Cranial Nerves: Nystagmus

Published on 09/04/2015 by admin

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Last modified 22/04/2025

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Cranial Nerves

Nystagmus

BACKGROUND

Nystagmus is an oscillation of the eyes. This can be a symmetrical oscillation—pendular nystagmus—or faster in one direction—jerk nystagmus. In jerk nystagmus there is a slow drift in one direction with a fast correction in the opposite direction. It is conventional to describe the nystagmus in the direction of the fast phase. If the oscillation is a twisting movement, this is torsional or rotatory nystagmus.

Nystagmus can be:

WHAT TO DO

Ask the patient to follow your finger with both eyes. Move the finger in turn up, down and to each side. Hold the finger briefly in each position at a point where the finger can easily be seen by both eyes.

Watch for nystagmus. Note:

• whether it is symmetrical, moving at the same speed in both directions (pendular nystagmus), or if there is a fast phase in one direction with a slow phase in the other (jerk nystagmus)

• the direction of the fast phase—is it in the horizontal plane, in the vertical plane or rotatory?

• the position of the eye when nystagmus occurs and when it is most marked

• whether it occurs only towards the direction of gaze (first degree), in the primary position of gaze (second degree) and whether it occurs with the fast phase going away from the direction of gaze (third degree)

• whether it affects the abducting eye more than the adducting eye

• whether it occurs in one direction only

• whether it occurs in the direction of gaze in more than one direction (multidirectional gaze-evoked nystagmus).

To decide whether it is central or peripheral, note:

Special test: optokinetic nystagmus (OKN)

This can be tested when a striped drum is spun in front of the eyes; this normally evokes nystagmus in the opposite direction to the direction of spin. This is a useful test for patients with hysterical blindness.

Tests for benign positional vertigo are described in Chapter 12.

WHAT YOU FIND

See Figure 10.1.

image

Figure 10.1 Flow chart: nystagmus

Decide whether central or peripheral.

Peripheral nystagmus is not associated with other eye movement abnormalities and usually has a rotatory component.

WHAT IT MEANS

• Nystagmoid jerks: normal.

• Pendular nystagmus: inability to fixate—congenital; occurs with albinisim and blindness and may occur in miners.

• Rotatory (or rotary) nystagmus:

– Pure rotatory nystagmus = central; peripheral horizontal nystagmus usually has a rotatory component.

• Vertical nystagmus (rare): indicates brainstem disease.

– Upbeat: indicates upper brainstem. Common causes: demyelination, stroke, Wernicke’s encephalopathy.

– Downbeat: indicates medullary–cervical junction lesion. Common causes: Arnold–Chiari malformation, syringobulbia, demyelination.

• Horizontal nystagmus (common):

– Ataxic nystagmus: nystagmus of abducting eye > > adducting eye, associated with internuclear ophthalmoplegia (see Chapter 9). Common causes: multiple sclerosis, cerebrovascular disease.

– Multidirectional gaze-evoked nystagmus: nystagmus in the direction of gaze, occurring in more than one direction. Always central—cerebellar or vestibular. Cerebellar syndrome. Common causes: drugs, alcohol, multiple sclerosis. Rarer causes: cerebellar degeneration, cerebellar tumours.

– Central vestibular syndromes. Common causes: younger patients—multiple sclerosis; older patients—vascular disease.

– Unidirectional nystagmus: second- and third-degree horizontal nystagmus is usually central; if peripheral it must be acute and associated with severe vertigo. First-degree horizontal nystagmus may be central or peripheral:

peripheral:

– peripheral vestibular syndromes. Common causes: vestibular neuronitis, Ménière’s disease, vascular lesions

central:

– unilateral cerebellar syndrome. Common causes: as central vestibular syndromes. Rarer causes: tumour or abscess

– unilateral central vestibular syndrome. Common causes: as central vestibular syndromes.

• Unusual and rare eye movement abnormalities:

– Opsoclonus: rapid oscillations of the eyes in the horizontal rotatory or vertical direction—indicates brainstem disease, site uncertain, often a paraneoplastic syndrome

– Ocular bobbing: eyes drifting up and down in the vertical plane—associated with pontine lesions.