Acquired Disorders

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Chapter 102

Acquired Disorders

Acquired disorders of the stomach in children are not common and can be conceptualized as disorders with an underlying congenital predisposition (e.g., gastric volvulus), as inflammatory (e.g., peptic ulcer disease), and as tumors or tumor-like conditions. From a radiologic point of view, fluoroscopic contrast studies remain the mainstay of diagnostic examinations for most abnormalities of the stomach. However, depending on the specific concern and underlying clinical conditions, the stomach can also be evaluated with cross-sectional imaging such as ultrasound and computed tomography (CT), as well as nuclear medicine studies.

Gastric Volvulus

Etiology: Normally, the stomach is relatively fixed in the peritoneal cavity at the esophagogastric junction, with four additional ligaments: (1) gastrohepatic, (2) gastrosplenic, (3) gastrocolic, and (4) gastrophrenic (Fig. 102-1) Gastric volvulus is defined as an abnormal rotation of the stomach of more than 180 degrees around its long (organoaxial) or short (mesenteroaxial) axes (Fig. 102-2, A and B), causing a closed loop obstruction, with consequences such as incarceration, strangulation, and perforation.1 Predisposing factors for gastric volvulus include congenital or acquired absence of one or more ligaments as isolated abnormalities or conditions such as asplenia and diaphragmatic defects.

In organoaxial gastric volvulus, an inversion of the position of the greater and lesser curves of the stomach occurs, with the greater curvature positioned to the right and superior to the lesser curvature. In mesenteroaxial gastric volvulus, the stomach folds on its short axis; this leads to reversal of the relationship between the gastroesophageal junction and the pylorus. Clinically, two primary scenarios exist. The first is the acute fulminant presentation, most often encountered in the mesenteroaxial type, with sudden and persistent vomiting and acute abdominal pain.1 The chronic intermittent presentation is more often associated with the organoaxial type, with less specific symptoms, including recurrent abdominal pain, vomiting, and gastric distension.2

Imaging: Abdominal radiographs in patients with gastric volvulus typically show marked gastric distension. The stomach becomes spherical, with paucity of distal bowel gas, indicating gastric outlet obstruction (Fig. 102-3, A). Other findings include diaphragmatic elevation and the presence of two air-fluid levels in the stomach. Occasionally, the type of gastric volvulus can be inferred by the gastric configuration: a pylorus projecting over the gastric fundus and an unusual nasogastric tube course are suggestive of the mesenteroaxial type, whereas an inversion of the relationship of the greater and lesser curvatures is suggestive of the organoaxial type; mixed types also occur, with combined imaging findings.

Although, in most cases, plain radiographs are highly suggestive of the diagnosis, the upper gastrointestinal (UGI) series remains the diagnostic procedure of choice, demonstrating the type of volvulus and evidence of gastric outlet obstruction. If performed, other imaging modalities such as CT can also be useful in demonstrating the abnormal orientation of the stomach (see Fig. 102-3, B) as well as associated anomalies such as heterotaxy or the presence of pneumatosis.2

Spontaneous Gastric Perforation

Etiology: Spontaneous perforation of the stomach is an uncommon event mainly seen in the neonatal period as a cause of pneumoperitoneum.5 The etiology is unknown, but possibilities include sudden gastric distension with a degree of ischemia attributable to perinatal hypoxia, a more distal bowel obstruction, and congenital focal absence of the muscle of the gastric wall.68 Beyond the neonatal period, perforation is rare and usually secondary to trauma (tubes, catheters), surgery (fundoplication), caustic ingestion, or peptic ulcer.1 The most common presenting manifestations of perforation include sudden onset of abdominal distension, ileus, respiratory distress, and, less frequently, cyanosis, fever, vomiting, and bloody stool.9

Gastritis and Gastropathy

Gastritis is a nonspecific term that refers to the presence of inflammatory cells within the gastric wall; the diagnosis is made histologically, as the mucosa may appear normal at endoscopy. It differs from gastropathies, which demonstrate evidence of epithelial damage and regeneration but have little in the way of inflammatory infiltrate, and are often associated with specific conditions such as portal hypertensive gastropathy.

In children, inflammatory changes in the stomach can result from several etiologies, including infections (e.g., secondary to Helicobacter pylori), severe stress (e.g., during a serious illness), chemicals (e.g., ingestion of corrosive substance), eosinophilic gastritis, hypertrophic gastropathy (Ménétrier disease of childhood), and secondary to other systemic entities such as Crohn disease and chronic granulomatous disease.

Peptic Ulcer Disease

Etiology: Peptic ulcer disease represents ulceration of the gastric or duodenal mucosa resulting from, on the one hand, an imbalance between the mucosal protective mechanisms and, on the other, the aggressive factors of acid and pepsin production, injury, and infection.11 The gel layer, a protective bicarbonate and mucous barrier lining the stomach, is approximately 0.2 to 0.5 mm in thickness and consists of 95% water and 5% mucin glycoprotein. Breaches in this gel layer, secondary to H. pylori or antiinflammatory drugs, result in a continuum of damage to the underlying mucosa, with ulceration occurring when damage extends to the muscular layer.

Peptic ulcer disease in children may be primary or secondary (induced by drugs, alcohol, stress, or metabolic disease), with each form having different manifestations and prognostic implications. H. pylori has been recognized as a common human pathogen associated with both inflammatory and malignant conditions of the upper gastrointestinal tract, and affects nearly all children with peptic ulcer disease.12 Primary peptic ulcers are associated with H. pylori infection.

In addition to being classified as primary and secondary, peptic ulcers can also be classified according to the site of involvement (gastric or duodenal). Gastric ulcers are mostly seen in neonates and young children, whereas duodenal ulcers are more common after the neonatal period and tend to be secondary to systemic illness or chronic intake of medications such as non-steroidal antiinflammatory agents. Zollinger-Ellison syndrome causes secondary peptic ulcer disease, often with multiple ulcerations caused by increased acid generated by a gastrin-producing tumor (Fig. 102-4).11,13

Symptoms of ulcer disease vary with age; infants and young children present with feeding problems and vomiting. In some patients, the first sign of peptic ulcer disease may be upper or lower GI hemorrhage or acute severe abdominal pain due to perforation. Pain can be nocturnal or occur early in the morning. Unlike in adults, the pain is neither precipitated nor relieved by meals or antacid use.11

Imaging: Endoscopy has assumed the primary role in the diagnosis of ulcer disease over the past two decades, while the role of the radiologist has dramatically decreased and is now limited to the incidental case, as UGI contrast studies have been demonstrated to have a high false-negative rate for ulcer detection.14,15 However, these studies, as an initial tool to evaluate the child with abdominal pain and vomiting, may incidentally demonstrate the ulcer. Perforated ulcers may be incidentally identified on CT in the evaluation of a child with acute abdominal pain (Fig. 102-5).

Hypertrophic Gastropathy (Ménétrier Disease)

Etiology: Hypertrophy of the gastric rugal folds, in association with protein-losing enteropathy, in childhood is labeled Ménétrier disease, or hypertrophic gastropathy of childhood.16 The clinical, pathologic, and etiologic factors of this disease in children differ from those of the adult form. In adults, the disease is chronic and premalignant. In children, the disease is self-limiting, with a peak age of presentation of 5 years. Presentation includes acute vomiting, diarrhea, upper abdominal pain, and anorexia. Peripheral edema is usually present and may be associated with ascites and pleural effusions. Rarely, signs of GI bleeding occur with coexisting ulceration of the gastric rugae. The etiology of the disease remains unknown; however, it has been previously associated with several infectious agents, including cytomegalovirus, H. pylori, mycoplasma, herpes virus, and Giardia lamblia.

Imaging: Diagnosis is most commonly made with UGI contrast studies demonstrating thickened gastric mucosal folds in the fundus and body, sparing the antrum and pylorus, with normal appearance of the small bowel.17 Ultrasound has also been successfully used in diagnosis.18 On the CT scan, similar findings of thickened rugal folds in the fundus and body of the stomach can be seen, with sparing of the antrum (Fig. 102-6). Endoscopy confirms the diagnosis. Differential diagnosis includes eosinophilic gastritis, primary gastric lymphoma, gastric carcinoma, inflammatory pseudotumor, gastric varices, Zollinger-Ellison syndrome, lymphangiectasia, and anisakiasis if there is a history of ingestion of raw fish.16

Treatment and Follow-up: The disease in children is self-limiting, as mentioned above.16 After correction of hypoproteinemia, complete clinical recovery usually occurs within 2 to 4 weeks, although symptoms found on radiologic and endoscopic assessment may require months to resolve.19

Chronic Granulomatous Disease

Etiology: Chronic granulomatous disease (CGD) of childhood is a hereditary disorder of neutrophil function, which is typically inherited as an X-linked recessive disorder, but three autosomal recessive defects have also been identified. The genetic alteration leads to a defect in activation of the NADPH (nicotinamide adenine dinucleotide phosphate-oxidase) molecule within the phagocyte, preventing the formation of free radical superoxide in the “respiratory burst,” and resulting in survival of catalase-positive organisms within the phagocytes, with chronic inflammatory reaction and granuloma formation.20 In the stomach, narrowing of the gastric antrum is a distinctive manifestation of CGD, occurring in 16% of cases.21 Gastric outlet obstruction occurs in the X-linked recessive form more commonly than in the autosomal recessive form and presents at a mean age of 44 months, usually with severe vomiting.22 Histologically, a granuloma forms within the involved antral wall; however, the etiology of the antral wall thickening is unclear, as an infectious agent is not typically isolated.23

Imaging: A patient with CGD and signs of gastric outlet obstruction should be initially evaluated with either an ultrasound or a UGI contrast study. The patient’s medical history is vital to obtain the correct diagnosis. Ultrasound demonstrates the circumferential antral wall thickening. The UGI contrast study shows concentric antral narrowing and evaluates the degree of gastric obstruction.21 To detect the gastric wall thickening on CT, the stomach should be distended. Although CT is not the primary modality to assess gastric involvement, it may be helpful in identifying disease in other areas of involvement such as mesenteric adenopathy and hepatic or splenic involvement. The differential diagnosis of gastric antral involvement includes peptic ulcer disease, Crohn disease, (Fig. 102-7), and eosinophilic gastritis.24,25

Eosinophilic Gastritis

Gastric Tumors and Tumor-Like Conditions

Gastrointestinal Foreign Bodies

The ingestion of foreign objects is relatively common in pediatric patients. This is a potentially serious problem, with peak occurrence between 6 months and 3 years of age. However, significant morbidity occurs in only approximately 1% of the patients, with many patients remaining asymptomatic.30,31 Since some foreign bodies may remain in the stomach, it is important to identify them and be aware of complications that could occur if these foreign bodies are not removed.

Etiology: Coins and smooth, blunt objects account for most ingested foreign bodies; however, the materials commonly ingested differ, according to geography and cultural group.32 In addition to the complications related to the size and shape of the foreign object, some ingested foreign bodies such as batteries can lead to toxicity because of their chemical composition (Fig. 102-9) or to mechanical problems and pressure necrosis, as can occur after ingestion of multiple magnets.

Imaging: Approximately 64% of foreign bodies are radiopaque and can be identified on plain films.30 Non-radiopaque ingested objects include those made of wood or plastic. Images of the neck, chest, and abdomen are indicated when foreign body ingestion is suspected; the child must be imaged from the mouth to the anus. Fluoroscopic studies using water-soluble contrast may be useful in identifying cases of suspected non-opaque foreign body ingestion.32

Treatment and Follow-up: Although 90% of foreign bodies that have passed through the esophagus do so spontaneously, removal of sharp objects before they enter the duodenum is recommended.32,33 Once the foreign body has passed through the stomach, caregivers of the child are instructed to review the stool to verify that the object has been expelled. If, after a week, the child has not excreted the object, a radiograph is necessary to locate it; if it is still in the duodenum, endoscopic removal is indicated.34 Disk or button batteries require special attention and should be endoscopically removed because of the damage caused by their direct corrosive effects. If they are located within the esophagus, button batteries should be removed emergently because of the potential for burns and strictures. Removal from the stomach is more important with larger batteries that are less likely to pass spontaneously.33,35

Bezoars

Bezoars are foreign bodies within the stomach or other portions of the GI tract that form from the accretion of nondigestible materials and increase in size over time. The term bezoar originates from the Arabic word “badzehr.” The original meaning of the Arabic word was “antidote for poisons” because bezoars from animals were thought to have healing or magical powers and were used as homeopathic treatment for a wide variety of maladies such as seizure disorders and bubonic plague.36

Patients with bezoars can be asymptomatic or present with relatively nonspecific symptoms such as epigastric discomfort. Other complaints include bloating, nausea and vomiting, early satiety, halitosis, dysphagia, and failure to thrive.

Etiology: Patients with developmental delay and psychiatric illnesses such as anorexia nervosa are at increased risk for bezoars. Predisposing factors include prior gastric surgery, diabetes mellitus with gastroparesis, cystic fibrosis, intrahepatic cholestasis, and renal failure.

The three most common bezoar types are (1) trichobezoars composed of ingested hair, (2) phytobezoars composed of plant matter, and (3) lactobezoars composed of undigested milk curds (Box 102-1). Trichobezoars usually result from swallowing of multiple small amounts of hair plucked from the head or fibers from fur, rugs, or garments. The hairs or fibers become lodged in the gastric mucosal folds and over a period, an intraluminal mass develops. The bezoar forms a cast of the lumen of the stomach and a tail may extend into the duodenum as well. Additional bezoars may occur more distally in the bowel (Fig. 102-10) and occasionally may extend throughout the intestine, in which case, it is termed “Rapunzel syndrome.”36

Phytobezoars are composed of plant matter such as cellulose and fruit tannins. They develop most frequently following the ingestion of high-fiber vegetables and fruits, and in adults, they are seen most frequently in patients who have had prior surgery.

Lactobezoars (Fig. 102-11) occur in pediatric patients with a history of prematurity and who are given a highly concentrated formula; additional risk factors include poor neonatal gastric motility and dehydration.

Gastric Tumors

Etiology: Tumors of the stomach, whether primary or metastatic, are rare in children. The differential diagnosis of a gastric mass includes polyps, lymphoma, GI stromal tumor (GIST), leiomyosarcoma, teratoma, and inflammatory pseudotumor.

Polyps, which may occur anywhere along the GI tract, are the most common gastric tumors in children. Isolated gastric polyps are typically benign hyperplastic polyps or are related to pancreatic heterotopia. Polyps can be part of a syndrome such as hamartomatous polyps in Peutz-Jeghers syndrome or adenomatous polyps in Gardner syndrome and familial adenomatous polyposis. Gastric polyps may be seen in up to 60% of patients with familial polyposis syndrome, and lifelong endoscopic surveillance of these patients is warranted because of the potential for malignant transformation of adenomatous polyps.37 An increased risk of malignancy is also seen in patients with Peutz-Jeghers syndrome.3841

Primary gastric lymphoma can be divided into mucosa-associated lymphoid tissue (MALT) lymphoma and non-MALT lymphoma.42,43 MALT lesions typically arise in response to a stimulus such as H. pylori infection and are rare in children.44,45 Non-MALT primary gastric lymphomas are also rare and are usually high-grade non-Hodgkin lymphomas of B-cell origin, usually of the Burkitt type.46

GIST are mesenchymal neoplasms derived from the muscle wall of hollow viscera in the GI tract and are thought to perhaps be derived from the interstitial cells of Cajal. These tumors are very rare in pediatric patients and are thought to represent a majority of tumors previously carrying the diagnoses of leiomyomas, leiomyosarcomas, and leiomyoblastomas.47 However, unlike those tumors, GIST neoplasms are positive for c-KIT and PDGFRA kinase protein and gene mutations, although the pathology in pediatric patients may not be as clear.4850 These tumors may be found in the gastric antrum or body, are more commonly found in adolescent girls, and may be associated with pulmonary chondroma and extra-adrenal paraganglioma (Carney triad), or neurofibromatosis type-1.47,50

Leiomyoma and leiomyosarcoma are also mesenchymal neoplasms; unlike GIST, these tumors are c-KIT and PDGFRA negative but do demonstrate smooth muscle markers. They are uncommon in children, the peak age at presentation being the sixth decade. Although polypoid leiomyomas are the most common smooth muscle neoplasm arising in the GI tract, they are very rare outside of the esophagus and rectosigmoid; likewise, the malignant leiomyosarcoma in the stomach is very rare.51

Gastric teratomas comprise less than 1% of teratomas in pediatric patients and occur much more frequently in the sacrococcygeal region, the mediastinum, and gonads.52 Gastric teratomas show a striking male predominance and present early in life in neonates and infants.53,54

Inflammatory pseudotumor, also known as plasma cell granuloma, is composed of myofibroblasts, fibroblasts, histiocytes, plasma cells, and lymphocytes. It occurs most commonly in the lung but can occur rarely in the stomach. It is associated with microcystic anemia, hypergammaglobulinemia, and elevated sedimentation rate.55

Gastric neoplasms have similar presentations, which include palpable mass, GI bleeding, anemia, abdominal pain, and, less frequently, gastric outlet obstruction. In cases of lymphoma, constitutional symptoms can be present.

Imaging: Polyps can be seen on UGI contrast study series as pedunculated or sessile smooth mucosal lesions arising from the gastric wall. Adenomatous polyps are usually antral and multiple. The appearance is similar on CT, requiring appropriate gastric distension to secure the diagnosis (Fig. 102-12).56

In both the rare primary and the more common secondary gastric lymphomas, CT reveals focal or diffuse mural masses that can protrude into the gastric lumen (Fig. 102-13) or cause mass effect on adjacent structures. Multifocal intestinal involvement can be present, as well as hepatosplenomegaly and regional or distant adenopathy. On UGI, mucosal nodularity, rugal thickening, and masses with or without associated ulceration can be seen.45 CT–positron emission tomography (CT-PET) is used in the contemporary staging of lymphoma in children and to assess disease activity and involvement of distant sites, particularly in lymph nodes that do not meet size criteria for pathologic involvement.57,58

Other tumors such as GIST are seen as masses extending into the gastric lumen (Fig. 102-14) or as mass effect on adjacent structures. Extension beyond the stomach is best appreciated on cross-sectional imaging such as CT or magnetic resonance imaging. CT-PET is useful in the assessment of distant metastases.50 When calcifications are present, teratoma may be suspected.52

Treatment and Follow-up: Once the diagnosis of a mass has been suggested on imaging studies, it should prompt endoscopic evaluation and biopsy for confirmation. The treatment of gastric lymphoma, which still remains controversial, is usually chemotherapy, but H. pylori–eradicating therapy has been also advocated.59,60 CT-PET is currently used to monitor response to treatment.57,58

Resection is the first-line treatment and the only treatment that may lead to full remission in patients with primary GIST and other solid gastric tumors. It may be possible to remove smaller lesions endoscopically. In very advanced inoperable or metastatic disease, chemotherapy with targeted c-KIT tyrosine kinase inhibitors has proven very effective in GIST. CT-PET is the imaging modality of choice for monitoring the response to chemotherapy.61,62

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