Cancer of the Kidney

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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Chapter 82

Cancer of the Kidney

Summary of Key Points

• Renal cell carcinoma (RCC) accounts for 3% of malignancies in adults.

• Cigarette smoking (in more than 20% of cases) and obesity (in more than 30%) are established causal factors for RCC.

• Four percent of cases of RCC arise from hereditary syndromes.

• Different subtypes of RCC are characterized by distinct clinical behavior, genetic abnormalities, and molecular signatures.

• Clear cell RCC is the most common histologic subtype, representing approximately 70% of all sporadic RCCs.

• The von Hippel-Lindau tumor suppressor gene is genetically and epigenetically altered in more than 75% of sporadic cases of clear cell RCC.

• Prognosis for RCC is dependent on tumor histologic type, grade, and stage.

• Nephron-sparing surgery has become the gold standard, when feasible.

• Follow-up guidelines for resected RCC include history, physical examination, periodic metabolic panels, and abdominal and chest computed tomography (CT) studies 4 to 6 months after surgery.

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