Disorders of Thrombosis and Hemostasis

Published on 06/06/2015 by admin

Filed under Pediatrics

Last modified 06/06/2015

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54 Disorders of Thrombosis and Hemostasis

The coagulation system is complex with intricately balanced interactions between the vascular endothelium, platelets, procoagulant, and anticoagulant proteins. With vascular injury, a cascade of interactions occurs between platelets and procoagulant proteins to initiate clot formation. After clot formation is initiated, anticoagulant proteins are activated to inhibit excessive clot formation. A dysregulation in this finely tuned system can lead to either a bleeding diathesis or a prothrombotic disorder.

Etiology And Pathogenesis