H&E at high power shows lipofuscin pigment in centrizonal hepatocytes.
![image](/wp-content/uploads/2017/04/image01500.jpeg)
Periodic acid-Schiff with diastase digestion accentuates the granular pigment in centrizonal hepatocytes
![image](/wp-content/uploads/2017/04/image01499-1.jpeg)
![image](/wp-content/uploads/2017/04/image01501.jpeg)
Fontana-Masson stain highlights the increased lipofuscin marked by black staining in the centrizonal hepatocytes.
![image](/wp-content/uploads/2017/04/image01502.jpeg)
Prussian blue stain for iron is negative and helps to confirm that the cytoplasmic pigment is not hemosiderin.
CLINICAL ISSUES
Epidemiology
• Age
Often diagnosed at puberty, possibly related to increased hemoglobin turnover and inhibition of bilirubin glucuronidation by endogenous steroid hormones
![image](/wp-content/uploads/2017/04/image01415-259.jpeg)
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