1 INTRODUCTION

Obstructive sleep apnea syndrome (OSAS) is characterized by intensive snoring and daytime sleepiness, due to repeated obstruction of the upper airway during sleep. OSAS is defined as periods of complete cessation of oronasal airflow for a minimum of 10 seconds (apnea) and periods of more than 30% reduction in oronasal airflow, accompanied by a decrease of more than 4% in ongoing paO₂ (hypopnea), with an Apnea/Hypopnea Index (AHI) of more than 5, accompanied by daytime symptoms.¹ The prevalence of obstructive sleep apnea in the middle-aged is 2% of women and 4% of men.² It has been estimated that at least 80% of all moderate and severe OSAS in the general population is likely being missed.³

OSAS has adverse effects on daytime quality of life such as daytime sleepiness and diminished intellectual performance. OSAS is of growing significance because of its increasingly recognized high incidence and association with neurocognitive symptoms and cardiovascular disease.^4,5 In severe OSAS there is an increased risk of being involved in traffic accidents.^6,7 Therefore OSAS is treated for its symptoms, in the attempt to reduce morbidity and mortality.

In 1981 nasal continuous positive airway pressure (NCPAP), which acts as a pneumatic splint, was introduced as treatment of OSAS and has been considered the gold standard for treatment of severe OSAS since (Fig. 10.1A & B).⁸ It is a safe therapeutic option with few contraindications or serious side effects.⁹ Unfortunately many patients experience NCPAP therapy as intrusive and the acceptance and (long-term) compliance of NCPAP are at best moderate. A vast body of literature was published in the last decade on the subject of (long-term) compliance of NCPAP, with rates ranging from 46% to 89%.^10–23 Improvements in NCPAP technology, in particular the introduction of automatic adjustments of the NCPAP pressure throughout the night (auto-CPAP), and attempts to enhance acceptance and compliance have been introduced.^24–32 We were interested to see if these actions have led to better acceptance and compliance as compared to earlier reported data.

Fig. 10.1 A, without NCPAP. Obstruction of the upper airway during sleep, in this case at both retropalatal and retrolingual level. B, With NCPAP. The positive intraluminal pressure keeps the upper airway open.

2 METHODS

We acquired data on (long-term) compliance and therapy failure by sending questionnaires to 256 patients who were offered NCPAP in the past.

3 RESULTS AND DISCUSSION

OSAS represents a relatively new disease entity, and is currently the most dynamic area in otolaryngology/head and neck surgery, with regard to both diagnostic work-up and therapy.

Treatment of OSAS consists of lifestyle changes (weight reduction, cessation of alcohol misuse, sleep hygiene), and can be subdivided into conservative treatment (oral device or NCPAP), surgery to (minimal invasive to invasive) and combined modalities.

NCPAP has come to be regarded as the gold standard treatment for OSAS in the last decade.³³ In the pioneering phase of management of OSAS this view was understandable as uvulopalatopharyngoplasty (UPPP) was the almost exclusively surgical alternative for OSAS treatment. Metaanalysis by Sher et al. in 1996 showed a success rate of UPPP (in unselected patients) of only 40%.³⁴

NCPAP therapy in severe OSAS is successful if it is accepted by the patient. Unfortunately only a limited number of patients are compliant with NCPAP therapy. Many patients refuse its use upfront, or experience problems such as leakage, dry eyes, and blocked nasal passage. Many patients use NCPAP on only a few days per week, and/or only a limited number of hours per night. NCPAP is also troublesome for patients who travel often or sleep on camping grounds. The use of NCPAP therapy does not improve the anatomy of the upper airway, and patients remain dependent on its use lifelong.