Intussusception

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7.10 Intussusception

Clinical

Clinically, the four classic symptoms and signs of vomiting, abdominal pain, abdominal mass and bloody stool described in patients with intussusception are present in less than one half of patients with the disease.1,2 Intestinal obstruction is often the presenting sign.

The patient is usually in the infant age group and is previously healthy and well nourished, with acute onset of symptoms. The presentation is one of sudden onset of intermittent colicky abdominal pain, manifesting as episodic bouts (1–10 minutes) of crying. One of the descriptions sometimes given by the caregivers is the drawing up of the legs to the child’s abdomen and then kicking the legs in the air. The child is often inconsolable during an episode of distress. Often the child will appear pale due to increased vagal tone caused by the telescoping bowel. Between the episodes, the child may be flat, lethargic or fall asleep exhausted, whereas some children will resume normal activity until another bout of distress occurs.

There is poor feeding, vomiting, and there may be passage of loose or watery stools. The child may have one or more episodes of loose stool which may be followed by blood or mucus per rectum within 12–24 hours. The mixture of mucus and shed blood described as ‘redcurrant jelly’ is a late sign. The diarrhoea, which occurs early, may lead to a misdiagnosis of gastroenteritis, so intussusception should be considered in any young child having episodic distress in the setting of a diarrhoeal illness. Initially the vomiting is non-bilious but it becomes bilious when intestinal obstruction occurs. There may be a preceding upper respiratory tract infection, which can sometimes distract from the true cause of the child’s distress. This condition is unusual in children who are malnourished. The child usually appears chubby and in good health. The child when observed will be seen to have paroxysmal crying spells which represent episodes of abdominal pain between periods of lethargy. In late presentations, the child may be floridly shocked and minimally reactive from collapse.

One must be mindful of the small subset of ‘encephalopathic’ intussusceptions that present without symptoms to suggest a gastrointestinal problem (‘painless presentation’). These children will present with lethargy, sweating and pallor which may be episodic.

Most children appear pale, but with pink conjunctivae. On examination, a right hypochondrium or mid-abdominal sausage-shaped mass may be palpated and this is best felt when the child is quiet between spasms of colic. Abdominal palpation may be soft and appear non-tender in some cases, whereas some children will elicit non-specific guarding. If obstruction has occurred distension and tenderness will be present. The nappy should be checked for any blood, and in suspicious cases a gentle rectal swab may reveal otherwise occult blood. Rarely, the bowel can progress to present rectally and prolapse. The presence of fever and leukocytosis are late signs and may indicate transmural gangrene and infarction. The occurrence of intestinal gangrene and infarction can be suggested by the presence of peritonitis, with the physical signs of rigidity and involuntary guarding.

Often patients with intussusception do not present with classic signs and symptoms, which may lead to an unfortunate delay in diagnosis, with disastrous consequences. Therefore it is essential to maintain a high index of suspicion for intussusception when evaluating a child presenting with abdominal pain, especially those less than 5 years of age or those who have HSP and episodic severe pain.

Investigations

All children should be resuscitated and stabilised prior to any imaging.

Abdominal X-ray

A plain abdominal radiograph may be performed, as a screen or if a reliable ultrasound is not readily available. Early in the course of the disease it may be normal, or it may show an absence of air in the right upper quadrant and a right-sided soft tissue shadow giving an impression of an intracolonic mass. There may be dilated small bowel and an absence of intraluminal gas in the region of the caecum. The presence of stool and air fluid levels in the caecum makes the diagnosis of intussusception less likely.3,4 The accuracy of plain radiography in diagnosis or exclusion of intussusception ranges from 40 to 90%. In cases of established bowel obstruction, distended bowel loops and air-fluid levels will be present. The presence of any free air indicates perforation and precludes non-operative intervention.

Traditionally, the diagnosis of intussusception is made by the use of an enema, either using air or barium. Contrast enema is a quick and reliable investigation and is often also therapeutic. Barium has traditionally been the contrast material used but perforation can result in barium and faecal peritonitis.57 The availability of near-isotonic water media and the use of air as a contrast medium8,9 have changed the traditional therapeutic approach. The advantages of air reduction are its rapidity and safety compared with barium. In the case of perforation during the procedure, air enema has been shown to result in a smaller tear than hydrostatic enema with markedly less spillage of faeces.10 In addition, air has no deleterious consequences within the abdominal cavity.11,12

Findings on contrast examination include the classical ‘coiled spring sign’, which is caused by the contrast material tracking around the lumen of the oedematous intestine and the ‘meniscus sign’ is produced by rounded apex of the intussusceptum protruding into the column of contrast material.13

Outcome

Various authors have reported reduction rates of between 80 and 90% using air enema.1920,2628 The perforation rate is quoted to be less than 1%.18,19 Factors that are associated with lower reduction and higher perforation rate, especially if more than one of the following are present: (a) patient’s age: younger than 3 months or older than 5 years; (b) long duration of symptoms, especially if more than 48 hours; (c) passage of blood per rectum; (d) significant dehydration; (e) small bowel obstruction and (f) the presence of dissection sign on contrast study.2025

Surgical reduction is now performed after failure to achieve reduction or when it is contraindicated to perform non-operative reduction.

The overall mortality rate of intussusception is less than 1%.18 Mortality rates observed among children in industrialised countries are lower than those in developing countries.1,2833 Some of these deaths are preventable and may be related to reduced access to or delays in seeking health care, factors known to be associated with mortality in children with intussusception.3133 Therefore, early diagnosis and management play an important role in the reduction of mortality.

References

1 Simon R.A., Hugh T.J., Curtin A.M. Childhood intussusception in a regional hospital. Aust N Z J Surg. 1994;64:699-702.

2 Kim Y.S., Rhu J.H. Intussusception in infancy and childhood: analysis of 385 cases. Int Surg. 1989;74:114-118.

3 Heller R.M., Hernanz-Schulman M. Applications of new imaging modalities to the evaluation of common pediatric conditions. J Pediatr. 1999;135(5):632-639.

4 Sargent M.A., Babyn P., Alton D.J. Plain abdominal radiography in suspected intussusception: a reassessment. Pediatr Radiol. 1994;24:17-20.

5 Grobmyer A., Kerlan R., Peterson C., Dragstedt L. Barium peritonitis. Am Surg. 1984;50:116-120.

6 Mahvoubi S., Sherman N., Ziegler M. Barium peritonitis following attempted reduction of intussusception. Clin Pediatr. 1983;23:36-38.

7 Yamamura M., Nishi M., Furubayashi H., et al. Barium peritonitis. Report of a case and review of the literature. Dis Colon Rectum. 1985;28:347-352.

8 de Campo J.F., Phelan E. Gas reduction of intussusception. Pediatr Radiol. 1989;19:297-298.

9 Shiels W.E.2d, Maves C.K., Hedlund G.L., Kirks D.R. Air enema for diagnosis and reduction of intussusception: clinical experience and pressure correlates. Radiology. 1991;181:169-172.

10 Shiels W.E.2d, Kirks D.R., Keller G.L., et al. John Caffey Award. Colonic perforation by air and liquid enemas: comparison study in young pigs. AJR Am J Roentgenol. 1993;160:931-935.

11 Hernanz-Schulman M., Foster C., Maxa R., et al. Fecal peritonitis and contrast media: experimental protocol to assess synergistic effects and to compare relative safety of barium sulfate, water-soluble ionic media, saline and air. Presented at the 35th Annual Meeting of The Society for Pediatric Radiology. Orlando, Florida. 1992. May 14–17

12 Hernanz-Schulman M., Vanholder R., Schulman G. Inhibition of neutrophil phagocytosis by barium sulfate. Presented at the 37th Annual Meeting of The Society for Pediatric Radiology. Colorado Springs, Colorado. 1994. Apr 28–May 1

13 del-Pozo G., Albillos J., Tejedor D., et al. Intussusception in Children: Current concepts in diagnosis and enema reduction. Radiographics. 1999;19:299-319.

14 Bhisitkul D.M., Listernick R., Shkolnik A., et al. Clinical application of ultrasonography in the diagnosis of intussusception. J Pediatr. 1992;121:182-186.

15 Bowerman R., Silver T., Jaffe M. Real-time ultrasound diagnosis of intussusception. Radiology. 1982;143:527-529.

16 del-Pozo G., Albillos J., Tejedor D. Intussusception: US findings with pathologic correlation – the crescent-in doughnut sign. Radiology. 1996;199:688-692.

17 Pendergast L.A., Wilson M. Intussusception: a sonographer’s perspective. J Diagn Med Sonogr. 2003;19(4):231-238.

18 DiFore J.W. Intussusception. Semin Pediatr Surg. 1999;8:214-220.

19 Hadidi A.T., El Shal N. Childhood intussusception: a comparative study of nonsurgical management. J Pediatr Surg. 1999;34:304-307.

20 Katz M., Phelan E., Carlin J.B., Beasley S.W. Gas enema for the reduction of intussusception: relationship between clinical signs and symptoms and outcome. AJR. 1993;160:363-366.

21 den Hollander D., Burge D.M. Exclusion criteria and outcome in pressure reduction of intussusception. Arch Dis Child. 1993;68:79-81.

22 Reijnen J.A.M., Festen C., van Roosmalen R.P. Intussusception: factors related to treatment. Arch Dis Child. 1990;65:871-873.

23 Barr L.L., Stansberry S.D., Swischuk L.E. Significance of age, duration, obstruction, and the dissection sign in intussusception. Pediatr Radiol. 1990;20:454-456.

24 Stephenson C.A., Seibert J.J., Strain J.D., et al. Intussusception: clinical and radiographic factors influencing reducibility. Pediatr Radiol. 1989;20:57-60.

25 Fishman M.C., Borden S., Cooper A. The dissection sign of nonreducible ileocolic intussusception. AJR. 1984;143:5-8.

26 Gorenstein A., Raucher A., Serour F., et al. Intussusception in children: Reduction with repeated delayed air enema. Radiology. 1998;206:721-724.

27 Ein S.H., Alton D., Padler S.B., et al. Intussusception in the 1990’s: Has 25 years made a difference? Pediatr Surg Int. 1997;12:402-405.

28 Ein S.H., Alton D., Palder S.B., et al. Intussusception in the 1990s: has 25 years made a difference? Pediatr Surg Int. 1997;12:374-376.

29 van Heek N.T., Aronson D.C., Halimun E.M., et al. Intussusception in a tropical country: comparison among patient populations in Jakarta, Jogyakarta, and Amsterdam. J Pediatr Gastroenterol Nutr. 1999;29:402-405.

30 Meier D.E., Coln C.D., Rescorla F.J., et al. Intussusception in children: international perspective. World J Surg. 1996;20:1035-1039.

31 Stringer M.D., Pledger G., Drake D.P. Childhood deaths from intussusception in England and Wales, 1984-9. Br Med J. 1992;304:737-739.

32 Adejuyigbe O., Jeje E.A., Owa J.A. Childhood intussusception in Ile-Ife, Nigeria. Ann Trop Paediatr. 1991;11:123-127.

33 Mangete E.D., Allison A.B. Intussusception in infancy and childhood: an analysis of 69 cases. West Afr J Med. 1994;13:87-90.