Fig. 8.1
Answers selected by the audience for Case 1
-
In January 2014, BP 124/68, proteinuria 1.5 g/day, urinary RBC 5-9/HPF, eGFR 55 mL/min/1.73 m2. Renal biopsy: acute lesion (endocapillary hypercellularity) (+), chronic lesion (+). In May 2014, BP 124/68, proteinuria 1.5 g/day, urinary RBC 5-9/HPF, eGFR 55 mL/min/1.73 m2.
Case 2
48-year-old female with no medication (see Fig. 8.2 for the questionnaire result)

Fig. 8.2
Answers selected by the audience for Case 2
-
In November 2013, BP 128/78, proteinuria 1.8 g/day, urinary RBC11-20 /HPF, eGFR 100 mL/min/1.73 m2. Renal biopsy: acute lesion (endocapillary hypercellularity) (+). After 6 months of medication with ACEI, in May 2014, BP 118/70, proteinuria 1.2 g/day, urinary RBC 11-20/HPF, eGFR 100 mL/min/1.73 m2.
References
1.
Berger J, Hinglais N. Intercapillary deposits of IgA-IgG. J Urol Nephrol. 1968;74:694–5.
3.
Berthoux F, Mohey H, Laurent B, Mariat C, Afiani A, Thibaudin L. Predicting the risk for dialysis or death in IgA nephropathy. J Am Soc Nephrol. 2011;22:752–61.CrossRefPubMedPubMedCentral
4.
5.
Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB, et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol. 2011;22:1795–803. doi:10.1681/ASN.2011050464.CrossRefPubMedPubMedCentral
6.
7.
Radhakrishnan J, Cattran DC. The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines—application to the individual patient. Kidney Int. 2012;82:840–56. doi:10.1038/ki.2012.280.CrossRefPubMed
8.
10.
11.
12.
13.
14.
15.
16.
17.
Yagame M, Tomino Y, Miura M, Suga T, Endoh M, Nomoto Y, et al. Clinical effect of dipyridamole in patients with IgA nephropathy. Tokai J Exp Clin Med. 1986;11:329–33.PubMed
18.
Lee GS, Woo KT, Lim CH. Controlled trial of dipyridamole and low-dose warfarin in patients with IgA nephritis with renal impairment. Clin Nephrol. 1989;31:276.PubMed
19.
Reid S, Cawthon PM, Craig JC, Samuels JA, Molony DA, Strippoli GFM. Non-immunosuppressive treatment for IgA nephropathy. Cochrane Database Syst Rev. 2011. doi:10.1002/14651858.CD003962.pub2.
20.
Horita Y, Tadokoro M, Taura K, Ashida R, Hiu M, Taguchi T, et al. Prednisolone co-administered with losartan confers renoprotection in patients with IgA nephropathy. Ren Fail. 2007;29:441–6.CrossRefPubMedPubMedCentral
21.
Mustonen J, Pasternack A, Rantala I. The nephrotic syndrome in IgA glomerulonephritis: response to corticosteroid therapy. Clin Nephrol. 1983;20:172–6.PubMed
22.
Kobayashi Y, Fujii K, Hiki Y, Tateno S. Steroid therapy in IgA nephropathy: a prospective pilot study in moderate proteinuric cases. Q J Med. 1986;61:935–43.PubMed
23.
24.
25.
26.
Samuels JA, Strippoli GFM, Craig JC, Schena FP, Molony DA. Immunosuppressive agents for treating IgA nephropathy. Cochrane Database Syst Rev. 2003;4:CD003965.
27.
Henderson L, Masson P, Craig JC, Flanc RS, Roberts MA, Strippoli GF, et al. Treatment for lupus nephritis. Cochrane Database Syst Rev. 2012;12:CD002922.PubMed
28.
29.
30.
31.
Tan CH, Loh PT, Yang WS, Chan CM. Mycophenolate mofetil in the treatment of IgA nephropathy: a systematic review. Singapore Med J. 2008;49:780–5.PubMed
32.
33.
34.
Miura N, Imai H, Kikuchi S, Hayashi S, Endoh M, Kawamura T, et al. Tonsillectomy and steroid pulse (TSP) therapy for patients with IgA nephropathy: a nationwide survey of TSP therapy in Japan and an analysis of the predictive factors for resistance to TSP therapy. Clin Exp Nephrol. 2009;13:460–6. doi:10.1007/s10157-009-0179-1.CrossRefPubMed
35.
36.
37.
Rasche FM, Schwarz A, Keller F. Tonsillectomy does not prevent a progressive course in IgA nephropathy. Clin Nephrol. 1999;51:147–52.PubMed
38.
Sato M, Hotta O, Tomioka S, Horigome I, Chiba S, Miyazaki M, et al. Cohort study of advanced IgA nephropathy: efficacy and limitations of corticosteroids with tonsillectomy. Nephron Clin Pract. 2003;93:137–45.CrossRef
39.
Kawamura T, Yoshimura M, Miyazaki Y, Okamoto H, Kimura K, Hirano K, Special IgA Nephropathy Study Group, et al. A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy. Nephrol Dial Transplant. 2014;29:1546–53. doi:10.1093/ndt/gfu020.CrossRefPubMedPubMedCentral