Infections of the Outer Eye

Published on 08/03/2015 by admin

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Last modified 22/04/2025

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4 Infections of the Outer Eye

VIRAL INFECTIONS

Viruses are a common cause of infection of the external eye where they produce a wide variety of disease ranging from mild transient conjunctivitis to more serious infections in which conjunctival or corneal involvement may lead to scarring and, in some cases, blindness. Adenovirus, picornavirus, herpes simplex virus and varicella zoster virus may all cause isolated conjunctivitis, but commonly patients have some corneal or eyelid involvement, thus serving to remind the clinician that the whole of the external eye and adnexae may be a target for the same infection. The spread of the virus to the eye may occur by direct inoculation from an infected source, from indirect transmission by fomites, or neuronal spread in the case of latent herpetic infection. Less commonly, viral eye disease may be part of a generalized viral infection in which the eye is only one of several organs involved (e.g. cytomegalovirus, rubella, human immunodeficiency virus (HIV) infection). Where no specific therapy exists for viral infection of the external eye symptomatic treatment is usually all that is required until resolution takes place. In cases where specific therapy exists, for example in herpes simplex or varicella zoster virus infections, early accurate diagnosis is essential so that treatment with an antiviral may be started early enough to influence the course of the disease.

ADENOVIRUS

Adenovirus infection may be due to a variety of different serotypes that can vary in their clinical presentation and epidemiology. Epidemic keratoconjunctivitis is associated with adenovirus serotypes 8 and 19, which produce a severe and highly contagious form of disease. Pharyngoconjunctival fever, associated with serotypes 3 and 8 also occurs in epidemic form when, as its name suggests, it is associated with upper respiratory tract infection. Sporadic disease has been associated with adenovirus serotypes 1, 2, 4, 5, 11, 13, 14, 15, 20, 21, 23, 24 and 29. Although the severity of adenovirus infections may vary considerably certain clinical features are common to the majority of cases.

A typical case of moderate severity presents with acute bilateral but unequal, swelling and erythema of the eyelids associated with conjunctival inflammation and a watery serous discharge. There may be associated pre-auricular lymphadenopathy, a history of contact with other similar cases or a recent illness of the upper respiratory tract. Although the conjunctival changes resolve over 7–14 days, patients are often left with ocular irritation and discomfort for several weeks. This is due to tear film changes secondary to conjunctival scarring or keratitis.

HERPES SIMPLEX

Herpes simplex infection of the eye may be the result of either primary or recurrent infection. Ocular disease, in common with herpes labialis, is usually caused by herpes simplex virus (HSV) type I, in contrast to genital infection which is associated with HSV type II. Primary infection affects hitherto unexposed individuals who have no immunity to the virus and is acquired following inoculation from an infectious source. It characteristically occurs in children and young adults up to the age of 15 years as after that age serological evidence of exposure to HSV is present in 50–90 per cent of individuals. In primary infection the lesions occur on the skin around the mucocutaneous junctions and are associated with regional lymphadenopathy. In the nonimmunocompromised patient the primary disease heals within 3 weeks although the virus then persists in latent form. In the immunocompromised patient generalized infection may occur requiring systemic antiviral therapy. Recurrent infection in the eye may take the form of blepharoconjunctivitis similar to that occurring in primary disease although it usually runs a shorter time course. However, corneal disease is more common with characteristic dendritic ulceration occurring in the epithelium with deeper corneal stromal keratitis or keratouveitis becoming more common with successive recurrent attacks.

Primary herpes simplex infection normally induces a specific antibody response with the production of IgM initially and later raised IgG levels which persist. Intracellular virus is not accessible to antibody and the role of the humoral response is mainly in limiting the spread of the virus during viraemia and promoting antibody-dependent cell-mediated cytotoxicity. There is good evidence that cell-mediated immunity plays an important role in combating HSV infection as protection against infection can be transferred to immunosuppressed animals by T lymphocytes but not by antibody and the disease is more severe where there is suppressed cell-mediated immunity. Herpetic disease may be more severe, and frequently bilateral, in patients with atopy.

HERPES ZOSTER

Herpes zoster ophthalmicus results from the activation of latent varicella zoster virus in the trigeminal ganglion with neuronal spread of virus through the first (ophthalmic) division of the nerve. The resulting vesicular eruption follows the distribution of the affected dermatome and may be preceded by a few days of neuralgic pain in the same area. A wide spectrum of ocular involvement may occur, including conjunctivitis, keratitis, corneal anaesthesia, iritis (see Ch. 10), secondary glaucoma or optic neuritis. Possible mechanisms of tissue damage include direct viral invasion, vasculitis and neuritis. Isolated ocular motor nerve palsies may also occur as a result of contiguous viral spread within the cavernous sinus. Systemic treatment with an antiviral drug early in the course of the disease shortens the duration and extent of the rash and reduces long-term ocular complications and postherpetic neuralgia, which can be disabling in some patients. Herpes zoster infections usually occur in otherwise healthy people but may be precipitated by debility or immunosuppression from other disease; they are also associated with HIV infection and acute retinal necrosis (see Ch. 10).

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Fig. 4.26 Corneal anaesthesia or hypoaesthesia is a frequent complication of herpes zoster ophthalmicus. When this is combined with defective lid function (see Fig. 4.23), exposure may result in drying with ulceration of the corneal epithelium. In this example a small perforation has appeared in the base of an ulcer in the inferior cornea.

CHLAMYDIAL INFECTIONS

Chlamydiae form a unique group of small bacteria comprising a single order and one genus, the Chlamydiae, with two species, Chlamydia trachomatis and Chlamydia pneumoniae, that cause human disease. Because they are obligatory intracellular parasites they were in the past considered to be viruses but have since been reclassified as bacteria as they are larger than viruses, possess both DNA and RNA, have a more complex structure with a cell wall, and are capable of division by binary fission. They are also sensitive to some antibiotics. Different subgroups of C. trachomatis produce different diseases, such as neonatal pneumonitis, lymphogranuloma venereum and oculogenital infections, in humans. Serotypes A, B, Ba and C are associated with trachoma, whereas serotypes D–K are associated with genitally transmitted disease causing conjunctivitis.

Chlamydiae are obligatory intracellular parasites. The diagnosis of chlamydial infection is now made either by the polymerase chain reaction (PCR) for chlamydial DNA or by enzyme immunoassay on conjunctival discharge; previously it was made by culture of conjunctival swabs in cell culture or the demonstration of the characteristic intracytoplasmic inclusion bodies in the conjunctival scrapings.

INCLUSION BODY CONJUNCTIVITIS

This is so called because of the inclusion bodies seen intracellularly on conjunctival smears. This form of conjunctivitis usually has a gradual onset over a period of several weeks. It is usually unilateral and the patient presents with an inflamed, watering and sticky eye accompanied by a slight ptosis. Keratitis is uncommon. There is associated pre-auricular lymph node enlargement. It is a sexually transmitted disease acquired from an infected partner following direct or indirect oculogenital contact.

TRACHOMA

Trachoma is one of the world’s leading causes of blindness. It has been estimated that about 500 million people have been affected by this disease of whom 100 million suffer some visual impairment and at least two million are totally blind. The disease results from repeated infection by Chlamydia trachomatis of serotypes A–C which may be made worse by superimposed bacterial infection. The disease has long been recognized as being hyperendemic in North Africa, the Middle East, the Indian subcontinent, the Far East and Australia but is also found in poorer parts of Central and Latin America. Transmission takes place from eye to eye by flies, fomites and body contact, and the maintenance and spread of the infection in a population are facilitated by overcrowding, poor conditions of hygiene and, especially, shortage of water for face washing. The blinding complications are caused by corneal opacity from conjunctival scarring and trichiasis with intercurrent bacterial infection.

Treatment of an infected individual consists of either oral antibiotics (sulfonamides, erythromycin or tetracycline) for 3 weeks or topical tetracycline ointment for 6 weeks. In communities with hyperendemic trachoma mass treatment with antibiotics may be effective in reducing the pool of infection but preventive measures including the provision of a plentiful water supply, improved sanitation and health education offer the only certain way of controlling the disease. Surgical management of trichiasis has a significant effect on reducing blindness.

The classical description of trachoma has four stages of disease progression: stage 1, small follicles on the conjunctiva; stage 2, mature follicles with diffuse infiltration and papillary hypertrophy; stage 3, conjunctival scarring and active inflammation; stage 4, inactive infection and scar tissue. Although these broad categories of disease may be recognized in a population with hyperendemic trachoma, the classification is of limited value in determining the prognosis in an individual patient as it takes no account of the cyclical changes brought about by reinfection, the severity of the disease or the degree of visual damage. The World Health Organization has introduced a simplified classification for primary eye care, which can be performed with a hand torch and loupe in the field and can be expanded by grading the severity. This consists of trachoma follicles (TF; five or more follicles on the central upper tarsus), trachomatous inflammation (TI; diffuse inflammation of the upper tarsal conjunctiva that obscures more than 50 per cent of the normal tarsal vessels), trachomatous scarring (TS), trichiasis or entropion (TT; deviated lashes touching the cornea) and corneal opacity (CO).

BACTERIAL INFECTIONS

Bacterial infections of the external eye usually respond rapidly to treatment with antibiotics, although under certain circumstances serious complications may follow. Superficial infections of the lids and conjunctiva may be treated with topical broad-spectrum antibiotic preparations, whereas deeper infections such as dacryocystitis and orbital cellulitis require systemic treatment. The most serious bacterial infections are those involving the cornea; these require urgent investigation and intensive treatment if loss of vision through corneal perforation, scarring or endophthalmitis is to be avoided (see Ch. 6).

CHRONIC BLEPHARITIS

Chronic blepharitis is a common bilateral condition. It can be associated with seborrheic dermatitis, rosacea, discoid lupus or atopic dermatitis although most patients have no other disease. Blepharitis itself can frequently be asymptomatic but its associated conjunctivitis or keratoconjunctivitis result in significant morbidity. Patients complain of redness of lid margins, soreness, irritation and burning with crusting of the lashes in the mornings. It can be classified clinically into two broad groups according to whether there is mainly anterior (skin and lashes) or posterior (meibomian) involvement. Hypersensitivity to staphylococcal antigens appears to play a role in the pathogenesis of the conjunctival and corneal complications.

BACTERIAL CONJUNCTIVITIS

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Fig. 4.51 Ophthalmia neonatorum can be due to Chlamydiae (see Fig. 4.35), but is more commonly a result of bacterial infection acquired during birth or from cross-infection in the neonatal period. Staphylococcal infections are the most common cause although gonococcal infection used to be a severe problem producing a florid purulent conjunctivitis that led to blindness from corneal involvement. In preantibiotic days, babies were treated prophylactically with silver nitrate drops postdelivery to prevent this complication. It is essential to visualize the cornea in any baby with conjunctivitis to exclude corneal ulceration.

LEPROSY

It has been only in recent years that leprosy has been recognized as a major cause of world blindness. It affects around 15 million people, of whom one million are blind. The ocular sequelae vary widely between racial groups and geographical location, and are related to the predominance of lepromatous leprosy, temperate climate and lack of health care. Damage to the eye occurs from direct invasion of the eye by the bacilli in lepromatous leprosy, and from loss of corneal sensation and defective lid closure from a seventh nerve palsy compounded by facial and hand deformities. Vision is lost from corneal exposure and infection, or from chronic iritis, miosis and cataract.

PARASITIC DISEASE AND INFESTATIONS

ONCHOCERCIASIS (RIVER BLINDNESS)

This disease is caused by the microfilaria Onchocerca volvulus and is endemic in central Africa and in central and southern America, where it was probably introduced through slavery. The vector is the blackfly species Simulium which feeds in rapidly flowing water. The adult transmits larva to the human host. The larvae spread subcutaneously and mature to adult worms forming rubbery nodules that contain both male and female worms. The worms can be up to 50 cm in length and may live for 10 years. The female produces millions of microfilaria which migrate subcutaneously throughout the body. These can survive for up to 18 months to reinfect the blackfly and repeat the cycle. About 8–10 million people are infected; one million of these are blind. In highly infected areas 100 per cent of the population are affected and 50 per cent are blind.

The effects of the infestation are confined to the skin and the eye and are produced by the low-grade inflammatory reaction that is incited by dying microfilaria. Vision is lost from sclerosing keratitis, chronic anterior uveitis, chorioretinitis or optic neuritis. Visual loss may be exacerbated by treatment that kills the microfilaria thus producing further inflammation. Ivermectin, which prevents the microfilaria from leaving the adult female is the principal microfilaricidal agent.