Published on 03/03/2015 by admin
Filed under Neurology
Last modified 03/03/2015
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Chapter 5
DEFINITION
Acute inflammatory demyelinating polyneuropathy (AIDP)
Acute motor axonal neuropathy (AMAN)
Chronic inflammatory demyelinating polyneuropathy (CIDP)
EPIDEMIOLOGY
Prevalence
Age
Gender
AETIOLOGY
PATHOLOGY
Demyelination
Axonal loss
OUTCOME AND PROGNOSIS
SIGNS AND SYMPTOMS
Motor
Sensory
Autonomic dysfunction
Secondary complications
Guillain–Barré syndrome (GBS) is included in the wider group of peripheral polyneuropathies and is an autoimmune disease affecting the peripheral nervous system (PNS) characterized by a rapid demyelination, followed by remyelination. There are several types of GBS.
This is the most common form.
Also termed acute motor and sensory axonal neuropathy (AMSAN).
As the name suggests, this involves a more chronic onset than other forms of GBS. Typically, patients with CIDP have a chronic progressive or relapsing remitting illness developing over at least 2 months but then potentially continuing for many years.
GBS affects about one person in 40 000 each year in the UK.
It can occur at any age from infancy onwards but is slightly more common in the elderly.
It is more common in men than in women.
The definitive cause of GBS is uncertain, however in many cases there appears to be a prior infection, e.g. glandular fever or campylobacter. Recent surgery is also recognized as a triggering event.
Neurological Assessment A Clinicians Guide
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