chapter 55 Child health and development
INTRODUCTION AND OVERVIEW
Infancy and childhood are characterised by a range of issues that broadly fall into three categories (Box 55.1):
SCREENING
Developmental assessments should include hearing, vision (including strabismus), language acquisition, fine motor skills, social skills and family dynamics. Enquiries need to be made about physical activity, nutrition, time spent watching television, accident prevention and sun protection.1 Given their high incidence, screen for iron deficiency and vitamin D deficiency in at-risk groups.
Children have tended to be the objects of healthcare; their opinions have frequently been ‘downgraded’ by healthcare professionals. Yet children also ‘acquire health-related knowledge through informal learning at home … they use their knowledge to promote their own well-being, in the context of and in interaction with social and physical features of their environment’.2 Children actively participate in the maintenance of healthy lifestyles (their own and others’). A child-to-child approach to health education (albeit with reference to older children) is in operation worldwide, and acknowledges children as active participants in health promotion and maintenance of healthy lifestyles.3
GROWTH MONITORING
ATOPY
The prevalence of asthma and eczema among children (Fig 55.1) is increasing around the world.4 The notion of an ‘atopic march’ from eczema through to rhinitis has been coined,5 implying that early intervention may reduce the prevalence of disease in later life.
In our striving for cleanliness there is increasing evidence that skin sensitisation to known environmental allergens provokes immune responses that lead to eczema and, later, asthma. Immune provocation in susceptible individuals appears to trigger a cascade of events aggravated by early antibiotic exposure that may lead to medium- and long-term atopy.6
ECZEMA
Forty-six per cent of children with eczema have used complementary medicines by the time of presentation to a dermatologist,7 usually driven by their parents’ sense that standard advice has failed. Adverse effects of eczema include symptoms of itching and soreness, which cause sleeplessness. Sleep deprivation leads to tiredness, mood changes and impaired psychosocial functioning of the child and family, particularly at school and work. At the more severe end of the spectrum, embarrassment, comments, teasing and bullying may cause social isolation and may lead to depression or school avoidance. The child’s lifestyle is often limited, particularly with respect to clothing, holidays, staying with friends, owning pets, dietary exclusions, swimming or the ability to play or do sports. Restriction of normal family life, difficulties with complicated treatment regimens and increased work in caring for a child with eczema lead to parental exhaustion and feelings of hopelessness, guilt, anger and depression.8
ASSESSMENT
TREATMENT
Diet
Chinese herbal medicine
Individualised concoctions of Chinese herbal teas have been shown to be efficacious in a small number of randomised controlled trials from one centre.9 In general there were about 10 plant extracts in each preparation and few side effects were noted. In other trials there was no clear benefit. However, there have been reports of hepatic and nephro-toxicity, and hypersensitivity reactions.
Essential fatty acids
Patients with atopic dermatitis are thought to have a reduced rate of conversion from linoleic acid to gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid, or arachidonic acid, compared with healthy subjects. Replacement of GLA, in the form of primrose oil or borage oil, may therefore benefit some patients. There are many randomised controlled studies assessing the effects of GLA, with most studies indicating an improved epidermal barrier on GLA application and others showing no effect, depending on the vehicle used for application.10,11 Note that, in the latter study, evening primrose oil proved to have a stabilising effect on the stratum corneum barrier, but this was apparent only with the water-in-oil emulsion, not the amphiphilic emulsion for topical use. Oral evening primrose oil capsules do not, however, have a useful effect.
PREVENTION AND EDUCATION
Supplementation with the probiotic Lactobacillus rhamnosus has been found to substantially reduce the cumulative prevalence of eczema, but not atopy, by 2 years in susceptible individuals with a family history of eczema when given to the mother during pregnancy and for 6 months after birth.18 Other probiotics are less effective and the choice of Lactobacillus in this context seems to be important.18
Recent recommendations delay introduction of dairy products, eggs, nuts, fish and shellfish up to 36 months19,20 in high-risk situations but not for infants with no family history. However, there is a contrary view that suggests that early antigen exposure in small amounts, in an immune tolerance exercise, might prevent disease later.21
ALLERGIC RHINITIS
There is often a history of allergy in the child (infantile eczema) or the family.
TREATMENT
ASTHMA
(See also Ch 41, Respiratory medicine.)
Between 100 and 150 million people around the globe suffer from asthma, and this number is rising. Worldwide, deaths from this condition have reached over 180,000 annually.22
DIAGNOSIS
Children aged over 6 years can have spirometry testing.
Allergy testing should be organised.
All children diagnosed with asthma will need an asthma management plan carefully developed with the child and their parents or carers, and conveyed to all carers and schools. The asthma action plan (Fig 55.2) chosen should be appropriate for the person’s age, educational status, language and culture.
PROPHYLAXIS
SUPPLEMENTATION
Dietary supplementation with omega-3 fatty acids, zinc and vitamin C has been shown to significantly improve asthma control, pulmonary function tests and pulmonary inflammatory markers in children with moderately persistent bronchial asthma, either singly or in combination.24 Similarly, adequate intake of vitamin D and sun exposure are important in reducing the risk of asthma.
MANAGING ACUTE ASTHMA ATTACKS IN A CHILD
Beta2 agonist inhalers (salbutamol) and a spacer device should be available to the child at all times. Assessment and initial management of a child with acute asthma are summarised in Tables 55.1 and 55.2.
ANAPHYLAXIS IN CHILDREN
Anaphylaxis may occur as an acute allergic response to food allergens, medication, envenomation, vaccines, food additives and others.27 In some cases the causative agent is not identified.
Treatment
Whether in or out of hospital, help is called immediately and treatment initiated while awaiting advanced equipment and expertise. As soon as the clinical signs support the diagnosis of anaphylaxis, intramuscular adrenaline should be administered immediately while awaiting advanced equipment and expertise before an ambulance arrives.28
Bronchospasm should be treated as per the emergency management of severe asthma.
IRON DEFICIENCY
It is recognised that iron deficiency is associated with a range of developmental and behavioural problems in infancy and childhood that are reversible with iron supplementation and correction of the iron deficiency. Intellectual deficits arising from iron deficiency in infancy do persist into later years, if treatment is delayed. A high degree of suspicion is useful in infancy, as anaemia is a late manifestation of iron deficiency. Risk factors include prolonged breastfeeding without supplementation, more than six breastfeeds per day after 6 months, high cow’s milk intake after 12 months and poor solid intake because of high milk intake. Primary prevention of iron deficiency in infants and toddlers can be addressed by a range of measures (Box 55.2), and screening after 12 months is reasonable, particularly in high-risk groups. While prolonged breast feeding is beneficial, without an appropriate solid intake after 6–12 months iron deficiency is much more likely, and so care is required in advising about nutritional supplementation. Some infants become more iron deficient than others, probably because of feeding practices after birth but also because of the degree of intrauterine iron accumulation in the last trimester before birth. Preterm birth and intrauterine growth restriction interrupt normal iron stores and therefore are likely to lead to frank deficiency later if not addressed earlier.