-same patient as presented in figure 19-1A (PB ×500).

FIGURE 19–1C Small lymphocytes with smudge cell (PB ×1000).

FIGURE 19–1D (BM ×500).

B cell prolymphocytic leukemia

Morphology

FIGURE 19–2A (PB ×500).

FIGURE 19–2B (PB ×1000).

FIGURE 19–2C (BM ×500).

FIGURE 19–2D (BM ×1000).

Peripheral blood:

Medium-sized cells (approximately twice the size of small lymphocyte), one prominent nucleolus, moderately condensed chromatin; small-to-moderate slightly basophilic cytoplasm

Absolute lymphocytosis, usually >100 × 10⁹/L

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