159 Hypertensive Disorders in Pregnancy
Hypertensive disorders associated with pregnancy are not uncommon, occurring in approximately 7% of pregnancies. Guidelines from the Society of Obstetricians and Gynecologists have classified hypertension of pregnancy into two categories: preexisting or gestational with preeclampsia superimposed on either gestational or preexisting chronic hypertension.1 The National High Blood Pressure Education Working Group on High Blood Pressure in Pregnancy classified hypertension as: (1) chronic hypertension, (2) preeclampsia-eclampsia, (3) preeclampsia superimposed on chronic hypertension, and (4) gestational hypertension which is transient during pregnancy or chronic hypertension identified in the latter half of pregnancy.2 Gestational hypertension including preeclampsia occurs de novo after 20 weeks of gestation. Chronic hypertension will either be preexisting before the pregnancy or manifest earlier than the 20th week of gestation. Chronic hypertension is present in up to 22% of women of childbearing age. Approximately 1% of pregnancies are complicated by chronic hypertension, 5% to 6% by gestational hypertension, and 1% to 2% of all pregnancies are associated with preeclampsia. Preeclampsia occurs in 20% to 25% of women with preexisting chronic hypertension.
Chronic hypertension is seen more commonly in women older than 35 years of age. Preeclampsia is also seen more frequently in the older parturient but also in younger women of less than 18 years of age. Predisposing factors for the development of hypertension and/or preeclampsia during pregnancy include a family history of hypertension or preeclampsia, preexisting diabetes mellitus, black race, obesity (BMI ≥ 30), vascular or renal disorders, primigravid state, preeclampsia with a previous pregnancy, migraine history, and multiple gestational pregnancies.3 Smoking during pregnancy may actually decrease the incidence of hypertension and preeclampsia during pregnancy, although this is controversial.4 Hypertensive disorders in pregnancy are a significant leading cause of maternal mortality and morbidity, particularly when preeclampsia is superimposed on preexisting chronic hypertension. A pregnancy-related mortality of 15.7% was reported as a result of hypertensive disorders in the United States from 1991 to 1999.5
Blood Pressure Measurements in Pregnancy
The definition of hypertension during pregnancy has been controversial in the past. Hypertension is now most commonly defined as a blood pressure (BP) greater than 140/90 mm Hg. Recently there has been a general consensus that the degree of increase in systolic (SBPs) and diastolic blood pressures (DBPs) may actually be more important than the baseline values. Many authors now agree that significant hypertension in pregnancy is defined by an increase of at least 30 mm Hg in the SBP and an increase in the DBP of at least 15 mm Hg. Treatment of a DBP greater than 110 mm Hg or a SBP greater than 160 mm Hg is advocated because of the increase in maternal complications with this degree of hypertension.6
Physiologic Changes in Pregnancy
Essential to the management of hypertension in pregnancy is an understanding of the normal physiologic changes in cardiac output, vasomotor tone, and systemic BP that occur. During pregnancy, cardiac output increases by 30% to 40% in the second trimester, peaking at about the 24th week of gestation. The increase in cardiac output during the first two trimesters of pregnancy is primarily caused by increased maternal blood volume. Cardiac output plateaus for the remainder of the pregnancy until labor. An increase in cardiac output is seen with each uterine contraction. Cardiac output increases again during the immediate postpartum period after delivery of the fetus and the placenta. It is during this period that cardiac output is highest due to the so-called autotransfusion effect (see Chapter 158).
Causes of Hypertension in Pregnancy
There are multiple causes of hypertension during pregnancy (Box 159-1). The most common hypertensive states are gestational hypertension without the presence of proteinuria, essential chronic hypertension, and preeclampsia (gestational hypertension with significant proteinuria). This classification is clinically useful to the practitioner, but the risk from systemic hypertension is significant for all three conditions, regardless of the specific cause of high BP. Hypertension during pregnancy is associated with an increased risk of death for both mother and fetus. Severe maternal hypertension during pregnancy is associated with placental abruption and intrauterine growth retardation.7
Essential chronic hypertension (i.e., hypertension that was present before the pregnancy, whether diagnosed or undiagnosed) persists in the postpartum period and accounts for approximately one-third of all cases of hypertension during pregnancy. Essential chronic hypertension may manifest during the first 20 weeks of pregnancy. Women who develop hypertension without proteinuria in the last trimester of pregnancy may have essential hypertension, either unmasked or precipitated by the pregnancy. In these cases of de novo presentation of hypertension, care must be exercised to rule out other non–pregnancy-related causes of hypertension such as renal artery stenosis, polycystic kidneys, glomerular or interstitial renal disease, pheochromocytoma, coarctation of the aorta, primary aldosteronism, Cushing’s syndrome, hyperthyroidism, and hyperparathyroidism. Previously undiagnosed essential chronic hypertension is a consideration, particularly in older multiparous women. As the age of parturients has increased, the incidence of essential hypertension in pregnant women has also increased. For some patients, the initial diagnosis of hypertension may be made during a routine prenatal visit with an obstetrician. For some patients, this prenatal visit is their first encounter with a physician as an adult. Essential hypertension should be suspected if there is a family history of hypertension, diabetes, or obesity. If there is a suspicion of preexisting essential hypertension, cardiac echocardiography should be performed to evaluate for left ventricular hypertrophy, which would suggest that hypertension has been a problem for an extended period. If extremes of BP are avoided with treatment, there is no significant worsening of maternal and perinatal outcomes for pregnant patients with essential hypertension. Complications related to intrapartum hypertension, such as placenta previa, placental abruption, and preeclampsia, are less likely with judicious treatment of elevated BP. Patients with essential hypertension have not been shown to have a higher incidence of preeclampsia, particularly if BP is well controlled. In general, mortality and morbidity are not increased in patients with uncomplicated mild chronic hypertension However, morbidity and mortality are both increased in those patients with severe uncontrolled hypertension, and this is further complicated by superimposed preeclampsia.8
Pathology of Preeclampsia
Preeclampsia is a pregnancy-related multisystem disease process that usually occurs after the 32nd week of gestation. Systemic hypertension and significant proteinuria (0.3 g or greater in a 24-hour urine collection) are invariably present. Clinical onset is usually characterized by rapid weight gain associated with generalized edema, followed by onset of hypertension or proteinuria or both. The incidence of preeclampsia in the United States is 5% to 7%. The highest frequency occurs in young primigravidas, and the second highest incidence is in older multiparous women, a group that has a higher maternal mortality rate than the young primigravidas. The incidence is higher in patients with preexisting hypertension or renal vascular disease, and the symptoms may present earlier than the 32nd gestational week in these patients. Diastolic hypertension is most often seen in association with preeclampsia. It is less common to record SBP values greater than 160 mm Hg. If the SBP is greater than 200 mm Hg, the clinician should consider the possibility of underlying essential hypertension, which may be superimposed on the preeclamptic state. Because preeclampsia is a multisystem disease process, it may imitate or mask other pathologic conditions, and a thorough investigation to rule out other coexisting pathologies should be carried out.9 Familial prevalence of preeclampsia has been reported.10,11 In some cases, preeclampsia manifests 1 to 7 days after delivery.12,13 Most commonly, if preeclampsia is present in the postpartum period, it manifests as the HELLP syndrome, a severe variant of the preeclamptic spectrum of diseases.14 This syndrome always includes some, if not all, of the following features: microangiopathic hemolytic anemia (H), elevated liver enzymes (EL), and low platelets (LP). The syndrome can develop without substantial BP changes or with no significant changes compared with BP readings taken during the pregnancy.
A significant elevation of the BP in the second trimester is associated with an increased risk of preeclampsia later in the pregnancy.15 One-third of pregnant women with mean arterial pressures greater than 90 mm Hg in the second trimester develop preeclampsia later during pregnancy. Only 2% of women with mean arterial pressures less than 90 mm Hg develop preeclampsia. Relatively mild hypertension early in pregnancy, which might be ignored in nonpregnant patients, should not be overlooked or dismissed in the parturient. As many as 25% of all pregnant women have slightly elevated BPs in the last month of pregnancy, but the incidence of preeclampsia is also highest during this period. Accordingly, clinicians must remain vigilant when faced with new-onset hypertension and look for other signs and symptoms that might suggest the presence of the preeclamptic syndrome.
The exact pathogenesis of preeclampsia is still unknown, although it is believed to be related to endothelial cell injury and dysfunction that occurs in most maternal organs as a result of toxic substances released from a poorly perfused placenta. Genetic and immunologic factors also have been implicated in the pathogenesis of preeclampsia.16,17 The generalized vasospasm that occurs in preeclampsia is responsible for many of the organ-specific signs and symptoms seen in this multisystem disease. Widespread vasospasm is associated with increased circulating levels of vasoconstrictors, increased sensitivity to angiotensin II, and decreased levels of vasodilators. An imbalance in circulating angiogenic factors is emerging as a prominent mechanism that mediates endothelial dysfunction and the clinical signs and symptoms of preeclampsia.18 There is an imbalance in the ratio of prostacyclin to thromboxane production that contributes to the pathogenesis of preeclampsia, although preeclampsia is not simply a state of prostacyclin deficiency. This idea has prompted studies of low-dose aspirin to prevent development of preeclampsia. Duley et al. reviewed 59 trials involving 37,560 women that examined the use of antiplatelet agents in preeclampsia. Antiplatelet agents including low-dose aspirin showed moderate benefits when used for prevention of preeclampsia and its consequences, decreasing preterm births, fetal and neonatal deaths, and small-for-gestational age babies. However, they recommended that further information would be required to assess which women are most likely to benefit, when treatment is best started, and at what dose.19 The maternal organs most affected in preeclampsia are the kidneys, brain, liver, and hematologic system. Despite a lack of understanding of the exact pathogenesis of preeclampsia, significant improvements in identification of the disease, monitoring, and management of these complex cases has improved perinatal and maternal morbidity and mortality. If vasospasm affects the uteroplacental bed, the incidence of intrauterine growth retardation, stillbirths, and neonatal deaths increases.20
Peripheral edema is a common symptom and complaint of pregnant women that cannot be ignored, because it may herald the onset of preeclampsia. The majority of women with preeclampsia present with generalized edema, and significant weight gain is the first symptom. However, since peripheral edema is a ubiquitous symptom during pregnancy, it is no longer considered a hallmark trait of preeclampsia. Preeclampsia is often manifested initially by peripheral edema that is usually accompanied by a gradual increase in BP. Sodium retention is partly responsible for edema formation and hypertension. In normal pregnancy, the glomerular filtration rate increases by as much as 50%. There is a concomitant increase in sodium reabsorption by the renal tubules and a 60% to 80% increase in renal blood flow. Renal blood flow increases because of the increase in cardiac output and a decrease in renal vascular resistance. In preeclampsia, sodium retention is caused by a decrease in the glomerular filtration rate, possibly resulting from vasospasm of the renal vasculature, commonly seen in preeclampsia. Renin and aldosterone secretion decrease in patients with preeclampsia, probably as a result of extracellular volume expansion and associated edema. The exact cause of the decreased activity of these factors is unknown, but it may be related to decreased renal prostaglandin synthesis, increased systemic BP, or expansion of extracellular volume. In spite of the decreased levels of renin and aldosterone, sensitivity to angiotensin II is increased, a factor that may play a role in the pathogenesis of hypertension in preeclampsia.21 Vascular maladaptation with increased vasomotor tone, endothelial dysfunction, and increased sensitivity to angiotensin II and norepinephrine in preeclampsia may be explained on the basis of angiotensin II-mediated mechanisms. Although sodium retention occurs in preeclampsia, blood volume actually can be diminished compared with that in normotensive pregnant patients.22 Plasma volume contracts as extracellular fluid is preferentially shifted from the vascular space to the interstitium. However, the decrease in plasma volume does not indicate volume depletion in patients with preeclampsia. In contrast to hypovolemic patients, cardiac output is increased and central venous and pulmonary capillary wedge pressures are normal to high in patients with preeclampsia.23 These data guide the management of preeclampsia, because efforts should be directed to BP control rather than injudicious volume resuscitation.
Hyperuricemia in preeclampsia occurs at least in part because of decreased renal excretion of uric acid. However, the development of hyperuricemia frequently predates increases in serum blood urea nitrogen and creatinine, suggesting that other mechanisms are involved as well. Hyperuricemia has been used as a marker of severity of preeclampsia, and it is a risk factor for fetal mortality.24
Clinical Presentation of Preeclampsia
Severity of illness is defined as mild, moderate, or severe depending on the presenting signs and symptoms and associated comorbidities. Because of the multisystem nature of the process, preeclampsia may manifest with a wide spectrum of organ-specific abnormalities in addition to the general findings of edema, hypertension, and proteinuria. Because the pathologic abnormalities associated with preeclampsia are not necessarily secondary to hypertension, the severity of preeclampsia does not always correlate with the degree of BP elevation.15 BP elevations are classified as mild, moderate, or severe. Hypertension in preeclampsia may result from increases in systemic vascular resistance and cardiac output.
In mild preeclampsia, SBP is 130 to 140 mm Hg and DBP is 80 to 95 mm Hg. Peripheral edema is minimal, and there are no associated visual or cerebral symptoms. In moderately severe preeclampsia, the SBP may increase to as high as 150 to 160 mm Hg, and the DBP can be as high as 110 mm Hg. An increase in SBP of 25 mm Hg or more and an increase in DBP of 15 mm Hg or more suggests the presence of moderate to severe preeclampsia. Peripheral edema, hyperreflexia, and visual symptoms are present with moderately severe preeclampsia. In severe forms of preeclampsia, the SBP is greater than 160 mm Hg, and the DBP is 110 mm Hg or greater. In severe preeclampsia, there are signs of multiple organ system involvement. Pulmonary, cardiac, renal, and neurologic disturbances may be present. Severe renal involvement in preeclampsia leads to glomeruloendotheliosis, which manifests as marked proteinuria (excretion of greater than 5 g protein daily). Oliguria (urine output less than 500 mL/day) is also common, and the serum creatinine concentration is usually greater than 1.6 mg/dL. Acute renal failure is relatively rare, although clinical evidence of renal involvement in preeclampsia significantly increases perinatal mortality.25 Hepatic involvement is manifested by epigastric or right upper quadrant pain with elevated circulating levels of bilirubin and transaminases. Severe preeclampsia itself is the commonest cause of hepatic tenderness and liver dysfunction in pregnancy.26 Severe hepatic pathology can result in subcapsular hematomas and lacerations that may require surgical intervention. Neurologic changes may include persistent headaches, visual disturbances, focal neurologic deficits, and severe hyperreflexia with or without clonus. Computed tomography of the brain may show cerebral edema, especially in the occipital region.
Severe preeclampsia associated with central nervous system irritability, manifesting as generalized tonic-clonic seizures not caused by other cerebral pathology, is defined as eclampsia.27 Eclampsia can occur without significant hypertension or proteinuria. Cardiovascular and respiratory changes can manifest as pulmonary edema, resulting from iatrogenic fluid overload, acute systolic left ventricular failure, or diastolic left ventricular dysfunction secondary to chronic essential hypertension. Pulmonary edema may also result from increased capillary permeability or from a decrease in colloid osmotic pressure that occurs to some extent during normal pregnancy but can be accentuated by preeclampsia.28 Hematologic disturbances consist of thrombocytopenia, disseminated intravascular coagulation, and hemolysis.
It is unknown whether preeclampsia leads to persistent chronic hypertension after delivery, although it seems that this is unlikely. Nevertheless, an episode of preeclampsia may identify a subgroup of women with increased risk for eventual development of essential hypertension at a later time. In a recent study, women with preeclampsia had an increased risk of cardiovascular disease death later in life, independent of other measured risk factors.29 These findings reinforced previously reported recommendations that a history of preeclampsia should be used to target women at risk for cardiovascular disease. Debate continues as to whether the presence of preeclampsia or the duration of the disease process may be responsible for influencing factors that later lead to the development of essential hypertension. Women who develop preeclampsia superimposed on previously undiagnosed essential hypertension or underlying renal disease are predisposed to the later development of essential hypertension.
Other Causes of Hypertension in Pregnancy
Some of the less common causes of hypertension are listed in Box 159-1.
Renal artery stenosis can be associated with preeclampsia. Medical therapy with antihypertensive agents is recommended. Although ideal therapy for these patients would include angiotensin-converting enzyme (ACE) inhibitors, these agents are contraindicated during pregnancy, and other alternatives must be employed.30
General Treatment Principles
The benefits of a well-balanced low-salt diet and exercise have been shown to decrease the incidence and severity of hypertension. Bennett conducted a retrospective analysis of women who had prior bariatric surgery before becoming pregnant. These patients had lower rates of hypertensive disorders in subsequent pregnancies.31 Previously, some experts were concerned that aggressive management of hypertension in pregnancy might be detrimental, perhaps because hypertension improved uterine blood flow. These concerns appear to be unfounded, because later studies showed that uterine blood flow either increases or shows no change after hypertension is controlled. Nevertheless, caution must be exercised to ensure that treatment of hypertension during pregnancy does not induce hypotension, which adversely affects maternal hemodynamics and compromises fetal well-being. There is significant correlation between maternal BP control and fetal morbidity, and evidence now suggests that antihypertensive treatment for severe hypertension results in improved perinatal outcome. The development of mild hypertension or preeclampsia at or near term is associated with minimal maternal and neonatal complications. However, the onset of severe gestational hypertension and/or severe preeclampsia early in gestation is associated with significant maternal and perinatal complications.32 General recommendations for management and monitoring of hypertension in pregnant patients include stabilization and treatment of acute changes in BP. Specific goal-directed therapy is indicated for various organ system abnormalities that may be present, particularly in those patients with moderate to severe preeclampsia. If proteinuria is not present and there is no suspicion of preeclampsia, conservative management on an outpatient basis is usually adequate. Immediate hospitalization with bed rest is recommended for patients presenting with proteinuria if there is a high index of suspicion for the diagnosis of preeclampsia.
Antihypertensive Drug Therapy
There is now an extensive pharmaceutical armamentarium available for the treatment of hypertension in pregnancy. In 1979, the U.S. Food and Drug Administration (FDA) established categories for all drugs with potential and real adverse effects on the fetus.33 Although helpful to the clinician, these categories most often do not reflect current scientific knowledge regarding specific teratogenic effects of the drugs.34
The FDA categories are listed in Table 159-1. Most antihypertensive drugs used during pregnancy are classified as category C. Thiazide diuretics, prazosin, and α-methyldopa are designated as category A; metoprolol is a category B agent. Because most antihypertensive drugs are used later in pregnancy, the potential teratogenic effects of these drugs are usually not of concern. However, if treatment is initiated for patients with preexisting essential hypertension or early onset gestational hypertension, teratogenic effects must be considered when choosing antihypertensive drugs. It may be necessary to change antihypertensive therapy early in pregnancy, if the patient is taking drugs that could increase the risks of fetal abnormalities.
Category | Description |
---|---|
A | Controlled studies in pregnant women have not demonstrated any risk to the fetus in the first trimester. These drugs are considered to be relatively safe for use during pregnancy. |
B | No known specific risks are associated with use of the drug in pregnancy, but controlled human studies are lacking. If adverse effects were shown in animal reproduction studies, these were not confirmed in controlled human trials. |
C | Studies in women and animals are not available, or studies in animals have revealed adverse effects on the fetus. Most new drugs fall into this category. These drugs should be given only if the potential benefit justifies the potential risk to the fetus. |
D | These drugs have shown a definite fetal risk in controlled human trials. However, their use may be necessary during pregnancy, and a risk-benefit assessment needs to be considered for the use of these agents. |
X | These drugs have shown a definite risk to the fetus, and their use is contraindicated because the potential risks to the fetus outweigh the potential benefits. |
FDA, U.S. Food and Drug Administration.
Conservative drug therapy is advocated for moderately severe preeclampsia, but the treatment of choice for severe preeclampsia and associated end-organ involvement is immediate delivery of the fetus. Delay in delivery for patients with severe preeclampsia and end-organ involvement can result in serious maternal and fetal complications. If the fetus is of mature gestational age, factors influencing the decision to deliver are dependent on progression of the disease process, assessment of fetal lung maturity, and status of the cervix. Conservative management of preeclamptic patients at a gestational age less than 24 weeks is associated with serious maternal complications, and termination of the pregnancy should be considered. For patients at 28 to 32 weeks of gestation, conservative management with vigilant monitoring and assessment should be performed in a hospital setting. There is not enough evidence from the limited trials performed to recommend either early delivery or expectant care for women with severe preeclampsia before 34 weeks of pregnancy.35
During pregnancy, the clinician must decide when to use antihypertensive medications and what level of BP to target. The choice of antihypertensive agents is more limited in pregnancy, since not all available antihypertensive drugs have been adequately evaluated in pregnant women, and some agents are contraindicated.36 A first-line drug still used today in the pregnant patient, although less commonly in the general populace, is oral α-methyldopa, a central α2-adrenergic agonist. Historically this has been a first-line drug of choice for many obstetricians over the years, and there has been little evidence to convince them otherwise. The starting dose is 250 mg orally 2 to 3 times a day for the first 48 hours of treatment. Dosing can be increased every 2 days until the desired BP level is achieved. The maximum daily dose is 4 g. β-Adrenergic blocker therapy with oral labetalol, a combined α- and β-adrenergic antagonist, has become popular as a single-agent antihypertensive. The recommended initial dose is 100 mg orally twice daily. The dose can be increased as indicated, either semiweekly or weekly. The maintenance dose is usually 200 to 400 mg administered twice daily. The benefits of β-adrenergic blockade make this an attractive drug for parturients with underlying chronic essential hypertension and possible cardiac and vascular involvement. Diuretics also may be used, although care must be exercised to prevent excessive fluid losses, which can exacerbate the decrease in blood volume associated with preeclampsia. As mentioned previously, ACE inhibitors and angiotensin II receptor antagonists should be avoided intrapartum because these agents can increase perinatal morbidity and mortality.
For acute and emergent drug therapy for severe hypertension, intravenous (IV) antihypertensive drugs should be used; IV infusions are particularly attractive because they provide rapid control of BP and can be titrated easily. Intravenous hydralazine, a direct arteriolar vasodilator, remains the standard for many obstetricians, although other drugs may be preferable since hydralazine may decrease BP precipitously.37 Excessive lowering of BP is a particular problem when hydralazine is administered to preeclamptic patients with contracted blood volume. If hydralazine is used, it should be given as 5- to 10-mg IV boluses every 15 to 30 minutes until BP is controlled. Onset of the hypotensive effect is 10 to 20 minutes, and duration of action is about 8 hours. Infusions of hydralazine are difficult to titrate and may be associated with increased incidence of fetal distress.
There remains considerable debate concerning the use of β-adrenergic blockers in pregnancy because of the potential risks of fetal bradycardia and a decrease in perfusion to the uteroplacental bed. Beta-blockers have been used during pregnancy without evidence of teratogenic effects. Although there is limited experience, they are considered as indicated in pregnant women with hypertension, mitral stenosis with pulmonary hypertension, coarctation of the aorta, ischemic heart disease, supraventricular and ventricular arrhythmias, and can be continued during delivery.2,38,39 Esmolol has been used widely for heart rate control in pregnancy, but its efficacy is limited as an antihypertensive agent.
Antihypertensive drugs commonly used during pregnancy are listed in Table 159-2.
TABLE 159-2 Antihypertensive Drugs Commonly Used in Pregnancy
Type | Agents |
---|---|
Oral | α-Methyldopa |
Labetalol | |
Clonidine | |
Diuretics | |
Parenteral | Labetalol |
Hydralazine | |
Sodium nitroprusside | |
Nitroglycerin |
Key Points
Magee L, Cham C, Waterman EJ, et al. Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis. BMJ. 2003;327:955.
Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;359:785.
AACE Hypertension Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of hypertension. Endocr Pract. 2006;12:193.
Magee LA, Helewa M, Moutquin J-M, et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. J Obstet Gynaecol Can. 2008;30:S1.
Seely EW, Maxwell C. Chronic hypertension in pregnancy. Circulation. 2007;115:e188-e190.
1 Magee LA, Helewa M, Moutquin J-M, et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. J Obstet Gynaecol Can. 2008;30:S1-S48.
2 Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183:S1-S22.
3 Facchinetti F, Allais G, Nappi RE, et al. Migraine is a risk factor for hypertensive disorders in pregnancy: a prospective cohort study. Cephalalgia. 2009;29:286-292.
4 Wikstrom AK, Stephansson O, Cnattingius S. Tobacco use during pregnancy and preeclampsia risk: effects of cigarette smoking and snuff. Hypertension. 2010;55:1254-1259.
5 Chang J, Elam-Evans LD, Berg CJ, et al. Pregnancy-related mortality surveillance—United States, 1991-1999. MMWR Surveill Summ. 2003;52:1-8.
6 AACE Hypertension Task Force. American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of hypertension. Endocr Pract. 2006;12:193-222.
7 Thadhani RI, Johnson RJ, Karumanchi A. Hypertension during pregnancy. Hypertension. 2005;46:1250-1251.
8 Seely EW, Maxwell C. Chronic hypertension in pregnancy. Circulation. 2007;115:e188-e190.
9 Madejczyk M, Kruszynski G, Breborowicz G. Etiopathology of preeclampsia. Arch Perinat Med. 2009;15:144-151.
10 Roes M, Sieben R, Raijmakers MTM, et al. Severe preeclampsia is associated with a positive family history of hypertension and hypercholesterolemia. Hypertens Pregnancy. 2005;24:259-271.
11 Arngrimsson R, Bjornsson S, Geirsson RT, et al. Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol. 1990;97:762-769.
12 Munjuluri N, Lipman M, Valentine A, et al. Postpartum eclampsia of late onset. BMJ. 2005;331:1070-1071.
13 Stella CL, Sibai BM. Preeclampsia: Diagnosis and management of the atypical presentation. J Mat Neonat Med. 2006;19:381-386.
14 Baxter JK, Weinstein L. HELLP Syndrome: The state of the art. Obstet Gynecol Survey. 2004;59:838-845.
15 Lindheimer MD, Taler SJ, Cunningham FG. Hypertension in pregnancy. J Am Soc Hypertens. 2010;4:68-78.
16 Bdolah Y, Karumanchi SA, Sachs BP. Recent advances in understanding of preeclampsia. Croat Med J. 2005;46:728-736.
17 Karumanchi SA, Baumwell S. Pre-eclampsia: Clinical manifestations and molecular mechanisms. Nephron Clin Pract. 2007;106:c72-c81.
18 Duley L, Henderson-Smart DJ, Meher S, et al. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2007, Issue 2. Art. No.: CD004659. DOI: 10.1002/14651858.
19 von Dadelszen P, Menzies J, Gilgoff S, et al. Evidence-based management for preeclampsia. Front Biosci. 2007;12:2876-2889.
20 Shah DM. Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol. 2005;288:F614-F625.
21 Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357:53-56.
22 Bosio PM, McKenna PJ, Conroy R, et al. Maternal central hemodynamics in hypertensive disorders of pregnancy. Obstet Gynecol. 1999;94:978-984.
23 Powers RW, Bodnar LM, Ness RB, et al. Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery. Am J Obstet Gynecol. 2006;194:160.e1-160.e8.
24 Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;359:785-799.
25 Hay JE. Liver disease in pregnancy. Hepatology. 2008;47:1067-1076.
26 Sibai BM. Diagnosis, prevention, and management of eclampsia. Obstet Gynecol. 2005;105:402-410.
27 Sciscione A, Ivester T, Largoza M, et al. Acute pulmonary edema in pregnancy. Obstet Gynecol. 2003;101:511-515.
28 Mongraw-Chaffin ML, Cirillo PM, Cohn BA. Preeclampsia and cardiovascular disease death. Hypertension. 2010;56:166-171.
29 Cooper WO, Hernandez-Diaz S, Arbogast P, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Eng J Med. 2006;354:2443-2451.
30 Bennett WL, Gilson MM, Jamshidi R, et al. Impact of bariatric surgery on hypertensive disorders in pregnancy: retrospective analysis of insurance claims data. BMJ. 2010;340:C1662.
31 Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003;102:181-192.
32 U.S. Food and Drug Administration. Pregnancy labeling. FDA Drug Bulletin. 1979;9:23.
33 Briggs Gerald G, Freeman Roger K, Yaffe Sumner J, editors. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk, 8th ed, Philadelphia, Pa: Lippincott Williams and Wilkins, 2008.
34 Churchill D, Duley L. Interventionist versus expectant care for severe pre-eclampsia before term. Cochrane Database Syst Rev 2002, Issue 3. Art. No.: CD003106. DOI: 10.1002/14651858.
35 Lindheimer MD, Umans JG. Explaining and predicting preeclampsia. N Engl J Med. 2006;355:1056-1058.
36 Podymow T, August P. Update on the use of antihypertensive drugs in pregnancy. Hypertension. 2008;51:960.
37 Magee L, Chan C, Waterman EJ, et al. Hydralazine for treatment of severe hypertension in pregnancy: Meta-analysis. BMJ. 2003;327:955.
38 Oakley C, Child A, Iung B, et al. Task force on the management of cardiovascular diseases during pregnancy of the European Society of Cardiology. Expert consensus document on management of cardiovascular diseases during pregnancy. Eur Heart J. 2003;24:761-781.
39 Lopez-Sendo J, Swedberg K, McMurray J, et al. Expert consensus document on β-adrenergic receptor blockers. The task force on beta-blockers of the European Society of Cardiology. Eur Heart J. 2004;25:1341-1362.