Basophil maturation

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 22/04/2025

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8 Basophil maturation

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FIGURE 8–1 Basophilic sequence—Basophil. Maturation parallels that of the neutrophil; however, immature stages are very rare and generally seen only in basophil proliferative disorders.

Basophil

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FIGURE 8–2A Basophil.

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FIGURE 8–2B Basophil. Note that granules are water-soluble and may be dissolved during the staining process, leaving clear area in the cytoplasm.

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FIGURE 8–2C Electron micrograph of basophil (×28,750).

Size:

10-14 μm

Nucleus:

Usually two lobes connected by thin filaments without visible chromatin

Nucleoli:

Not visible

Chromatin:

Coarse, clumped

Cytoplasm:

Lavender to colorless

Granules:

Primary:

Rare

Secondary:

Variable in number with uneven distribution, may obscure nucleus (Figure 8-2A); deep purple to black; irregularly shaped. Granules are water-soluble and may be washed out during staining; thus they appear as empty areas in the cytoplasm (Figure 8-2B).

N/C RATIO:

Cytoplasm predominates

Reference interval:

Bone marrow:

<1%

Peripheral blood:

0% to 1%

Refer to Table 1-1 for more examples.

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FIGURE 8–3 Maturation parallels that of the neutrophil; however, immature stages are very rare and generally seen only in basophil proliferative disorders. (A) Basophil.

All photomicrographs are ×1000 original magnification with Wright-Giemsa staining unless stated otherwise.

All photomicrographs are ×1000 with Wright-Giemsa stain unless stated otherwise.

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