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Age
n
2.5 %
50.0 %
97.5 %
3–5 months
18
0.14
0.20
0.26
6–8 months
19
0.14
0.22
0.31
9–11 months
31
0.14
0.22
0.34
1 year
70
0.16
0.23
0.32
2 years
73
0.17
0.24
0.37
3 years
88
0.21
0.27
0.37
4 years
81
0.20
0.30
0.40
5 years
96
0.25
0.34
0.45
6 years
102
0.25
0.34
0.48
7 years
85
0.28
0.37
0.49
8 years
56
0.29
0.40
0.53
9 years
36
0.34
0.41
0.51
10 years
44
0.30
0.41
0.57
11 years
58
0.35
0.45
0.58
Uemura et al. [4]
Table 2

Between 12 and 16 years old in males and females. Reference values of serum creatinine in Japanese adolescents
Sex
Males
Females
Age
n
2.5 %
50.0 %
97.5 %
N
2.5 %
50.0 %
97.5 %
12 years
15
0.40
0.53
0.61
54
0.40
0.52
0.66
13 years
30
0.42
0.59
0.80
38
0.41
0.53
0.69
14 years
17
0.54
0.65
0.96
40
0.46
0.58
0.71
15 years
15
0.48
0.68
0.93
22
0.47
0.56
0.72
16 years
30
0.62
0.73
0.96
27
0.51
0.59
0.74
Uemura et al. [4]
eGFR (mL/min/1.73 m2) = 110.2 × (reference serum Cr/patient’s serum Cr) + 2.93
Reference serum Cr levels (Cr (mg/dL)) are shown by the following two equations of body length (Ht (m)):
Male patients: Cr = −1.259 Ht5 + 7.815 Ht4 – 18.57 Ht3 + 21.39 Ht2 – 11.71 Ht + 2.628
Female patients: Cr = −4.536 Ht5 + 27.16 Ht4 – 63.47 Ht3 + 72.43 Ht2 – 40.06 Ht + 8.778
A simple serum Cr-based eGFR formula for bedside use was also determined for Japanese children between the ages of 2 and 11 years ([6], PMID: 23564380):
eGFR (mL/min/1.73 m2) = 0.35 × Ht/Cr × 100
The Committee also reported reference values for serum cystatin C levels ([7], PMID: 23446519), a cystatin C-based equation for eGFR in Japanese children and adolescents ([8], PMID: 24253614), and reference values for serum β2 microglobulin (Table 3) ([9], PMID: 22797889).

Table 3

Reference values of serum β2 microglobulin levels in Japanese children
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All subjects
Boys
Girls
Age
n
2.5 %
50 %
97.5 %
n
2.5 %
50 %
97.5 %
n
2.5 %
50 %
97.5 %
3–5 months
21
1.5
1.8
3.2
17
1.5
1.8
3.2
4
1.6
1.8
2.1
6–8 months
18
1.4
1.8
2.6
14
1.4
1.9
2.6
4
1.6
1.6
2.3
9–11 months
29
1.3
1.7
3.3
15
1.3
1.7
3.3
14
1.3
1.8
3.2
1 year
69
1.4
1.7
3.1
32
1.4
1.7
3.2
37
1.2
1.6
3.0
2 years
73
1.0
1.5
2.5
40
1.0
1.5
2.2
33
1.0
1.5
3.4
3 years
85
1.0
1.5
2.3
46
1.1
1.5
2.3
39
1.0
1.5
2.4
4 years
78
1.1
1.4
2.5
42
1.0
1.4
2.1
36
1.1
1.4
3.1
5 years
94
1.1
1.4
2.3
46
1.1
1.5
2.7
48
1.0
1.4
2.2
6 years
101
1.1
1.4
2.3
43
1.1
1.4
2.4
58
1.0
1.5
2.3
7 years
83
1.0
1.4
2.1
36
0.9
1.3
2.1
47
1.0
1.4
2.2
8 years
55
1.0
1.4
2.5
19
1.0
1.4
1.8
36
1.0
1.4
2.3
9 years
37
1.0
1.4
2.1
18
1.1
1.4
1.8
19
1.0
1.4
2.1
10 years
42
0.9
1.3
1.9
11
1.1
1.4
1.6
31
0.9
1.3
1.9
11 years
58
1.0
1.3
2.3
19
1.1
1.3
2.1
39
1.0
1.2
2.4
12 years
69
1.0
1.3
1.8
14
1.2
1.3
1.5
55
0.9
1.3
1.9
13 years
68
1.0
1.3
1.8
30
1.0
1.4
2.0
38
1.0
1.2
1.5
14 years
57
0.9
1.3
2.0
17
1.1
1.4
2.0
40
0.9
1.2
1.7
15 years
35
0.8
1.2
1.8
15
0.8
1.2
1.8
20
0.8
1.1
1.7
16 years
59
0.8
1.2
1.8
30
0.8
1.2
1.8
29
0.8
1.1
1.4
All ages
1,311
1.0
1.4
2.3
504
1.0
1.4
2.3
627

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