Joints and connective tissues

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chapter 33 Joints and connective tissues

HISTORY AND EXAMINATION

The history and physical examination are the two most important components of the diagnostic process for identifying the cause of musculoskeletal symptoms, and pattern recognition is the key to diagnosis.

Some arthropathies present with an acute onset of pain, with peak intensity reached within hours or days; in others it occurs gradually over weeks to months. The clinical pattern may be monarticular, oligoarticular or polyarticular. Variations of these patterns may occur within the same disorder. For example, rheumatoid arthritis may present as an acute monarthritis of the knee before spreading to other joints, or as an acute polyarthritis. Although almost any arthropathy may begin as a monarthritis, the initial pattern of certain disorders is characteristically monarticular, with pain, redness and swelling. Certain diagnoses, such as infection or crystal arthritis, should be suspected in this situation (see Box 33.2). Infectious monarthritis is an important diagnosis to make early, as joint damage can occur if untreated.

Chronic monarthritis is the presenting manifestation of a variety of joint disorders, some of which are listed in Box 33.3. Involvement of two to four joints is usually referred to as oligoarthritis. There are a number of conditions in which involvement of two or three joints rather than one may significantly narrow the differential diagnosis, including pseudogout and psoriatic arthritis. The third pattern is the one in which polyarticular involvement dominates the clinical picture. A variety of inflammatory and non-inflammatory disorders, both common and uncommon, may present as polyarthritis (see Table 33.1).

TABLE 33.1 Distribution of common oligo- and polyarthritides

  Symmetric Asymmetric
Inflammatory

Degenerative/crystal-induced Infectious

DIAGNOSIS

As noted above, the history and physical examination are the two most important aspects of the diagnostic process in patients complaining of musculoskeletal systems. However, laboratory tests and imaging may help in confirming a suspected diagnosis or excluding certain conditions.

IMAGING PROCEDURES

X-rays

Plain X-rays often provide useful diagnostic information in patients with inflammatory or degenerative arthritis (see Table 33.2).

TABLE 33.2 Typical X-ray findings in osteoarthritis vs rheumatoid arthritis

  Osteoarthritis Rheumatoid arthritis
Joint space narrowing Yes Yes
Erosions No Yes
Periarticular osteoporosis No Yes
Subchondral sclerosis Yes No

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