Esophagectomy

Published on 16/04/2015 by admin

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Last modified 16/04/2015

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Chapter 5

Esophagectomy

Indications

Because of the associated morbidity, most esophagectomies are performed on cancer patients (Fig. 5-2, A and B). Benign indications arise from absolute loss of function caused by end-stage motility disorders or from refractory strictures (Fig. 5-2, C). Worldwide, the primary esophageal cancer is squamous cell type, the result of dietary insults or smoking. In North America, however, this is no longer true: 80% or more of esophageal cancers are now adenocarcinomas related to gastroesophageal reflux and Barrett syndrome (metaplasia).

Radical resectional surgery remains the only cure for invasive esophageal cancers that are relatively resistant to radiation and chemotherapy. Neoadjuvant chemoradiation, however, is gaining popularity as a treatment for stage II and stage III cancers, although the survival benefit is not great. Overall, the 5-year survival rate for esophageal cancer is dismal: 18% for all patients and 25% for those able to have surgery.

Preemptive esophagectomy for patients with Barrett syndrome with high-grade dysplasia once was the most frequent indication for esophagectomy at most high-volume centers. This is no longer the case; endoscopic treatments such as radiofrequency ablation and cryotherapy are now effective low-morbidity alternatives.

Surgical Approaches

Active controversy surrounds the necessity for surgery, with minimalists stressing the morbidity of radical surgery and the poor survival statistics for patients with esophageal cancers. Recently, however, the trend has been for more radical en bloc resections, which offer survival advantages for patients with some early-stage cancers.

The three main approaches to esophagectomy are transhiatal, Ivor Lewis, and “three-hole,” or modified McKeown. Increasingly, all three approaches are performed with laparoscopy or thoracoscopy for an approach called minimally invasive esophagectomy (MIE). Choosing among the three approaches depends partly on the surgical indication (e.g., transhiatal approach for benign and low-grade cases), stage of cancer, and location of the tumor. The approach is mostly determined by institutional and surgeon preference, because no overwhelming evidence exists to demonstrate that one approach is dramatically better than the others.

Reconstruction of the resected esophagus is most often performed using the stomach, either tubularizing it or as a “whole-stomach” interposition. Less frequently, a colonic interposition is used, and, rarely, a jejunal interposition, often with microvascular augmentation. Because the vascularity of any of these conduits is tenuous at best, the surgeon needs to be familiar with the other esophageal replacement options.

Transhiatal Esophagectomy

The transhiatal esophagectomy is performed with the patient supine and the left side of the neck prepped and exposed. Either an upper midline incision or, increasingly, a five-port laparoscopic access is performed. Exploration is performed to rule out disseminated tumor, which would obviate resection in most cases. The greater curvature of the stomach is retracted anteriorly, and the gastrocolic omentum is divided from the spleen to the hepatic flexure, wide of the gastroepiploic blood supply, which is critical for the viability of the gastric graft (Fig. 5-3, A). Once the greater curvature is fully mobilized, the retrogastric adhesions to the peritoneum are divided. The lesser curvature of the stomach is then mobilized, a Kocher maneuver is performed to mobilize the duodenum, and the gastrohepatic ligament is divided near its attachment to the liver (Fig. 5-3, B). This exposes the D1 node area, which is routinely dissected.

Node dissection margins include the porta hepatis (hepatic portal) structures, the hepatic artery, and the vena cava (Fig. 5-4, A

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