15 Drug interactions – 2
| T | F | |
|---|---|---|
| 1. Diclofenac does not increase serum lithium levels. |  |
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| 2. Clinically important interactions occur between diazepam and orphenadrine. |  |
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| 3. Drug interactions may occur at protein binding sites in the plasma. |  |
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| 4. Doxazosin can be used safely with reboxetine. |  |
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| 5. An interaction between disulfiram and warfarin occurs in the liver. |  |
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| 6. Enalapril increases lithium levels. |  |
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| 7. Fluoxetine increases lithium levels. |  |
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| 8. Drug interactions do not occur in the gastrointestinal tract. |  |
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| 9. Together with lithium, haloperidol should not be given at doses higher than 20 mg daily. |  |
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| 10. Patients taking MAOIs should avoid pickled herring. |  |
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| 11. Ibuprofen may reduce lithium levels. |  |
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| 12. Imipramine is incompatible with tyramine rich foodstuffs. |  |
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| 13. Drug interactions do not occur in the kidney. |  |
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| 14. Muscle relaxants interact with MAOIs. |  |
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| 15. Mixing drugs in syringes can cause drug interactions. |  |
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| 16. Interaction by mixing drugs in a syringe is an example of pharmacodynamic drug interaction. |  |
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| 17. MAOIs may interact significantly with TCAs. |  |
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| 18. Methadone may interact significantly with TCAs. |  |
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| 19. TCAs potentiate the pressor effects of noradrenaline. |  |
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| 20. Valproate impairs the efficacy of oral contraceptive drugs. |  |
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| 21. Decreased intestinal absorption of drugs, caused by the anticholinergic effect of amitriptyline, is an example of pharmacodynamic drug interaction. |  |
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| 22. Induction of liver microsomal enzymes is an example of pharmacodynamic drug interaction. |  |
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| 23. Clinically important interactions occur between phenobarbitone and oral contraceptives. |  |
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| 24. Fluoxetine increases the serum levels of TCAs. |  |
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| 25. St John’s wort increases the levels of warfarin. |  |
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