Disorders of elastic tissue

Published on 11/03/2015 by admin

Filed under Pathology

Last modified 22/04/2025

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12 Disorders of Elastic Tissue

Elastic tissue basics 253

Solar elastotic syndromes 258

Solar elastosis 258

Nodular elastosis with cysts and comedones 258

Elastotic nodules of the ears 259

Collagenous and elastotic plaques of the hands 259

Erythema ab igne 260

Variable or minor elastic tissue changes 263

Leprechaunism 263

Scar tissue 263

Marfan’s syndrome 263

Elastosis perforans serpiginosa

Elastic tissue basics

• Responsible for elasticity and resilience of skin

• Verhoeff-van Gieson (black) or Pinkus acid orcein (dark brown) stains identify elastic fibers

• Major amino acids = desmosine and isodesmosine which crosslink between two tropoelastin polypeptides (need copper)

• Elastic fibers = 90% elastin (produced by fibroblasts/smooth muscle) and 10% fibrillin:

– three types of elastic fibers = oxytalan fibers (immature, not crosslinked, run perpendicular to basement membrane); elaunin fibers (more mature, crosslinked, run parallel to basement membrane like in “E”); and mature elastic fibers (majority crosslinked)

• Retinoic acid, TNF-α, and vitamin D can decrease elastin

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