Published on 04/03/2015 by admin
Filed under Hematology, Oncology and Palliative Medicine
Last modified 04/03/2015
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Chapter 76
Laura Doyon, Alexander Greenstein and Adrian Greenstein
• Small bowel tumors are rare, with incidence of less than 10% of new gastrointestinal cancer diagnoses and less than 1% of all new diagnosed cancers each year.
• Genes involved include APC and KIT and mismatch-repair genes.
• Malignant small bowel tumors consist of carcinoid (37.4%), adenocarcinoma (36.9%), lymphomas (17.3%), and gastrointestinal stromal tumors (GISTs) (8.4%).
• Staging is based on the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system. Gastrointestinal (GI) lymphoma is staged with the Ann Arbor system based on lymphatic and extra lymphatic involvement above and below the diaphragm.
• Primary therapy for small bowel neoplasms is surgical resection. Appropriate lymphadenectomy must be performed for adenocarcinoma and carcinoid tumors.
Abeloffs Clinical Oncology Review
