Cancer of the Penis

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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Cancer of the Penis

Jonathan E. Heinlen and Daniel J. Culkin

Summary of Key Points

Incidence

• Penile cancer is rare in developed countries, but responsible for a large proportion of solid tumors in males where sanitation and medical care are poor.

Biological Characteristics

• Most penile cancer is squamous cell carcinoma and many are associated with high-risk human papilloma virus (HPV) infection.

• Presentation is typically with localized disease with predictable spread to regional lymph nodes preceding widespread metastasis.

Primary Therapy

• Penile sparing treatment is indicated for minimally invasive disease

• Penectomy remains the standard of care for invasion into corpora or urethra.

• Radiation has a growing role in the treatment of small lesions.

Adjuvant Therapy

• Lymphadenectomy remains an important element of treatment in men with intermediate- and high-risk disease.

• Sentinel lymph node biopsy is gaining acceptance using newer techniques

Locally Advanced Disease and Palliation

• Multimodal therapy is investigational for advanced disease.

• Treatment of bladder outlet obstruction is an important consideration

Treatment of Metastatic Disease

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