Acute coronary syndromes

Published on 14/03/2015 by admin

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Chapter 7 Acute coronary syndromes

Symptoms and signs which may indicate an acute coronary syndrome (ACS) need to be identified as soon as possible, ideally by the patient, so that treatment can be initiated to avoid or minimise myocardial damage and to avert the risk of life-threatening complications. A defibrillator must be immediately available with staff trained in its use. Assign a high priority at triage to patients with a history of chest pain, breathlessness, syncope or palpitations. Provide ECG monitoring and supplemental oxygen and insert an intravenous cannula as soon as possible. Send blood samples for testing and provide analgesia (nitrates and/or morphine) and, unless contraindicated, give oral aspirin (300 mg).

Cardiac risk factors increase the likelihood of cardiac disease, particularly in those under the age of 40; however, their absence does not exclude the diagnosis. Atypical pain or even the absence of pain is also relatively common (e.g. in diabetics and the elderly), and observation and investigation over a period of time may be required in some cases.

DIAGNOSING AND STRATIFYING ACUTE CORONARY SYNDROMES

History, examination, investigation and management proceed rapidly and concurrently and senior staff should be contacted as soon as possible (see Figure 7.1).

Typical presentations of ACS involve chest discomfort at rest or for prolonged periods (prolonged is defined as > 10 minutes, not relieved by sublingual nitrates) or recurrent chest discomfort or discomfort associated with syncope or acute heart failure.

Some important points of immediate history include the time of onset of pain, exertionally-related pain, risk factors and comorbidities, allergies and contraindications to treatments.

Physical examination may show tachycardia or bradycardia, hyper- or hypotension, sweating, nausea or evidence of heart failure (dyspnoea, basal crepitations, third heart sound, poor peripheral perfusion). Importantly there may be no specific physical findings in some patients with ACS.

Note that although cardiac myonecrosis is demonstrated by increased levels of cardiac biomarkers (troponins, creatine kinase-myocardial band (CK-MB)) and can occur in ACS with or without ECG changes, the indication for initial urgent reperfusion therapy is acute ECG change.

Tests to include are listed in Table 7.2.

Table 7.2 Tests to aid in the diagnosis and stratification of patients with ACS

Test Comment
Full blood count Anaemia or polycythaemia may need treatment, baseline platelet count (particularly if heparin is to be used)
Coagulation PT and APTT Guides anticoagulant therapy
Serum chemistry

Renal function Troponin I or T∗∗ May take up to 6 hours to rise, two or more measurements over time may be required; remains elevated 5–14 days Serum lipids Initiating treatment of hyperlipidaemia within the first few days may be required Blood glucose Diabetes may be undiagnosed (especially mild NIDDM); close control of blood glucose levels improves outcomes Chest X-ray May show heart failure, cardiomegaly. Do not delay urgent treatment to obtain a CXR. Do not send potentially unstable patient out of resuscitation monitoring area for CXR

APTT, activated partial thrombin time; CXR, chest X-ray; eGFR, estimated glomerular filtration rate; NIDDM, non-insulin dependent diabetes mellitus; PT, prothrombin time

Additional tests such as high-sensitivity C-reactive protein (CRP) and B-type natriuretic protein (BNP) or Pro-BNP are still being evaluated. In some settings bedside cardiac echocardiography can be valuable as it may be able to provide information on wall motion (myocardial ischaemia or infarction), ejection fraction (heart failure, systolic or diastolic dysfunction), valvular disease (aortic stenosis, acute mitral valve chordae disruption), free wall rupture, aortic or pericardial disease. Drug screening (cocaine, amphetamines) may be relevant. An alternative diagnosis of pulmonary embolism can sometimes be made when significant right heart abnormality is seen on echo.

∗∗