Complications and legal considerations of laser and light treatments

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11 Complications and legal considerations of laser and light treatments

General considerations

It is beyond the scope of this chapter to discuss the specifics in setting up a laser unit. However, there are a number of medical–legal issues that can arise if laser treatments are done in unaccredited facilities, by untrained staff, or without the proper safety equipment.

Accreditation is a voluntary process by which a facility is able to measure itself against nationally recognized standards. There are several organizations through which a facility can accredit itself. The American Osteopathic Association (AOA), the Joint Commission on Accreditation of Health Care Organizations (JCAHO) and the Accreditation Association for Ambulatory Health Care (AAAHC) all accredit organizations and facilities.

Displaying certificates of accreditation serves as a reassurance to patients, the public, and to other healthcare professionals that a facility has met an independent standard of quality.

The geographic location of where treatments are done will determine the regulations of who can utilize a laser or light device. Each regulatory board has different rules. In some jurisdictions, only a physician may legally operate a laser or light device. Other jurusdictions require a certain amount of training and certification. Some require that a physician has evaluated the patient before the procedure is performed. It is up to the individuals involved to find out the established rules of their jurisdiction.

Eye protection within the workplace is mandated depending on location. In the US, guidance for protective eyewear is outlined by the American National Standards Institute (ANSI) Z136 series. This is published and constructed by the Laser Institute of America (LIA). In Europe, eye protection guidelines are outlined in the EN 207. Further suggestions include warning signs on the door to warn anyone entering the operating room.

General complications

The most common complications of laser treatment are: burning, prolonged erythema, hypo- or hyperpigmentation, reactivation of herpes simplex virus, and acneiform eruption.

Burning can be a common complication of a variety of lasers. Burning can occur with the use of vascular, hair removal, and non-ablative rejuvenation lasers as well as intense pulsed light (IPL) devices. When a burn occurs, it is usually due to one of three possible causes: too high a fluence, too short a pulse duration, or insufficient epidermal cooling. Most lasers have initial recommended settings, which are fairly safe parameters with appropriate technique and adequate epidermal cooling. Depending on the severity of the burn, there is usually little that is required in terms of treatment. With only a slight burn, there may be prolonged erythema. With a more severe burn, however, blistering and scarring may develop. Occurrences of more severe hypertrophic scarring have been minimized with the advent of newer technology and the disuse of more scar-prone lasers such as the continuous wave argon laser.

Prolonged erythema can be defined in a number of ways. Erythema is an expected result with the use of most lasers. The duration of erythema is often only 24–72 hours. Prolonged erythema has been reported with all laser and light devices. In general, no treatment is required except reassurance. Non-ablative lasers generally have a shorter duration of erythema, whereas ablative resurfacing lasers have a higher rate of persistent erythema, which can last from weeks to several months.

Hyperpigmentation (Fig. 11.1) is a very common complication and possibly the most common in darker skin types (see the study by Sriprachya-anunt and colleagues). It has been described with the use of almost every laser and light device in darker skin types. In one study by Moreno-Arias and co-workers, it was observed in 16% of patients undergoing IPL treatment. Goh reported that it can be as high as 45% in patients with skin types IV–VI. Wareham et al reported that the pulse dye laser can cause hyperpigmentation, especially on the lower legs and where there is inadequate post-treatment sun protection and sun avoidance. Hyperpigmentation was also seen by Chowdhury and colleagues with the KTP laser. With the ablative CO2 laser, post-inflammatory hyperpigmentation (PIH) is common and was reported by Badawi et al to occur in 20–30% of Fitzpatrick III and 100% of Fitzpatrick IV patients. Mahmoud et al found the Er : YAG laser to have a PIH rate of 50% in patients with skin type IV–V (Fig. 11.2). Even non-ablative fractional lasers can cause problems with PIH; in a 2010 study by Chan et al there was an 18.2% rate in 47 patients treated. Although rarer, PIH has also been reported (e.g. by Choudhary et al and Kuperman-Beade et al) to occur with the use of Q-switched lasers. In darker skin types, it can be fairly common; it was reported by Lapidoth & Aharonowitz to occur in up to 44% of darker-skinned patients. As noted above, vascular lasers were also found by Clark et al to result in PIH, albeit more rarely.

Hypopigmentation is a less common complication and is most commonly seen with the use of Q-switched lasers for tattoo removal as well as vascular lasers for port-wine stains. Hypopigmentation from Q-switched lasers may be transient, but it can also be permanent. Depigmentation was also reported (by Fitzpatrick & Goldman) to occur with Q-switched lasers. In the treatment of port-wine stains, the pulse dye laser has incidence rates of 2–31% of hypopigmentation. Longer pulse durations with the pulse dye laser seem to lessen the possibility of this complication. The ablative lasers have all been found to cause hypopigmentation (e.g. studies by Trelles and by Ward & Baker). Permanent hypopigmentation has also been described with the use of the CO2 laser and, in a recent 10-year follow-up study by Prado and colleagues, 8.7% of patients had problems with permanent hypopigmentation.

Reactivation of herpes simplex virus (HSV) is a possible complication for which prophylactic antivirals are often given, especially with resurfacing lasers. However, in a recent retrospective study by Trelles of patients not given antiviral prophylaxis, less than 1% of 600 patients developed reactivation of HSV with the use of a resurfacing laser. In another retrospective study by Campbell & Goldman, only 1.1% of 373 patients developed herpes reactivation with fractionated CO2 laser resurfacing. Despite a low incidence rate, the potential for scarring with disseminated HSV infection can make this a serious complication.

Acneiform eruptions can occur with any laser and light device and may be due to either procedure or after care. Reported rates depend on the treatment, but in the three studies by Campbell & Goldman, Nanni & Alster, and Neaman et al they ranged from 3 to 15% of patients with resurfacing lasers. This is a relatively benign complication with self-resolution expected.

Scarring has been reported with almost every cutaneous laser and light source (Figs 11.311.6). The actual incidence is fairly small, yet overaggressive treatment with any laser or light device can cause it. Hypertrophic scarring is most common with the older continuous wave lasers, most of which are no longer commonly used in office practice.

Specific laser complications

The complications covered above are common to almost all laser and light devices. However, there are some specific complications or considerations of various subsets of lasers.

Q-switched lasers

In the study by Kuperman-Beade and co-workers, the most common adverse effects of the Q-switched lasers included hypo- and hyperpigmentation, textural change, and scarring after treatment (see Fig. 11.1). Melanin is the main competing chromophore and transient hypopigmentation as well as permanent depigmentation with the Q-switched ruby laser can be seen (see the study above and those by Bernstein and Choudhary et al). Grevelink et al found that the Q-switched Nd : YAG laser with its longer wavelength has less chance of hypopigmentation than the Q-switched ruby laser. In darker-skinned individuals, if a Q-switched laser other than the Nd : YAG laser is used then decreasing the fluence may help prevent hypopigmentation, according to Kuperman-Beade et al.

Hyperpigmentation is less common with the Q-switched lasers than hypopigmentation; however, Choudhary et al found that bleaching agents may help prevent this in the treatment of darker-skinned individuals, and that the use of longer wavelength lasers may also minimize hyperpigmentation. Textural change is rarer and can be seen with an incidence of up to 12% with the alexandrite laser, as reported in the study by Fitzpatrick & Goldman.

A rarer but reported side effect is an allergic reaction post-treatment. In studies by Kuperman-Beade et al, England et al, and Ashinoff et al, this was mostly seen with red cinnabar pigment and can present as a nodular scaly pruritic eruption or as an immediate urticarial eruption. Ashinoff et al reported that this may be secondary to extracellular dispersal of tattoo pigment.

Paradoxical tattoo pigment darkening is a well-recognized possible complication when treating red, pink, skin tone, and white dyes. Kuperman-Beade et al found that it can rarely also happen with blue, green, and yellow dyes. The reduction of ferric and titanium dioxide are thought to be the causative factor in this darkening. This darkening is often resistant to further treatment by Q-switched lasers. Further, Arndt et al found that Q-switched laser treatment in a patient with any history of gold salt ingestion will produce a permanent dark blue dyspigmentation know as chrysiasis. Chrysiasis can be challenging to treat. Addtionally, transient immune reactions were seen by Izikson et al with laser treatment.

A rare but very serious complication is compartment syndrome. This was reported by Kuperman-Beade et al and by Rheingold et al in the circumferential treatment of the forearm with a Q-switched Nd : YAG laser.

Ablative lasers

The ablative lasers have come a long way in terms of safety. From continuous wave to pattern scanner to fractionated technology, technology has continuously been updated to improve safety while retaining efficacy. Continuous wave CO2 lasers had a high incidence of scarring and hypertrophic scarring along with pigmentary disturbances.

For the most part, fractionated technology is being used in combination with ablative lasers to improve safety. However, even with fractionation, hypertrophic scarring of the neck has been reported (e.g. by Avram et al with fractionated CO2 laser resurfacing).

Long-term hypopigmentation in the use of CO2 laser resurfacing was reported by Ward & Baker. It seems to be more common in fair-skinned individuals There is some evidence (by Grimes et al) that hypopigmentation is a result of suppressed melanogenesis rather than true destruction of melanocytes, and treatment with the excimer laser was shown by Raulin to repigment hypopigmented areas. Transient ectropion has additionally been reported by Neaman et al to occur very rarely as a potential complication. Milia also occurred in Nanni & Alster’s study in up to 10% of patients after resurfacing; this can easily be treated with standard extraction.

Infections are fairly uncommon, but can be bacterial, viral and/or fungal, as found in the study by Alam et al. Dissemination of the wart virus with transient eruption and subsequent self-resolution has been described by Torezan and colleagues. Abscess formation with Mycobacterium fortuitum 1 month after CO2 laser resurfacing was also reported by Rao and co-workers.

IPL-specific complications

IPL treatment is very well tolerated in general, but it has a higher learning curve with an increased number of variables. These variables include filters, pulse duration, fluence, the ability to double or triple pulse, and a variety of indications. Crusting and blistering occur in approximately 2–16% of patients; further, persistent local heat sensation lasting longer than 24 hours occur in 2% of patients. A rare complication of IPL treatment seen by Vlachos & Kontoes was the development of terminal hairs within a treated port-wine stain. Scarring has been only rarely reported (see the studies by Ho et al and Raulin et al and Fig. 11.6). Treatment of tanned patients can produce obvious hypopigmentation. Paradoxical hair growth has been reported (by Babilas et al, and Moreno-Arias et al), along with transient hypopigmentation and post-inflammatory hyperpigmentation especially in patients with darker skin and Mediterranean or middle-eastern background. Leukotrichia was also found to develop, along with temporary color change from black to yellow color, in studies by Radmanesh et al.

Legal aspects

Regardless of training, quality of equipment, and rigidity in patient selection, it is almost inevitable that, over a lifetime, certain complications will occur in the hands of any healthcare practitioner. In most cases, these will not result in legal action. However, if legal action is taken, then the most common interaction between a healthcare operator and healthcare law is in the realm of negligence.

Four elements must be present for there to be cause of action in negligence: duty, breach of duty, causation, and damages. A suing plaintiff must show the presence of all four elements to be successful in his or her claim.

The duty of a physician performing energy-based laser or light treatments is to perform that procedure in accordance with the ‘standard of care’. Although the elements of a cause of action in negligence are derived from formal legal textbooks, the standard of care is not necessarily derived from a textbook. It is also not articulated by any judge. The standard of care is defined by some as whatever an expert witness says it is and what a jury will believe. In a case against a physician performing laser / light source treatments, the specialist must have the knowledge and skill ordinarily possessed by a specialist in that field, and have used the care and skill ordinarily possessed by a specialist in that field in the same or similar locality under similar circumstances. A dermatologist, physician extender, or for that matter an internist performing these procedures will all be held to an equal standard. A failure to fulfill such a duty may lead to loss of a lawsuit by that individual. If the jury accepts the suggestion that the provider mismanaged the case and that the negligence led to damage of the patient, then liability will ensue. Conversely, if the jury believes an expert who testifies for a defendent doctor, then the standard of care in that particular case has been met. In this view, the standard of care is a pragmatic concept, decided case by case and based on the testimony of an expert physician. The sued physician is expected to perform the procedure in a manner of a reasonable physician. He or she need not be the best in his / her field, but need only perform the procedure in a manner that is considered by an objective standard as reasonable.

It is important to note that where there are two or more recognized laser methods of treating the same condition, a physician does not fall below the standard of care by using any of the acceptable methods even if one method turns out to be less effective than another method. Finally, in many jurisdictions, an unfavorable result due to an ‘error in judgment’ by a physician is not in and of itself a violation of the standard of care if the physician acted appropriately prior to exercising his / her professional judgment.

Evidence of the standard of care in a specific malpractice case includes laws, regulations, and guidelines for practice, which represent a consensus among professionals on a topic involving diagnosis or treatment, and the medical literature including peer-reviewed articles and authoritative texts. In addition, the view of an expert is crucial. Although the standard of care may vary from state to state, it is typically defined as a national standard by the profession at large.

Most commonly, for litigation purposes, expert witnesses articulate the standard of care. The basis of the expert witness and the origin of the standard of care, is grounded in the following:

The standard of care is the way in which the majority of the physicians in a similar medical community would practice. It is the method by which other laser physicians deal with their daily performance of cosmetic dermatology. If, in fact, the expert does not practice like the majority of other physicians, then the expert will have a difficult time explaining why the majority of the medical community does not practice according to his / her ways.

Complications following laser- and light-based treatments can occur. They are not necessarily acts of negligence. If the treating provider acts in accordance with the standard of care, it is unlikely that the physician will lose a lawsuit based on negligence.

Further reading

Accreditation Association for Ambulatory Health Care. Accreditation handbook for ambulatory healthcare. Wilmette, IL: Accreditation Association for Ambulatory Health Care; 2000.

Adamic M, Troilius A, Adatto M, et al. Vascular lasers and IPLS: guidelines for care from the European Society for Laser Dermatology (ESLD). Journal of Cosmetic and Laser Therapy. 2007;9(2):113–124.

Alam M, et al. A prospective trial of fungal colonization after laser resurfacing of the face: correlation between culture positivity and symptoms of pruritus. Dermatologic Surgery. 2003;29(3):255–260.

Alster TS, Lupton JR. Prevention and treatment of side effects and complications of cutaneous laser resurfacing. Plastic and Reconstructive Surgery. 2002;109(1):308–316. discussion 317-318

Anvari B, et al. A comparative study of human skin thermal response to sapphire contact and cryogen spray cooling. IEEE Transactions Biomedical Engineering. 1998;45(7):934–941.

Ashinoff R, Levine VJ, Soter NA. Allergic reactions to tattoo pigment after laser treatment. Dermatologic Surgery. 1995;21(4):291–294.

Avram MM, et al. Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing. Lasers in Surgery and Medicine. 2009;41(3):185–188.

Babilas P, et al. Intense pulsed light (IPL): a review. Lasers in Surgery and Medicine. 2010;42(2):93–104.

Badawi A, et al. Retrospective analysis of non-ablative scar treatment in dark skin types using the sub-millisecond Nd : YAG 1,064 nm laser. Lasers in Surgery and Medicine. 2011;43(2):130–136.

Bernstein EF. Laser treatment of tattoos. Clinical Dermatology. 2006;24(1):43–55.

Bernstein LJ, et al. The short- and long-term side effects of carbon dioxide laser resurfacing. Dermatologic Surgery. 1997;23(7):519–525.

Bolognia JL, Jorizzo JL, Rapini RP, 2nd edn. Dermatology, Mosby Elsevier, Philadelphia, 2008;vol 2

Breadon JY, Barnes CA. Comparison of adverse events of laser and light-assisted hair removal systems in skin types IV-VI. Journal of Drugs in Dermatology. 2007;6(1):40–46.

Campbell TM, Goldman MP. Adverse events of fractionated carbon dioxide laser: review of 373 treatments. Dermatologic Surgery. 2010;36(11):1645–1650.

Casey AS, Goldberg D. Guidelines for laser hair removal. Journal of Cosmetic and Laser Therapy. 2008;10(1):24–33.

Chan HH, et al. Clinical application of lasers in Asians. Dermatologic Surgery. 2002;28(7):556–563.

Chan NP, et al. The use of non-ablative fractional resurfacing in Asian acne scar patients. Lasers in Surgery and Medicine. 2010;42(10):710–715.

Choudhary S, et al. Lasers for tattoo removal: a review. Lasers in Medical Science. 2010;25(5):619–627.

Chowdhury MM, Harris S, Lanigan SW. Potassium titanyl phosphate laser treatment of resistant port-wine stains. British Journal of Dermatology. 2001;144(4):814–817.

Clark C, et al. Treatment of superficial cutaneous vascular lesions: experience with the KTP 532 nm laser. Lasers in Medical Science. 2004;19(1):1–5.

Drosner M, Adatto M. Photo-epilation: guidelines for care from the European Society for Laser Dermatology (ESLD). Journal of Cosmetic and Laser Therapy. 2005;7(1):33–38.

England RW, Vogel P, Hagan L. Immediate cutaneous hypersensitivity after treatment of tattoo with Nd : YAG laser: a case report and review of the literature. Annals of Allergy, Asthma and Immunology. 2002;89(2):215–217.

Fitzpatrick RE, Goldman MP. Tattoo removal using the alexandrite laser. Archives of Dermatology. 1994;130(12):1508–1514.

Fitzpatrick RE, Lupton JR. Successful treatment of treatment-resistant laser-induced pigment darkening of a cosmetic tattoo. Lasers in Surgery and Medicine. 2000;27(4):358–361.

Furrow BF, Greaney TL, Johnson SH, Jost TS, et al. Liability in health care law, 3rd edn. St Paul, MN: West Publishing; 1997.

Goh CL. Comparative study on a single treatment response to long pulse Nd : YAG lasers and intense pulse light therapy for hair removal on skin type IV to VI – is longer wavelengths lasers preferred over shorter wavelengths lights for assisted hair removal. Journal of Dermatologic Treatment. 2003;14(4):243–247.

Goldberg DJ. Laser dermatology: pearls and problems. Oxford: Blackwell; 2007. p ix, 188

Graber EM, Tanzi EL, Alster TS. Side effects and complications of fractional laser photothermolysis: experience with 961 treatments. Dermatologic Surgery. 2008;34(3):301–305. discussion 305-307

Grevelink JM, et al. Laser treatment of tattoos in darkly pigmented patients: efficacy and side effects. Journal of the American Academy of Dermatology. 1996;34(4):653–656.

Grimes PE, et al. Laser resurfacing-induced hypopigmentation: histologic alterations and repigmentation with topical photochemotherapy. Dermatologic Surgery. 2001;27(6):515–520.

Gundogan C, et al. [Repigmentation of persistent laser-induced hypopigmentation after tattoo ablation with the excimer laser]. Hautarzt. 2004;55(6):549–552.

Hardaway CA, Ross EV, Paithankar DY. Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase II. Journal of Cosmetic and Laser Therapy. 2002;4(1):9–14.

WS Ho, et al. Treatment of port wine stains with intense pulsed light: a prospective study. Dermatologic Surgery. 2004;30(6):887–890. discussion 890-891

WS Ho, et al. Use of onion extract, heparin, allantoin gel in prevention of scarring in Chinese patients having laser removal of tattoos: a prospective randomized controlled trial. Dermatologic Surgery. 2006;32(7):891–896.

Hunzeker CM, Weiss ET, Geronemus RG. Fractionated CO2 laser resurfacing: our experience with more than 2000 treatments. Aesthetic Surgery Journal. 2009;29(4):317–322.

Iyer S, Fitzpatrick RE. Long-pulsed dye laser treatment for facial telangiectasias and erythema: evaluation of a single purpuric pass versus multiple subpurpuric passes. Dermatologic Surgery. 2005;31(8 pt 1):898–903.

Izikson L, Avram M, Anderson RR. Transient immunoreactivity after laser tattoo removal: Report of two cases. Lasers in Surgery and Medicine. 2008;40(4):231–232.

Joint Commission International. Joint Commission International accreditation standards for ambulatory care, 2005. Oakbrook Terrace, IL: Joint Commission International; 2005. p v

Kauvar ANB, Hruza GJ. Principles and practices in cutaneous laser surgery. Boca Raton: Taylor & Francis; 2005. p 815

Kelly KM, et al. Cryogen spray cooling in combination with nonablative laser treatment of facial rhytides. Archives of Dermatology. 1999;135(6):691–694.

Khan R. Lasers in plastic surgery. Journal of Tissue Viability. 2001;11(3):103–107. 110-112

Kono T, et al. Comparison study of a traditional pulsed dye laser versus a long-pulsed dye laser in the treatment of early childhood hemangiomas. Lasers in Surgery and Medicine. 2006;38(2):112–115.

Kuperman-Beade M, Levine VJ, Ashinoff R. Laser removal of tattoos. American Journal of Clinical Dermatology. 2001;2(1):21–25.

Lapidoth M, Aharonowitz G. Tattoo removal among Ethiopian Jews in Israel: tradition faces technology. Journal of the American Academy of Dermatology. 2004;51(6):906–909.

Laubach HJ, et al. Skin responses to fractional photothermolysis. Lasers in Surgery and Medicine. 2006;38(2):142–149.

Levine VJ, Geronemus RG. Adverse effects associated with the 577- and 585-nanometer pulsed dye laser in the treatment of cutaneous vascular lesions: a study of 500 patients. Journal of the American Academy of Dermatology. 1995;32(4):613–617.

Mahmoud BH, et al. Safety and efficacy of erbium-doped yttrium aluminum garnet fractionated laser for treatment of acne scars in type IV to VI skin. Dermatologic Surgery. 2010;36(5):602–609.

Manuskiatti W, Fitzpatrick RE, Goldman MP. Long-term effectiveness and side effects of carbon dioxide laser resurfacing for photoaged facial skin. Journal of the American Academy of Dermatology. 1999;40(3):401–411.

Moreno-Arias GA, Castelo-Branco C, Ferrando J. Side-effects after IPL photodepilation. Dermatologic Surgery. 2002;28(12):1131–1134.

Nanni CA, Alster TS. Complications of carbon dioxide laser resurfacing. An evaluation of 500 patients. Dermatologic Surgery. 1998;24(3):315–320.

Neaman KC, et al. Outcomes of fractional CO2 laser application in aesthetic surgery: a retrospective review. Aesthetic Surgery Journal. 2010;30(6):845–852.

Nelson AA, Lask GP. Principles and practice of cutaneous laser and light therapy. Clinical Plastic Surgery. 2011;38(3):427–436.

Nelson JS, et al. Dynamic epidermal cooling during pulsed laser treatment of port-wine stain. A new methodology with preliminary clinical evaluation. Archives of Dermatology. 1995;131(6):695–700.

Nelson JS, et al. Dynamic epidermal cooling in conjunction with laser-induced photothermolysis of port wine stain blood vessels. Lasers in Surgery and Medicine. 1996;19(2):224–229.

Olbricht SM, et al. Complications of cutaneous laser surgery. A survey. Archives of Dermatology. 1987;123(3):345–349.

Prado A, et al. Full-face carbon dioxide laser resurfacing: a 10-year follow-up descriptive study. Plastic and Reconstructive Surgery. 2008;121(3):983–993.

Rao J, Golden TA, Fitzpatrick RE. Atypical mycobacterial infection following blepharoplasty and full-face skin resurfacing with CO2 laser. Dermatologic Surgery. 2002;28(8):768–771. discussion 771

Radmanesh M, et al. Leukotrichia developed following application of intense pulsed light for hair removal. Dermatologic Surgery. 2002;28(7):572–574. discussion 574

Radmanesh M, et al. Burning, paradoxical hypertrichosis, leukotrichia and folliculitis are four major complications of intense pulsed light hair removal therapy. Journal of Dermatologic Treatment. 2008;19(6):360–363.

Radmanesh M. Paradoxical hypertrichosis and terminal hair change after intense pulsed light hair removal therapy. Journal of Dermatologic Treatment. 2009;20(1):52–54.

Raulin C, et al. Treatment of port-wine stains with a noncoherent pulsed light source: a retrospective study. Archives of Dermatology. 1999;135(6):679–683.

Raulin C, et al. [Excimer laser. Treatment of iatrogenic hypopigmentation following skin resurfacing]. Hautarzt. 2004;55(8):746–748.

Rheingold LM, Fater MC, Courtiss EH. Compartment syndrome of the upper extremity following cutaneous laser surgery. Plastic and Reconstructive Surgery. 1997;99(5):1418–1420.

Sriprachya-anunt S, et al. Facial resurfacing in patients with Fitzpatrick skin type IV. Lasers in Surgery and Medicine. 2002;30(2):86–92.

Tanzi EL, Williams CM, Alster TS. Treatment of facial rhytides with a nonablative 1,450-nm diode laser: a controlled clinical and histologic study. Dermatologic Surgery. 2003;29(2):124–128.

Torezan LA, Osorio N, Neto CF. Development of multiple warts after skin resurfacing with CO2 laser. Dermatologic Surgery. 2000;26(1):70–72.

Trelles MA. Laser resurfacing today and the ‘cook book’ approach: a recipe for disaster? Journal of Cosmetic Dermatology. 2004;3(4):237–241.

Vlachos SP, Kontoes PP. Development of terminal hair following skin lesion treatments with an intense pulsed light source. Aesthetic Plastic Surgery. 2002;26(4):303–307.

Ward PD, Baker SR. Long-term results of carbon dioxide laser resurfacing of the face. Archives of Facial Plastic Surgery. 2008;10(4):238–243. discussion 244-245

Wareham WJ, et al. Adverse effects reported in pulsed dye laser treatment for port wine stains. Lasers in Medical Science. 2009;24(2):241–246.