Carotid artery stenting

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Chapter 26 Carotid artery stenting

INTRODUCTION

Stroke is the third leading cause of death in the developed world.1 Internal carotid artery (ICA) stenosis is a major cause of ischaemic stroke, with the risk being related to the degree of stenosis and the presence of recent symptoms.2,3 Carotid endarterectomy (CEA) has become the preferred method of treatment for patients with asymptomatic or symptomatic high grade ICA stenosis, supplanting medical therapy alone. The time has now come to regard carotid artery stenting (CAS) as a realistic alternative to CEA. This statement is based on the availability of safe techniques, on trial evidence and the presence of a cohort of over 12 000 patients that have been treated successfully worldwide.4

HISTORY

Atherosclerosis of the carotid bifurcation was suggested as a risk factor for stroke over 50 years ago.5 Surgery of this area was developed at a similar time by Eastcott in the UK, and Debakey in the US.6,7 Following this, CEA became a popular procedure amongst vascular surgeons. In the USA alone, more than 100 000 CEA procedures were performed in 1985, well before the publication of randomised controlled trial data.8 In the ensuing confusion about indications and outcomes, a number of trials began to clarify the correct role for CEA in both symptomatic and asymptomatic patients.9,1012 CEA remains the most common vascular operation in the US.

The report of first carotid angioplasty was published in 1983, with stenting becoming popular in the early 1990s.13,14 By 1994, Roubin et al. were performing CAS on a routine basis in the USA.15 Distal protection devices (DPD) were developed in a primitive form in 1987.16 It has really been the development of more usable DPD that has lead to the rapid growth of CAS in recent years.4

PATIENT SELECTION

Three major patient groups need to be considered for carotid intervention:

Symptomatic

Three trials have addressed the issue of the treatment of symptomatic ICA stenosis. The VA trial was terminated early due to publication of the results of the other two.17 (Table 26.1).

The North American Symptomatic Carotid Endarterectomy Trial (NASCET) randomised 2885 patients with 30–99% ICA stenoses at angiography and recent stroke (CVA) or transient ischaemic attack (TIA) to medical therapy or CEA. In patients with 70–99% stenosis, operation reduced two-year ipsilateral CVA risk from 26% to 9% (relative risk reduction 65%) and combined major CVA and death rates from 13.1% to 2.5% (relative risk reduction 81%).9 In those with 50–69% stenosis, five-year ipsilateral CVA risk was reduced from 22.2% to 15.7% (relative risk reduction 29%).18 There was no benefit in patients with stenosis <50%, although this group still had an event rate of 15–19% at two years, suggesting medical therapy also needed to be improved.

The European Carotid Surgery Trial (ECST) randomised 3024 patients with symptomatic ICA stenosis in a similar manner, using duplex ultrasound criteria of >60% stenosis.10,19 In patients with 70–99% stenosis, at three years, risk of ipsilateral CVA was reduced from 16.8% to 10.3% (relative risk reduction 39%). Risk of major stroke or death was reduced from 11% to 6% (relative risk reduction 45%). There was no benefit in patients with <70% duplex stenosis.

A meta-anaylsis of these and the VA trial suggested most benefit in men, those >75, and those treated within two weeks.20 So, for symptomatic patients, a duplex stenosis of >70–75% (angiographic >50%) should be treated to improve prognosis. American guidelines suggest that the surgeon should have <6% peri-procedural CVA and death rates for the procedure to be useful.21

Asymptomatic

The value of CEA in asymptomatic ICA stenosis is less clear. Three small initial trials failed to show a benefit, but may have been underpowered to do so.2224 However, there are now two larger trials which have shown positive results12,25 (Table 26.1).

The Asymptomatic Carotid Atherosclerosis Study (ACAS) studied 1662 patients under the age of 80 with >60% ultrasound stenosis, randomizing them to CEA or medical therapy.25 At five years, the risk of ipsilateral CVA or death was reduced from 11% to 5.1% by CEA. The value of the procedure in women was not proven.

The Asymptomatic Carotid Surgery Trial (ACST) randomized 3120 patients, and again used >60% stenosis on ultrasound as the entry criterion, and showed that after five years, ipsilateral CVA or death rate was reduced from 11.8% to 6.4% by CEA.12

So, in asymptomatic patients, a stenosis of >60% could be treated, if the patient is male, <80-years-old, and has a good chance of living for five years. Since the benefits was mainly in those with >75% stenosis, this is a more robust cut-off to use, matching an angiographic stenosis of 50% by NASCET criteria (Fig. 26.3).

It should be recalled that the background event rate is <2% stroke risk per year, which would be reduced to 1% by the procedure. This compares well with the risk reductions offered by lipid lowering therapy, or comparing the benefit of Clopidogrel over Aspirin in patients with vascular disease.26–27 American guidelines suggest that the surgeon should have a <3% peri-procedural CVA and death rate for asymptomatic patients for the procedure to be useful.21

Pre-cardiac surgery

Those patients with asymptomatic ICA stenoses facing CABG or valve surgery have elevated peri-operative CVA risk. Whether carotid intervention is beneficial in some or all is controversial, since CEA itself can carry a higher risk in the presence of severe cardiac disease.28 A review of the limited data suggests that the hemodynamic consequences may not be relevant with a unilateral stenosis, but if the numerical addition of the stenoses of the ICA on both sides is >140%, then intervention on the more severe side is acceptable.29 If brain imaging suggests an inadequate collateral supply to the hemisphere supplied by a tight carotid stenosis, then this unilateral stenosis may be worth treating. On the basis of the SAPPHIRE trial (see below), CAS would seem the more appropriate therapy in such cases.30

CAS versus CEA

Trials of CAS versus medical therapy are unlikely to be performed as CEA has been shown to be better than medical therapy in patients with significant ICA stenosis. Thus, on-going trials would need to confirm that CEA and CAS are equivalent if CAS is to become the mainstay of treatment for ICA stenosis. There are patients, however, who have been shown to be at elevated operative risk, and who might benefit from a percutaneous approach if risks were shown to be lower.28,3133 (Table 26.2).

TABLE 26.2 INDICATION TO PERFORM CAS RATHER THAN CEA

CONDITION DETAILS
High Medical Age >80
Co-morbidity Coronary disease (CAD) with acute myocardial infarction (AMI) <4 weeks ago
Any severe CAD
Congestive cardiac failure
Dialysis dependant renal failure
Chronic airways disease (FEV1 <1 L)
Uncontrolled diabetes mellitus
Local surgical factors Restenosis after Endarterectomy (CEA)
Radiation induced Carotid stenosis
Anatomically high ICA stenosis (above C2)
Prior neck scarring or surgery
Contralateral recurrent laryngeal nerve (RLN) injury
Contralateral internal carotid artery occlusion

CEA carries risks, including CVA, surgical haematoma, cranial nerve injury and risks related to anaesthesia.34 These risks in real life are higher than those reported in the trials, both due to patient and indeed operator selection, since the best and largest volume operators often participate in these studies.35 The same operator volume dependency has also been seen for CAS, with early cases having a higher complication rate than later ones, the so-called ‘learning curve’.36 Even in early experience of 528 cases of CAS from Roubin et al., however, the safety of CAS became clear. Despite 83% of the symptomatic patients being ineligible for CEA by NASCET criteria due to co-morbidity, 30-day CVA and death rates were 7.4%, comparable to those for CEA in the NASCET trial.

There are now two published randomised trials of CAS against CEA. The Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS) randomised 504 patients with symptomatic ICA stenosis to balloon angioplasty (only 26% got a stent) or CEA. This showed that 30-day stroke and death rates were equivalent in both arms at 9%, but that hematomas and cranial nerve injuries were higher in the CEA arm (Fig. 26.1). Although it was argued that the peri-operative risk was too high in the CEA arm, these were experienced surgeons who had participated in previous trials, and in fact it was CAS, which was still a novel procedure, without the use of DPDs, that should have been disadvantaged.37

The Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) study was the first trial to compare CEA with modern CAS utilising DPD.30 All patients were considered high risk (Table 26.2). A total of 723 patients were enrolled with stenoses of >50% if symptomatic or >80% if asymptomatic. Of these, 307 were randomised to CAS versus CEA. However, 409 were considered unsuitable for CEA and were put in the CAS registry, whilst only seven patients were considered unsuitable for CAS, and were placed in the CEA registry. All CAS procedures were done with the Angioguard DPD and Precise stent (Cordis, Johnson and Johnson). The outcome of 30-day stroke and death rate was 3.1% for CAS versus 3.3% for CEA (p=ns). More interestingly, the rate in the stent registry was also only 3% (Fig. 26.2). Myocardial infarction was defined as rise of creatinine kinase twice the upper limit of normal. The combined endpoint of the study (death/CVA/MI) occurred in 5.8% of the CAS group versus 12.6% of the CEA group (p=0.047). The same trend was seen in asymptomatic and symptomatic patients, and was maintained at one year.

Thus, in higher risk patients with symptomatic or asymptomatic ICA stenosis, results of CAS are as good if not better than CEA. On this basis, CAS is a reasonable alternative strategy to be offered to such patients.

For lower risk patients, results of ongoing trials are awaited, but there appears no logical reason to assume CAS will not also be the treatment of choice in this larger cohort.3840,41

Key investigations

Carotid duplex scanning

Due to ease of access, the carotid duplex ultrasound scan has become the screening tool of choice. There is considerable skill involved in performing and interpreting the scan. There is a correlation between stenosis assessed at angiography and duplex measurement (Fig. 26.3). Attempts have been made to try to improve plaque characterisation, and these may develop further with the advent of virtual histology. There is some data to suggest that plaque morphology predicts outcome after intervention, although the jury is still out.42,43

TECHNIQUE FOR CAS

Planning and pre-treatment

Gaining a stable working platform

The patient should be comfortable with a head cushion to maintain a stable position. There should be electrocardiographic and haemodynamic monitoring attached. An intravenous line should be available and functional.

A standard technique should be employed to gain familiarity with the approach (Table 26.3). Various catheter shapes are available to try to intubate the common carotid artery selectively, including Vitek, Berenstein and Sidewinder. Problems arise with a bovine origin of the left CCA or deep-seated origins of the great arteries (Fig. 26.4). Most commonly the procedure used by radiologist involves a long sheath as the conduit, whilst cardiologists prefer a 7 F or 8 F guide catheter. Care needs to be taken not to perforate a branch of the ECA with the stiff wire used to support placement of the guide catheter. The ability to store a roadmap of the lesion allows easy passage of the angioplasty wire or DPD.

TABLE 26.3 SUMMARY OF TECHNIQUE TO PERFORM CAROTID ARTERY STENTING IN STANDARD CASES.

MODIFIED FROM HOBSON ET AL.55

Distal filter

Proximal occlusion

Distal balloon occlusion requires crossing the ICA lesion with the device, inflation of a low pressure balloon to block the passage of debris distally during CAS, and removal of debris by aspiration prior to the end of the procedure. Because blood flow is interrupted, the patient may become restless due to cerebral hypoperfusion. Therefore, the CAS procedure must be completed within a few minutes.

Filter DPDs use 80–100 micron filters inserted via the guide catheter or sheath, and deployed beyond the ICA stenosis. The blood flow is maintained, and so the procedure is better tolerated. However, movement of the device can result in spasm or even dissection of the ICA, and if apposition is not perfect, some debris can still pass upwards to the brain. The device is re-captured after the CAS procedure and withdrawn through the stent.

The third device involves the proximal occlusion of the CCA and the external carotid artery (ECA). A large catheter with an extension arm for the ECA is advanced into the CCA. Occlusion balloons mounted on the catheter are inflated in the CCA and then the ECA. This creates a negative pressure in the ICA and should allow the collaterals in the circle of Willis to produce reverse flow, preventing distal embolisation into the ICA. The stent procedure is then performed and aspiration performed to clear debris from the ICA prior to device removal.

Balloon, stent and closure

Once the DPD is in place, if the lesion is tight, with less than a 2 mm diameter, or looks calcified, the pre-dilatation with a 3 mm × 20 mm balloon is recommended. Direct stenting may be performed for less severe stenoses. It is vital to give atropine 600 micrograms prior to balloon inflation. Failure to do so will result is bradycardia and hypotension which can be difficult to manage and may be prolonged.

Complications and management

General complications common to all percutaneous vascular procedures, such as femoral puncture complications, bradycardia, and hypotension are dealt with elsewhere. This section will focus on those related to CAS specifically.

Perforation of ECA

If seen on angiography, then bleeding is occurring at a rate of at least 3 ml/minute.48 Continued bleeding may cause substantial sub-glottic swelling and may necessitate intubation to protect the airway. If conservative management fails, there may be a need to embolise the branch of the ECA that is bleeding with a coil, glue or foam.49

CONCLUSIONS

CEA is not as invasive as CABG surgery, whilst CAS carries higher risks than PCI since the brain is more unforgiving than the myocardium. However, as with the coronary field, the move towards the development of less invasive treatments is unrelenting and with the appropriate training, many interventionalists will be able to perform CAS safely. As with coronary intervention, case selection in the early phase of the ‘learning curve’ will allow the program to develop. The more difficult lesion can still be referred for CEA until sufficient catheter skills have developed (Fig. 26.5).

It is important to pay attention to initial patient selection and appropriate investigation. This is best done in the context of a multi-disciplinary team (MDT). Selection of technique to be employed, choice of equipment, and meticulous pre-operative, peri-operative and post-operative care is vital to ensure that the procedure is performed at lowest possible risk. Careful liaison with the MDT allows clinical governance and audit to be transparent and honest.

The evidence base comparing CAS to CEA is enlarging, with both registry and trial data. There is a position of clinical equipoise in low-risk patients, but for high risk patients, if an intervention is planned, CAS makes a strong case to be the favoured treatment.

A review by NICE in the UK is awaited, but present guidelines on the management of stroke suggest that CAS is a rapidly evolving procedure and encourage those performing stenting to take part in the ICSS trial (http://www.nice.org.uk/page.aspx?o=218167).

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