Endocrine Complications

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 0 (0 votes)

This article have been viewed 869 times

Chapter 61

Endocrine Complications

Summary of Key Points


• Endocrine dysfunction may occur as a direct result of cancer or may be a consequence of cancer therapy (e.g., surgery, radiation, chemotherapy, biological agents, and hormone therapy). Endocrine dysfunction may be an intentional consequence or an adverse effect of antineoplastic therapy.

• Hypopituitarism with clinically significant deficiencies of growth hormone, thyrotropin, gonadotropin, and corticotrophin may result from radiation (cranial or total body irradiation), surgery, or chemotherapy.

• Thyroid dysfunction from neck irradiation, immune therapy (interleukin-2), and small molecule tyrosine kinase inhibitors such as sunitinib may result in either hyperthyroidism or hypothyroidism.

• Gonadal dysfunction after surgery, radiotherapy, or chemotherapy results in disruption of puberty, infertility, and premature menopause.

• Adrenal dysfunction from agents such as ketoconazole or aminoglutethimide may result in glucocorticoid or mineralocorticoid deficiency.

• Pancreatitis and, occasionally, pancreatic exocrine or endocrine deficiencies may result from chemotherapy (l-asparaginase and streptozotocin).