3 Antidepressants
| T | F | |
|---|---|---|
| 1. Antidepressants relieve pain mainly by their antidepressant effect. |  |
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| 2. Amitriptyline decreases REM sleep in the elderly. |  |
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| 3. Clomipramine is used for studies of noradrenaline neurotransmission. |  |
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| 4. Duloxetine is an SNRI (serotonin-noradrenaline reuptake inhibitor). |  |
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| 5. Bifrontal ECT (electroconvulsive therapy) is effective in depression. |  |
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| 6. ECT is contraindicated in patients with cognitive impairment. |  |
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| 7. Retrograde amnesia is a side-effect of ECT. |  |
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| 8. EEG (electroencephalogram) change is still apparent 2 months after ECT. |  |
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| 9. ECT and amitriptyline have synergistic action. |  |
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| 10. Bilateral ECT is more rapidly effective than unilateral ECT in severe depression. |  |
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| 11. Memory problems improve towards the end of a course of ECT. |  |
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| 12. Imipramine and CBT (cognitive behavioural therapy) are equally effective in treating moderate depression. |  |
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| 13. Erectile dysfunction is more common than ejaculatory failure with clomipramine. |  |
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| 14. mCPP is a 5-HT2A antagonist. |  |
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| 15. Mirtazapine is an antagonist at H1 receptors. |  |
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| 16. Mirtazapine causes indirect 5-HT1A stimulation. |  |
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| 17. Moclobemide does not cause a tyramine reaction. |  |
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| 18. Pindolol blocks postsynaptic 5-HT1A receptors. |  |
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| 19. Reboxetine blocks 5-HT2 receptors. |  |
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| 20. SSRIs cause insomnia due to their action on the 5-HT2A receptor. |  |
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| 21. Tricyclic antidepressants (TCAs) can cause peripheral neuropathy. |  |
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| 22. TCAs increase REM latency. |  |
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| 23. Gastric lavage is of no use 6 hours after severe TCA overdose. |  |
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| 24. Venlafaxine has a half-life of 12 hours. |
