Endocrine system

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Chapter 4 Endocrine system

Hypothyroidism

Case history

Suzanne Beaumont is 32 years old. She has come to the clinic at the recommendation of her friend. Suzanne is here primarily for help with weight loss. During your consultation you discover Suzanne is experiencing significant fatigue despite sleeping at least 10 hours every night and is feeling more depressed than she has ever felt before.

Suzanne tells you she is experiencing worsening constipation, her hair and skin have become very dry and, in recent months, has been having problems with facial hair growth and a recurrence of facial acne (she had some problems with acne in her teen years, but that was nearly 15 years ago). Suzanne explains that she is embarrassed about her weight and is beginning to feel isolated from her friends and family because her physical appearance makes her reluctant to go out in public.

Suzanne is also experiencing aches and pains in her body. She doesn’t exercise very much, and is too embarrassed to go to the gym or go walking because of her appearance. She is currently unemployed and, apart from having to go shopping, she rarely leaves the house.

Suzanne has hopes of having children one day; however, she is not currently in a relationship and says she doesn’t really think anyone would be interested in her at the moment anyway. Her parents want her to find a husband and settle down to having children soon so they can enjoy having grandchildren before they are too old. Suzanne has had irregular periods for the past couple of years and she never knows when they will come but they are at least three months apart. When she does get her period the blood flow is extremely heavy and that is another reason she does not like to go out much after a few months without having had a period in case she is caught out. She is thankful she does not experience any period pain these days.

Suzanne can’t understand why she has put on so much weight over the past three years when her appetite has decreased and she doesn’t seem to enjoy food the way she used to. Apart from concerns about her appearance, she would really like to feel well and energetic again.

Suzanne has not been to a doctor in years and doesn’t know if we can help her but says it feels good to finally talk about her problems with someone.

TABLE 4.1 COMPLAINT

Analogy: Skin of the apple

AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES Onset  

Understanding the cause (client)   What do you think has been causing the significant increase in weight? I don’t know, but something is really wrong, I think. Even my periods are going wrong. Your practitioner impression
Suzanne is obviously obese. Your first impression of her is someone who lacks confidence and is quite unsure of herself.  

TABLE 4.2 CONTEXT

Analogy: Flesh of the apple Context: Put the presenting complaint into context to understand the disease.
AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES
Family health  
Has anyone else in your family experienced similar problems? My mum is pretty big, but not as big as I am. Her sister is a lot like me, she’s really big.
Supplements and side effects of medication  
Are you taking any supplements or medications from the doctor? I went to the chemist and got a multivitamin and I also bought some weight-loss tablets, but they haven’t helped my energy or my weight.
Endocrine/reproductive  
Did your irregular period cycle come on suddenly or begin to slow down gradually? I used to be more regular and then it began to slow down and chop and change. Now I get confused about when it’s going to come.
Stress and neurological  
Do you feel stressed at the moment? Yes. I feel so bad about putting on this weight and I know I don’t do enough exercise, but I feel so tired all of the time.
Eating habits and energy  
Describe your diet. Suzanne’s description of her diet indicates it is quite healthy, containing good amounts of whole foods, fresh fruit and vegetables. She insists her portion sizes are normal and on further questioning her description of her portion sizes indicates she is not eating excessive amounts at mealtimes.

TABLE 4.3 CORE

Analogy: Core of the apple with the seed of ill health Core: Holistic assessment to understand the client
AREAS OF INVESTIGATION AND EXAMPLE QUESTIONS CLIENT RESPONSES
Support systems  
Do you have a good support system? I have my parents and some friends.
Emotional health  
Do you think you are depressed? I think I am.
Stress release  
How do you manage your stress? I don’t know, I just usually read or watch TV.
Family and friends  
Do you spend much time with family or friends? I see my parents at least once a week. I haven’t seen my friends much recently since I feel really embarrassed whenever I go out with them. They’re always nice to me, but I just feel they think I should try harder.
Action needed to heal  
What do you think you need to do to get better? I really don’t know, I’ve tried dieting and exercising but it didn’t really work. I’m hoping you can help me.
Long-term goals  
What are your long-term goals? To get slimmer and fitter and to get my energy back. I want to get a job and am thinking of retraining and doing something different.

TABLE 4.4 SUZANNE’S SIGNS AND SYMPTOMS [2, 68]

Results of medical investigations

Suzanne has not had any medical investigations.

TABLE 4.5 UNLIKELY DIAGNOSTIC CONSIDERATIONS [2, 711]

CONDITIONS AND CAUSES WHY UNLIKELY
INFECTION AND INFLAMMATION
Chronic salpingo-oophoritis: irregular cycle; can be minimal or excessive menstrual bleed Usually congestive dysmenorrhoea is the predominant symptom; associated with purulent discharge, fever, period pain and abdominal pain
Postpartum thyroiditis: transient hypothyroid after pregnancy No pregnancies that we know of
ENDOCRINE/REPRODUCTIVE
Diabetes: anovulatory cycles Urinalysis NAD
Primary dysmenorrhoea: lower abdominal pain, can get worse with menstrual cycle Period pain usually begins at menarche and is often associated with no pelvic abnormality, nausea vomiting, headache and dizziness
Secondary dysmenorrhoea: acquired due to pathology; period pain begins several years after menarche and due to a pelvic abnormality No menstrual pain
Endometriosis: irregular periods No significant pelvic pain or pain on menstrual bleed reported; no bleeding from the bowel; usually brown discharge with associated abdominal and pelvic pain
Premenstrual syndrome: pain in the abdomen before menses Will experience premenstrual mood changes, feel teary, bloated and swollen 1–12 days before her period; experiences a dull pelvic ache, abdominal bloating
Ovarian cyst: irregular periods Ovarian cysts almost never cause heavy menstrual bleeding
Ovulatory bleed: have a bleed mid-cycle as well as regular menses and ovulation has occurred Feel emotional, premenstrual symptoms such as ovulation pain (mittelschmerz) and mood changes; usually spotting or light bleed at time of ovulation, regular cycle; check basal body temperature as it will be biphasic and fluctuate indicating ovulation has occurred

Case analysis

TABLE 4.6 POSSIBLE DIFFERENTIAL DIAGNOSIS

NOT RULED OUT BY TESTS/INVESTIGATIONS ALREADY DONE [2, 711, 5658]
CONDITIONS AND CAUSES WHY POSSIBLE WHY UNLIKELY
FAMILY HEALTH
Familial or idiopathic hirsutism: excess hair growth would not be typically androgenic Excess hair appearing on hormonal influenced areas of the body where hair will grow, such as the face Check if family history of excess hair growth for females
ALLERGIES AND IRRITANTS
Food intolerance/allergy Fatigue, depression; skin and hair changes; constipation Need to gain more insight into Suzanne’s diet and associated symptoms
CANCER AND HEART DISEASE
Thyroid cancer Deep voice, thyroid swelling Will have signs of pain in neck or throat, difficulty swallowing, nodule or lump around laryngeal prominence, trouble breathing, difficulty speaking, hoarse throat; thyroid gland will have a single firm nodule that has developed rapidly
Ovarian, uterine cancer Heavy irregular bleeding No vaginal discharge reported
Adult onset and congenital adrenal hyperplasia/adrenal tumour: can cause primary and secondary amenorrhoea anovulatory cycles Usually presents with severe acne and hirsutism; can present with anovulatory irregular menstrual bleeding Check if there was rapid development of symptoms and how severe symptoms of virilisation are; usually will be severe and can include symptoms such as frontal balding, enlarged clitoris
TRAUMA AND PRE-EXISTING ILLNESS
Congenital – dyshormonogenesis: genetic defects in synthesis of thyroid hormone – primary cause Goitre and hypothyroid symptoms Rare condition; may have associated deafness; need to investigate for family history of thyroid disease; will present with childhood symptoms such as dwarfism, mental retardation, pot belly, delayed bone age
OBSTRUCTION AND FOREIGN BODY
Intestinal obstruction (bowel cancer, adhesions, hernias, faecal impaction with overflow) Abdominal constipation No vomiting, abdominal pain and distension
FUNCTIONAL DISEASE
Thyroid benign nodules: follicular adenomas, cysts, focal thyroiditis Deep voice, thyroid swelling, hypothyroid symptoms Nodules develop rapidly
Fibromyalgia: pain in axial skeleton with tender points that has lasted more than 3 months Tiredness, aches and pains more common in women; can be worse from being in cold weather; depression Will often present with irritable bowel symptoms, difficulty sleeping; normal laboratory results; rule out organic reasons for symptoms
Obstructive sleep apnoea Fatigue during the day; more common when overweight or obese; does not usually complain of ‘sleepiness’ but fatigue generally Need to define if Suzanne does not feel well rested in the morning and if she snores during the night; can be made worse by alcohol consumption prior to sleeping
Obesity BMI 35; lack of exercise; usually general distribution of weight gain Goitre visible; usually no other abnormal health features other than being overweight; appetite is usually increased; oedema present (unusual); need to define if Suzanne has a family history of obesity; need to define if Suzanne’s weight gain has been gradual with increased caloric intake and/or with eating more sugar
Chronic fatigue syndrome: fatigue for at least 6 months that has no physical, psychoses, bipolar affective disorder, eating disorder or organic brain disease Severe disabling fatigue affects both mental and physical functioning for at least 6 months; sleeping more, depression, feelings of guilt, social withdrawal, crying spells; muscular aches and pains Goitre indicates a physical reason for fatigue; need to define if Suzanne’s fatigue improves as the day progresses
Functional constipation Constipation, lack of exercise, stress Need to check if more than 1 in 4 bowel motions is lumpy and hard, and causes strain, a feeling of incomplete evacuation or blockage; need to check if manual help is needed to facilitate a bowel motion passing; does she have fewer than 3 evacuations in a week?
DEGENERATIVE AND DEFICIENCY
Iodine deficiency: iodine required for thyroid hormone synthesis – primary cause Goitre and hypothyroid or euthyroid In mountainous areas of Alps, Himalayas, South America, Central Africa; thyroid gland can have multiple nodules
Pernicious anaemia: lack of B12 absorption due to immune destruction of intrinsic factor in atrophic gastritis and loss of stomach parietal cells Fatigue, slow movements, cognitive impairment, can present with hypothyroidism Usually low blood pressure and rapid heart rate, shortness of breath, swollen red tongue, diarrhoea, can also present with hyperthyroidism
Anaemia: iron deficiency, pernicious anaemia, due to heavy menstrual bleeding Fatigue, depression Usually signs of shortness of breath, palpitations, increased heart rate
INFECTION AND INFLAMMATION
Post-subacute thyroiditis: primary cause Goitre and hypothyroid symptoms Would be a transient condition of infective origin rather than the symptoms gradually building up over time; soft tender, sometimes painful goitre
Riedel’s thyroiditis: fibrous tissue infiltrates and replaces the thyroid gland Goitre hypothyroid symptoms; more common in women Very hard goitre; rare form of thyroid disease
Osteoarthritis Pain in many joints and more common in women Usually develops in older age groups; presents with signs of limited range of movement, bony swellings and instability of joints; not necessarily associated with severe fatigue; need to check family history as it can be congenital and begin at an early age
Postviral infection Depression, fatigue Need to rule out if Suzanne has had viral symptoms prior to feeling fatigued and depressed
SUPPLEMENTS AND SIDE EFFECTS OF MEDICATION
Drugs: lithium, antithyroid medication, cytokines Cause hypothyroid symptoms Need to check medication history
ENDOCRINE/REPRODUCTIVE
Hypothalamic-pituituary disease: tumour, hypopituitarism is secondary cause of hypothyroidism Goitre; symptoms of hypothyroid such as irregular periods, depression, weight gain, slow pulse, constipation, low body temperature Blood tests will rule out secondary causes of hypothyroidism
Hypothyroidism: cause of secondary amenorrhoea due to hyperprolactinaemia and endocrine disorder; anovulatory cycles Goitre, weight gain, fatigue, depression, irregular periods, heavy menses, constipation, increased facial hair (hirsutism), puffy eyes, deep voice, dry hair, low body temperature, slow pulse, muscle aches, slow movements, change in appetite  
Subclinical hypothyroidism [59, 60] Weight gain, fatigue, depression, irregular periods, heavy menses, constipation, change in appetite Need to check if serum TSH levels are above limit and T3 and T4 levels present as normal; could indicate clinical hypothyroidism may develop
Pregnancy Irregular periods; missed periods; most common cause of secondary amenorrhoea; can present with vaginal discharge and pelvic/abdominal pain Suzanne claims she is not sexually active at the moment and has no partner; pregnancy can present with fever; will have signs of breast tenderness and may have morning sickness
Uterine fibroids and polyps: fibroids form due to excess oestrogen and can cause symptoms of heavy bleeding, uterine enlargement Usually causes menorrhagia (blood loss of 80 mL per day and lasting more than 7 days) Often maintains normal cycle unless submucosal or nearly extruded
Polycystic ovarian syndrome (PCOS): extremely common cause of secondary amenorrhoea; anovulatory cycles Irregular menstrual cycles, acne, increased facial hair (hirsutism), weight gain; irregular periods came on slowly Can occur with androgenic alopecia (thinning of hair on the head such as men have); may not be associated with heavy menstrual bleeding
Cushing’s syndrome: cause amenorrhoea, irregular menstrual cycles Irregular menstrual cycles, increased facial hair, depression, weight gain, higher scale blood pressure There was not a rapid development of symptoms; no moon-shaped face or frontal balding; urinalysis NAD and indicating no glucose intolerance or diabetes that can be associated with Cushing’s syndrome
Dysfunctional uterine bleeding (DUB): endometrial hyperplasia, PCOS, from taking exogenous oestrogen; endocrine dysfunction; (not associated with inflammation, tumour or pregnancy) anovulatory hormone-related bleeding is most common Usually causes bleeding with unpredictable volume and frequency; often accompanied by menorrhagia (heavy bleed with regular cycle) but interval between periods is shorter to make the cycle appear irregular No use of exogenous oestrogen reported
Anovulatory bleeding: have irregular bleed that appears menstrual although no ovulation has occurred; can be associated with both short and long cycles Irregular cycle; no significant premenstrual symptoms reported to show evidence of regular association with menses cycle; bleed is painless and unexpected; blood volume can be excessive but irregular; physical findings will often include hirsutism, acne Check basal body temperature; if anovulatory it will not fluctuate (monophasic)
Oestrogen-withdrawal bleeding: causes intermenstrual bleeding; occurs when the endometrium proliferates and becomes unstable when oestrogen drops below threshold; can happen outside of the secretory phase or in the absence of progesterone Common cause of irregular periods in reproductive years, especially if ovulation has not occurred; menstrual bleeding is prolonged and profuse when it does occur; bleed is painless  
Progesterone-withdrawal bleeding: only occurs when there is an oestrogen-primed endometrium; can occur when oestrogen therapy continued and progesterone stopped; also when progesterone is administered to test endogenous oestrogen Irregular menstrual bleed; often present in conditions such as amenorrhoea  
Oestrogen-breakthrough bleeding – 1st type: when oestrogen levels are low but constant causing sections of endometrium to degenerate Intermenstrual bleed Need to investigate if experience any spotting of blood
Oestrogen-breakthrough bleeding – 2nd type: oestrogen levels are well above threshold causing endometrium to become hyperplastic and outgrow blood-borne hormone supply Causes degeneration of endometrium with prolonged and irregular bleeding More common in oestrogen-based tumours
AUTOIMMUNE DISEASE
Atrophic thyroiditis: (autoimmune) most common cause of primary hypothyroidism; will cause atrophy and fibrosis of the thyroid gland Goitre; may be intermittent and recover; symptoms of hypothyroidism; common in women Check for the presence of antithyroid antibodies and pernicious anaemia; thyroid gland will be enlarged, sometimes painful and soft swelling
Hashimoto’s thyroiditis: [58] important to rule out an autoimmune cause of primary hypothyroidism Goitre; common in women More often presents in late middle age
Rheumatoid arthritis Muscle aches and pain; common in women, fatigue due to anaemia of chronic disease Check if family history of rheumatoid arthritis
Systemic lupus erythematosus Generalised aches and pains, skin changes, more common in women, increased fatigue See if there is a butterfly rash on Suzanne’s face
STRESS AND NEUROLOGICAL DISEASE
Depression: important differential diagnosis to rule out before exploring other possibilities of mental or organic causes for fatigue symptoms    
Primary origins
Primary depression and endogenous depression are associated conditions that are regarded as primary disorders, i.e. that do not occur secondarily to other medical or psychiatric disorders; these terms refer to depression that is caused by internal chemical and biological factors rather than external stressors
   
Type 1 – major (clinical) depression Has at least five symptoms of depression every day for more than 2 weeks, which causes considerable incapacity with daily activities; people often describe symptoms in physical terms; depressed daily, loss of interest in daily activities, change of appetite, weight gain, increased fatigue, slower movements, feelings of worthlessness Need to define if Suzanne feels worse in the morning and has a sense of apprehension; visible goitre indicates the feelings of depression come from a secondary origin
Dysthymia: mild depressive illness Could be experiencing ‘double depression’ if Suzanne has had intermittent periods of depression in the past; symptoms include tiredness, lack of interest in life and low mood Lasts intermittently for 2 years or more; need to determine if Suzanne has had a tendency to have episodes of feeling low prior to the onset of her physical changes
Secondary origins
Reactive depression and associated conditions that occur after or in response to a pre-existing medical or psychiatric disorder; brought on by external life experiences
   
Seasonal affective disorder: secondary to the winter months Symptoms include increased sleep, tiredness, change in appetite, weight gain Need to determine if Suzanne has experienced episodes of depression during the winter months in the past; usually appetite increases
Psychological
Functional fatigue (depression)
Tiredness that has lasted several months Need to determine if Suzanne’s fatigue improves as the day progresses; determine if her fatigue began after a specific life event or only when her physical symptoms began
EATING HABITS AND ENERGY
Causal factor:Diet high in brassica and cassava foods: when in excess can cause hypothyroid symptoms Symptoms of underactive thyroid Need to ask if Suzanne regularly eats broccoli, spinach, cabbage, cauliflower, brussels sprouts, kale, collard greens, pak choi and tapioca is in Suzanne’s diet
Causal factor:Lack of exercise Weight gain, fatigue, depression  

TABLE 4.7 DECISION TABLE FOR REFERRAL [2, 712]

COMPLAINT CONTEXT CORE
Referral for presenting complaint Referral for all associated physical, dietary and lifestyle concerns Referral for contributing emotional, mental, spiritual, metaphysical, lifestyle and constitutional factors
REFERRAL FLAGS REFERRAL FLAGS REFERRAL FLAGS

ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE ISSUES OF SIGNIFICANCE REFERRAL REFERRAL REFERRAL

Signs and symptoms warrant further investigations for a definitive diagnosis of hypothyroidism [56, 57]; we have a duty of care to Suzanne to encourage her to be informed regarding possible treatment using thyroxine medication [58, 60]

Dietary assessment

TABLE 4.8 FURTHER INVESTIGATIONS THAT MAY BE NECESSARY [2, 611, 13, 57, 60]

TEST/INVESTIGATION REASON FOR TEST/INVESTIGATION
FIRST-LINE INVESTIGATIONS:
Pelvic, vaginal, abdominal examination Check for bulging uterus, ovaries can be palpable in PCOS, abdominal rebound tenderness, overactive bowel sounds, genital deformities, signs of trauma
Musculoskeletal examination Back strain, trauma, deformities, inflammation
Human chorionic gonadotropin (HCG) blood test/radioimmunoassay (RIA) Pregnancy, ectopic pregnancy
Full blood count Check for signs of infection, virus or allergic reaction; rule out anaemia
‘Free’ T4: available for tissue action Measures only the unbound active T4 hormone; will be low in hypothyroid
Thyroxine-binding globulin (TBG) – binds T4 and T3 in plasma Will be increased in hypothyroidism
Thyroid antibody: blood test thyroid perioxidase antibody, antithyroglobulin antibody Autoimmune causes of hypothyroidism
Serum cholesterol Can be raised in hypothyroidism
ESR/CRP Inflammation such as in systemic lupus erythematosus (SLE) and rheumatoid arthritis
Progesterone level Test 7 days before menstruation due to see if ovulation has occurred; low serum progesterone level in anovulatory cycles
Oestradiol
LH (luteinising hormone) due to pulsatile action of this hormone it may not be accurately measured on one random sample
PRL (prolactin) commonly raised in secondary amenorrhoea
Testosterone
SHBG (sex hormone-binding globulin) Low SHBG would indicate the presence of elevated levels of free androgens
Fasting blood glucose test Raised levels can indicate diabetes mellitus, Cushing’s syndrome
Cervical smear To detect cervical cancer
HOME TESTS:
Basal body temperature
Ovulation prediction kits Designed to detect an increase in urinary luteinising hormone (LH) excretion 24–36 hrs prior to ovulation
Diet dairy Assess caloric intake and possible food sensitivities
IF NECESSARY:
Serum aspartate transferase Will be increased from muscle and liver in hypothyroid
Serum creatine kinase levels Increased with associated myopathy in hypothyroidism
Sodium levels Low due to increase in ADH and slow free water clearance
Thyrotropin releasing hormone (TRH) TRH is released in the hypothalamus to stimulate release of TSH from pituitary; determine hypothalamic-pituitary disease
Anti-nuclear antibody Autoimmune disorders, SLE, rheumatoid arthritis
RH factor Rheumatoid arthritis
Epstein-Barr virus blood test Postviral symptoms, may show that Suzanne has had this virus in the past without realising it
Abdominal and pelvic x-ray/ultrasound Most accurate diagnosis of PCOS, ovarian mass, ovarian cyst or tumour, retroverted uterus, tubo-ovarian abscesses, fibroids, trauma; intestinal obstruction
Brain scan CT/MRI Pituitary tumour
Back x-ray CT scan and MRI Degenerative disc disease, disc prolapse, Ankylosing spondylitis, Paget’s disease, osteoporosis

Confirmed diagnosis

Suzanne and hypothyroidism

Suzanne is a 32-year-old woman who has come to the clinic asking for help with weight loss – she has now reached a BMI of 35. Additionally Suzanne is experiencing significant fatigue despite sleeping long hours at night, has worsening constipation, a lack of appetite and is depressed. She has also been experiencing irregular and heavy periods, has developed facial hair growth and acne, dry skin and hair and suffers from generalised aches and pains in her body. On the whole Suzanne is feeling very low about herself and this is not made any better by her family being disappointed that she does not yet have a husband and children. Suzanne is currently unemployed and does not leave her home often. She is not exercising because she is too embarrassed to do so outside of her home and is not motivated on her own.

On physical examination it became evident that Suzanne has a visible goitre, deep voice, puffy eyes, slow movements and speech, low body temperature and pulse rate and high blood pressure. Suzanne required immediate referral for a medical and mental health assessment. A medical diagnosis of hypothyroidism was confirmed, which explains the range of symptoms she has been experiencing.

Hypothyroidism is an ailment characterised by under-activity of the thyroid gland (i.e. insufficient production of thyroid hormones). The most ‘observable’ sign of hypothyroidism is a goitre and low basal temperature in the morning. Other symptoms include fatigue, weight gain, memory and mental impairment, dry skin, cold intolerance, decreased concentration, constipation, depression, loss of hair, coarse hair, muscle and joint pain, goitre, hyperlipidaemia, irregular periods, infertility, hoarseness, yellow skin, lowered body temperature, drooping swollen eyes, reduced or excessive sweating, brittle nails, diminished sex drive and slow healing.

Hypothyroidism occurs most frequently in women over the age of 40 (however, men and teenagers may also have hypothyroidism). It is possible for a woman or man to have symptoms of subclinical hypothyroidism for many years before developing a clinical manifestation of the disease. Approximately 50 per cent of people with hypothyroidism are unaware they have the condition [56]. Although clients with this disorder can be asymptomatic, some clients have subtle findings including alteration in lipid metabolism as well as abnormalities in cardiac, gastrointestinal, neuropsychotic and reproductive functions [57].

General references used in this diagnosis: 2, 7, 8, 10, 11, 56–58

NB:

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