Aortic stenosis

Published on 02/04/2015 by admin

Filed under Internal Medicine

Last modified 22/04/2025

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5 Aortic stenosis

Salient features

Examination

Advanced-level questions

What investigations would you do?

Note: The degree of aortic stenosis is graded as mild (valve area >1.5 cm2), moderate (>1.0 to 1.5 cm2) or severe (≥1.0 cm2).

ECG usually shows left ventricular hypertrophy, ST–T changes, possibly left axis deviation, later left atrial hypertrophy (negative P waves in V1), conduction abnormalities from calcification of conducting tissues (first-degree heart block, left bundle branch block).

Chest radiograph may show cardiac enlargement, post-stenotic dilatation of aorta (a bicuspid valve should be suspected if the proximal aorta is greatly enlarged), calcification of aortic valve (particularly in older patients) (Fig. 5.3).

Echocardiography is useful in:

Exercise testing in adults with aortic stenosis has been discouraged largely because of safety; it should not be performed in symptomatic patients as it may be fatal; in asymptomatic patients an abnormal haemodynamic response (e.g. hypotension) is sufficient to consider aortic valve replacement. In selected patients it may be useful to provide a basis for advice about physical activity.

Cardiac catheterization is done to assess the coronary circulation and to confirm or clarify the diagnosis. When the echocardiogram is inadequate, cardiac haemodynamics using both left- and right-heart catheterization is indicated and requires:

How would you manage this patient?

If the patient is asymptomatic and the valvular gradient is <50 mmHg, then observation. Surgery is not recommended in asymptomatic patients.

Valve replacement in the following circumstances:

Often, patients require coronary artery bypass grafts during aortic valve replacement.

Balloon valvuloplasty should be limited to moribund patients requiring emergency intervention or those with a very poor life expectancy from other pathology. In one study, although in-hospital mortality rates were similar to those following conventional surgical replacement, there were more deaths in the valvuloplasty group in the subsequent follow-up period (J Am Coll Cardiol 1992;20:796–801).