Gastrointestinal system

Published on 23/05/2015 by admin

Filed under Internal Medicine

Last modified 22/04/2025

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 0 (0 votes)

This article have been viewed 1957 times

Chapter 3 Gastrointestinal system

Peptic ulcer

Case history

Forty-year-old Dan Noble has come to the clinic for help with digestive discomfort. Dan has been experiencing episodic problems with heartburn and uncomfortable burning or gnawing sensations in the center of his abdomen that seem to occur about an hour after eating. Sometimes Dan also experiences heartburn or discomfort at night when he is in bed. When he gets a particularly bad episode he initially feels a sharp pain that then seems to become more like a dull ache after a while; it may last a couple of hours. The pain will often come on when he is hungry and before he eats a meal. He hasn’t had any recurrent vomiting or diarrhoea accompanying his symptoms but sometimes feels a bit nauseous. He does remember vomiting one time when he had a bad episode and it relieved the symptoms of pain. He thought he must have had a stomach bug.

Dan finds that if he eats something his symptoms usually improve, although his appetite on the whole has decreased significantly. When symptoms are bad he gets a feeling of fullness very quickly after eating. He went to his local pharmacy and was given a bottle of antacid liquid, which does improve his symptoms.

Dan tells you he is the principal of a small independent school. He loves his job, but things have been quite stressful for the past couple of years because the school has been undergoing some major changes as they implement new policies and procedures for both teaching and administrative staff, as well as undertaking a new building program. He feels his stress levels have been quite high in the past but are now lessening because the new buildings have now been completed and staff seem to have adjusted to the changes.

Dan has been experiencing the symptoms on and off for about six months, but they seem to be getting worse and occurring more frequently. His wife tells him he is stressed and has lost weight so has suggested he might be able to get herbal or nutritional supplements to help with his stress.

When you ask Dan about other symptoms he tells you he sometimes gets tension headaches, particularly if he’s had a busy week. He usually takes aspirin or ibuprofen, which work well for him. Apart from the stomach problems and occasional headaches Dan says he feels pretty good most of the time. He drinks 5–6 cups of coffee a day and more if things are particularly busy and he needs to keep going. He also often works through his lunch break and eats when he can, which is often on the run. Dan has noticed if he eats spicy foods he is more likely to experience the stomach problem, so

TABLE 3.1 COMPLAINT [111]

Analogy: Skin of the apple

AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES

Your practitioner impression Dan appears tense and uncomfortable; he shuffles in his seat. He appears physically and emotionally uncomfortable. Seems lacking in vitality. Rating scale   On a scale of 1 to 10 how would you rate the abdominal discomfort, with 10 being as bad as can be? When I get a sharp pain it is 8 out of 10 and when there is the dull ache it is about 6 out of 10.

TABLE 3.2 CONTEXT

Analogy: Flesh of the apple Context: Put the presenting complaint into context to understand the disease
AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES
Cancer and heart disease  
Do you experience indigestion that is usually only related to physical activity? (angina) No. I can often feel it when I am lying still.
Functional disease  
So would you say your indigestion is not related to physical activity? (heartburn, oesophageal reflux) I can get the pain when I am still or when I am moving but most often when I am not moving.

TABLE 3.3 CORE

Analogy: Core of the apple with the seed of ill health Core: Holistic assessment to understand the client
AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES
Daily activities  
How often does the abdominal discomfort disturb you during the night? If I don’t take the antacids I can be up most nights for a week and then it will settle down a bit.
Action needed to heal  
What do you think is important to do for your symptoms to clear up in the short term? Coming today to see you to help with the stomach pain and stress levels. Maybe have more medical tests to find out what the pain actually is because it doesn’t seem to be going away in a hurry.

TABLE 3.4 DAN’S SIGNS AND SYMPTOMS

he usually avoids it. Dan doesn’t drink alcohol during the week, but will relax on the weekends with a bottle or two of red wine.

Dan realises he needs to manage his stress better and is hoping that reducing his stress will improve his digestive symptoms.

Results of medical investigations

No medical investigations have been carried out yet.

TABLE 3.5 UNLIKELY DIAGNOSTIC CONSIDERATIONS [2, 7, 8, 10, 11, 54]

CONDITIONS AND CAUSES WHY UNLIKELY
CANCER AND HEART DISEASE
Congestive heart failure Blood pressure within normal limits; urinalysis NAD
Cluster headaches: common to begin in males between the ages of 40 and 60; no family history associated with cluster headaches Extremely severe headaches, stabbing and burning; usually unilateral and pain behind eye radiating to the front of the face
INFECTION AND INFLAMMATION
Kidney infection Abdominal pain usually is lower and will radiate to lower back and groin rather than upper abdomen and shoulder; no urine crystals and red blood cells
Sinus headache: headache worse on waking in the morning No upper respiratory symptoms mentioned, no frontal facial pain reported; need to check if dull ache is aggravated by bending
ENDOCRINE/REPRODUCTIVE
Diabetes: delayed gastric emptying and complains of early fullness, nausea, bloating Urinalysis NAD

Case analysis

TABLE 3.6 POSSIBLE DIFFERENTIAL DIAGNOSIS

Not ruled out by tests/investigations already done [2, 711, 55, 57, 59, 61, 65]
CONDITIONS AND CAUSES WHY POSSIBLE WHY UNLIKELY
CANCER AND HEART DISEASE
Angina: brought on by physical activity and emotion; will be relieved by nitroglycerin Burning sensation in chest, fast pulse Usually not related to eating or abdominal symptoms; acute onset of symptoms; pain relieved by lying down
Gastric tumour: can have history of Helicobacter pylori (H. pylori) infection [67] Pain relieved by food or antacids nausea; early satiety, weight loss, lack of appetite May present with diarrhoea; no mention of blood or mucus in stools, abdominal distension or frequent vomiting; pain made worse or relieved by food
OBSTRUCTION AND FOREIGN BODY
Acute gallstone pancreatitis: pain in the abdomen that is radiating, nausea, decreased appetite; commonly caused by gallstones that block the pancreatic drainage; often associated with alcoholic binges Pain in upper abdomen Upper abdominal pain usually radiates to the lower back; usually associated with significant fever, nausea, vomiting and change in bowel motions; will usually have lower abdominal symptoms such as flatulence
OCCUPATIONAL TOXINS AND HAZARDS
Causal factor:
Sick building syndrome
Headaches worse after working several days in a row; new buildings recently constructed No upper respiratory complaints or fatigue reported
Causal factor:
Eye strain
Headaches will generally occur after several days at work Unusual unless work requires close vision or eyeglasses are not appropriate
FUNCTIONAL DISEASE
Causal factor:
Intestinal gas: from decreased motility and overgrowth of bacteria
Indigestion More common in the elderly, vague symptoms of abdominal discomfort; will have lower abdominal symptoms such as flatulence
Causal factor:
Gas entrapment: hepatic or splenic flexure syndrome
Can have abdominal discomfort that is referred as chest pain Made worse by bending over
Causal factor:
Duodenal loop distention
Indigestion, nausea Specific to right upper quadrant pain, or pain in the right shoulder
Causal factor:
Hiatus hernia
Heartburn, indigestion when associated with oesophagitis Heartburn is a rare symptom of hiatus hernia unless accompanied by oesophagitis
Functional gastrointestinal disorder Can have indigestion symptoms made worse by stress No reports of diarrhoea alternating with constipation; symptoms would be vague and non-specific if a functional disorder; usually continuous pain with no significant weight loss; will have lower abdominal symptoms such as flatulence
Heartburn: not usually related to physical activity, brought on by oesophageal spasm [53] Burning sensation in the chest, felt when lying down, caffeine frequently causes symptoms; pain related to meals and made worse by lying down Pain would be intermittent over several minutes and recur over long periods; pain would radiate to the neck, jaw, arms and back; pain would be felt after heavy meals and bending over; certain foods can cause and relieve heartburn
Non-ulcer dyspepsia: may have H. pylori; pain or discomfort in the centre of the chest/upper abdomen [53, 56, 58] Upper abdominal pain, feeling full quickly after eating, lack of appetite, nausea, belching, vomiting, bloating, burning sensation in chest or abdomen No difficulty swallowing or vomiting mentioned by Dan; symptoms at night rare with non-ulcer dyspepsia; pain is usually worse after eating and not usually relieved by antacids with non-ulcer dyspepsia; diffuse abdominal pain is more common than precise location
Reflux-dyspepsia
Oesophageal reflux (gastro-oesophageal reflux disease, GORD; gastroesophageal reflux disease, GERD)/peptic oesophagitis/spasm: pain not brought on by exercise; may be precipitated by gastric juices, bile and duodenal juices and eating in general; treatment for H. pylori is not useful for reflux dyspepsia [64, 66]; more likely diagnosis if hiatus hernia present; it is possible to have symptoms of epigastric pain without heartburn and reflux in GORD/GERD [52, 55, 56]
Tightness in chest, lack of appetite, becomes full quickly; common cause of heartburn symptoms that are relieved by antacids and made worse by lying down or bending over; will have chest pain; waterbrash symptoms signifies reflux; belching In reflux, dyspepsia pain may radiate to the back, arms and neck; usually no nocturnal pain; can get nocturnal asthma and cough; common in pregnant women; chest and upper abdominal pain will be worse on stooping and after large meals; heartburn will be experienced more frequently than once every fortnight and acid regurgitation more than once a week; will have excess belching; possible to have overlapping condition with peptic ulcer; may have associated symptoms of asthma or chronic cough
Dysmotility dyspepsia: caused by delayed gastric emptying rather than gastric hypersecretion; indigestion always brought on by eating; no H. pylori present [56] Upper abdominal pain, nausea, early fullness, can be affected by stress; symptoms of heartburn reported Symptoms often continuous, vomiting more than once every second month, hunger after feeling full quickly, heaviness after eating fatty foods or milk, bloating and distension in the abdomen; need to check if have any food intolerances
Causal factor:
Aerophagia
Belching, heartburn symptoms, oesophageal reflux, functional GI disease  
DEGENERATIVE AND DEFICIENCY
Ulcer-like dyspepsia
Peptic ulcer: gastric/stomach ulcer, duodenal ulcer, oesophageal ulcer; abdominal pain may be relieved by meals; can have overlapping symptoms of heartburn; will have H. pylori infection; risk factors are age 40 years and over, cigarette smoking, use of NSAIDs, family or past medical history of ulcer disease [56, 65]
Can point to where burning epigastric pain is in the abdomen and show clearly where it is radiating to; gnawing pain; associated symptoms of nocturnal abdominal pain, nausea, decreased appetite, early satiety, weight loss; symptoms have periodicity like an ulcer and be pain-free for several weeks; can develop from chronic anxiety, tension; abdominal pain relieved by small amount of specific foods or antacids; vomiting can provide relief from pain; taking aspirin and ibuprofen for tension headaches; no significant reflux May have vomiting on onset and previous history of ulcer disease; can have haematemesis (vomiting of blood); a common sign with a peptic ulcer is a fear to eat, but not with a duodenal ulcer; possibly has concurrent reflux dyspepsia with ulcer dyspepsia
Cervical arthritis Headache at the base of the head/neck area No specific neck pain reported
Anaemia: organic dyspepsia; pernicious anaemia (B12 deficiency) can cause indigestion and may develop from atropic gastritis and be linked to persistant infection with H. pylori bacteria in the stomach Eating fewer meals, weight loss Need to assess mineral absorption, variety of food groups, quantity of meals; usually associated with a long history of indigestion
INFECTION AND INFLAMMATION
Causal factor:
H. pylori: improved by bismuth salts or antibiotics
Causes bloating, pain in the stomach; involved in peptic ulcer disease, gastric tumour Not in oesophageal reflux or dysmotility functional dyspepsia
Gastritis: inflammation of stomach lining that can be made worse by aspirin, NSAIDs, corticosteroids, antibiotics, antiasthma agents; atropic gastritis from autoimmune destruction of parietal cells leading to lack of intrinsic factor and potentiating lack of B12 Abdominal pain, indigestion, burning; loss of appetite, sense of fullness, nausea; vomiting can provide relief from pain; taking aspirin and ibuprofen for tension headaches Pain will be worse after eating in gastritis; often associated with alcoholism; vague indigestion is more common in gastritis rather than specific location
Giardia Can present with upper abdominal symptoms such as nausea, bloating and persist for months Symptoms will be persistent symptoms rather than episodic and may have diarrhoea
Chronic appendicitis Upper abdominal intermittent pain, nausea, vomiting on one occasion No constipation or fever
Cholecystitis: chronic and acute gall bladder inflammation Symptoms can be vague gastrointestinal disturbance; biliary colic, right abdominal pain The pain of gallstone colic/cholecystitis does not have periodicity like an ulcer; specific to right upper quadrant pain, or pain in right shoulder; will have lower abdominal symptoms such as flatulence
Hepatitis Pain in upper abdomen that is radiating; nausea; loss of appetite No increased diarrhoea or lower abdominal symptoms mentioned
Crohn’s disease Abdominal pain; lesions can be from mouth to anus; weight loss, abdominal pain, low-grade fever and nausea; inflammation is deep and patchy No blood or mucus in stools; no diarrhoea mentioned or recurrent episodes of watery bowel motions during day and night; no fever
SUPPLEMENTS AND SIDE EFFECTS MEDICATION/DRUGS
Causal factor:
Drug ingestion: NSAIDs, antibiotics, potassium or iron supplements, alcohol, corticosteroids, theophylline derivatives, isoproterenol, anticholinergics
Heartburn and indigestion, can cause H. pylori negative gastritis, lower esophageal pressure; taking aspirin and ibuprofen for his tension headaches increases the risk of developing a peptic ulcer  
ENDOCRINE/REPRODUCTIVE
Pancreatic disorders: chronic pancreatitis, vipoma (endocrine pancreatic tumour), Zollinger-Ellison syndrome Symptoms of abdominal pain, episodes of pain, fatty diet; Zollinger-Ellison syndrome can present like a peptic ulcer (without H. pylori infection) with pain at night, nausea and lack of appetite Symptoms of diarrhoea and steatorrhoea usually present; rare condition; will be from a long history of indigestion and often related to alcohol abuse
STRESS AND NEUROLOGICAL DISEASE
Migraine headache: severe painful headaches; often unilateral and located in the front and temporal regions of the head Stress can exacerbate, can have indigestion and nausea as a complaint Dan’s headaches not aggravated by or related to sound or light; migraine headaches usually improve upon waking and after sleep; no indication of nausea and vomiting associated with headache
Causal factor:
Stress [25, 26]
Headaches, heartburn, indigestion  
EATING HABITS AND ENERGY
Causal factor:
Food intolerance amine/salicylate sensitivity
Headaches, drinking red wine, dairy; may be delayed sensitivity; salicylate sensitivity or overload can cause gastritis Need to ask more regarding if the headaches are after eating particular foods that usually trigger migraine headaches
Causal factor:
Dehydration
Lack of water in the diet, dull headaches, drinking excess tea and coffee, drinking alcohol  

TABLE 3.7 DECISION TABLE FOR REFERRAL [2, 7, 8, 10, 12]

Complaint Context Core
Referral for presenting complaint Referral for all associated physical, dietary and lifestyle concerns Referral for contributing emotional, mental, spiritual, metaphysical, lifestyle and constitutional factors
REFERRAL FLAGS REFERRAL FLAGS REFERRAL FLAGS

ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE REFERRAL DECISION REFERRAL DECISION REFERRAL DECISION

TABLE 3.8 FURTHER INVESTIGATIONS THAT MAY BE NECESSARY [2, 610, 11, 13, 54]

TEST/INVESTIGATION REASON FOR TEST/INVESTIGATION
FIRST-LINE MEDICAL INVESTIGATIONS:
Abdominal inspection: guarding, rebound tenderness, palpation, abnormal pulsations (auscultation) Signs of appendicitis, pancreatitis, kidney swelling, enlarged liver, bowel obstruction, perforated ulcer; positive Murphy’s sign for inflamed gall bladder; hiatus hernia signs, swallowed air; mid-epigastric tenderness in gastric and peptic ulcer
Full blood count Anaemia, inflammation, allergies
C-urea breath test H. pylori
IgG antibodies H. pylori
When CRP is high it can indicate a bacterial infection
Stool test Occult blood in stool may indicate ulcer or carcinoma, H. pylori
IF NECESSARY:
Oesophageal motility studies Cardiospasm, reflux oesophagitis
Bernstein test (dilute hydrochloric acid in the distal oesophagus) Produce symptoms of oesophagitis
Oesophageal pH monitoring Reflux oesophagitis GORD/GERD; may not determine oesophagitis
Endoscopy [60, 62] Confirmation of peptic ulcer, gastric tumour, non-ulcer dyspepsia; may not always define GORD/GERD or H. pylori
GI radiographs Oesophageal reflux, gas entrapment, gall bladder disease
Gastroscopy Gastritis
Serum gastrin levels To confirm or rule out Zollinger-Ellison syndrome and gastrinoma
Serum amylase Pancreatitis
Small-bowel follow through Exclusion or confirmation of Crohn’s disease

Confirmed diagnosis

Dan and peptic ulcer

Dan is a 40-year-old man presenting at the clinic for help with digestive discomfort, which has come and gone over the past six months. When his symptoms are bad he experiences heartburn, a gnawing pain in the centre of his chest, a sharp pain that can become dull and lasts for a couple of hours and occasional nausea. Dan can experience symptoms before eating but will become full very quickly. He has an overall lack of

TABLE 3.9 DECISION TABLE FOR TREATMENT (ONCE DIAGNOSIS IS CONFIRMED)

Complaint Context Core
Treatment for the presenting complaint and symptoms Treatment for all associated symptoms Treatment for mental, emotional, spiritual, constitutional, lifestyle issues and metaphysical considerations
TREATMENT PRIORITY TREATMENT PRIORITY TREATMENT PRIORITY

NB: Tests to monitor Dan’s vitamin and mineral levels should be done after 6 weeks and again after 8–12 weeks to ensure levels stay within normal range; dosage can be adjusted if necessary based on test results

appetite and has lost weight recently. Dan says he is definitely burping more often and his symptoms can be worse when he is lying down at night. During the consultation Dan reveals that although he loves his job as a principal of a small school, he has experienced excessive stress with changes in procedures and staff as well as building renovations. He takes aspirin or ibuprofen regularly for tension headaches and has been drinking up to six cups of coffee a day and sometimes skips meals.

Dan required immediate referral and was diagnosed with a peptic ulcer, a condition involving the development of an ulcer near the acid-bearing area of the stomach, duodenum, oesophagus or jejunum. Epigastric pain that a person can point to is a key feature of peptic ulcers.

Peptic ulcers can be single or multiple open sores affecting the mucous membranes and are usually caused by failure of the digestive tract to withstand the action of pepsin and hydrochloric acid. This usually occurs because the mucous membranes become thinner, rather than as a result of excess pepsin or hydrochloric acid. A major cause of peptic ulcers is Helicobacter pylori (also known as Campylobacter pylori) infection [63]. Additional triggers include excess intake of NSAIDs, which results in thinning of the gastric mucosa and large dosages of pharmaceutical glucocorticosteroids. This influences the production of excessive quantities of pepsin, excessive long-term consumption of alcohol (ethanol) and the increased ingestion of the nicotinic acid form of vitamin B3 on an empty stomach releasing high levels of stomach acid. Stress has a significant impact on existing peptic ulcers and heartburn can be frequently experienced. Risk factors for developing a peptic ulcer are being over 40 years of age, cigarette smoking and family or past medical history of ulcer disease.

General references used in this diagnosis: 2, 6–11, 57, 59, 65

Prescribed medication

Dietary suggestions

Food allergies should be tested for and managed appropriately [17, 18]. Milk should be avoided because it can significantly increase stomach-acid production [17, 18, 33].

Fermented milk products, such as yoghurt containing live cultures of bifidobacteria and lactobacillus, may be helpful [16, 34, 35]; although, if Dan is allergic or intolerant to dairy products he should avoid them [17, 18].

Encourage Dan to increase consumption of soluble fibre from fruit and vegetables [1618].

Encourage Dan to avoid foods that he knows aggravate his symptoms, and also avoid refined sugars [16, 17].

Encourage Dan to avoid coffee, alcohol and chocolate [15].

Encourage Dan to avoid spicy foods, spearmint, peppermint, fatty foods, carbonated beverages, orange juice and tomato juice [10].

Cabbage and other cruciferous vegetables should be included in Dan’s diet every day [1618]. The juice of half a head of cabbage or eating the cabbage raw may be beneficial during an acute episode [16, 18]. Cabbage can help prevent recurrence of ulcers [16] and has ulcer healing properties [17, 18].

Encourage Dan to eat bananas every day. Bananas stimulate gastric mucosal cell growth and help maintain the protective layer on the gastric mucosa [17, 18]. Banana is also helpful to relieve acute symptoms of dyspepsia and heartburn [16].

Ginger tea may reduce symptoms of dyspepsia [16, 18].

One tablespoon of unpasteurised Manuka honey taken on an empty stomach at bedtime can relieve ulcers [16].

Encourage Dan to increase his intake of foods rich in vitamin A. Vitamin A helps maintain the integrity of the mucosal barrier and protect gastric mucosa from damage [16, 17, 19, 22].

Encourage Dan to reduce consumption of fatty foods and saturated fat [15, 16] and increase consumption of foods containing omega-3 fatty acids [16]. Olive oil is a good choice due to its antioxidant properties [16]. Diets high in olive oil are associated with a higher percentage of ulcer healing and reduced ulcerogenesis from NSAIDs [16].

Encourage Dan to consume garlic and onions every day [18]. Garlic is effective against Helicobacter pylori [19]. If Dan’s reflux symptoms persist he may find avoiding garlic and onions reduces oesophageal pressure and therefore symptoms of reflux [10].

Encourage Dan to take lecithin granules daily. The phosphatidylcholine in lecithin is gastroprotective [17, 44].

Physical treatment suggestions

TABLE 3.10 HERBAL TEA

Alternative to coffee
HERB FORMULA RATIONALE
Chamomile flowers
Matricaria recutita
2 parts Anti-inflammatory [16, 19, 20]; spasmolytic [16, 19, 20]; carminative [16, 19, 20]; antimicrobial [19, 20]; alpha-bisabolol in chamomile promotes tissue granulation and tissue regeneration in ulcers [19, 20, 36]; chamomile can prevent formation of ulcers [19, 36] and reduces healing time [19, 36]; anti-inflammatory action interrupts tissue destruction cycle and provides symptomatic relief [16]
Ginger root powder
Zingiber officinale
½ part Anti-nausea [19, 20]; anti-ulcer activity [19, 20]; anti-inflammatory [19, 20]; analgesic [19, 20]; inhibitory effect on H. pylori [19, 37]
Lemon balm
Melissa officinalis
1 part Anti-inflammatory [19]; analgesic [19]; antispasmodic [19, 21, 23]; antimicrobial [19, 23]; anxiolytic [19, 23]; sedative [19, 21, 23]; beneficial for gastrointestinal conditions associated with nervousness or anxiety [19, 21]
Chickweed
Stellaria media
2 parts Demulcent [19, 23]; antiulcer [23]; beneficial in gastric irritation [23]
Infusion: 1 tsp per cup – 1 cup 3–4 times daily

TABLE 3.11 HERBAL POWDER

HERB FORMULA RATIONALE
Deglycyrrhizated licorice root powder [15, 18]
Glycyrrhiza glabra
1 part Anti-inflammatory [19, 20]; mucoprotective [19, 20]; promotes mucosal repair and reduces symptoms of active ulcers [19, 20]; antimicrobial [19, 20]; anti-H. pylori properties [38]; adrenal tonic [20]
Slippery elm bark powder
Ulmus fulva
1 part Nutritive demulcent [19, 21]; emollient [19, 21]; traditionally used for inflammatory conditions of the gastrointestinal tract [19, 21] and for dyspepsia [19], gastric reflux [19] and peptic ulcers [19]
Marshmallow root powder
Althea officinalis
1 part Demulcent [21, 23]; emollient [21, 23]; vulnerary [21, 23]
One heaped teaspoon mixed to a smooth paste with a little water 3 times daily before meals. Two heaped teaspoons in water can be taken as required to alleviate acute symptoms of heartburn.

TABLE 3.12 HERBAL FORMULA (1:2 LIQUID EXTRACTS)

Made with ethanolic extract herbal liquids (alcohol removed)
HERB FORMULA RATIONALE
Meadowsweet
Filipendula ulmaria
70 mL Anti-inflammatory [19, 23]; analgesic [19, 23]; gastroprotective [19, 23]; normalises stomach acid [16]; promotes healing of stomach ulcers [19, 39]; positive effect on antioxidant status of gastric tissue [40]; traditionally used for dyspepsia, heartburn and hyperacidity [21, 23]
Golden seal
Hydrastis canadensis (cultivated/plantation source)
40 mL Antimicrobial [19, 23]; mucous membrane trophorestorative [19, 23]; anti-inflammatory [19, 23]; vulnerary [19, 23]; bitter tonic [19, 23]; traditionally used for dyspepsia and gastritis [41]; beneficial for peptic ulcers [23]; inhibits growth of H. pylori [48]
Siberian ginseng
Eleutherococcus senticosus
30 mL Adaptogenic [19, 20]; immunomodulator [19, 20]; tonic [19, 20]; beneficial to improve stress response and increase energy levels [19, 20]
Skullcap
Scutellaria lateriflora
30 mL Nervine tonic [23]; spasmolytic [23]; mild sedative [21, 23]; traditional indications include nervous tension and anxiety [21, 23]
Rhodiola
Rhodiola rosea
30 mL Adaptogenic [42]; tonic [42]; traditionally used to treat fatigue, depression and nervous system disorders [42]; effective in reducing symptoms of generalised anxiety disorder [43]
Dosage: 200 mL Dose: 10 mL twice daily before meals

TABLE 3.13 NUTRITIONAL SUPPLEMENTS

SUPPLEMENT AND DOSE RATIONALE
Supplement providing a daily dose of approx 2000 mg vitamin C, 500 IU vitamin E, 5000 IU vitamin A, 2000 mg mixed bioflavanoids and 10 mg elemental zinc in divided doses [17, 18] Vitamins C, E and zinc enhance wound healing and recovery [17, 18, 22, 24]; zinc supplementation reduces the incidence, severity and number of gastric lesions [17, 18]; lower levels of vitamin C have been found in people with peptic ulcers [68]; bioflavanoids have anti-allergic properties [18, 22]; may inhibit H. pylori [18] and help prevent ulcer formation [18]; vitamins A [18, 24] and E [18] help maintain integrity of the mucosal barrier
Omega-3 fish oil
3 × 1000 mg capsules twice daily [17, 19]
Anti-inflammatory [17, 19, 22]; protective against peptic ulcer disease [17]
L-glutamine
1500 mg daily in divided doses [18]
Protects gastrointestinal mucosa from damage and promotes repair [19, 45]; indicated for use to prevent and heal peptic ulcers [22, 45]
High-potency practitioner-strength multivitamin and mineral complex providing therapeutic doses of B-group vitamins
Dosage as recommended by manufacturer
B vitamins are beneficial to support Dan’s stress response [19, 22]; a broad-spectrum multivitamin and mineral supplement can help increase levels of essential nutrients and antioxidants which may be deficient due to Dan’s diet and lifestyle
High-potency practitioner-strength probiotic supplement containing therapeutic levels of human strain Lactobacillus and Bifidobacterium organisms [46, 47]
Dosage as recommended by manufacturer
Probiotic supplementation can inhibit H. pylori [46, 47] and in combination with antibiotic therapy may increase its eradication rate [46, 47] and reduce antibiotic side effects [46]; probiotics can stabilise gastric barrier function [46] and decrease mucosal inflammation [46]

References

[1] Talley N.J., O’Connor S. Pocket Clinical Examination, third edn. Australia: Churchill Livingstone Elsevier; 2009.

[2] Kumar P., Clark C. Clinical Medicine, sixth edn. London: Elsevier Saunders; 2005.

[3] Silverman J., Kurtz S., Draper J. Skills for Communicating with Patients, second edn. Oxford: Radcliff Publishing; 2000.

[4] Neighbour R. The Inner Consultation: how to develop an effective and intuitive consulting style. Oxon: Radcliff Publishing; 2005.

[5] Lloyd M., Bor R. Communication Skills For Medicine, third edn. Edinburgh: Churchill Livingstone Elsevier; 2009.

[6] Douglas G., Nicol F., Robertson C. Macleod’s Clinical Examination, twelfth edn. Churchill Livingstone Elsevier; 2009.

[7] Jamison J. Differential Diagnosis for Primary Care, second edn. London: Churchill Livingstone Elsevier; 2006.

[8] Polmear A., ed. Evidence- Based Diagnosis in Primary Care. Churchill Livingstone Elsevier; 2008:274–283.

[9] Berkow R.M.D., Fletcher A.J.M.D., Beers M.H.M.D. The Merck Manual, sixteenth edn. Rathway, N.J: Merck Research Laboratories; 1993. (later edition)

[10] Seller R.H. Differential Diagnosis of Common Complaints, fifth edn. Philadelphia: Saunders Elsevier; 2007.

[11] Collins R.D. Differential Diagnosis in Primary Care, fourth edn. Philadelphia: Lippincott Williams & Wilkins; 2008.

[12] D. Peters, L. Chaitow, G. Harris, S. Morrison, Integrating Complementary Therapies in Primary Care, London, Churchill Livingstone, 2002.

[13] Pagna K.D., Pagna T.J. Mosby’s Diagnostic and Laboratory Test reference, third edn. USA: Mosby; 1997. (later edition)

[14] Numans M., Lau J., de Wit N., et al. Short-term treatment with protonpump inhibitors as a test for gastroesophageal reflux disease. Ann Intern Med. 2004;140:518–527.

[15] El-Hashemy S. Naturopathic Standards of Primary Care. Toronto: CCNM Press Inc; 2007.

[16] Jamison J. Clinical Guide to Nutrition & Dietary Supplements in Disease Management. Edinburgh: Churchill Livingstone; 2003.

[17] Osiecki H. The Physicians Handbook of Clinical Nutrition, seventh edn. Eagle Farm: Bioconcepts; 2000.

[18] J.E. Pizzorno, M.T. Murray, H. Joiner-Bey, The Clinicians Handbook of Natural Medicine, second edn, St Louis, Churchill Livingstone, 2008.

[19] Braun L., Cohen M. Herbs & Natural Supplements: An evidence based guide, second edn. Sydney: Elsevier; 2007.

[20] Mills S., Bone K. Principles & Practice of Phytotherapy; Modern Herbal Medicine. Edinburgh. London: Churchill Livingstone; 2000.

[21] British Herbal Medicine Association. British Herbal Pharmacopoeia. BHMAA; 1983.

[22] Osiecki H. The Nutrient Bible, seventh edn. Eagle Farm: BioConcepts Publishing; 2008.

[23] Mills S., Bone K. The Essential Guide to Herbal Safety. St Louis: Churchill Livingstone; 2005.

[24] Higdon J. An Evidence Based Approach to Vitamins and Minerals. New York: Thieme; 2003.

[25] Levenstein S. Stress and peptic ulcer: life beyond helicobacter. British Medical Journal. 1998;316:538–541.

[26] Levenstein S., Ackerman S., Kiecolt-Glaser J.K., Dubois A. Stress and Peptic Ulcer Disease. Journal of the American Medical Association. 1999;281(1):10–11.

[27] Jorm A.F., Christensen H., Griffiths K.M., Parslow R.A., Rodgers B., Blewitt K.A. Effectiveness of complementary and self-help treatments for anxiety disorders. Medical Journal of Australia. 2004;181(7):S29–S46.

[28] Byrne A., Byrne G.D. The effect of exercise on depression, anxiety and other mood states: A review. J Psychosom Res. 1993;37(6):565–574.

[29] Moyer C.A., Rounds J., Hannum J.W. A Meta-Analysis of Massage Therapy Research. Psychological Bulletin. 2004;130(1):3–18.

[30] Field T., Robinson G., Scafidi F., Nawrocki R., Goncalves A. Massage therapy reduces anxiety and enhances EEG pattern of alertness and math computations. International Journal of Neuroscience. 1996;86:197–205.

[31] Li Y., Tougas G., Chiverton S.G., Hunt R.H. The Effect of Acupuncture on Gastrointestinal Function and Disorders. The American Journal of Gastroenterology. 2008;87(10):1372–1381.

[32] Takahashi T. Acupuncture for functional gastrointestinal disorders. Journal of Gastroenterology. 2006;41:408–417.

[33] Ippoliti A.F., Maxwell V., Isenberg J.I. The Effect of Various Forms of Milk on Gastric-Acid Secretion. Annals of Internal Medicine. 1976;84(3):286–289.

[34] Rodriguez C., Medici M., Rodriguez A.V., Mozzi F., de Valdez F. Prevention of chronic gastritis by fermented milks made with exopolysaccharide-producing Streptococcus thermophilus strains. Journal of Dairy Science. 2009;92:2423–2434.

[35] Elmstahl S., Svenssen U., Berglund G. Fermented milk products are associated to ulcer disease, Results from a cross sectional population study. European Journal of Clinical Nutrition. 1998;52:668–674.

[36] Szelenya I., Isaac O., Thiemer K. Pharmacological experiments with compounds of chamomile. III. Experimental studies of the ulcerprotective effect of chamomile. Planta Med. 1979;35(3):218–227.

[37] Nostro A., Cellini L., DiBartolomeo S., Cannatelli M.A., DiCampli E., Procopio F., Grande R., et al. Effects of combining extracts (from propolis or Zingiber officinale) with clarithromycin on Helicobacter pylori. Phytotherapy Research. 2006;20(3):187–190.

[38] Fukai T., Maruma A., Kaitou K., Kanda T., Terada S., Nomura T. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sciences. 2002;71:1449–1463.

[39] Barnaulov O.D., Denisenko P.P. Anti-ulcer action of a decoction of the flowers of the dropwort, Filipendula ulmaria (L.) Maxim [Article in Russian]. Farmakol Toksikol. 1980;43(6):700–705.

[40] Vasiliauskas A., Keturkienë A., Leonavièienë L., Vaitkienë D. Influence of Herb Filipendula ulmaria (L.) Maxim Tincture on Pro-/antioxidant Status in Gastric Tissue with Indomethacin-induced Gastric Ulcer in Rats. Acta Medica Lituanica. 2004;11(1):31–36.

[41] Goldenseal (Hydrastis Canadensis). An annotated bibliography. In: Predny M., Chamberlain J. Gen. Tech. Rep. SRS-88. Asheville, NC: U.S. Department of Agriculture, Forest Service, Southern Research Station, 2005. Available from http//www.sfp.forprod.vt.edu/

[42] Morgan M., Bone K. Rhodiola rosea – Rhodiola. Mediherb Phytotherapist’s Perspective. 2005;47:1–4.

[43] Bystritsky A., Kerwin L., Feusner J.D. A Pilot Study of Rhodiola rosea (Rhodax®) for Generalized Anxiety Disorder (GAD). The J Altern Complement Med. 2008;14(2):175–180.

[44] Dunjic B.S., Axelson J., Ar’Rajab A., Larsson K., Bengmark S. Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats. Scandinavian Journal of Gastroenterology. 1993;28(1):89–94.

[45] Elia M., Lunn P.G. The Use of Glutamine in the Treatment of Gastrointestinal Disorders in Man. Nutrition. 1997;13(7–8):743–747.

[46] Gotteland M., Brunser O., Cruchet S. Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori? Alimentary Pharmacology and Therapeutics. 2006;23(8):1077–1086.

[47] Felley C., Michetti P. Probiotics and Helicobacter pylori. Best Practice & Research Clinical Gastroenterology. 2003;17(5):785–791.

[48] Mahady G.B., Pendland S.L., Stoia A., Chadwick L.R. in: Vitro Susceptibility of Helicobacter pylori to Isoquinoline Alkaloids from Sanguinaria canadensis and Hydrastis canadensis. Phytotherapy Research. 2003;17:217.

[49] Buchman D.D. The complete book of water healing. New York: Contemporary Books, McGraw-Hill Companies; 2001.

[50] Blake E. Philadelphia. In: Chaitow L., Blake E., Orrock P., Wallden M., Sinder P., Zeff J. Naturopathic Physical Medicine: Theory and Practice for Manual Therapists and Naturopaths. Churchill Livingstone Elsevier, 2008.

[51] Boyle W., Saine A. Lectures in Naturopathic Hydrotherapy. Oregon: Eclectic Medical Publications. 1988.

[52] Lin M., Triadafilopoulos G. Belching: dyspepsia or gastroesophageal reflux disease? Am J Gastroenterol. 2003;98:2139–2145.

[53] Ahmad M.A., Metz D.C. Dyspepsia and heartburn. Rheum Dis Clin North Am. 1999;25:703–718.

[54] Bazaldua O.V., Schneider F.D. Evaluation and management of dyspepsia. Am Fam Physician. 1999;60:1773–1788.

[55] Dent J. Definitions of reflux disease and its separation from dyspepsia. Gut. 2002;50(Suppl. 4):17–20.

[56] Jones M.P. Evaluation and treatment of dyspepsia. Posgrad Med J. 2003;79:225–229.

[57] Richter J.E. Dyspepsia: organic causes and differential characteristics from functional dyspepsia. Scand J Gastroenterol. 1991;26(Suppl. 182):11–16.

[58] Dickerson L.M., King D.E. Evaluation and management of nonulcer dyspepsia. Am Fam Physician. 2004;70(1):107–114.

[59] Schroeder B.M. Evaluation of epigastric discomfort and management of dyspepsia and GERD. Am Fam Physician. 2003;68(6):1215–1216. 1219–1220

[60] Moayyedi P., Talley N., Fennerty M., et al. Can the clinical history distinguish between organic and functional dyspepsia? JAMA. 2006;295:1566–1576.

[61] Spiller R. Anorexia, nausea, vomiting and pain. BMJ. 2001;323:1354–1357.

[62] Ford A., Qume M., Moayyedi P., et al. Helicobacter pylori ‘test and treat’ or endoscopy for managing dyspepsia: an individual patient data meta-analysis. Gastroenterology. 2005;128:1838–1844.

[63] Weijnen C., Numans M., de Wit N., et al. Testing for Helicobacter pylori in dyspeptic patients suspected of peptic ulcer disease in primary care: cross sectional study. BMJ. 2001;323:71–75.

[64] Chan F., Wu J., Ching J., et al. Effect of Helicobacter pylori eradication on treatment of gastro-oesophageal reflux disease: a double blind, placebo controlled, randomized trial. Gut. 2004;53:174–179.

[65] Heikkinen M., Pikkarainen P., Eskelinen M., et al. GP’s ability to diagnose dyspepsia based only on physical examination and patient history. Scand J Prim Healthcare. 2000;18:99–104.

[66] Fox J.G., Wang T.C. Helicobacter pylori–not a good bug after all. N Engl J Med. 2001;345:829–831.

[67] Hohenberger P., Gretschel S. Gastric Cancer. Lancet. 2003;362:305–315.

[68] O’Connor H., Schorah C., Habibzedah N., et al. Vitamin C in the human stomach: relation to gastric pH, gastroduodenal disease, and possible sources. Gut. 1989;30:436–442.

Irritable bowel syndrome

Case history

Adrian Nixon, 45, is a sound engineer who works on theatre productions. Adrian works long hours and loves his work. He is here at the recommendation of a colleague to get an alternative perspective on the digestive problems he is experiencing.

Adrian has experienced episodes of alternating diarrhoea and constipation associated with left-sided lower abdominal pain over the past four years. He can also feel quite bloated at times and suffers from excessive wind.

Adrian had this problem when he was in his early 20s but it seemed to settle down. The return of his symptoms has coincided with his divorce four years ago. Adrian explains that the divorce was very stressful and he believes his emotional turmoil had a lot to do with the problem returning. He would like to explore and address this aspect of his problem.

Adrian explains that his abdominal pain can be quite acute and the only thing that seems to relieve it is when he passes a bowel motion. When he experiences diarrhoea he can pass up to six motions a day, which are quite small and thin. Sometimes the diarrhoea is watery or slimy, but he hasn’t noticed any blood or froth. Adrian’s digestive problems are not accompanied by a loss of appetite, nausea or vomiting.

When you ask Adrian about his diet he admits it is not very good. He lives on his own and doesn’t enjoy cooking. Since his divorce he has eaten mostly takeaway or frozen convenience meals. His favourite foods are Thai and Chinese. Adrian drinks a lot of tea and coffee at work, eats on the run and doesn’t think he drinks enough water. Adrian is a social drinker but that happens rarely these days as he has not felt like socialising with friends and colleagues for a while now. He prefers to just go home and says he has never enjoyed drinking alcohol alone.

TABLE 3.14 COMPLAINT [110]

Analogy: Skin of the apple

AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES Your practitioner impression Adrian is open to being helped and is interested in amelioration of symptoms along with understanding underlying cause. Adrian has vitality. Rating scale   How would you rate the diarrhoea and constipation discomfort out of 10, with 10 being as bad as can be? With acute pain it can feel like a 9 out of 10 and on a daily level it can be 6 out of 10.

TABLE 3.15 CONTEXT

Analogy: Flesh of the apple Context: Put the presenting complaint into context to understand the disease
AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES
Family health history  
Is there a family history of similar symptoms to what you have been experiencing? My brother used to complain a lot of digestive concerns before he died in a motorcycle accident 10 years ago.
Trauma and pre-existing illness  
Have you experienced any other illness that may seem unrelated to your current symptoms? I’ve been tested for haemochromatosis. My mother has this condition passed down from both her parents. I have one gene but have been told I won’t develop symptoms.
Functional disease  
Do you experience urgency to pass a watery bowel motion in the morning when you wake? (colon and functional disorder) Sure do, right on time!
Infection and inflammation  

TABLE 3.16 CORE

Analogy: Core of the apple with the seed of ill health Core: Holistic assessment to understand the client
Areas of investigation and example questions Client responses
Emotional health  
Can you remember a time when you felt extremely healthy and happy? I felt great around my 40th birthday. My wife and son were with me and we had a really special day. I remember feeling I had everything I needed to make me happy.
Education and learning  
Do you feel like you have learned anything significant about yourself through the process of your divorce over the past four years? I was surprised at how much sadness and anger I had to deal with and how long it took me to let go. I learned that I’ve been working through much underlying grief from my brother’s death. I have learned that I really miss seeing my son.

TABLE 3.17 ADRIAN’S SIGNS AND SYMPTOMS

Results of medical investigations

No investigations have been performed at this stage.

TABLE 3.18 UNLIKELY DIAGNOSTIC CONSIDERATIONS [1, 36, 11]

Conditions and causes Why unlikely
OBSTRUCTION AND FOREIGN BODY
Kidney stones: hyperoxaluria disorders of uric acid metabolism may develop with inflammatory bowel disease and dehydration Colic pain usually radiates from the loin to the groin about every 10 minutes; it can be very sharp pain in acute episodes; urinalysis NAD
DEGENERATIVE AND DEFICIENCY
Peptic/duodenal ulcer: abdominal pain and bloating Not common to be associated with diarrhoea; usually severe episodes of upper or midgut abdominal pain; usually will not eat due to pain after ingesting food
INFECTION AND INFLAMMATION
Gastroenteritis: abdominal pain, diarrhoea Associated with vomiting, nausea and fever; Adrian has no low-grade fever; acute gastritis is usually self-limiting and lasts less than a week; it is possible, however, to develop functional bowel disease after an acute infective episode [62]
Bacterial infection: e.g. Yersinia enterocolitica, Escherichia coli, Shigella, Staphylococcal enterocolitis, ileocaecal TB; diarrhoea is the main symptom; may cause ulceration and inflammation; diarrhoea, abdominal pain, bloating [73, 74] Usually self-limiting and acute in duration between 1 and 10 days depending on bacterial toxin; violent vomiting can be associated; no bloody diarrhoea reported
Viral infection: retrovirus, hepatitis; diarrhoea, tired, nausea, fatigue, weight loss; recently travelled to new environment No history or signs of jaundice; stools are not pale; no fever, nausea or change in appetite
Parasitic infection: giardia, amoebiasis

Stools become very pale with mucus; loss of appetite or weight loss is not a dominant symptom for Adrian; no nausea, headache or blood or significant mucus in stools Hepatitis/fatty liver: can be due to family history of haemochromatosis No jaundice or yellow sclera; usually upper abdominal pain or middle of gut; no loss of appetite or nausea Cholecystitis: chronic and acute gall bladder inflammation; symptoms can be vague gastrointestinal disturbance; biliary colic that resembles functional bowel disorders Usually severe right-sided, upper abdominal pain; no fever or nausea associated with symptoms Causal factor:
H. pylori infection: abdominal pain, bloating Pain usually clearly located in middle of the abdomen; usually nausea is associated with stomach bloating; often do not feel like eating ENDOCRINE/REPRODUCTIVE Diabetes: diabetic neuropathy causes chronic diarrhoea, gastric stasis and bacterial overgrowth Adrian has not reported increased urination or thirst; abdominal pain can be general as well as local to the left side; urinalysis NAD Addison’s disease: weight loss, dehydration, nausea, diarrhoea, abdominal pain No loss of body hair or skin pigmentation reported; urinalysis NAD

Case analysis

TABLE 3.19 POSSIBLE DIFFERENTIAL DIAGNOSIS

Not ruled out by tests/investigations already done [1, 37, 11, 13, 5759]
CONDITIONS AND CAUSES WHY POSSIBLE WHY UNLIKELY
ALLERGIES AND IRRITANTS
Food allergy: typically to cow’s milk, egg, soya, peanut, wheat and fish [29, 67] Diarrhoea, cramping colic Often presents with swelling of lips and tongue, urticaria skin rash, conjunctivitis, rhinitis, anaphylaxis and difficulty breathing; has not linked symptoms to a particular food yet
Lactose and fructose intolerance [29, 78] Abdominal pain, bloating, watery and frothy diarrhoea; possible recurrent abdominal pain with onset of lactose ingestion No nausea; need to investigate how Adrian’s diet has changed
CANCER AND HEART DISEASE
Bowel cancer, polyps, gastrointestinal lymphoma [58] Usually associated with alternating diarrhoea and constipation; more common in middle-aged men; carcinomas and polyps can cause irritation and hypermotility Usually presents with blood in the stool; abdominal pain is more often an advanced symptom
Lymphoma: malignant lymphadenopathies may infiltrate the small intestine and cause diarrhoea and malabsorption; increased risk if coeliac disease present Diarrhoea No significant weight loss and fatigue recently; usually associated with significant fever and night sweats
OBSTRUCTION AND FOREIGN BODY
Intestinal obstruction e.g. faecal impaction with overflow Abdominal pain, constipation, diarrhoea, abdominal distension; can be acute and recurrent abdominal pain Can cause vomiting; Adrian’s abdominal pain is not exclusively worse after eating meals
FUNCTIONAL DISEASE
Functional abdominal pain syndrome [59] Abdominal discomfort that can be continuous Abdominal pain is not exclusively connected with physiological events such as eating or passing a bowel motion
Functional diarrhoea [59] Chronic diarrhoea and anxiety; no bleeding from the bowel, weight loss or ongoing fatigue; bowel motions are watery and mushy Usually symptoms are in absence of abdominal pain; Adrian has bowel motions first thing in morning but need to clarify if he also has further passing during the day; defecation not exclusively after eating food for Adrian
Functional constipation: more than 1 in 4 bowel motions are lumpy, hard and need to strain, has feeling of incomplete evacuation or blockage; has fewer than 3 evacuations a week and may need manual help to facilitate bowel motions [59] Constipation Adrian has constipation that alternates with diarrhoea and has more than 3 evacuations a week
Functional abdominal bloating [59] Bloating and visible distension Functional bloating will not usually be relieved by passing a bowel motion
Irritable bowel syndrome: a combination of functional pain, diarrhoea, constipation and bloating [57, 59] Diarrhoea, recurrent episodes, symptom-free episodes, stress; abdominal pain on lower left side; usually alternates between constipation and diarrhoea; bowel motions are rarely nocturnal; poor diet  
DEGENERATIVE AND DEFICIENCY
Ulcerative colitis Diarrhoea and lower abdominal pain Usually affects the rectum alone; may spread to the whole colon but rarely affects the ileum; no blood and mucus in stools, which would usually be present; no significant weight loss, fever or fatigue
Diverticular disease: diverticula and diverticulitis Chronic symptoms include abdominal pain and diarrhoea; usually pain in the left lower abdomen; can experience erratic bowel habits; more common for those eating a low-fibre diet Usually affects people who are over 50 years of age; usually would present with blood or mucus in stools
Causal factor:
Bile acid malabsorption: due to conditions such as Crohn’s disease, coeliac disease, increased small intestine transit, diabetic diarrhoea, postinfective gastroenteritis [62]
Under-diagnosed cause of chronic diarrhoea; when terminal ileum fails to reabsorb bile salts causes diarrhoea and increases colonic motility  
INFECTION AND INFLAMMATION
Appendicitis Abdominal pain, constipation; can be vague symptoms before an acute episode More common to be right-sided abdominal pain, but can refer to the left side in some cases; usually associated with midgut belly button pain; diarrhoea not as common as a key symptom; no fever, vomiting or loss of appetite
Crohn’s disease Diarrhoea, recurrent episodes of watery bowel and lower abdominal pain No key symptoms of weight loss, fever, nausea or blood and mucus in stools; Adrian only passes a bowel motion during the day
Small-bowel disease Chronic bacteria overgrowth due to small-bowel obstruction – diarrhoea, lower abdominal discomfort Weight loss is not a key symptom
Candidiasis and dysbiosis Diarrhoea and abdominal distension Adrian has not been on medication or antibiotics recently; no reports of feeling significant fatigue; abdominal pain is not a key symptom of candidiasis
SUPPLEMENTS AND SIDE EFFECTS MEDICATION/DRUGS
Supplement or food additive abuse: excess vitamin C or magnesium? Diarrhoea, abdominal pain Adrian is not taking any supplements at this time
Drug induced (e.g. Pseudomembranous colitis) Diarrhoea caused by recent antibiotic use (allow overgrowth of fungi), laxatives, antihypertensives, NSAIDs Not usually associated with episodic abdominal pain; no recent antibiotic use
ENDOCRINE/REPRODUCTIVE
Pancreatic disorders: chronic pancreatitis, vipoma (endocrine pancreatic tumour), Zollinger-Ellison syndrome [79] Symptoms of abdominal pain, episodes of diarrhoea, fatty diet; slimy bowel motion Constipation not usually a symptom; no significant blood or mucus reported in stools; usually upper abdominal pain similar to ulcer or gall bladder colic
Hyperthyroidism Diarrhoea and anxiety, weight loss; common to present between 20 and 40 years of age No goitre or eye symptoms presenting as clinical markers; Adrian not experiencing high levels of anxiety now or restlessness, energy levels are moderate
AUTOIMMUNE DISEASE
Coeliac disease [71] Abdominal pain, poor diet, diarrhoea More often upper abdominal pain with bloating
STRESS AND NEUROLOGICAL DISEASE
Depression [65, 69, 72] Often presents as physical symptoms such as diarrhoea; spending more time on his own since his divorce 4 years ago No loss of appetite, still very active at work, no significant fatigue reported
Anxiety [69, 70, 72, 79] Not as socially active as he used to be, diarrhoea No reports on lack of sleep, palpitations, tight chest, difficulty breathing, loss of appetite, fast talking
Phobia: intense fear to specific or set of stimuli that are predictable Has mentioned not socialising as much recently Adrian is not experiencing symptoms of anxiety that are restricted to a specific event; has not mentioned avoidance of a specific object or event
EATING HABITS AND ENERGY
Causal factor:
Dehydration
Chronic diarrhoea, not drinking much water, drinking a lot of tea and coffee; symptoms can be asymptomatic, however, colicky pain in the abdomen may be present that can be dull, constant and intermittent  

TABLE 3.20 DECISION TABLE FOR REFERRAL [1, 36, 12]

COMPLAINT CONTEXT CORE
Referral for presenting complaint Referral for all associated physical, dietary and lifestyle concerns Referral for contributing emotional, mental, spiritual, metaphysical, lifestyle and constitutional factors
REFERRAL FLAGS REFERRAL FLAGS REFERRAL FLAGS

ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE REFERRAL DECISION REFERRAL DECISION REFERRAL DECISION

TABLE 3.21 FURTHER INVESTIGATIONS THAT MAY BE NECESSARY [16, 11, 14]

TEST/INVESTIGATION REASON FOR TEST/INVESTIGATION
FIRST-LINE INVESTIGATIONS:
Abdominal examination: guarding, rebound tenderness, palpation, abdnormal pulsations (auscultation) Monitor bloating and distension for abdominal mass
Full blood count Low haemoglobin in Crohn’s disease, detect anaemia of chronic disease (usually normocytic, normochromic anaemia, and rarely megaloblastic due to B12 deficiency), inflammation, infection or tumour; iron deficiency anaemia; white-blood-cell count raised in appendicitis
ESR (erythrocyte sedimentation rate)/CRP (C-reactive protein) Inflammation, tumour, infection
Blood electrolytes Addison’s disease, kidney infection, dehydration
Stool test [68] Detect ova, parasites, bacteria, calprotectin and fat levels, and occult blood; if acidic stools are passed it indicates lactose intolerance
Abdominal x-ray Appendicitis, intestinal obstruction, ulcerative colitis
Elimination diets Detect food intolerance
IF NECESSARY:
Hydrogen breath test To detect bacterial overgrowth; when bacteria is metabolised by lactose or glucose there is a production of hydrogen; can detect fructose intolerance
Liver function test Hepatitis, substance abuse
Fasting blood glucose test Diabetes, Addison’s disease, raised in pancreatitis
Antigliadin antibodies Check if antibodies to gluten are present in blood
Sigmoidoscopy To test for Crohn’s disease
Colonoscopy and biopsy Rule out bowel cancer, polyps, inflammatory bowel disease, diverticulitis or haemorrhoids
Serum B vitamins and iron Possible malabsorption and poor diet [16]
Hair tissue mineral analysis To determine the presence of heavy metals [16] and ascertain tissue mineral status due to malabsorption and poor diet

Confirmed diagnosis

Adrian and irritable bowel syndrome

Adrian has come to the clinic for help with a longstanding digestive concern that returned four years ago after he went through a divorce. Adrian has maintained his employment as a sound engineer and really enjoys his work. He has become socially isolated following his divorce and experienced significant emotional turmoil resulting from the failure of his marriage. Adrian does not enjoy cooking and prefers to eat out alone.

Adrian’s digestive symptoms required immediate referral to rule out organic and inflammatory causes for the diarrhoea, abdominal pain and constipation. The confirmed diagnosis is a functional bowel disorder, which is extremely common and usually has a clinical presentation of left iliac fossa pain in the abdomen relieved by wind or passing a bowel motion.

The condition of irritable bowel syndrome (IBS) has a working criteria [57] of symptoms including abdominal discomfort for 12 or more weeks with at least two of the following features [59]:

A more generalised criterion for IBS is that the condition involves abdominal discomfort with changeable bowel motions in the absence of structural or biochemical disorders [57]. However, it is suggested more research is needed to ascertain whether low-grade inflammation may be present for some individuals with IBS [65].

The pain experienced with IBS can be very acute and intense requiring hospitalisation at times. Abdominal bloating is a common symptom and the condition is more prevalent in women than men, often associated with the menstrual cycle. The history of the condition can be longstanding with varying episodes of discomfort.

There can be symptom-free intervals and symptoms are often associated with: increased stress, sexual and emotional abuse and trauma; family history of bowel disease and other social factors; and diet [57, 69, 72].

General references used in this diagnosis: 2, 4, 5, 11, 57–61, 63, 75

Prescribed medication

Adrian has chosen not to take prescribed antidepressant medication until he has tried natural therapies and works through his emotional issues. He has agreed to work collaboratively and be monitored regularly by his GP while trying a more natural approach.

TABLE 3.22 DECISION TABLE FOR TREATMENT (ONCE DIAGNOSIS IS CONFIRMED)

Complaint Context Core
Treatment for the presenting complaint and symptoms Treatment for all associated symptoms Treatment for mental, emotional, spiritual, constitutional, lifestyle issues and metaphysical considerations
TREATMENT PRIORITY TREATMENT PRIORITY TREATMENT PRIORITY

Physical treatment suggestions

TABLE 3.23 HERBAL FORMULA (1:2 LIQUID EXTRACTS)

HERB FORMULA RATIONALE
Damiana
Turnera diffusa
50 mL Traditionally used in Western herbal medicine as an antidepressant and anxiolytic [19, 21, 22]; particularly beneficial where there is a sexual factor involved [19]
Skullcap
Scutellaria laterifolia
40 mL Nervine tonic [45]; spasmolytic [15, 45]; mild sedative [15, 45]; BHP indication for nervous tension [21]
St John’s wort
Hypericum perforatum
60 mL Antidepressant [19, 20, 39]; anxiolytic [20, 39]; nervine [19, 20]
Rhodiola
Rhodiola rosea
50 mL Adaptogen [42, 44]; tonic [42, 44]; antidepressant [42, 43]; anxiolytic [4244]
Supply: 200 mL Dose: 10 mL twice daily

TABLE 3.24 HERBAL TEA

Alternative to tea and coffee
HERB FORMULA RATIONALE
Chamomile
Matricaria recutita
3 parts Antispasmodic [19, 20]; sedative [19, 20]; anti-inflammatory [19, 20]; carminative [20]; traditionally used to treat gastrointestinal conditions such as colic, flatulence, cramping, diarrhoea, restlessness and anxiety [19, 20, 39, 21]
Peppermint
Mentha × piperita
2 parts Spasmolytic [19, 20]; carminative [19, 20]; traditionally use therapeutically for digestive disorders such as colic, flatulence, cramping [19, 20]; peppermint oil has been shown to improve symptoms of IBS [19, 39]
Lemon balm
Melissa officinalis
1 part Anxiolytic [19, 22] sedative [19, 22]; spasmolytic [19, 22]
Ginger root powder
Zingiber officinalis
¼ part Carminative [19, 20]; spasmolytic [19, 20]; traditionally used therapeutically for digestive disorders such as colic, cramping and flatulence [19, 20, 39]
Infusion: 1 tsp per cup, 1 cup three to four times daily

TABLE 3.25 TABLET ALTERNATIVE TO HERBAL LIQUID: MAY IMPROVE COMPLIANCE

HERB DOSE PER TABLET RATIONALE
St John’s wort
Hypericum perforatum
750 mg See above
Damiana
Turnera diffusa
675 mg See above
Schisandra
Schisandra chinensis
625 mg Adaptogen [19, 23]; hepatoprotective [19]; nervine tonic [23]
Skullcap
Scutellaria laterifolia
500 mg See above
Dose: 2 tablets twice daily

TABLE 3.26 ADDITIONAL FORMULA TO HERBAL TONIC OR TABLET

HERB DOSE RATIONALE
Slippery elm bark powder capsules or powder
Ulmus fulva
One 500 mg capsule 4 times daily [21, 39] or ½ tsp powder mixed with hot water 3–4 times daily [19] Nutritive demulcent [19, 21]; bulking agent and prebiotic [40]; traditionally used for diarrhoea and constipation [19, 39]; indicated for use in IBS [19, 39, 40]
Peppermint oil
Mentha × piperita
One 200 mg enteric coated capsule 3 times daily [41] See above
Enteric-coated peppermint oil improves symptoms of IBS [1619, 39, 41]

TABLE 3.27 NUTRITIONAL SUPPLEMENTS

SUPPLEMENT AND DOSE RATIONALE
High-potency practitioner-strength probiotic supplement containing Lactobacillus plantarum [1517, 37, 46, 47] and Lactobacillus GG [37]
Dosage as directed by the manufacturer
Supplementation with specific strains of probiotics may improve symptoms of IBS [1518, 37, 46, 47]; probiotic supplementation can improve intestinal health [50]
Prebiotic supplement containing fructo-oligosaccharides (FOS) [16, 37]
Dosage as directed by the manufacturer
Taking a prebiotic together with a probiotic supplement can support growth of the probiotic organisms [48]; supplemental FOS may improve symptoms of IBS [16, 49]
High-potency practitioner-strength multivitamin and mineral supplement providing therapeutic doses of essential micronutrients
Dosage as directed by the manufacturer
Adrian’s diet is poor and lacking in important micronutrients; diarrhoea may have depleted nutrient levels [81]; particularly important if tests show Adrian has specific micronutrient deficiencies

References

[1] Douglas G., Nicol F., Robertson C. Macleod’s Clinical Examination, twelfth edn. Churchill Livingstone Elsevier; 2009.

[2] Talley N.J., O’Connor S. Pocket Clinical Examination, third edn. Australia: Churchill Livingstone Elsevier; 2009.

[3] Kumar P., Clark C. Clinical Medicine, sixth edn. London: Elsevier Saunders; 2005.

[4] Polmear A. Evidence- Based Diagnosis in Primary Care. Churchill Livingstone Elsevier; 2008.

[5] Jamison J. Differential Diagnosis for Primary Care, second edn. London: Churchill Livingstone Elsevier; 2006.

[6] Collins R.D. Differential Diagnosis in Primary Care, fourth edn. Philadelphia: Lippincott Williams & Wilkins; 2008.

[7] Seller R.H. Differential Diagnosis of Common Complaints, fifth edn. Philadelphia: Saunders Elsevier; 2007.

[8] Lloyd M., Bor R. Communication Skills For Medicine, third edn. Edinburgh: Churchill Livingstone Elsevier; 2009.

[9] Neighbour R. The Inner Consultation: how to develop an effective and intuitive consulting style. Oxon: Radcliff Publishing; 2005.

[10] Silverman J., Kurtz S., Draper J. Skills for Communicating with Patients, second edn. Oxford: Radcliff Publishing; 2000.

[11] Berkow R., Fletcher A.J., Beers M.H. The Merck Manual, sixteenth edn. Rathway, N.J: Merck Research Laboratories; 1993. (later edition)

[12] D. Peters, L. Chaitow, G. Harris, S. Morrison, Integrating Complementary Therapies in Primary Care, London, Churchill Livingstone.

[13] Chaitow L., Blake E., Orrock P., Wallden M., Sinder P., Zeff J. Natropathic physical Medicine: Theory and Practice for Manual Therapists and Naturopaths. Philadephia: Churchill Livingstone Elsevier; 2008.

[14] Pagna K.D., Pagna T.J. Mosby’s Diagnostic and Laboratory Test reference, third edn. USA: Mosby; 1997. (later edition)

[15] Jamison J. Clinical Guide to Nutrition & Dietary Supplements in Disease Management. Edinburgh: Churchill Livingstone; 2003.

[16] Osiecki H. The Physicians Handbook of Clinical Nutrition, seventh edn. Eagle Farm: Bioconcepts; 2000.

[17] J.E. Pizzorno, M.T. Murray, H. Joiner-Bey. The Clinicians Handbook of Natural Medicine, second edn, St Louis: Churchill Livingstone

[18] El-Hashemy S. Naturopathic Standards of Primary Care. Toronto: CCNM Press Inc; 2007.

[19] Braun L., Cohen M. Herbs & Natural Supplements: An evidence based guide, 2nd edn. Sydney: Elsevier; 2007.

[20] Mills S., Bone K. Principles & Practice of Phytotherapy; Modern Herbal Medicine. Edinburgh, London: Churchill Livingstone; 2000.

[21] British Herbal Medicine Association. British Herbal Pharmacopoeia. BHMAA.

[22] Mills S., Bone K. The Essential Guide to Herbal Safety. St Louis: Churchill Livingstone; 2005.

[23] Bone K. Clinical Applications of Chinese and Ayurvedic Herbs: Monographs for the Western Herbal Practitioners. In Warwick. Phytotherapy Press; 1996.

[24] Coates M.D., Mahoney C.R., Linden D.R., Sampson J.E., Chen J., Blaszyk H., Crowell M.D., et al. Molecular Defects in Mucosal Serotonin Content and Decreased Serotonin Reuptake Transporter in Ulcerative Colitis and Irritable Bowel Syndrome. Gastroenterology. 2004;126:1657–1664.

[25] Mawe G.M., Coates M.D., Moses P.L. Intestinal Serotonin Signalling In Irritable Bowel Syndrome. Alimentary Pharmacology & Therapeutics. 2006;23(8):1067–1076.

[26] Fukudo S., Nomura T., Hongo M. Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut. 1998;42:845–849.

[27] Collins S.M., Piche T., Rampal P. The putative role of inflammation in the irritable bowel syndrome. Gut. 2001;49:743–745.

[28] Barbara G., DeGiorgio R., Stanghellini V., Cremon C., CorinalAdriani R. A role for inflammation in irritable bowel syndrome? Gut. 2002;51:i41–i44.

[29] Alun Jones V., Shorthouse M., McLaughlan P., Workman E., Hunter J.O. Food intolerance: a major factor in the pathogenesis of irritable bowel syndrome. Lancet. 1982;320(8303):1115–1117.

[30] Shaw G., Srivastava E.D., Sadlier M., Swann P., James J.Y., Rhodes J. Stress management for irritable bowel syndrome: a controlled trial. Digestion. 1991;50(1):36–42.

[31] Salmon P. Effects of physical exercise on anxiety, depression, and sensitivity to stress: A unifying theory. Clinical Psychology Review. 2001;21(1):33–61.

[32] Lustyk M., Kathleen B., Jarrett M.E., Bennett J.C., Heitkemper M.M. Does a Physically Active Lifestyle Improve Symptoms in Women With Irritable Bowel Syndrome? Gastroenterology Nursing. 2001;24(3):129–137.

[33] Van Dulmen A.M., Fennis J.F., Bleijenberg G. Cognitive Behavioural Group Therapy for Irritable Bowel Syndrome: Effects and Long Term Follow Up. Psychosomatic Medicine. 1996;58:508–514.

[34] Boyce P., Gilchrist J., Talley N.J., Rose D. Cognitive-behaviour therapy as a treatment for irritable bowel syndrome: a pilot study. Australian and New Zealand Journal of Psychiatry. 2000;34(2):300–309.

[35] Guthrie E., Creed F., Dawson D., Tomenson B. A randomised controlled trial of psychotherapy in patients with refractory irritable bowel syndrome. The British Journal of Psychiatry. 1993;163:315–321.

[36] Field T., Robinson G., Scafidi F., Nawrocki R., Goncalves A. Massage therapy reduces anxiety and enhances EEG pattern of alertness and math computations. International Journal of Neuroscience. 1996;86:197–205.

[37] Spanier J.A., Howden C.W., Jones M.P. A Systematic Review of Alternative Therapies in the Irritable Bowel Syndrome. Archives of Internal Medicine. 2003;163:265–274.

[38] Edge J. A pilot study addressing the effect of aromatherapy massage on mood, anxiety and relaxation in adult mental health. Complementary Therapies in Nursing & Midwifery. 2003;9:90–97.

[39] Basch E.M., Ulbricht C.E. Natural Standard Herb & Supplement Handbook: The Clinical Bottom Line. St Louis: Elsevier Mosby; 2005.

[40] Morgan M. The numerous healing properties of Slippery Elm. A Phytotherapist’s Perspective. 2004;42:1–2.

[41] Grigoleit H.G., Grigoleit P. Peppermint Oil in Irritable Bowel Syndrome. Phytomedicine. 2005;12(8):601–606.

[42] Morgan M. Rhodiola rosea: Rhodiola. A Phytotherapists Perspective. 2005;47:1–4.

[43] Bystritsky A., Kerwin L. J.E. Feusner, A Pilot Study of Rhodiola rosea (Rhodax®) for Generalised Anxiety Disorder (GAD). The J Altern Complement Med. 2008;14(2):175–180.

[44] Morgan M., Bone K. Herbs to Enhance Energy and Performance. A Phytotherapist’s Perspective. 2008;124:1–3.

[45] Awad R., Arnason J.T., Trudeau V., Bergeron C., Budzinski J.W., Foster B.C., Merali Z. Phytochemical and biological analysis of Skullcap (Scutellaria laterifolia L.): A medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):640–649.

[46] Quigley E.M.M., Flourie B. Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. Neurogastroenterology and Motility. 2007;19(3):166–172.

[47] Hussain Z., Quigley E.M.M. Systematic review: complementary and alternative medicine in the irritable bowel syndrome. Alimentary Pharmacology and Therapeutics. 2006;23:465–471.

[48] Macfarlane G.T., Cummings J.H. Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health? British Medical Journal. 1999;318:999–1003.

[49] Olesen M., Gudmand-Høyer E. Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome. American Journal of Clinical Nutrition. 2000;72:1570–1575.

[50] Maretau P., Seksik P., Jian R. Probiotics and intestinal health effects: a clinical perspective. British Journal of Nutrition. 2002;88(S1):S51–S57.

[51] Bijkerk C.J., de Wit N.J., Muris J.W., Whorwell P.J., Knotterus J.A., Hoes A.W. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. British Medical Journal. 2009;339:b3154.

[52] Blake E. Chaitow L., Blake E., Orrock P., Wallden M., Sinder P., Zeff J. Naturopathic Physical Medicine: Theory and Practice for Manual Therapists and Naturopaths. Churchill Livingstone Elsevier: Philadelphia, 2008.

[53] Buchman D.D. The complete book of water healing. New York: Contemporary Books, McGraw-Hill Companies; 2001.

[54] Boyle W., Saine A. Lectures in Naturopathic Hydrotherapy. Oregon: Eclectic Medical Publications. 1988.

[55] Watrous L.M. Constitutional hydrotherapy: from nature cure to advanced naturopathic medicine. Journal of Naturopathic Medicine. 1997;7(2):72–79.

[56] Sinclair M. Modern Hydrotherapy for the Massage Therapist. Baltimore: Lippincott Williams & Williams; 2008.

[57] Talley N., Weaver A., Zinsmeister A., et al. Onset and disappearance of gastrointestinal and functional gastrointestinal disorders. American Journal of Epidemiol. 1992;136:117–165.

[58] Hamilton W., Round A., Sharp D., et al. Clinical features of colorectal cancer before diagnosis: a population based case-control study. British Journal of Cancer. 2005;93:399–405.

[59] Thompson W., Longstreth G., Drossman D., et al. Functional bowel disorders and functional abdominal pain. Gut. 1999;45(Supp. II):43–47.

[60] Camilleri M. Management of irritable bowel syndrome. Gastroenterology. 2001;120:652–668.

[61] Castle M.Z.D., Silk D.B.A., Libby G.W. Review article: the rationale for antidepressant therapy in functional gastrointestinal disorders. Alimentary Pharmacology and Therapeutics. 2004;19:969–979.

[62] Spiller R.C. Postinfectious irritable bowel syndrome. Gastroenterology. 2003;124:1662–1671.

[63] Wilson S., Roberts L., et al. Prevelance of irritable bowel syndrome: a community survey. Br J Gen Pract. 2004;54:495–502.

[64] Coates M.D., et al. Molecular Defects in Mucosal Serotonin Content and Decreased Serotonin Reuptake Transporter in Ulcerative Colitis and Irritable Bowel Syndrome. Gastroenterology. 2004;126:1657–1664.

[65] Barbara G., DeGiorgio R., Stanghellini V., Cremon C., CorinalAdriani R. A role for inflammation in irritable bowel syndrome? Gut. 2002;51:i41–i44.

[66] Heyman M. Gut barrier dysfunction in food allergy. European Journal of Gastroenterology and Hepatology. 2005;17(12):1270–1285.

[67] Talley N. When to conduct testing in patients with suspected irritable bowel syndrome. Rev Gastroenterol Discord. 2003;3(Suppl. 3):S18–S24.

[68] Tibble J., Sightorsson G., Foster R., et al. Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease. Gastronenterology. 2002;123:450–460.

[69] Whitehead W., Palsson O., Jones K. Systematic review of the comorbidity of irritable bowel syndrome with other disorders; what are the causes and implications? Gastroentorology. 2002;122:1140–1156.

[70] Ford M.J., Camilleri M.J., Hanson R.B. Hyperventilation, central autonomic control, and colonic tone in humans. Gut. 1995;37:499–504.

[71] Sanders D., Carter M., Hurlstone D., et al. Association of adult celiac disease with irritable bowel syndrome: a case–control study in patients fulfilling the ROME II criteria referred to secondary care. Lancet. 2001;358:1504–1508.

[72] Drossman D., McKee D., Sandler R., et al. Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology. 1988;95:701–708.

[73] Kass B. Traveller’s diarrhoea. Australian Family Physician. 2005;34(4):243–247.

[74] Hunter P.R. Drinking water and diarrheal disease due to Escherichia coli. Journal of Water Health. 2003;1(2):65–72.

[75] Thomas P., Forbes A., Green J., et al. Guidelines for the investigation of chronic diarrhoea. Gut. 2003;52(Suppl. v):v1–v15.

[76] Shaw A., Davies G. Lactose intolerance problems in diagnosis and treatment. Journal of Clinical Gastroenterol. 1999;28:208–216.

[77] Etemad B., Whitcomb D.C. Chronic Pancreatitis: diagnosis, classification, and new genetic developments. Gastroenterology. 2001;120:682–707.

[78] Tache Y., Martinez V., Million M., Wang L. Stress and the gastrointestinal tract III. Stress-related alternations of gut motor function: role of brain corticotropin-releasing factor receptors. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2001;280(2):G173–G177.

[79] Wapnir R. Zinc Deficiency, Malnutrition and the Gastrointestinal Tract. The Journal of Nutrition. 2000;130:1388S–1392S.

[80] Takahashi T. Acupuncture for functional gastrointestinal disorders. Journal of Gastroenterology. 2006;41:408–417.

Gallstones (cholecystitis)

Case history

Karin Andersen, 29, has been travelling in Australia for the past six months and is currently working as a nanny for a farming family in order to save some money so she can do more travelling. Before coming to Australia Karin had been working in the family business in Denmark, which she had been doing since she left high school. Last year she decided she needed a radical change in her life and chose to take some time off to travel and see the world.

Karin has been experiencing pain in the upper right quadrant of her abdomen. Initially the pain was quite mild and only occurred intermittently. It would come on quite suddenly and then quickly subside. More recently she noticed the pain gradually building in intensity and becoming very severe and accompanied by a feverish feeling, sometimes taking up to an hour to abate. Karin has not experienced this pain before and has become anxious about what might be causing it. Karin has also been feeling slightly nauseous recently and her appetite has decreased. Additionally, she has noticed a pain in her right shoulder that radiates down her back, which she thought might have been caused by lifting little children. She went to a local GP who diagnosed gallstones with associated episodes of acute cholecystitis. The GP performed several medical investigations and advised Karin that if she develops more gallstones or if the acute attacks of pain become more frequent, she will need to consider having a laparoscopic cholecystectomy to remove her gall bladder. Prior to surgery she would be given intravenous antibiotics and pain relief. Because Karin’s symptoms have settled down over the past two days her GP has given her some time to rest without intervention other than oral analgesics.

Karin has come to the clinic at the recommendation of a neighbour and she is seeking an alternative opinion about how her gallstones could be managed. She would also like to learn how to prevent her condition getting any worse or returning in the future.

Karin’s menstrual period is regular and she has never suffered from pain or heavy bleeding. She has noticed a change in her bowel motions in the last six months though, which she forgot to tell her doctor. She experiences diarrhoea alternating with constipation and wonders whether her current diet may be contributing to that.

Karin has been consuming a lot more milk, cheese, red meat and bread since she started working as a nanny. This is not the diet she was used to in Denmark. She would like to eat a more balanced diet but is not comfortable talking to her employers about it because it’s the way they have always eaten.

When she was in Denmark Karin used to be more physically active, playing sport and cycling with her friends. When Karin first began working as a nanny she lost a lot of weight very quickly but now seems to be putting it back on, which she thinks is because of her new diet!

Karin tells you she sometimes feels homesick, but when she left home her relationship with her parents was very strained and she has not had contact with them for 12 months (although they know where she is staying in Australia). Karin says she had to make a break and begin a life of her own away from the confines of her family. She still feels bitterness towards her parents because they resisted supporting her making her own decisions about her life. Karin is looking forward to more travel and would like to meet other people her own age. She is currently saving money so she can go on an organised tour.

During the consultation Karin reveals that her mother has experienced similar symptoms. Karin did not tell this to her GP in case the doctor insisted she contact her parents to find about her family health history and to tell them about what is happening.

TABLE 3.28 COMPLAINT [110]

Analogy: Skin of the apple

AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES Onset   When did you first notice the abdominal pain? About 3 months after I started working as a nanny. Rating scale   How would you rate the abdominal pain out of 10, with 10 being as bad as can be? When the pain is bad it feels like a 10 out of 10 and then it can subside to a 2.

TABLE 3.29 CONTEXT

Analogy: Flesh of the apple Context: Put the presenting complaint into context to understand the disease
AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES
Obstruction  
How does movement affect your abdominal pain? (obstruction of gall bladder, biliary tree or ureter from stones will be relieved by movement) Yes. Sometimes when I have the pain I just need to keep moving, I feel really restless and cannot keep still.
Recreational drug use  
Have you had any significant amounts of alcohol recently? I have not told my host family, but the daughter of the family next door and I like to go out on a weekend and drink a fair bit of beer and spirits and I stay with her overnight. It helps me feel like I’m still on holiday.

TABLE 3.30 CORE

Analogy: Core of the apple with the seed of ill health Core: Holistic assessment to understand the client
AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES
Home life  
How are you getting on with the family you are living with in Australia? They are nice people and very accepting of me. They are hard workers though and expect a lot of me. They don’t know how much pain I’m in sometimes.
Action needed to heal  
If your parents were here now, what would you want to say to them regarding how you left each other? I wish they took the time to listen to me before judging me.

TABLE 3.31 KARIN’S SIGNS AND SYMPTOMS [1, 3, 5]

TABLE 3.32 RESULTS OF MEDICAL INVESTIGATIONS [13, 5, 6, 11, 13]

TEST RESULTS
Abdominal examination: guarding, rebound tenderness, palpation, abnormal pulsations (auscultation) No sign of appendicitis, pancreatitis, kidney swelling, enlarged liver, bowel obstruction or perforated ulcer; positive Murphy’s sign for inflamed gall bladder
Cholecystography: oral ingestion of radio-opaque iodinated dye with x-ray Lack of all dye passing through bile duct into the gall bladder indicates mild acute cholecystitis
Plain abdominal x-ray Reveals gallstones, rules out intestinal obstruction, appendicitis
Ultrasound examination Reveals distension of gall bladder for acute cholecystitis, shows gall bladder wall thickening, distention of gall bladder and presence of biliary sludge
Full blood count Moderate leucocytosis
ESR/CRP Inflammation status raised
Cholesterol blood test Raised
Fasting blood lipid test High LDL, low HDL
Liver biochemistry blood work Serum bilirubin, alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GT) and aminotransferase slightly raised
Serum amylase levels Not elevated
Serum albumin levels Not elevated
Stool test No ova, parasites, bacteria and fat, or occult blood; stools not acidic stools, which would indicate lactose intolerance
Electrolyte blood test All within normal range
Urine microscopic investigation No urine crystals and red blood cells
Serum assay for β-HCG Negative
Fasting blood-sugar test NAD

TABLE 3.33 UNLIKELY DIAGNOSTIC CONSIDERATIONS

Diagnostic considerations that have been ruled out [1, 3, 57, 11]
CONDITIONS AND CAUSES WHY UNLIKELY
FAMILY HEALTH – INHERITED
Choledochal cyst: due to congenital cystic disease of the bile duct Symptoms similar to bile duct stones usually present in childhood; has not experienced current symptoms in the past
Caroli’s syndrome: rare inherited disease of bile duct and liver; can be associated with gallstones; intermittent abdominal pain and fever with mild jaundice present; family history of symptoms No dilated intrahepatic ducts detected on ultrasound
CANCER AND HEART DISEASE
Gall bladder polyp: adenomas most common benign neoplasm of gall bladder; polyps are inflammatory and composed of cholesterol deposits Ultrasound did not pick up polyp size masses
Primary cancer of the gall bladder: adenocarcinoma; may only be detected at time of cholecystectomy for gallstones; more common in women; gall bladder stones and polyps, and chronic cholecystitis has been associated with gall bladder cancer; symptoms of rapid weight loss and gallstones Usually occurs from 60 years of age and onwards; CRP did not indicate cancer
Primary cancer of the bile duct: cholangiocarcinoma Rare cancer; associated with significant jaundice and imaging did not show signs; CRP did not indicate cancer
Hypertension Blood pressure is in normal range
OBSTRUCTION AND FOREIGN BODY
Acute cholangitis (inflammation of bile duct) and bile duct stones: abdominal pain, biliary colic symptoms Fever is rare unless biliary sepsis has caused septicaemia; usually has significant jaundice; x-ray and ultrasound did not reveal stones in the common bile duct; serum amylase usually mildly elevated
Bile pigment gallstones: black and brown stones (less common than cholesterol) No significant haemolytic disease or duct disease
Kidney stones: severe abdominal pain Abdominal pain usually is lower and radiates to the lower back and groin rather than the upper abdomen and shoulder; no urine crystals and red blood cells
Intestinal obstruction: pain in the abdomen, nausea, decreased appetite and change in bowel motion Usually nausea, vomiting and constipation as key symptoms; abdominal x-ray and ultrasound did not detect obstruction
Constipation: can cause slow colonic transit time that influences bile salt pool Abdominal x-ray showed no faecal mass
DEGENERATIVE AND DEFICIENCY
Perforated peptic ulcer: pain in the abdomen that is radiating, nausea, decreased appetite [41] Usually vomiting on onset and previous history of ulcer disease; serum amylase levels not raised significantly; ultrasound did not detect any sign of ulcers; the pain of gallstone colic/cholecystitis does not have periodicity like an ulcer
INFECTION AND INFLAMMATION
Non-calculous cholecystitis: chronic inflammation in the wall of the gall bladder without gallstones Ultrasound scanning revealed the presence of gallstones; this condition is more common in the elderly and critically ill
Appendicitis: pain in the upper right quadrant of the abdomen that is radiating, nausea, loss of appetite, increased diarrhoea and constipation, change in diet Abdominal ultrasound did not detect an inflammation of the appendix
Acute gallstone pancreatitis: pain in the abdomen that is radiating, nausea, decreased appetite, change in bowel motions; commonly caused by gallstones that block the pancreatic drainage; often associated with alcoholic binge Usually associated with significant fever, nausea and vomiting; upper abdominal pain radiates to the lower back rather than the shoulder like gallstone pain; serum amylase levels usually markedly raised; no pancreatic swelling shown in the abdominal examination or ultrasound; no dilated intrahepatic ducts detected on ultrasound
Hepatitis: pain in the upper right quadrant of the abdomen that is radiating, nausea, loss of appetite, increased diarrhoea and constipation, change in diet; serum bilirubin, alkaline phosphatase (ALP), γ-Glutamyl transpeptidase (γ-GT) and aminotransferase slightly raised Serum albumin levels not elevated; no anaemia or viral markers in full blood count; no liver abnormalities detected on the abdominal ultrasound examination
Crohn’s disease: can affect bile salt content in the colon to predispose to cholesterol gallstones; diarrhoea experienced with change of diet; ESR raised indicating inflammation Usually low haemoglobin in Crohn’s disease, did not detect anaemia of chronic disease (usually normocytic, normochromic anaemia, and rarely megablastic due to B12 deficiency); no blood or mucus in stools; abdominal x-ray showed no indication of inflammation in the large intestine or colon
ENDOCRINE/REPRODUCTIVE
Diabetes: can influence gall bladder motility to predispose to cholesterol gallstones Urinalysis NAD; fasting blood-sugar NAD
Pregnancy/ectopic or normal: Karin is of child-bearing age and may be sexually active; pain is building in intensity, pain in the abdomen with nausea and loss of appetite Will have symptoms of missed or delayed menstrual period, vaginal discharge, lower abdominal pain; serum assay for β-HCG test is negative
Ovarian cyst: abdominal pain Abdominal ultrasound did not detect a cyst on the ovaries; abdominal pain is usually lower and radiates to the lower back rather than the upper abdomen and shoulder
AUTOIMMUNE DISEASE
Primary sclerosing cholangitis: chronic autoimmune cholestatic liver disease with fibrosis and inflammation of the bile duct; often associated with inflammatory bowel disease; often raised serum alkaline phosphatase More common in men over 40 years of age; no itching of skin or significant jaundice

TABLE 3.34 CONFIRMED DIAGNOSIS [3, 5, 11, 40]

CONDITION RATIONALE
Acute cholecystitis/gallstone colic (cholesterol gall stones) Pain in the right upper quadrant that can be mild, subside quickly and then gradually build in intensity; severe upper right abdominal pain develops; feverish feeling and nausea are associated symptoms; pain radiating to the right shoulder is indicative of referred pain from the gall bladder; can be asymptomatic for years; change of diet to include more high-cholesterol foods; episode of rapid weight loss recently; feeling ‘bitter’ towards family with suppressed anger; can present with family history of gall bladder symptoms
Test results Positive Murphy’s sign for inflamed gall bladder; ultrasound revealed minimal gallstones that have caused pressure on the neck of the gall bladder and cystic duct

TABLE 3.35 POSSIBLE FURTHER DIFFERENTIAL DIAGNOSIS [37, 11]

Not ruled out by tests/investigations already done
CONDITIONS AND CAUSES WHY POSSIBLE WHY UNLIKELY
ALLERGIES AND IRRITANTS
Lactose intolerance Abdominal pain, bloating, watery and frothy diarrhoea; possible recurrent abdominal pain with onset of lactose ingestion; Karin’s diet has significantly changed since she came to Australia No nausea; need to understand more how Karin’s diet has changed
RECREATIONAL DRUG USE
Alcohol abuse: γ-GT raised in liver biochemistry Can be raised even with a small intake of alcohol; binge drinking will exacerbate symptoms of cholecystitis Can be raised in parallel to ALP in gall bladder disorders; if raised when serum ALP is normal that is more likely to indicate alcohol abuse
FUNCTIONAL DISEASE
Irritable bowel syndrome Pain in the abdomen, alternating between diarrhoea and constipation; pain often presents similar to cholecystitis and may have in conjunction Pain not necessarily relieved by passing a bowel motion
INFLAMMATION
Chronic cholecystitis: chronic inflammation of the gall bladder giving rise to vague symptoms of indigestion, distension and upper abdominal discomfort; can be similar to functional bowel disease; can be clinically connected to gallstones Thickening of gall bladder wall detected on ultrasound Not an isolated condition because connected with gallstones; not clear whether Karin had this before her gallstones developed; has not had current symptoms ever before
AUTOIMMUNE DISEASE
Coeliac disease Abdominal pain, poor diet, diarrhoea; more often upper abdominal pain; diet has significantly changed since being in Australia; family history of symptoms Significant lower abdominal bloating not reported
STRESS AND NEUROLOGICAL
Causal factor:
Stress
Being away from home, wanting more finances to go travelling, unresolved issues with parents, significant health concern while being in a foreign country; can exacerbate functional bowel disease  
EATING HABITS AND ENERGY
Causal factor:
Hypercholesterolaemia: increased cholesterol
Karin has been eating more red meat, dairy products and bread than she used to  

Case analysis

Working diagnosis

Gallstones

It is difficult to ascertain the prevalence of gallstones in the general population because they are often asymptomatic (silent) producing no significant physical symptoms for years. However, gallstones do seem to be more common in North America, Scandinavia and South America and young women are likely to report having gallstones more frequently than men. The difference between male and female prevalence is thought to decrease with age. Although gallstones are mostly asymptomatic, they may lodge in the neck of the gall bladder or in the cystic duct giving rise to biliary pain or acute cholecystitis. Gallstones can also move into the common bile duct causing biliary obstruction and producing severe pain and jaundice. It is medically understood that gallstones themselves do not produce colicky pain, indigestion, chronic right abdominal pain or intolerance to fatty foods they are often correlated with. However, if there is a temporary obstruction of the common bile duct by a stone moving from the gall bladder, physical symptoms of gallstone colic/dyspepsia can be experienced. When this occurs symptoms may include feelings of fullness after eating, increased belching, flatulence and abdominal distension, particularly after overindulgence in fatty foods.

Gallstones are classified into those made up of cholesterol (80 per cent of all gallstones) and those made up of bile pigment. Karin has been diagnosed with cholesterol stones. These stones are partly derived from dietary sources, and are also synthesised in the liver, small intestine, skin and adrenals. Cholesterol stones develop in bile when there is an excess of cholesterol relative to bile salts and phospholipids (supersaturated bile). This can occur due to an excess of cholesterol or a decrease in bile salts. Risk factors for cholesterol stones developing include:

Acute cholecystitis

About 90 per cent of acute cholecystitis cases result from an obstruction of the neck of the gall bladder by gallstones. This leads to lack of gall bladder emptying, distension and inflammation. Sometimes the inflammation is mild and quickly subsides and the person may only feel a small amount of pain. It is more common for inflammation to become more severe giving rise to an acute rapid onset of pain that is localised to the middle of the abdomen or specifically in the right upper quadrant. It is at this stage that many people realise for the first time they have gallstones. The pain is continuous and increases gradually in intensity and can radiate to the back and the right shoulder. An episode of pain will slowly ease and there will usually be pain-free periods for between 30 and 360 minutes. The person may also feel nauseous, feverish and often will vomit. At this stage mild jaundice may occur.General references used in this diagnosis: 1, 3, 5, 6, 11, 40

TABLE 3.36 DECISION TABLE FOR TREATMENT PRIOR TO REFERRAL

COMPLAINT CONTEXT CORE
Treatment for the presenting complaint and symptoms Treatment for all associated symptoms Treatment for mental, emotional, spiritual, constitutional, lifestyle issues and metaphysical considerations
TREATMENT PRIORITY TREATMENT PRIORITY TREATMENT PRIORITY

NB: Herbal choleretics and cholagogues are contraindicated in septic cholecystitis where there is a risk of peritonitis; collaborative management of Karin’s case with her GP is therefore essential to ensure there are no contraindications to herbal therapy

TABLE 3.37 DECISION TABLE FOR REFERRAL [3, 5, 11, 12]

COMPLAINT CONTEXT CORE
Referral for presenting complaint Referral for all associated physical, dietary and lifestyle concerns Referral for contributing emotional, mental, spiritual, metaphysical, lifestyle and constitutional factors
REFERRAL FLAGS REFERRAL FLAGS REFERRAL FLAGS
ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE
REFERRAL DECISION REFERRAL DECISION REFERRAL DECISION

TABLE 3.38 FURTHER INVESTIGATIONS THAT MAY BE NECESSARY [1, 36, 11, 13]

Test/investigation Reason for test/investigation
FIRST-LINE INVESTIGATIONS:
Hydrogen breath test To detect bacterial overgrowth; when bacteria is metabolised by lactose or glucose there is a production of hydrogen
Elimination diet Detect food intolerance
IF NECESSARY:
Oral tolerance lactose test Determine lactose metabolism
Antigliadin antibodies Check if antibodies to gluten are present in blood indicating coeliac disease
p-ANCA (anti-neutrophil cytoplasmic antibody) Detect primary sclerosing cholangitis
Serum immunoglobulins IgG and IgM Cirrhosis of the liver, postviral disease and autoimmune disease of the liver
Serum autoantibodies AMA Primary biliary cirrhosis of the liver
Magnetic resonance cholangiography (MRC) Delineates fluid volume in bile tree, detect primary sclerosing cholangitis
Sprial CT scanning Detect bile duct dilatation; can exclude carcinoma as the cause of the bile duct obstruction; define if opaque or cholesterol stones; acute pancreatitis
Endoscopic ultrasound scanning of the bile duct and gall bladder Identify stones at the distal end of the common bile duct; invasive procedure
Endoscopic retrograde cholangiography (ERC) Detects primary sclerosing cholangitis
Endoscopy Peptic ulcer
Sigmoidoscopy Confirm Crohn’s disease and eliminate from differential diagnosis list
Liver histology Confirms primary sclerosing cholangitis

Dietary suggestions

Encourage Karin to drink six to eight glasses of water every day to ensure the water content of the bile is maintained [15].

Encourage Karin to try to include turmeric in her diet as often as possible [15]. Turmeric is a choleretic [21] and is used traditionally to improve poor digestion [21]. It has also been demonstrated to reduce gallstone size [24].

Encourage Karin to reduce her consumption of animal protein, refined carbohydrates, sugar, saturated fats and dietary cholesterol [15, 16].

Encourage Karin to avoid all fried foods [15].

Encourage Karin to increase consumption of fruit, vegetables and legumes [15, 16].

Encourage Karin to increase her consumption of foods containing omega-3 fatty acids, particularly from cold-water fish [15].

Encourage Karin to increase her consumption of soluble fibre [15, 16].

Determine whether Karin has any food allergies and manage accordingly [15].

Karin could include buckwheat regularly in her diet [15]. Buckwheat enhances bile acid synthesis, reduces concentration of cholesterol in the gall bladder and decreases gallstone formation [15].

Karin could consume 1–2 tsp of lecithin granules daily [15, 16]. The phosphatidyl choline in lecithin increases phospholipids in bile, which can improve bile solubility, therefore reducing the risk of stone formation [16].

Karin may benefit from drinking lemon juice. Lemon juice increases hepatobiliary excretion and therefore may improve digestive function [25].

Physical treatment suggestions

TABLE 3.40 HERBAL FORMULA (1:2 LIQUID EXTRACTS)

HERB FORMULA RATIONALE
Fringe tree
Chionanthus virginicus
40 mL Choleretic [18, 21]; cholagogue [18, 19, 21]; traditionally used for cholecystitis
Dandelion root
Taraxacum officinale
40 mL Choleretic [18, 20]; cholagogue [19]; traditionally used to treat cholecystitis and gall stones [18, 19]
Boldo
Peumus boldo
20 mL Cholagogue [18, 19]; liver stimulant [18, 19]; traditionally used to treat gall bladder pain and gallstones [18, 19]; indicated for use in cholelithiasis with pain [19]
Globe artichoke
Cynara scolymus
40 mL Choleretic [21, 20]; cholagogue [21, 20]; antiemetic [21]; hepatoprotective [21, 20]
St Mary’s thistle
Silybum marianum
60 mL Choleretic [21]; hepatoprotective [21, 20]
Supply: 200 mL Dose: 5 mL 3 times daily

TABLE 3.41 HERBAL TEA

Alternative to tea and coffee
HERB FORMULA RATIONALE
Peppermint leaf

Mentha × piperita

3 parts Choleretic [20, 21]; antispasmodic [20, 21]; relieves nausea [20, 21]
Chamomile flower
Matricaria recutita
3 parts Choleretic [20]; antispasmodic [20, 21]; anti-inflammatory [20, 21]; mild sedative [20, 21]
Ginger root (powdered)
Zingiber officinale
¼ part Anti-emetic [20, 21]; anti-nausea [20, 21]; choleretic [20]; anxiolytic [20]; traditionally used to enhance digestion [21]
Infusion: 1 tsp per cup – 1 cup 3–4 times daily

TABLE 3.42 NUTRITIONAL SUPPLEMENTS

SUPPLEMENT AND DOSE RATIONALE
Omega-3 fish oil
3 × 1000 mg capsules twice daily [16, 38]
Omega-3 oils are essential for the normal formation of bile [15, 16, 38]; supplementation decreases biliary cholesterol saturation in gallstone disease [38] and improves gall bladder dysmotility [39]
Vitamin C
1000 mg twice daily [15, 16, 37]
High-dose vitamin C supplementation may reduce cholesterol stone formation by altering bile acid composition and increasing the time taken for gallstones to develop [16, 37]
Soluble fibre supplement
10 g twice daily [15]
Soluble fibre reduces biliary cholesterol saturation and cholesterol stone formation [16, 36]
Lipotropic supplement providing approx. 1000 mg choline [15, 16], 800 mg l-methionine [15, 16] and 3 g taurine [5, 15, 16] daily Lipotropic factors are essential for normal liver metabolism of fat and bile flow [15, 16]; taurine increases bile acid pool and prevents gallstone formation [5, 28]

References

[1] Douglas G., Nicol F., Robertson C. Macleod’s Clinical Examination, twelfth edn. Churchill Livingstone Elsevier; 2009.

[2] Talley N.J., O’Connor S. Pocket Clinical Examination, third edn. Australia: Churchill Livingstone Elsevier; 2009.

[3] Kumar P., Clark C. Clinical Medicine, sixth edn. London: Elsevier Saunders; 2005.

[4] Polmear A. Evidence-Based Diagnosis in Primary Care. Churchill Livingstone Elsevier; 2008.

[5] Jamison J. Differential Diagnosis for Primary Care, second edn. London: Churchill Livingstone Elsevier; 2006.

[6] Collins R.D. Differential Diagnosis in Primary Care, fourth edn. Philadelphia: Lippincott Williams & Wilkins; 2008.

[7] Seller R.H. Differential Diagnosis of Common Complaints, fifth edn. Philadelphia: Saunders Elsevier; 2007.

[8] Lloyd M., Bor R. Communication Skills For Medicine, third edn. Edinburgh: Churchill Livingstone Elsevier; 2009.

[9] Neighbour R. The Inner Consultation: how to develop an effective and intuitive consulting style. Oxon: Radcliff Publishing; 2005.

[10] Silverman J., Kurtz S., Draper J. Skills for Communicating with Patients, second edn. Oxford: Radcliff Publishing; 2000.

[11] Berkow R., Fletcher A.J., Beers M.H. The Merck Manual, sixteenth edn. Rathway, N.J: Merck Research Laboratories; 1993. (later edition)

[12] D. Peters, L. Chaitow, G. Harris, S. Morrison, Integrating Complementary Therapies in Primary Care, London, Churchill Livingstone, 2002.

[13] Pagna K.D., Pagna T.J. Mosby’s Diagnostic and Laboratory Test reference, third edn. USA: Mosby; 1997. (later edition)

[14] Jamison J. Clinical Guide to Nutrition & Dietary Supplements in Disease Management. Edinburgh: Churchill Livingstone; 2003.

[15] Pizzorno J.E., Murray M.T., Joiner-Bey H. The Clinicians Handbook of Natural Medicine, second edn. St Louis: Churchill Livingstone; 2008.

[16] Osiecki H. The Physicians Handbook of Clinical Nutrition, seventh edn. Eagle Farm: Bioconcepts; 2000.

[17] El-Hashemy S. Naturopathic Standards of Primary Care. Toronto: CCNM Press Inc; 2007.

[18] Mills S., Bone K. The Essential Guide to Herbal Safety. St Louis: Churchill Livingstone; 2005.

[19] British Herbal Medicine Association. British Herbal Pharmacopoeia. BHMAA; 1983.

[20] Braun L., Cohen M. Herbs & Natural Supplements: An evidence based guide, second edn. Sydney: Elsevier; 2007.

[21] Mills S., Bone K. Principles & Practice of Phytotherapy: Modern Herbal Medicine. Edinburgh, London: Churchill Livingstone; 2000.

[22] Diehl D.L. Acupuncture for Gastrointestinal and Hepatobiliary Disorders. The J Altern Complement Med. 1999;5(1):27–45.

[23] Takahashi T. Acupuncture for functional gastrointestinal disorders. Journal of Gastroenterology. 2006;41:408–417.

[24] Srinivasan K. Spices as influencers of body metabolism: an overview of three decades of research. Food Research International. 2005;38:77–86.

[25] Cherng S.C., Chen Y.H., Lee M.S., Yang S.P., Huang W.S., Cheng C.Y. Acceleration of hepatobiliary excretion by lemon juice on 99mTc-tetrofosmin cardiac SPECT. Nuclear Medicine Communications. 2006;27(11):859–864.

[26] Peters H.P.F., DeVries W.R., Vanberge-Henegouwen G.P., Akkermans L.M.A. Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract. Gut. 2001;48:435–439.

[27] Nielsen T.R., Carlson D.S., Lankau M.J. The Supportive Mentor as a Means of Reducing Work–Family Conflict. Journal of Vocational Behavior. 2001;59:364–381.

[28] Militante J.D., Lombardini J.B. Dietary taurine supplementation: hypolipidemic and antiatherogenic effects. Nutrition Research. 2004;24:787–801.

[29] Jorm A.F., Christensen H., Griffiths K.M., Parslow R.A., Rodgers B., Blewitt K.A. Effectiveness of complementary and self-help treatments for anxiety disorders. Medical Journal of Australia. 2004;181(7):S29–S46.

[30] Byrne A., Byrne G.D. The effect of exercise on depression, anxiety and other mood states: A review. J Psychosom Res. 1993;37(6):565–574.

[31] Field T., Robinson G., Scafidi F., Nawrocki R., Goncalves A. Massage therapy reduces anxiety and enhances EEG pattern of alertness and math computations. International Journal of Neuroscience. 1996;86:197–205.

[32] Moyer C.A., Rounds J., Hannum J.W. A Meta-Analysis of Massage Therapy Research. Psychological Bullettin. 2004;130(1):3–18.

[33] Blake E. Chaitow L., Blake E., Orrock P., Wallden M., Sinder P., Zeff J. Naturopathic Physical Medicine: Theory and Practice for Manual Therapists and Naturopaths. Philadelphia: Churchill Livingstone Elsevier, 2008.

[34] Buchman D.D. The complete book of water healing. New York: Contemporary Books, McGraw-Hill Companies; 2001.

[35] Boyle W., Saine A. Lectures in Naturopathic Hydrotherapy. Oregon: Eclectic Medical Publications. 1988.

[36] Schwesinger W.H., Kurtin W.E., Page C.P., Stewart R.M., Johnson R. Soluble Dietary Fiber Protects against Cholesterol Gallstone Formation. American Journal of Surgery. 1999;177:307–310.

[37] Gustafsson U., Wang F.H., Axelson M., Kallner A., Sahlin S., Einarsson K. The effect of vitamin C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: prolongation of the nucleation time. European Journal of Clinical Investigation. 2003;27(5):387–391.

[38] Berr F., Holl J., Jungst D., Fischer S., Richter W.O., Seifferth B., et al. Dietary N-3 Polyunsaturated Fatty Acids Decrease Biliary Cholesterol Saturation in Gallstone Disease. Hepatology. 1992;16:960–967.

[39] Jonkers I., Smelt A., Ledeboer M., Hollum M., Biemond I., Kuipers F., et al. Gall bladder dysmotility: a risk factor for gall stone formation in hypertriglyceridaemia and reversal on triglyceride lowering therapy by bezafibrate and fish oil. Gut. 2003;52:109–115.

[40] Dowling R.H. Review: pathogenesis of gallstones. Alimentary Pharmacology and Therapeutics. 2000;14(Suppl. 2):39–47.

[41] Marshall R.E., Anggiansah A., Owen W.A., et al. The relationship between acid and bile reflux and symptoms in gastro-oesophageal reflux disease. Gut. 1997 Feb;40(2):182–187.