Endocrine control

Published on 01/03/2015 by admin

Filed under Basic Science

Last modified 01/03/2015

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40

Endocrine control

Assessment of endocrine control

Many endocrine diseases arise from failure of control mechanisms (Table 40.1). Assessment of endocrine control presents particular difficulties.

Table 40.1

Examples of endocrine disease

Oversecretion

Cushing’s disease where a pituitary adenoma secretes ACTH

Undersecretion

Primary hypothyroidism where the thyroid gland is unable to make sufficient thyroid hormone despite continued stimulation by TSH

Failure of hormone responsiveness

Pseudohypoparathyroidism where patients become hypocalcaemic despite elevated plasma PTH concentration because target organs lack a functioning receptor signalling mechanism