Antipsychotics

Published on 23/05/2015 by admin

Last modified 23/05/2015

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4 Antipsychotics

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1. Atypical antipsychotics have a longer D₂ receptor occupancy than typical antipsychotics.
2. Clozapine is a potent D₂ antagonist.
3. Clozapine dissociates from D₂ receptors slowly.
4. Clozapine antagonizes D₃ and D₄ receptors.
5. Clozapine causes less postural hypotension than typical antipsychotics.
6. Clozapine produces less sedation than typical antipsychotic drugs.
7. Clozapine is contraindicated in the elderly.
8. The risk of clozapine-induced seizures is dose-related.
9. Aripiprazole is a D₂ partial agonist.
10. Olanzapine causes diabetes mellitus only at doses above 20 mg.
11. Quetiapine causes clinically significant hyperprolactinaemia.
12. Quetiapine has antihistaminic properties.
13. Quetiapine has a half-life of 6 hours.
14. Risperidone induces less akathisia than clozapine.
15. Akathisia usually starts within a week of initiating treatment with antipsychotics.
16. Neuroleptic malignant syndrome is characterized by gradual onset.
17. Neuroleptic malignant syndrome is associated with clear consciousness.
18. Neuroleptic malignant syndrome can be treated with a combination of a dopamine agonist and a calcium channel blocker.
19. Tardive dyskinesia can occur in antipsychotic naïve patients.
20. The prevalence of tardive dyskinesia in people on long-term antipsychotic treatment is more than 50%.
21. Tardive dyskinesia disappears during sleep.
22. Procyclidine can cause visual hallucinations.
23. Physical dependence can occur in long-term procyclidine use.
24. Antimuscarinic drugs are useful in the treatment of acute dystonia.
25. Bradykinesia responds better to antimuscarinic drugs than rigidity.