Forehead and temporal recontouring using calcium hydroxylapatite pre-mixed with lidocaine

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13 Forehead and temporal recontouring using calcium hydroxylapatite pre-mixed with lidocaine

Introduction

Although fillers are typically used for restoring volume loss to create a youthful appearance, an additional role of fillers is often overlooked – facial recontouring. The recontouring process not only corrects for defects but aims to restore facial proportion that may or may not have been present naturally in the patient who presents desiring correction.

One of the prime areas amenable to restructuring through fillers is the forehead and temple area. With time, the upper third of the face elongates as the hairline moves upward and the brow moves downward. Both intrinsic and extrinsic factors play a role. Sex, age, family history, and styling practices can influence hairline position while gravity, smoking, and sun exposure can cause keratinocytic dysplasia, which manifests as coarse wrinkles and a rough skin surface.

Initially, changes associated with aging such as rhytides can be corrected through neurotoxin use. Over time, skin laxity and relative muscle atrophy create temporal wasting and some brow ptosis, leading to decreased efficacy of neurotoxin for this area. Even in patients who are neurotoxin naïve, brow descent can occur through repetitive contractions of forehead depressor muscles and loss of elastic fibers. While many physicians focus on brow elevation, it is important to consider complementary filler placement in the forehead to optimize a younger appearance. (Coincidentally, brow elevation is on occasion noted in patients treated for forehead recontouring.)

In this chapter, we review a simple technique to replenish volume loss in the forehead and temples, improve skin laxity, and reposition facial structures to correct for descent using calcium hydroxylapatite (CaHA; Radiesse® [Merz Aesthetics, San Mateo, CA]). Though we primarily use CaHA, autologous fat and poly-L-lactic acid (PLLA; Sculptra® [Sanofi-Aventis US, Bridgewater, NJ] ) are also options and will be reviewed briefly.

Anatomy

Temple

The tissue layers in the temporal region are as follows: skin, subcutaneous fat, superficial temporal fascia, deep temporal fascia, and temporal muscle. When injecting in the temple, there are two main anatomical structures physicians want to avoid: the superficial temporal artery and the frontal branch of the facial nerve. Both of these structures are closely associated with the superficial temporal fascia. The superficial temporal fascia is loosely adherent to the subdermal fat and is a continuation of the galea aponeurotica system of the scalp and the superficial musculoaponeurotic system of the face.

The superficial temporal artery is a terminal branch of the external carotid artery. It originates in the parotid gland and crosses the zygomatic arch about 10 millimeters anterior to the tragus. The superficial temporal artery gives off numerous terminal branches, including the transverse facial, the middle temporal, the parietal, and the frontal artery. It is possible to palpate the pulse from this artery in the temporal region.

The frontal branch of the facial nerve supplies motor innervation to the muscles of facial expression of the eyebrows and forehead. It is found along the deep surface of the superficial temporal fascia and is considered to be a nerve at risk when performing procedures at the temple. The most common method of finding this ‘danger zone’ is to draw a line from the ear lobe to the lateral eyebrow and then from the tragus to the superior most forehead rhytid. The result will be a zone that corresponds to the usual trajectory path of the frontal branch. Transection with a needle can result in brow ptosis.

When injecting the temples it is important to stay superficial to the superficial temporal fascia and to avoid these vital structures in the subcutaneous fat. Rather than using a fanning technique to deposit product, as is often deployed in treatment of the cheeks, nasolabial folds, and other areas of the mid- and lower face, the physician should instead deposit product in a depot and distribute it to the temporal region via massage.

Selecting the right filler

There are many fillers to choose from when rejuvenating the upper third of the face. Autologous fat transfer can provide long-lasting results, though multiple treatment sessions are required and significant swelling and edema are postoperative consequences. Autologous fat is also less amenable in patients with HIV-associated lipoatrophy as the fat cells are more difficult to harvest and the fat graft tends to be less successful.

PLLA is another choice for filling, but again multiple treatment sessions spaced 4–6 weeks apart are required for optimal results. In these authors’ experience, the ideal dilution for PLLA is 8 mL of sterile water and 1 mL of 1% or 2% lidocaine. The product can be pre-mixed days in advance despite package instructions to mix 2 hours prior to injection with the final 1 mL of lidocaine added just prior to patient injection. Injection with image-inch (35 mm), 25-gauge needles attached to 3 mL syringes allows for even injecting and controlled dispersion of the product. It is critical that the patient massage the area post-procedure using the ‘rule of 5s’ – 5 times a day for 5 days for 5 minutes each time.

Hyaluronic acid (HA) fillers are viable in this area, although the more viscous products such as Perlane® (Medicis Aesthetics, Inc, Scottsdale, AZ) and Juvéderm® Ultra Plus (Allergan, Irvine, CA) are preferable to Restylane® (Medicis Aesthetics, Inc, Scottsdale, AZ) and Juvederm® Ultra (Allergan, Irvine, CA). This family of fillers is ideal when a reversible correction is desired. Adding 0.5 mL of 1% lidocaine per HA syringe and injecting the retrofrontalis muscle facilitates an even correction.

Again, assessments of the degree of temporal wasting and skin thickness are necessary before choosing which product is best. For HA fillers, the duration of action is typically 4–6 months.

In our clinical practices, we use CaHA more than we use the other products cited here, for these specific applications. The CaHA, especially mixed with lidocaine, lends itself to reliable placement without migration, and provides longevity at least comparable to the HAs and in most cases somewhat longer. Injection with CaHA is described in detail in the following sections.

Materials, injection sites, and injection techniques

Injection site for the forehead

The target in the suprabrow area is the suprabrow concavity. Specifically, this area extends inferiorly to the frontal bone supraciliary ridge and superiorly to the frontal eminence, approximately 3 cm away from the supraciliary arches. Laterally, the space to be injected is marked by extension into the temporal compartment below the temporal cheek fat (Fig. 13.2). The floor of the target injection area is the frontal supraperiosteum and the ceiling is the frontalis muscle.

When addressing the medial aspects of the area, injections should extend lateral to the projection of the supraorbital nerve. This projection is located >1 cm from the supraorbital notch or foramen. Injections should be executed at the subcutaneous level, with dermal filler placed at the supraperiosteal level behind the galeal fat pad (Fig. 13.3).

image

Figure 13.3 Injections should be executed at the subcutaneous level, with dermal filler placed at the supraperiosteal level behind the galeal fat pad.

Reproduced from Busso M 2010 Forehead contouring with calcium hydroxylapatite. Dermatologic Surgery 36(S3):1910-1913

Injection technique for forehead recontouring

A 27-gauge, image-inch (35 mm) needle is used to introduce the CaHA–lidocaine solution into the forehead. A threading bolus is used to place the product in the inferior frontal eminence (Fig. 13.4). The amount of product varies with each patient but the stated objective is reconstitution of the suprabrow arch. When sufficient product has been deposited using retrograde injection for introduction of the bolus, the area is then massaged so that the product is evenly distributed throughout the borders described in the section above. Volumes may range from 1.5 mL to 3.0 mL of CaHA, in addition to the volumes of diluent necessary for mixing.

image

Figure 13.4 A threading bolus is used to place calcium hydroxylapatite in the inferior frontal eminence.

Reproduced from Busso M 2010 Forehead contouring with calcium hydroxylapatite. Dermatologic Surgery 36(S3):1910-1913

In some cases, a brow lift has also been a fortunate consequence of forehead recontouring. This has occurred without any placement of product directly behind the brow. Even in the absence of a brow lift, however, the filler placement of the patients in a ‘horseshoe’ pattern has resulted in cosmetic benefits, including projection of the lateral eyebrow and reduction of transitions between the suprabrow, temporal, and cheek regions.

Note: After injection, the treated area will likely become edematous. This condition is self-limiting and will resolve in as little as 24 hours in some cases but as long as 10 days in others. An initial temporary brow droop, as opposed to brow lift, is the likely consequence of the diffusion of the lidocaine in the injected solution. The droop is quite short lived, resolving within several hours.

Injection technique for temple recontouring

As is the case with the forehead, a 27-gauge, image-inch (35 mm) needle can be used to deposit boluses of CaHA plus lidocaine. Depending on the severity of correction, volumes may range from 0.7 mL to as much as 3.0+ mL of CaHA per site. Injections are performed in a retrograde fashion as the needle is withdrawn, to limit inadvertent intravascular injection. After injection, the temples should be massaged vigorously to blend the product into the treated areas, but patients are not required to perform any massage procedures at home.

Note: Temporal ptosis can occur with this treatment, which is likely the result of anesthetic influencing the temporal facial motor nerve. However, as with post-injection forehead edema, this event is short lived and will self-resolve within several days.

Figures 13.5 and 13.6 are representative results of forehead and temple contouring. In Figure 13.5, a 45-year-old female received 3.0 mL of CaHA mixed with 2.0 mL of 1% lidocaine / normal saline diluent. In Figure 13.6, a 40-year-old female received 1.5 mL of CaHA mixed with 1 mL of 1% lidocaine for her forehead and 3.0 mL of CaHA blended with 1.0 mL of 1% lidocaine in her bilateral temple region.

Conclusion and discussion

As the 21st century opened, aesthetic physicians were accustomed to seeing the application of dermal fillers as an endeavor that involved chasing lines and wrinkles. Indeed, even the indications for CaHA and other fillers address remediation of fine lines and wrinkles. However, within 10 years, a sea change has occurred in the profession of dermatology in its approach to the use of fillers. Dermatologists now see fillers as tools to volumize the mid- and lower face. We believe that the upper face can also profit from volumizing, in particular by restoring the original contours of the forehead and reducing the skin laxity from the temporal areas. Although HAs and PLLA and perhaps even fat transfer may have utility in upper face recontouring, at present we have found that CaHA, pre-mixed with lidocaine immediately prior to injection, offers us the best treatment option for the forehead and temples. Its ease of injection, its spreadability, its efficacy, safety, and longevity are all positive attributes that allow us to inject the product with confidence into patients under our care.

Case Study 1

Sara is a 55-year-old female patient who consulted us to learn about non-surgical options for facial rejuvenation. On examination, it was established that periorbital volume reconstitution should be part of the antiaging regimen. CaHA was injected at the retrofrontalis level. Soon after the injection was started, a tree-like blanching with the base at the orbital rim was observed, most likely caused by vascular occlusion / compression of a supraorbital artery branch. Subsequent steps included immediate cessation of injection of filler and commencement of vigorous massage. No further changes were observed in subsequent days. Had a HA filler been injected, a hyaluronidase would have been administrated.

It is important to watch for any skin color changes while injecting any filler. Injecting lateral to the supraorbital vessels with a blunt cannula, in small amounts, diluted with anesthetic, will help to avoid this complication.

Further reading

Busso M. Vectoring approach to midfacial contouring using calcium hydroxylapatite and hyaluronic acid. Cosmetic Dermatology. 2009;22(10):522–528.

Busso M. Forehead contouring with calcium hydroxylapatite. Dermatologic Surgery. 2010;36(S3):1910–1913.

Busso M. Commentary on extrinsic addition of lidocaine to calcium hydroxylapatite. Dermatologic Surgery. 2010;36(11):1795.

Busso M, Voigts R. An investigation of changes in physical properties of injectable calcium hydroxylapatite in a carrier gel when mixed with lidocaine and with lidocaine/epinephrine. Dermatologic Surgery. 2008;34(1):S16–S24.

Hirmand H. Anatomy and nonsurgical correction of the tear trough deformity. Plastic and Reconstructive Surgery. 2010;125(2):699–708.

Jones D. Semi-permanent and permanent injectable fillers. Dermatologic Clinics. 2009;27(4):433–444.

Knize DM. An anatomically based study of the mechanism of eyebrow ptosis. Plastic and Reconstructive Surgery. 1996;97(7):1321–1333.

Knize DM. Anatomic concepts for brow lift procedures. Plastic and Reconstructive Surgery. 2009;124(6):2118–2126.

Le Louarn C, Buthiau D, Buis J. The face recurve concept: medical and surgical applications. Aesthetic Plastic Surgery. 2007;31(3):219–231. discussion 232

Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plastic and Reconstructive Surgery. 2007;119(7):2219–2227.

Sundaram H, Voigts R, Beer K, et al. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid. Dermatologic Surgery. 2010;36(S3):1859–1865.

Sykes JM. Applied anatomy of the temporal region and forehead for injectable fillers. Journal of Drugs in Dermatology. 2009;8(10, suppl):S24–S27.