Disorders of Nails and Skin

Published on 11/03/2015 by admin

Filed under Orthopaedics

Last modified 22/04/2025

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 5 (1 votes)

This article have been viewed 6308 times

Chapter 87 Disorders of Nails and Skin

Deformities and diseases of the toenails are some of the most common and most disabling foot problems in infants to the elderly. They range from minor annoyances to severe life- or limb-threatening conditions, and abnormalities of the toenails can be a sign of a systemic disease process. Often the pain associated with nail disorders has a marked effect on individuals’ daily lives. A study of 55 patients with nail disorders found that they were significantly correlated with dysfunction of the lower extremities and, in elderly patients, were likely to increase the risk of falling.

Anatomy

The normal nail complex consists of the nail plate, the nail bed, and the surrounding skin. The nail plate is the nail proper and consists of two components: the root, the portion of the nail plate that is beneath the skin, and the body, the exposed portion of the nail plate. The nail bed, has two components, the sterile matrix and the germinal matrix. In the skeletally mature foot, the germinal matrix extends from just distal to the lunula 5 to 8 mm proximally and deep to the eponychium or proximal nail fold. It is smoother and paler than the sterile matrix, unless the nail has recently been avulsed. The germinal matrix sends projections into the adjacent soft tissue that make complete nail ablation difficult. The germinal matrix contributes to longitudinal growth of the nail plate (Fig. 87-1A). The skin surrounding the nail plate includes the nail walls (labia ungues), the margins of skin that overhang the two lateral borders of the nail body; eponychium (proximal nail fold), the distal extension of the stratum corneum of skin that covers the nail root; and cuticle, the distal edge of the eponychium. It is doubtful that the eponychium, lateral nail folds, or nail bed (sterile matrix) contribute to longitudinal new growth of the nail plate, but this issue is not completely settled. Finally, the hyponychium is the horny thickening of the skin at the distal margin of the nail.

Ingrown Toenail (Onychocryptosis, Unguis Incarnatus)

Etiology

The term ingrown toenail is misleading. If used to designate a hook of nail caused by improper nail care growing into an overlapping nail fold that has obliterated the lateral nail groove, the term is acceptable (Fig. 87-1B). The most probable cause of the symptom complex is a combination of factors, however, only one of which may be an improperly trimmed nail. The condition is rare in people who do not wear shoes, and the most likely explanation is the absence of extrinsic pressure. Within the confines of the shoe toe box, the great toe is pushed toward the second toe, resulting in pressure against the lateral border of the nail, while the shoe itself exerts pressure on the medial side of the nail. This extrinsic pressure causes the nail fold to push into the sharp edge of an improperly cut nail, breaking the skin. The bacterial and fungal flora on the skin enter the open wound, albeit a small one, and inflammation results. A bottlenecked, poorly draining abscess follows, causing erythema, edema, hyperhidrosis, and tenderness. Finally, hypertrophic granulation tissue completes the clinical picture of the familiar infected ingrown toenail (Fig. 87-1C). The hypertrophic granulation tissue is slowly covered by epithelium, further inhibiting drainage and promoting edema. This process makes the nail even more vulnerable to injury by extrinsic pressure, and the cycle repeats itself.

Nonoperative Management

Stage I (Inflammatory Stage)

In stage I, the patient has mild erythema, swelling, and tenderness along the lateral nail fold. The treatment involves lifting the lateral edge of the nail plate from its embedded position in the dermis of the lateral nail fold. This is easier to perform if done after soaking the foot, which makes the nail softer and more pliable. Nonabsorbent cotton, wool, or acrylic mesh is passed beneath the corner of the nail (Fig. 87-1D). This is done gently because it is frequently painful. The patient may need a few days of intermittent warm soaks, a cutout shoe, and modification of activity before the local inflammation is reduced enough to allow this treatment. Once begun, however, the patient usually can introduce more material beneath the nail corner than can the physician. The patient repeats the treatment daily until the nail grows out and can then be trimmed properly. Proper trimming of the nail at right angles to the distal edge of the nail plate is shown in Figure 87-2, with the goal being a squared nail with corners protruding distal to the hyponychium. This treatment usually is successful in 2 to 3 weeks if as much material as is comfortable to the patient is placed beneath the nail edge each day.

Another conservative treatment option is nail splinting, which separates the nail plate from the soft tissue to provide a channel in which the nail can grow. A “gutter splint” that is affixed to the ingrown nail edge with adhesive tape or a formable acrylic resin such as cyanoacrylate can be fashioned from a sterilized vinyl intravenous drip infusion tube slit from top to bottom with one end cut diagonally for smooth insertion (Fig. 87-3). Gutter splints can be used with or without the application of an acrylic nail. The use of a resin splint also has been reported to be successful, although the duration of application was lengthy (9 months). Reported recurrence rates with various splinting techniques range from 8% to 48%.

A dynamic correction technique, orthonyxia, uses direct force to lift the nail from the nail fold and release the pressure exerted on the inflamed soft tissue. Generally, orthonyxia devices consist of two hooks placed on the sides of the nail and connected under tension by wire (Fig. 87-4), “super-elastic” wire, or shape-memory segments. Correction of the nail deformity has been reported to occur within 3 weeks in most patients. Cited advantages of splinting and orthonyxia techniques over operative treatment are less postoperative morbidity, shorter time to recovery, and better cosmetic results.

Total Nail Plate Removal

Total nail plate removal without concomitant matrix removal rarely is indicated, unless the abscess has circumducted the nail on both sides and beneath the eponychium so that partial nail plate removal would not provide adequate drainage.

Technique 87-1

The recurrence rate of ingrown toenail after total nail removal ranges from 32% to 78% in published reports; the recurrence rate after a second avulsion is 70% to 80%. The benefits of total nail avulsion are uniformly rapid relief of symptoms and resolution of infection.

Partial Nail Plate Removal

Partial nail plate removal differs little from total nail plate removal.

The recurrence rate is even higher after partial nail plate removal than after complete removal. In adolescents, however, this minor procedure, even if it must be repeated, is an attractive alternative to changing the appearance of the nail permanently. The patient, and especially the parents of an adolescent, must be told that the nail-forming matrix may be injured, and some permanent deformity, even if minor, may result (Fig. 87-8).

Removal of the Nail Edge and Ablation of the Nail Matrix

Phenol ablation of nail matrix of ingrown toenails is probably the most common procedure for onychocryptosis and can be done in the office setting.

Technique 87-3

Postoperative Care

The nail edge is covered with nonadherent gauze and a toe dressing (Fig. 87-9E), followed by release of the tourniquet. The patient is placed in a postoperative shoe and instructed to elevate the foot. The patient should be warned about the charred appearance of the skin that is evident when they remove their dressing after 2 to 3 days. Warm Epsom salt soaks are started once the dressing is removed, until the tissues have healed. Nonconstricting shoes are worn until all tenderness and drainage have ceased (Fig. 87-9F).

A systematic review of the literature determined that recurrence of the ingrown nail is less frequent after phenolization with simple avulsion of the nail than after more invasive excisional surgical procedures, and reported success rates with this technique have been as high as 98%. A comparison of surgical and phenol matricectomy in 72 patients, however, found a significantly higher recurrence rate in those with phenol matricectomy (32%) than in those with surgical matricectomy (7%). Trichloroacetic acid and sodium hydroxide have also been used for ablation of the nail matrix instead of phenol. Other methods used for ablation of the nail matrix include electrocoagulation and carbon dioxide laser vaporization. Laser ablation was reported to significantly reduce operative time and duration of postoperative pain, as well as allow a quicker return to daily activities.

The following procedures are probably better performed in the operating room, as opposed to the office setting.

Partial Nail Plate and Matrix Removal

Probably the most frequently done operative procedure for ingrown toenail is the one described by Winograd. Although his report involved only five patients, numerous subsequent reports have affirmed the usefulness of the technique. The Winograd technique is useful in late stage II or stage III disorders, especially after a previous, unsuccessful partial or complete nail removal. We have not found it necessary to treat the wound for several days before the procedure to reduce local infection, but have no objection to this being done.

Technique 87-4

Figure 87-10

(WINOGRAD)

image Beginning 5 to 8 mm proximal to the lunula, make a longitudinal incision in the eponychium extending distally (Fig. 87-11A), while scoring, but not penetrating, the nail plate until its distal edge is reached (Fig. 87-11B).

image Lift the eponychial flap by sharp dissection to reveal the nail root overlying the lateral margin of the germinal matrix. The remainder of the eponychium should be left undisturbed.

image Using a small nasal elevator or small, straight hemostat, lift the lateral border of the nail out of the nail fold by passing the instrument beneath the lateral fourth of the exposed nail.

image Incise this nail margin with a nail splitter (Fig. 87-11C) along the previously scored mark, being sure to reach the most proximal edge of the nail plate.

image With its eponychial cover already reflected, and the undersurface of the nail plate lifted off its bed (Fig. 87-11D), gently remove this segment of nail, exposing the underlying matrix (Fig. 87-11E).

image Remove the exposed matrix by sharp dissection using the scalpel.

image Retract the lateral nail fold to expose the lateral margin of the matrix. Remove the entire matrix, the sterile and germinal portions; take special care to remove the proximal portion of the germinal matrix to reduce the likelihood of recurrent nail formation (Fig. 87-11F).

image Even after great care, the patient occasionally develops a tiny nail remnant that may or may not be symptomatic. An attempt to bring the lateral margin of the nail fold to the remaining nail is optional; Heifetz recommended excision of part of the nail fold. The surgeon should be certain that the periosteum of the phalanx has been removed with the matrix (Fig. 87-11G) because this is the most certain means of matrix ablation.

image Return the proximal eponychial flap to its original location. Sutures to hold it there are optional (Fig. 87-11H).

image Apply a nonadherent dressing over the exposed phalanx, followed by a nonconstricting gauze wrap (Fig. 87-11I).

Recurrence rates vary in the literature from 0% to 86%. This rate can be lowered by full exposure of the germinal matrix, followed by its complete removal. Recurrence rates are higher in patients with previous nail ablations, likely secondary to scarring and therefore incomplete exposure of the germinal matrix.

Nail Plate and Germinal Matrix Removal

The procedure for nail plate and germinal matrix removal was originally described by Quenu in 1887 and popularized by Wilson in 1944. The essentials of this procedure are removal of the entire nail plate and germinal matrix while not disturbing the sterile matrix distal to the lunula (Fig. 87-12). The sterile matrix does not form true nail but continues to form flaky cornifications that might be cosmetically displeasing (Fig. 87-13). This procedure is rarely used but can be employed in middle-aged or elderly patients with multiple occurrences of nail problems from a variety of causes (incurvatum, onychogryposis, onychomycosis). Younger patients (usually male) with less concern for cosmesis who have had multiple operations for ingrown toenail also are good candidates for this procedure. It is often a good alternative to the terminal Syme procedure.

Technique 87-5

(QUENU; FOWLER; ZADIK)

image Remove the nail plate initially in the same manner as previously described (see Fig. 87-5).

image Raise the eponychium as a full-thickness flap by extending oblique incisions from both corners of the proximal nail fold approximately 1 cm proximally (Fig. 87-14A).

image Excise the inner 1 or 2 mm of nail fold on both sides of the nail.

image Excise the germinal matrix (Fig. 87-14B). Begin this incision 1 to 2 mm distal to the lunula or, if the lunula is indistinct, begin the incision one third the distance from the cuticle to the distal nail edge, and make it transverse across the sterile matrix.

image Retracting the lateral nail fold, remove each edge of the matrix from the distal phalanx by sharp dissection, being careful not to leave any germinal matrix in the recesses of the lateral grooves. The matrix follows the lateral curvature of the phalanx almost to the midlateral line, and this must be kept in mind during the lateral dissection to remove the matrix.

image With the distal edge and both lateral margins of the germinal matrix detached from the phalanx, the proximal edge and corners can be seen better. Retract the proximal nail fold proximally, and complete the removal of the matrix by sharp dissection (Fig. 87-14C).

image The extensor hallucis longus insertion centrally and fat and subcutaneous tissue at the corners must be exposed before adequate excision of the germinal matrix is possible. In addition, the periosteum on the dorsal and lateral borders of the distal phalanx should be removed by sharp dissection when the germinal matrix is excised.

image Return the eponychial flap to its previous location (Fig. 87-14C and D). Usually, it does not reach the remaining nail bed, but the gap is small and quickly closes with wound contraction. The use of sutures is optional.

Partial Nail Fold and Nail Matrix Removal

The rationale for partial nail fold and matrix removal and its modifications is to eliminate all parts of the pathological condition that are causing the symptoms yet leave the normal nail and soft tissue intact. The procedure involves wedge resection of the nail, nail bed, and nail fold (Fig. 87-15A). The chief complication of wedge resection has been recurrence of nail spicules (Fig. 87-16). The crucial factor in preventing spicules is removal of the germinal matrix. As Figure 87-17 shows, however, the apex of the wedge and the narrowest area of resection is at the most crucial tissue requiring removal—the matrix. The portion of the nail plate and lateral nail fold removed with the wedge is adequate. We have had no experience with the procedure, but believe it to be based on sound reasoning. If the patient understands that a part or all of the nail may regrow and be mildly deformed, the procedure is an acceptable treatment.

Technique 87-6

Figure 87-17

(WATSON-CHEYNE AND BURGHARD; O’DONOGHUE; MOGENSEN)

Technique 87-9

(JANSEY; BOSE)

Terminal Syme Procedure

The terminal Syme (Thompson-Terwilliger) procedure involves amputating the distal half of the distal phalanx, including the nail plate, matrix, nail folds, and underlying bone on which these structures rest. The procedure is recommended for adults who have had recurrent bouts of infected ingrown toenails that are unrelieved by less extensive procedures. It also can be used for various bone or soft tissue tumors around the nail and distal phalanx.

Complications of the terminal Syme procedure include osteomyelitis of the distal phalanx, epidermal inclusion cysts along the suture line, and troublesome nail spicules. In our experience, however, this is a dependable procedure, producing an excellent functional and acceptable cosmetic result in most patients (Fig. 87-24). Although the tip of the toe is initially bulbous and unattractive, the final appearance is rarely offensive to the patient. Meticulous technique and attention to detail are mandatory to avoid nail horns. In the presence of an abscess, drainage should be instituted first, and the local wound condition should be improved before performing the procedure. This step should not delay the procedure for more than 2 weeks and usually less.

Technique 87-10

image Use sharp dissection throughout the procedure except during the use of a bone cutter or saw to transect the distal phalanx 1 to 2 mm distal to the extensor and flexor hallucis longus insertions. The skin incision is illustrated in Figure 87-25A and B.

image Thompson and Terwilliger recommended that a skin margin of 4 mm be removed with the entire nail bed and transected part of the phalanx. The proximal margin of skin overlying the germinal matrix may extend more than 4 mm proximal to the cuticle, and it is recommended that the skin margin proximally measure 6 to 7 mm because the plantar flap would be long enough to reach the skin dorsally, and the extrinsic tendon insertions lie proximal to this point. In addition, a 2- to 3-mm skin margin distal to the hyponychium would suffice. The goal is to remove the matrix, nail, and bone in one piece and reduce the chance of troublesome nail recurrence.

image Make the incision straight to bone proximally, but on the sides do not bevel the blade toward the center until plantar to the lateral flares of the phalanx.

image Using a clamp, firmly grasp the phalanx and, with skin hooks retracting the plantar flap, continue sharp dissection along the plantar surface of the phalanx in a distal-to-proximal direction.

image Transect the phalanx and release any soft tissue remaining to complete the amputation (Fig. 87-25C and D). This method of dissection is similar to removing the heel pad from the calcaneus in a Syme amputation, which is how it got the name terminal Syme procedure.

image Smooth any irregularity of the remaining phalanx with a rongeur.

image Maintain strict hemostasis, and close the wound with nonabsorbable sutures without trimming the “dog ears.”

The use of a tourniquet was not encouraged by Thompson and Terwilliger. A tourniquet allows more precise dissection, however. It reduces the chance of injury to proper plantar digital nerves at the proximal part of the dissection and aids in identifying small vessels that can be cauterized, reducing the chance of hematoma after surgery.

Other Lesions of the Nails

Subungual Exostosis

Strictly speaking, this entity is not a primary nail abnormality; however, it usually is presented as a painful and deformed nail, leaving the examiner perplexed as to the cause of the pain and deformity (Fig. 87-27). In an adolescent, it is a sessile osteochondroma of the distal phalanx of the toe that has eroded through the nail matrix and frequently the nail plate. Routine radiographs of the feet may not show the exostosis because the technique does not emphasize the distal phalanx. Radiographs taken at oblique angles and magnified are helpful. Surgical excision is the treatment of choice.

image

FIGURE 87-27 A, Subungual exostosis arising from metaphyseal area of distal phalanx. B, After complete excision of lesion and portion of overlying nail bed.

(From Walling AK: Soft tissue and bone tumors. In Coughlin MJ, Mann RA, Saltzman CL, editors: Surgery of the foot and ankle, ed 8, Philadelphia, 2007, Elsevier.)

Technique 87-11

(LOKIEC ET AL.)

Glomus Tumor

The glomus tumor is an enigmatic, painful tumor that is rarely seen and represents a proliferation of the normal capsular-neural glomus apparatus. Patients commonly present with a painful, exquisitely tender mass beneath the nail that is accompanied by a faint bluish hue. Except for the slight change in color of the nail overlying the tumor, the nail may appear normal (Fig. 87-31). The nail is normal, and the mass seen through the nail plate is abnormal.

image

FIGURE 87-31 A, T2-weighted MRI scan shows glomus tumor on lateral side of distal phalanx. B, Exposure of glomus tumor.

(From Walling AK: Soft tissue and bone tumors. In Coughlin MJ, Mann RA, Saltzman CL, editors: Surgery of the foot and ankle, 8th edition, Philadelphia, 2007, Elsevier.)

Removal of the portion of the nail plate over the area of tenderness and excision of the matrix that appears involved along with a margin of normal-appearing matrix is the treatment of choice. The nail that returns should have a normal appearance, but the patient must be warned that this is unpredictable. Magnification and high-intensity lighting facilitate excision of these periungual and subungual masses.

Horst and Nunley described a technique for removal of glomus tumors that uses a full-thickness vascular skin flap to expose the tumor while preserving the nail and nail matrix. They reported complete relief of pain, no wound healing problems, and no recurrences in seven patients in whom this technique was used.

References

Aksakal AB, Oztas P, Atahan C, Gurer MA. Decompression for the management of onychocryptosis. J Dermatol Treatment. 2004;15:108.

Aksoy B, Aksoy HM, Civas E, et al. Lateral foldplasty with or without partial matricectomy for the management of ingrown toenails. Dermatol Surg. 2009;35:462.

Aldrich SL, Hong CH, Groves L, et al. Acral lesions in tuberous sclerosis complex: insights into pathogenesis. J Am Acad Dermatol. 2010;3:244.

Altinyazar HC, Dermirel CB, Koca R, Hosnuter M. Digital block with and without epinephrine during chemical matricectomy with phenol. Dermatol Surg. 2010;36:1568.

Bos AM, van Tilburg MW, van Sorge AA, Klinkenbijl JH. Randomized clinical trial of surgical technique and local antibiotics for ingrowing toenail. Br J Surg. 2007;94:292.

Bostanci S, Ekmekci P, Gurgey E. Chemical matricetomy with phenol for the treatment of ingrowing toenail: a review of the literature and follow-up of 172 treated patients. Acta Derm Venereol. 2001;81:181.

Bristow IR, de Berker DAR, Acland KM, et al. Clinical guidelines for the recognition of melanoma of the foot and nail unit. J Foot Ankle Res. 2010;3:25.

Cohen T, Busam KJ, Patel A, Brady MS. Subungual melanoma: management considerations. Am J Surg. 2008;195:244.

Córdoba-Fernández A, Rayo-Rosado R, Juárez-Jiménez JM. The use of autologous platelet gel in toenail surgery: a within-patient clinical trial. J Foot Ankle Surg. 2010;49:385.

Córdoba-Fernández A, Ruiz-Garrido G, Canca-Cabrera A. Algorithm for the management of antibiotic prophylaxis in onychocryptosis surgery. Foot (Edinb). 2010;20:140.

El-Shaer WM. Lateral fold rotational flap technique for treatment of ingrown nail. Plast Reconstr Surg. 2007;20:2131.

Espensen EH, Nixon BP, Armstrong DG. Chemical matrixectomy for ingrown toenails: is there an evidence basis to guide therapy? J Am Podiatr Med Assoc. 2002;92:287.

Farrelly PJ, Minford J, Jones MO. Simple operative management of ingrown toenail using bipolar diathermy. Eur J Pediatr Surg. 2009;19:304.

Finch JJ, Warshaw EM. Toenail onychomycosis: current and future treatment options. Dermatol Ther. 2007;20:31.

Gerritsma-Blecker CLE, Klaase JM, Geelkerken RH, et al. Partial matrix excision or segmental phenolization for ingrowing toenails. Arch Surg. 2002;137:320.

Goldberg LH. Chemical matricectomy of nails. Dermatol Surg. 2010;36:1572.

Grassbaugh JA, Mosca VS. Congenital ingrown toenail of the hallux. J Pediatr Orthop. 2007;27:886.

Hassel JC, Hassel AJ, Löser C. Phenol chemical matricectomy is less painful, with shorter recovery times but higher recurrence rates, than surgical matricectomy: a patient’s view. Dermatol Surg. 2010;36:1294.

Heidelbaugh JJ, Lee H. Management of the ingrown toenail. Am Fam Physician. 2009;79:303.

Herold N, Houshian S, Riegels-Nielsen P. A prospective comparison of wedge matrix resection with nail matrix phenolization for the treatment of ingrown toenail. J Foot Ankle Surg. 2001;40:390.

Horst F, Nunley JA. Technique tip: glomus tumors in the foot: a new surgical technique for removal. Foot Ankle Int. 2003;24:949.

Imai A, Takayama K, Satoh T, et al. Ingrown nails and pachyonychia of the great toes impair lower limb functions: improvement of limb dysfunction by medical foot care. Int J Dermatol. 2011;50:215.

Islam S, Lin EM, Drongowski R, et al. The effect of phenol on ingrown toenail excision in children. J Pediatr Surg. 2005;40:290.

Kim JY, Park JS. Treatment of symptomatic incurved toenail with a new device. Foot Ankle Int. 2009;30:1083.

Kim SH, Ko HC, Oh CK, et al. Trichloroacetic acid matricectomy in the treatment of ingrowing toenails. Dermatol Surg. 2009;35:973.

Kose O, Celiktas M, Kisin B, et al. Is there a relationship between forefoot alignment and ingrown toenail? A case-control study. Foot Ankle Spec. 2011;4:14.

Kruijff S, van Det RJ, van der Meer GT, et al. Partial matrix excision or orthonyxia for ingrowing toenails. J Am Coll Surg. 2008;206:148.

Kuru I, Sualp T, Ferit D, et al. Factors affecting recurrence rate of ingrown toenail treated with marginal toenail ablation. Foot Ankle Int. 2004;25:410.

Lee SK, Jung MS, Lee YH, et al. Two distinctive subungual pathologies: subungual exostosis and subungual osteochondroma. Foot Ankle Int. 2007;28:595.

Li J, Chen J, Hong G, et al. Clinical study of treatment for recalcitrant ingrown toenail by partial distal phalanx removal. J Plast Reconstr Aesthet Surg. 2009;62:1327.

Lokiec F, Ezra E, Krasin E, et al. A simple and efficient surgical technique for subungual exostosis. J Pediatr Orthop. 2001;21:76.

Matsumoto K, Hashimoto I, Nakanishi H, et al. Resin splint as a new conservative treatment for ingrown toenails. J Med Invest. 2010;57:321.

Mayser P, Freund V, Budihardja D. Toenail onychomycosis in diabetic patients: issues and management. Am J Clin Dermatol. 2009;10:211.

Mitchell S, Jackson C, Wilson-Storey D. Surgical treatment of ingrown toenails in children: what is best practice? Ann R Coll Surg Eng. 2010. Nov 12 [Epub ahead of print]

Nandedkar-Thomas MA, Scher RK. An update on disorders of the nails. J Am Acad Dermatol. 2005;52:877.

Noël B. Surgical treatment of ingrown toenail without matricectomy. Dermatol Surg. 2008;34:79.

Ozawa T, Nose K, Harada T, et al. Partial matricectomy with a CO2 laser for ingrown toenail after nail matrix staining. Dermatol Surg. 2005;31:302.

Ozdil B, Eray JC. New method alternative to surgery for ingrown nail: angle correction technique. Dermatol Surg. 2009;35:990.

Persichetti P, Simone P, Vecchi GL, et al. Wedge excision of the nail fold in the treatment of ingrown toenail. Ann Plast Surg. 2004;52:617.

Peyvandi H, Robarti RM, Yegane RA, et al. Comparison of two surgical methods (Winograd and sleeve method) in the treatment of ingrown toenail. Dermatol Surg. 2011;37:331.

Rounding C, Bloomfield S. Surgical treatments for ingrowing toenails. Cochrane Database Syst Rev. 18, 2005. CD001541

Sarifakioglu E, Sarifakioglu N. Crescent excision of the nail fold with partial nail avulsion does work with ingrown toenails. Eur J Dermatol. 2010;20:822.

Shaath N, Shea J, Whiteman I, Zarugh A. A prospective randomized comparison of the Zadik procedure and chemical ablation in the treatment of ingrown toenails. Foot Ankle Int. 2005;26:401.

Suga H, Mukouda M. Subungual exostosis: a review of 16 cases focusing on postoperative deformity of the nail. Ann Plast Surg. 2005;55:272.

Tan KB, Moncrieff M, Thompson JF, et al. Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting. Am J Surg Pathol. 2007;31:1902.

Tomczak RL. Embryology of the nail unit. In: Myerson, MS, ed. Foot and ankle disorders. Philadelphia: Saunders, 2000.

Vaccari S, Dika E, Balestri R, et al. Partial excision of matrix and phenolic ablation for the treatment of ingrowing toenail: a 36-month follow-up of 197 treated patients. Dermatol Surg. 2010;36:1288.

Yabe T, Takahashi M. A minimally invasive surgical approach for ingrown toenails: partial germinal matrix excision using operative microscope. J Plast Reconstr Aesthet Surg. 2010;63:170.

Yang G, Yanchar NL, Lo AY, Jones SA. Treatment of ingrown toenails in the pediatric population. J Pediatr Surg. 2008;43:931.

Supplemental References

Andrew T. Nail bed ablation, excise or cauterize? A controlled study [abstract]. J Bone Joint Surg. 1981;63B:634.

Anger MT. Treatment of ingrown toenail. Gaz d’Hop. 1889;62:760.

Bartlett R. A conservative operation for the cure of so-called ingrown toenail. JAMA. 1937;108:1257.

Bose B. A technique for excision of nail fold for ingrowing toenail. Surg Gynecol Obstet. 1971;132:511.

Burzotta JL, Turri RM, Tsouris J. Phenol and alcohol chemical matrixectomy. Clin Podiatr Med Surg. 1989;6:453.

Byrne DS, Caldwell D. Phenol cauterization for ingrowing toenails: a review of five years’ experience. Br J Surg. 1989;76:598.

Ceilley RI, Collison DW. Matricectomy. J Dermatol Surg Oncol. 1992;18:728.

Claeys R. The analysis of ground reaction forces in pathological gait secondary to disorders of the foot. Int Orthop. 1983;7:113.

Clarke BG, Dillinger KA. Surgical treatment of ingrown toenail. Surgery. 1947;21:919.

Cotting BE. In-fleshed toe nail: a new operation for radical relief. Boston Med Surg J. 1873;88:5.

Dixon GL, Jr. Treatment of ingrown toenail. Foot Ankle. 1983;3:254.

Dowd CN. Report of twenty-nine cases of in-growing toenail. Can Med Assoc J. 1935;32:298.

DuVries HL. Hypertrophy of the unguilabia. Chir Record. 1933;16:13.

Fortin PT, Freiberg AA, Rees R, et al. Malignant melanoma of foot and ankle. J Bone Joint Surg. 1995;77A:1396.

Fowler AW. Excision of the germinal matrix: a unified treatment for embedded toe-nail and onychogryphosis. Br J Surg. 1958;45:382.

Greig JD, Anderson GH, Ireland AJ, et al. The surgical treatment of ingrowing toenails. J Bone Joint Surg. 1991;73B:131.

Hashimoto K. Ultrastructure of the human toenail: I. Proximal nail matrix. J Invest Dermatol. 1971;56:235.

Heifetz CJ. Operative management of ingrown toenail. J Missouri Med Assoc. 1945;42:213.

Hettinger DF, Valinsky MS, Nuccio G, et al. Nail matrixectomies using radio wave technique. J Am Podiatr Med Assoc. 1991;81:317.

Jansey F. Etiologic therapy of ingrowing toenail. Q Bull Northwestern Univ Med Sch. 1955;29:358.

Kenerson V. Operations for ingrowing toe-nail and hallux valgus. N Y Med J. 1905;82:682.

Keyes EL. The surgical treatment of ingrown toenails. JAMA. 1934;102:1458.

Kojima T, Nagano T, Uchida M. Periungual fibroma. J Hand Surg. 1987;12A:465.

Lapidus PW. Complete and permanent removal of toe nail in onychogryphosis and subungual osteoma. Am J Surg. 1933;19:92.

Lewis BL. Microscopic studies of fetal and mature nail and surrounding soft tissue. Arch Dermatol Syphilol. 1954;70:732.

Lloyd-Davies RW, Brill GC. The aetiology and out-patient management of ingrowing toe-nails. Br J Surg. 1963;50:592.

Mogensen P. Ingrowing toenail. Acta Orthop Scand. 1971;42:94.

Multhopp-Stephens H, Walling AK. Subungual exostosis: a simple technique of excision. Foot Ankle Int. 1995;16:88.

Murray WR. Onychocryptosis: principles of non-operative and operative care. Clin Orthop Relat Res. 1979;142:96.

Murtagh J. Patient education: ingrowing toenails. Aust Fam Physician. 1993;22:206.

Ney GC. An operation for ingrowing toe nails. JAMA. 1923;80:374.

O’Donoghue DH. Treatment of ingrown toe nail. Am J Surg. 1940;50:519.

Pearson HJ, Bury RN, Wapples J, et al. Ingrowing toenails: is there a nail abnormality? J Bone Joint Surg. 1987;69B:840.

Persichetti P, Simone P, Vecchi GL, et al. Wedge excision of the nail fold in the treatment of ingrown toenail. Ann Plast Surg. 2004;52:617.

Pettine KA, Cofield RH, Johnson KA, et al. Ingrown toenail: results of surgical treatment. Foot Ankle. 1988;9:130.

Quenu P. Des limites de la matrice de l’ongle incarné: applications au traitement de l’ongle incarné. Bull Mém Soc Chir. 1887;13:255.

Samman PD. The human toe nail: its genesis and blood supply. Br J Dermatol. 1959;71:296.

Scott P. Ingrown toenails. Med J Aust. 1968;1:48.

Siegle RJ, Stewart R. Recalcitrant ingrowing nails: surgical approaches. J Dermatol Surg Oncol. 1992;18:744.

South DA, Farber EM. Urea ointment in the nonsurgical avulsion of nail dystrophies: a reappraisal. Cutis. 1980;25:609.

Stilwell G. On the treatment of ingrowing toe-nail. BMJ. 1872.

Thompson TC, Terwilliger C. The terminal Syme operation for ingrowing toenail. Surg Clin North Am. 1951;31:575.

Townsend AC, Scott PR. Ingrowing toenail and onychogryposis. J Bone Joint Surg. 1966;48B:354.

Watson-Cheyne W, Burghard FF. A manual of surgical treatment. London: Longmans, Green; 1912.

Wilson TE. Treatment of ingrowing toenails. Med J Aust. 1944;2:33.

Winograd AM. A modification in the technique of operation for ingrown toe-nail. JAMA. 1929;92:229.

Wright G. Laser matricectomy in the toes. Foot Ankle. 1989;9:246.

Zadik FR. Obliteration of the nail bed of the great toe without shortening the terminal phalanx. J Bone Joint Surg. 1950;32B:66.

Zaias N. The nail in health and disease. New York: SP Medical & Scientific Books; 1980.

Zook EG, Van Beek AL, Russell RC, et al. Anatomy and physiology of the perionychium: a review of the literature and anatomic study. J Hand Surg. 1980;5:528.

Zuber TJ, Pfenninger JL. Management of ingrown toenails. Am Fam Physician. 1995;52:181.