Dysphagia and weight loss in a middle-aged man

Published on 10/04/2015 by admin

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Last modified 10/04/2015

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Problem 12 Dysphagia and weight loss in a middle-aged man

You realize that his symptoms warrant investigation, even in the absence of any physical signs, and you go on to arrange some investigations.

Blood results are as follows:

A further investigation is performed and a representative film is shown (Figure 12.1).

Based on the radiological findings, the patient is referred for another investigation (Figure 12.2).

The lesion is biopsied and confirmed to be a moderately differentiated adenocarcinoma. The patient is referred for further staging investigations (Figure 12.3 and Figure 12.4.).

Various imaging investigations are performed and do not show any evidence of tumour dissemination. The tumour appears to be confined to the stomach wall, although there may be some thickening in the immediately adjacent tissues.

The patient and his diagnostic tests are discussed at a multidisciplinary meeting. The treatment recommendation is for neoadjuvant chemotherapy before and after surgical resection.

Following three cycles of chemotherapy (over 3 months) and 4 weeks of stabilization, the patient underwent surgery. Figure 12.5 shows the operative view of the upper abdomen.

The tumour showed extensive transmural infiltration by a moderately differentiated adenocarcinoma with involvement of the lymph nodes along the left gastric artery. The patient underwent three more cycles of chemotherapy 2 months following his gastrectomy. He initially did very well but died of disseminated disease 18 months later.