21 Darker skin types
Summary and Key Features
• Botulinum toxin is a safe and effective procedure in darker skin types
• In general, efficacy and safety profiles are similar to lighter skin types
• With appropriate use, side effects are uncommon
• Injection techniques are similar to lighter skin types
• Commonly treated areas are glabellar and horizontal forehead lines
Safety and efficacy of botulinum toxins in darker skin types
The safety and efficacy of botulinum neurotoxin type A in the treatment of glabellar lines has been well studied in numerous populations (Table 21.1). Published data pertaining to the safety and efficacy of botulinum toxin in non-white patient populations are reviewed herein.
African-Americans
Grimes & Shabazz conducted a Phase IV study of onabot-A in the treatment of glabellar lines in 31 African-American women with Fitzpatrick skin types V and VI. The authors assessed the safety and efficacy at doses of 20 and 30 units (U) of onabot-A. No statistically significant differences in efficacy or safety were observed between the two doses (Figs 21.1, 21.2). A maximal response was observed on day 30, with 92.4% and 100% response rates (i.e. a score of ‘none’ or ‘mild’ on the facial wrinkle scale) in the 20 U and 30 U groups respectively. Adverse events were mild and transient and did not differ between the dosing groups. They included mild tingling, slight headaches, and dullness of the forehead.
Pearl 1
Appropriate magnification of injection sites is important to avoid vessels in darker skin types.
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